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| 1 | Update on global epidemiology of viral hepatitis and preventive strategies显示文摘Viral hepatitis is one of the major public health concerns around the world but until recently it has drawn little attention or funding from global health policymakers.Every year 1.4 million people die from viral hepatitisrelated cirrhosis and liver cancer.However,the majority of the infected population are unaware of their condition.This population have significant obstacles to overcome such as lack of awareness,vulnerability,increased migration,disease stigma,discrimination,as well as poor health resources,conflict in policy development and program implementation.Despite implementing infection control measures over the last few decades eradication or significant disease reduction remains elusive.This study aims to present the current global prevalence status and examines potential elimination strategies.The information for this research were obtained through a systematic review,published scientific literatures,the official websites of various government organisations,international public health organisations and internationally recognised regulatory bodies over a period of 40 years between 1978 and2018. | Meryem Jefferies Bisma Rauff Harunor Rashid Thao Lam Shafquat Rafiq | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | Salinization Increase due to Climate Change Will Have Substantial Negative Effects on Inland Waters: A Call for Multifaceted Research at the Local and Global Scale显示文摘Globally,temperature and precipitation patterns are predicted to change markedly as a result of climate change.Particularly,the regions with a cold or hot semi-arid climate and the Mediterranean climate zone are expected to be strongly affected.1,2 A 25%–30%decrease in precipitation and increased evaporation are expected by the end of the 21st century in the Mediterranean region,to be accompanied by an even stronger reduction in runoff of up to 30%–40%,1,2 and this will lead to increasing salinization of lakes in these areas. | Erik Jeppesen Meryem Beklioglu Korhan Ozkan Zuhal Akyurek | 2020 | The Innovation2020，1，2： | 6 |
| 3 | c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1显示文摘AIM: To investigate the effect of stable c-Fos overexpression on immortalized human hepatocyte (IHH) proliferation. METHODS: IHHs stably transfected with c-Fos (IHH-Fos) or an empty vector (IHH-C) were grown in medium supplemented with 1% serum or stimulated with 10% serum. Cell proliferation was assessed by cell counts, 3H-thymidine uptake and fl ow cytometry analyses. The levels of cell cycle regulatory proteins (Cyclin D1, E, A) cyclin dependent kinases (cdk) cdk2, cdk4, cdk6, and their inhibitors p15, p16, p21, p27, to- tal and phosphorylated GSK-3β and epidermal growth factor receptor (EGF-R) were assayed by Western blot- ting. Analysis of Cyclin D1 mRNA levels was performed by reverse transcription-polymerase chain reaction and real-time polymerase chain reaction (PCR) analysis. Stability of Cyclin D1 was studied by cycloheximide blockade experiments. RESULTS: Stable c-Fos overexpression increased cell proliferation under low serum conditions and resulted in a two-fold increase in [3H]-thymidine incorpora- tion following serum addition. Cell cycle analysis by fl ow cytometry showed that c-Fos accelerated the cell cycle kinetics. Following serum stimulation, Cyclin D1 was more abundantly expressed in c-Fos overexpressing cells. Cyclin D1 accumulation did not result from increased transcriptional activation, but from nuclear stabilization. Overexpression of c-Fos correlated with higher nuclear levels of inactive phosphorylated GSK- 3β, a kinase involved in Cyclin D1 degradation and higher levels of EGF-R mRNA, and EGF-R protein compared to IHH-C both in serum starved, and in serum stimulated cells. Abrogation of EGF-R signalling in IHH- Fos by treatment with AG1478, a specif ic EGF-R tyrosine kinase