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| 1 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 2 | Euler-Lagrange/DEM simulation of wood gasification in a bubbling fluidized bed reactor显示文摘We present an Euler–Lagrange method for the simulation of wood gasification in a bubbling fluidized bed. The gas phase is modeled as a continuum using the 2D Navier–Stokes equations and the solid phase is modeled by a Discrete Element Method(DEM)using a soft-sphere approach for the particle collision dynamic. Turbulence is included via a Large-Eddy approach using the Smagorinsky sub-grid model.The model takes into account detailed gas phase chemistry,zero-dimensional modeling of the pyrolysis and gasification of each individual particle,particle shrinkage,and heat and mass transfer between the gas phase and the particulate phase.We investigate the influence of wood feeding rate and compare exhaust gas compositions and temperature results obtained with the model against experimental data of a laboratory scale bubbling fluidized bed reactor. | Michael Oevermann Stephan Gerber Frank Behrendt | 2009 | Particuology2009，7，4： | 15 |
| 3 | GIS在环保型养猪业区域规划中的应用显示文摘快速发展的养猪业在带来巨大社会效益和经济效益的同时也带来了许多环境问题,FAO从1998年开始启动了养殖业环境与发展项目,目的是为了在促进养殖业发展、增加经济效益的同时大幅度减少养殖业对环境的不利影响。该文是FAO项目中的一部分,主要是应用G IS技术工具,通过建立养猪业选址的指标体系,发展了可持续的畜牧业生产建设区域规划的决策辅助工具,以减少养猪业发展对环境带来的负面影响;并且将该技术在江西省的养猪大县万年县进行了具体的应用。 | 赵小敏 Gerrit J Carsjens Pierre Gerber | 2006 | 农业工程学报2006，22，9： | 12 |
| 4 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 5 | 利用强场多光子电离技术实现对多原子分子离子振动量子态的光学操控显示文摘利用飞秒光电子影像技术研究了碘甲烷分子在飞秒强激光场作用下的多光子电离动力学,在实验上实现了运用飞秒强场多光子电离技术对多原子分子离子的振动量子态进行光学操控.提高了飞秒激光的强度,从1.6×1013W/cm2提高到2.5×1013W/cm2.在增大的激光强度范围内,发现了新的能量组分,并对此进行归属.通过采集光电离的光电子影像可以得到强场电离后光电子的动能分布和角度分布两方面的信息,前期的研究主要侧重于讨论光电子动能随光强的变化,重点讨论了光电子角度分布随光强的变化,通过观察光电子角度分布的变化趋势对振动量子态调控机理进一步认识. | 刘玉柱 Gerber Thomas Knopp Gregor | 2014 | 物理学报2014，63，24： | 7 |
| 6 | Nitrogen and phosphorus balance analysis of cultivated land in Jiangsu plain,China显示文摘Jiangsu plain is located along the downstream of the Yangtze River, the north part of which is also the coast area of the Yellow Sea. The specific location makes the local environmental issues regionally important. This paper studied arable land area, plantation structure, livestock sector data, which shows that livestock sector contributes a big amount of nitrogen and phosphorus, in terms of the demand from the agriculture use in Jiangsu plain. But actually, there is still much mineral fertiliser used in agriculture, which causes the N and P produced from livestock sector being an important source of pollution to the environment. The paper suggests to tighten up manure management, in order to lead to a big reduction in the pollution to both soil and surface water. | ZOU Xinqing Pierre Gerber LI Haiyu LIU Qingsong WANG Qian SHEN Jingfen SHI Binwen | 2001 | Chinese Science Bulletin2001，46，S1： | 5 |
| 7 | 如何让学习障碍学生更好地进步:美国RTI模式及其启示显示文摘干预回应模式(Response to Intervention,简称RTI)是一个采用多层次结构,具有六个核心特征的教育干预模式,它为学习障碍学生提供评估和干预,并强调教师的作用以及教师对教学的反应。近年来RTI模式在美国发展迅速,在该模式受到普遍重视的同时,人们也开始反思RTI模式为教学带来的得失。对于学习障碍学生教学而言,可从四个方面看待RTI模式背后的教育理念及其带来的启示。 | 刘嘉秋 刘春玲 Michael Gerber | 2013 | 外国教育研究2013，40，3： | 5 |