inhibitor, prevented the phosphorylation of GSK-3β induced by serum stimulation and decreased Cyclin D1 stability in the nucleus. CONCLUSION: Our results clearly indicate a positive role for c-Fos in cell cycle regulation in hepatocytes. Importantly, we delineate a new mechanism by which c-Fos could contribute to hepatocarcinogenesis through stabilization of Cyclin D1 within the nucleus, evoking a new feature to c-Fos implication in hepatocellular carcinoma. | Meryem Güller Kahina Toualbi-Abed Agnès Legrand Laurence Michel Alain Mauviel Dominique Bernuau Fanny Daniel | 2008 | World Journal of Gastroenterology2008，14，41： | 6 |
| 4 | KAP Survey of Turkish University Students on Sexuality,reproductive Health,Drug Addiction and Violence显示文摘Objective To investigate the attitudes, behaviours and reflections of the university students, on sexuality, reproductive health, violence, smoking, alcohol and drug use, and to find out their expectations from a youth health service. Methods A total of 5 300 students (1 880 girls, 3 420 boys) from various faculties of Kyrykkale University were enrolled into this cross-sectional study. Students com- pleted the self-administered questionnaire as one of the researchers was present at the classroom. Research monitors five categories of priority health-risk behaviours among youth and young adults. Results Mean age of 3 420 male (64.5%) and 1 880 female (35.5%) students were 20.3 years. Among all 4 380 (82.9%) students [1 350 girls (71.8%), 3 030 boys (88.5%)] had some kinds of information about sexuality, however this dropped to 2 730 students (51.5%) within the context of adequacy. Friends were the major source (34%) for the first information on sexuality. Using a condom was the mostly heard method of contraception (46.9%) and interestingly 1.1% of the students had no knowledge on any of the protection methods. Among all 25.3% of the students (33.0% boys, 11.4% girls) had some kind of sexual intercourse, and within this group 58.8% experienced his/her first sexual relationship at 18 years of age and over; 53.9% were protected in all intercourses. Using a condom was the main way of protection for boys (63.7%) and pills were for the girls (73.9%). None of the female students mentioned having an abortion but 8% had friends who had undergone abortion. Tobacco use was 35.1% among the group, and 8.7% of the male and 3.6% of the female students were using drugs. Although 67.4% students claimed they never witnessed violence between their parents, 43.2% witnessed violence among their siblings, 67.0% beween friends, 72.6% in the streets and 64.2% in the school. About 30.0% of the students reported having weight problems, and 14.7% admitted visiting a doctor for that problem. If there would be a service provided for the adolescents in the university, 67% of thestudents would attend in case of a problem. Past experiences were important for us and we saw that among all 8% of the participants had some kind of sexual problem, within this group 50.7% felt uncomfortable during the visit and only 60.4% were satisfied with the care of the physician. Conclusion Our study results show the current situation of adolescents in Kyrykkale University and will be used to improve policies and programs to reduce priority health- risk behaviours among youth of our and surrounding provinces and establish a youth friendly service in Kyrykkale University within this purposes. | H■zel Selda Sanli Cihat Albayrak Meryem Fidan Serdar Agar Ayca | 2006 | Journal of Reproduction and Contraception2006，17，4： | 4 |
| 5 | Value of lead aVR in predicting acute occlusion of proximal left anterior descending coronary artery and in-hospital outcome in ST-elevation myocardial infarction: an electrocardiographic predictor of poor prognosis显示文摘 | Nazif Aygul Kurtulus Ozdemir Mehmet Tokac Meryem Ulku Aygul Mehmet Akif Duzenli Adnan Abaci Ahmet Bacaksiz Hüseyin Yazici Sait Bodur | 2008 | Journal of Electrocardiology2008，，4： | 2 |