| 8 | 基础及周期雄激素水平与体外受精刺激参数有关,但不能预测妊娠结局显示文摘Objective: To evaluate androgen levels before and during IVF. To assess for an association between androgen levels and IVF stimulation parameters or IVF pregnancy outcome. Design: Prospective cohort study. Setting: Residency-based IVF program. Patient(s): One hundred seventeen infertility patients. Intervention(s): Androgen levels were evaluated on basal day 3 and during the IVF stimulation cycle. Main Outcome Measure(s): Pregnancy outcome rates and IVF stimulation parameters. Result(s): Mean serum androgen levels did not differ among different pregnancy outcomes. Multiple linear regression analysis revealed that body mass index (BMI) and oocyte number had a significant positive association with basal testosterone levels. Mean ovarian volume correlated negatively and follicle number correlated positively with testosterone levels on day 6 of stimulation. Peak E2 and BMI correlated positively with testosterone on day of hCG administration. The interval change in androgen levels throughout the IVF cycle was not associated with outcome rates. Likewise, threshold analysis did not reveal any significant androgen level that affected pregnancy outcome. Conclusion(s): Serum androgen levels during IVF correlate with IVF stimulation parameters. However, these data do not support an influence of serum androgen levels on IVF pregnancy outcome rates. | Frattarelli J.L Gerber M.D. 朱晓明 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，11： | 4 |
| 9 | DMP1 prevents osteocyte alterations,FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease显示文摘During chronic kidney disease (CKD),alterations in bone and mineral metabolism include increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute to cardiovascular mortality.The osteocyte protein dentin matrix protein 1 (DMP1) reduces FGF23 and enhances bone mineralization,but its effects in CKD are unknown.We tested the hypothesis that DMP1 supplementation in CKD would improve bone health,prevent FGF23 elevations and minimize consequent adverse cardiovascular outcomes.We investigated DMP1 regulation and effects in wild-type (WT) mice and the Col4a3^-/- mouse model of CKD.Col4a3^-/- mice demonstrated impaired kidney function,reduced bone DMP1 expression,reduced bone mass,altered osteocyte morphology and connectivity,increased osteocyte apoptosis,increased serum FGF23,hyperphosphatemia,left ventricular hypertrophy (LVH),and reduced survival.Genetic or pharmacological supplementation of DMP1 in Col4a3^-/- mice prevented osteocyte apoptosis,preserved osteocyte networks,corrected bone mass,partially lowered FGF23 levels by attenuating NFAT-induced FGF23 transcription,and further increased serum phosphate.Despite impaired kidney function and worsened hyperphosphatemia,DMP1 prevented development of LVH and improved Col4a3^-/- survival.Our data suggest that CKD reduces DMP1 expression,whereas its restoration represents a potential therapeutic approach to lower FGF23 and improve bone and cardiac health in CKD. | Corey Dussold Claire Gerber Samantha White Xueyan Wang Lixin Qi Connor Francis Maralee Capella Guillaume Courbon Jingya Wang Chaoyuan Li Jian Q. Feng Tamara Isakova Myles Wolf Valentin David Aline Martin | 2019 | Bone Research2019，7，2： | 4 |
| 10 | Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease显示文摘Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.We investigated bone FGF23 regulation by circulating LCN2.At 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum FGF23.Lcn2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone cells.These results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in CKD.LCN2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD. | Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang Emily Lynch Tamara Isakova Jodie LBabitt Myles Wolf Aline Martin Valentin David | 2021 | Bone Research2021，9，3： | 4 |
| 11 | 比较应用对比增强MR与多层CT检测急性和慢性心肌梗死的特点 | Gerber B.L. Belge B. Legros G.J. 吴晓燕 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，0，7： | 4 |
| 12 | Understanding the Removal and Fate of Selected Drugs of Abuse in Sludge and Biosolids from Australian Wastewater Treatment Operations显示文摘Illicit and pharmaceutical drugs are considered to be emerging contaminants of concern,and much research effort has gone into assessing their occurrence in wastewater.However,little information exists on their presence in treated sludge or biosolids.In this study,we examined sludge and biosolids from a large metropolitan wastewater treatment plant(WWTP)in Australia to determine the occurrence of five drugs of abuse,including benzoylecgonine as indicator of cocaine consumption,methamphetamine and 3,4-methylenedioxy methamphetamine(MDMA)as representative illicit stimulants,and codeine and morphine as pharmaceuticals with potential environmental risk.The samples were solid-phase extracted and analyzed by liquid chromatography–tandem mass spectrometry(LC–MS/MS).Benzoylecgonine and MDMA were present in raw sludge but were notably degraded during solids treatment processes,and were not detected in the dewatered sludge(after treatment)or in biosolids.Methamphetamine,codeine,and morphine were detected in all biosolids samples at mean concentrations of 20–50 lg kg^-1.The presence of these three drugs in biosolids shows that these compounds are relatively stable in the solids and in soil,and can persist in biosolids for at least several years.A simple environmental risk assessment based on estimated risk quotients(RQs)for these compounds indicated that the potential environmental risks associated with the land application of biosolids are very low at typical Australian biosolids application rates. | Meena K.Yadav Cobus Gerber Christopher P.Saint Ben Van den Akker Michael D.Short | 2019 | Engineering2019，5，5： | 3 |
| 13 | 以肝脏为靶器官的基因治疗时重组腺病毒引起的急性肝炎显示文摘目的 研究腺病毒为载体的基因治疗时淋巴细胞在肝组织免疫反应中的作用,探讨免疫抑制疗法在腺病毒载体基因治疗中的可行性。 方法 取8只恒河猴,经不同路径输入携带大肠杆菌lacZ基因或荧火虫荧光素酶基因luc的重组腺病毒6只。其中4只进行免疫抑制治疗。将含lacZ的质粒DNA注入2只动物作为对照。用免疫组织化学法检测β2-MG、HLA-DR、CD3、CD4、CD8及CD20。 结果 腺病毒介导的基因治疗时肝脏的β2-MG、HLA-DR、CD3、CD4及CD8阳性细胞明显增多。腺病毒载体和转基因均与肝损害有关, 表现为一过性, 呈轻、中度无黄疸性肝炎。免疫抑制的动物只要处于免疫抑制状态下就没有肝炎的表现,基因表达的时间延长。质粒介导的基因转导效果差, 无肝损害及免疫反应。所有动物B淋巴细胞抗原CD20始终阴性。 结论 腺病毒介导的基因治疗时肝脏的β2-MG、HLA-DR、CD3、CD4及CD8阳性细胞明显增多, 造成轻、中度一过性肝损害。使用免疫抑制药物可避免肝损害的发生并延长基因表达的时间。 | 鲁慧英 Deborah Sullivan Srikanta Dash Michael A Gerber | 2001 | 中华肝脏病杂志2001，9，5： | 3 |
| 14 | Ambrisentan for the Treatment of Pulmonary Arterial Hypertension: Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2显示文摘 | Nazzareno Galiè Horst Olschewski Ronald J. Oudiz Fernando Torres Adaani Frost Hossein A. Ghofrani David B. Badesch Michael D. McGoon Vallerie V. McLaughlin Ellen B. Roecker Michael J. Gerber Christopher Dufton Brian L. Wiens Lewis J. Rubin | 2008 | Circulation2008，，23： | 2 |
| 15 | Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Statement for Health Professionals From the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association显示文摘 | Jane W. Newburger Masato Takahashi Michael A. Gerber Michael H. Gewitz Lloyd Y. Tani Jane C. Burns Stanford T. Shulman Ann F. Bolger Patricia Ferrieri Robert S. Baltimore Walter R. Wilson Larry M. Baddour Matthew E. Levison Thomas J. Pallasch Donald A. Fa | 2004 | Circulation2004，，17： | 2 |
| 16 | ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 Expert Consensus Document on Coronary Computed Tomographic Angiography显示文摘 | Daniel B. Mark Daniel S. Berman Matthew J. Budoff J. Jeffrey Carr Thomas C. Gerber Harvey S. Hecht Mark A. Hlatky John McB. Hodgson Michael S. Lauer Julie M. Miller Richard L. Morin Debabrata Mukherjee Michael Poon Geoffrey D. Rubin Robert S. Schwartz | 2010 | Journal of the American College of Cardiology2010，，23： | 2 |