| 6 | The role of intracellular protein O-glycosylation in cell adhesion and disease显示文摘Post-translational protein modification,including phosphorylation,is generally quick and reversible,facilitating rapid biologic adjustments to altered cellular physiologic demands.In addition to protein phosphorylation,other post-translational modifications have been identified.Intracellular protein O-glycosylation,the addition of the simple sugar O-linked N-acetylglucosamine (O-GlcNAc) to serine/threonine residues,is a relatively recently identified post-translational modification that has added to the complexity by which protein function is regulated.Two intracellular enzymes,O-GlcNAc transferase and O-GlcNAcase,catalyze the addition and removal,respectively,of O-GlcNAc to serine and threonine side-chain hydroxyl groups.Numerous proteins,including enzymes,transcription factors,receptors and structural proteins have been shown to be modified by intracellular O-glycosylation.In this review,the mechanism and relevance of O-GlcNAc protein modification are discussed in the context of cell adhesion and several representative diseases. | Meryem Bektas David S.Rubenstein | 2011 | The Journal of Biomedical Research2011，25，4： | 2 |
| 7 | Doppler eehocardiograph evaluation of pulmonary hypertension in patients undergoing hemodialysis显示文摘 | Tarrass Faissal Benjelloun Meryem Medkouri Ghislaine | 2006 | Hemodilysis international2006，10，4： | 1 |
| 8 | A Generating Model of Realistic Synthetic Heart Sounds for Performance Formance Assessment of Phonocardiogram Processing Algorithms 显示文摘 | Meryem Jabloun Philippe Ravier Olivier Buttelli | 2013 | Biomedical Signal Processing and Control2013，8，5： | 1 |
| 9 | Panoramic radiography and cone-beam computed tomography findings in preoperative examination of impacted mandibular third molars 显示文摘 | Ilkay P Cigdem S Meryem TA | 2014 | BMC Oral Health2014，14，： | 1 |
| 10 | Effect of in-trauterine device and oral contraceptive on vaginal flora andepithelium显示文摘 | Sababattin O Meryem C Sibel Hakverdi | 2007 | Saudi Med J2007，28，5： | 1 |
| 11 | Disorders of Lipid Metabolism and Chronic Kidney Disease in the Elderly 显示文摘 | Devasmita C Meryem T Moshe L | 2009 | Seminars in Neph- rology2009，29，6： | 1 |
| 12 | A novel method for production of activated carbon from waste tea by chemical activation with microwave energy显示文摘 | Emine Yagmur Meryem Ozmak Zeki Aktas | 2008 | Fuel2008，，15： | 1 |
| 13 | UV disinfection of treated wastewater in a large-scale pilot plant and inactivation of selected bacteria in a laboratory UV device显示文摘 | ABDENNACEUR H MERYEM M | 2000 | Bioresource Technology2000，74，： | 1 |
| 14 | Synthesis,characterization and electrochemistry of novel differently octasubstituted phthalocyanines显示文摘 | Kandaz M Yarasir Meryem N Koca A | | 0，，： | 1 |
| 15 | Existence of a macrophyte-dominated clear water state over a very wide range of nutrient concentrations in a small shallow lake显示文摘 | Meryem Beklioglu Brian Moss | 1996 | Hydrobiologia (-)1996，，1： | 1 |
| 16 | Synthesis, characterization and electrochemistry of novel differently octasubstituted phthalocyanines 显示文摘 | Mehmet K Meryem N U Yara S | 2002 | Polyhedron2002，21，3： | 1 |
| 17 | Acid leaching of coal and coal ashes显示文摘 | Meryem S Mehtap P Ake S | 2003 | Fuel2003，82，： | 1 |
| 18 | Acute exacerbation impairs endothelial function in patients with chronic obstructive pulmonary disease显示文摘 | Beste Uzben Emel Eryuksel Azra Meryem Tanrikulu | 2010 | Arch Turk Soc Cardiol2010，38，1： | 1 |
| 19 | Hysteresis in vegetation shift-Lake Mogan prognoses显示文摘 | Zhang Jingjie Jorgensen Sven Erik Beklioglu Meryem and Ince Ozlem | 2003 | Ecological Modelling2003，164，： | 1 |
| 20 | Comparison of the treatment performances of blast furnace slag-based and gravel-based vertical flow wetlands operated identically for domestic wastewater treatment in Turkey 显示文摘 | KORKUSUZ E A MERYEM B GOKSEL N D | 2005 | Ecological Engineering2005，24，： | 1 |
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