| 17 | Inspection of the human stomach using remote-controlled capsule endoscopy: a feasibility study in healthy volunteers (with videos)显示文摘 | Jutta Keller Christiane Fibbe Frank Volke Jeremy Gerber Alexander C. Mosse Meike Reimann-Zawadzki Elisha Rabinovitz Peter Layer Daniel Schmitt Viola Andresen Ulrich Rosien Paul Swain | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 18 | Development of Active Magnetic Bearings for High Speed Rotors 显示文摘 | Boehm J Gerber R Hartley J R | 1990 | IEEE Trans on Magnetics1990，26，4： | 2 |
| 19 | Effects of two types of exercise training on psychological well-being,sleep,quality of life and physical fitness in patients with high-grade glioma(WHO III and IV):study protocol for a randomized controlled trial显示文摘Background:There is existing evidence on whether and to what degree regular exercise training improves the quality of life(QoL)among cancer survivors.However,in regards to patients with high-grade glioma(HGG;WHO grade III and IV),no conclusive study has been performed so far.The present trial aims to fill this gap by examining whether psychological well-being,sleep,QoL and physical fitness might be improved with two different types of exercise,as compared to an active control condition.Active control condition represent individuals participating at regular meetings to talk about their current life situation,though,the meetings were not intended as that of the psychotherapy group.Regular meetings are of the same frequency,duration,and intensity as the exercise interventions.Methods:A total of 45 patients with HGG after undergoing neurosurgery and adjuvant radiotherapy,chemotherapy,or chemoradiotherapy will be consecutively and randomly assigned to(a)an endurance training,(b)a resistance training or(c)to an active control condition.The intervention will last for 6 consecutive weeks,consisting of 2 weekly sessions(30-45 min per session).Measurements would take place at three time points,namely at the beginning of the study(baseline),3 weeks after the beginning of the study,and 6 weeks after the beginning of the study.The last measurement also represents the end of the study.Aerobic exercise performance will be assessed objectively with a 6-min walking test,and a handgrip test will be used to assess the upper body strength.Further,participants will complete a battery of questionnaires covering sociodemographic information,QoL,sleep quality and sleep patterns,coping with stress,state-and trait-anxiety,depression,and fatigue.In parallel,experts will use the Hamilton Depres-sion Rating Scale to determine and rate participants’symptoms of depression.Significance:The present study will be the first to investigate and compare the impact of two different exercise modalities,namely endurance and resistance training,on physical fitness and dimensions of well-being,and sleep among patients with HGG who underwent neurosurgery followed by adjuvant radiotherapy,chemotherapy,or chemoradiotherapy.Importantly,unlike the majority of previous studies,the control condition consists of an active set-up to detect possible factual beneficial effects of exercise training,irrespective of social interactions. | Dominik Cordier Markus Gerber Serge Brand | 2019 | Cancer Communications2019，39，1： | 2 |
| 20 | CA6NM: New developmentsbased on 20 years experience 显示文摘 | Gysel W Gerber E Trautwein A | 1982 | Stainless Steel Castings1982，，3： | 2 |
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