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| 1 | 理解课堂中的形成性评价显示文摘形成性评价是一种能促进学生学习的有效策略,本文的核心问题正是如何理解课堂中的形成性评价。为此,本文将首先介绍目前美国教育系统中存在的一些问题,并就此问题提出一个可能的解决方案——形成性评价。在简要的背景回顾和文献综述之后,文章将提出我们建构的形成性评价工作模型。接着,本文将从我们围绕形成性评价设计的教师专业发展项目,以及我们自身的探索出发,讨论形成性评价面临的一些新问题。最后便是根据这些新问题,分析如何进一步理解形成性评价。 | Ellen Osmundson 何珊云 王小平 | 2012 | 全球教育展望2012，，4： | 85 |
| 2 | Autophagy: for better or for worse显示文摘Autophagy 是降级的降级小径损坏了的 lysosomal 或过剩房间部件进基本 biomolecules,它然后回来被再循环进 cytosol。在这个方面, autophagy 在一个连续降级新生周期驾驶 biomolecules 的流动。Autophagy 通常被认为在应力或差的滋养的条件下面保护房间的支持幸存的机制。当前的研究清楚地证明 autophagy 在重要生物过程完成众多的功能。它在开发被含有,区别,天生、适应的免疫,变老并且房间死亡。另外,积累证据表明在 autophagy 和几人的疾病和肿瘤开发之间的有趣的连接。因此, autophagy 似乎是在细胞和有机体的生活和死亡的一个重要播放器。尽管有 autophagy 的增长知识, autophagic 机械通过调整这些多样的过程的机制完全没被理解。在这评论,我们给表明小径的 autophagic 的全面概述,它的角色一般来说细胞的过程和它的连接到房间死亡。另外,我们在场发信号到疾病的有缺点的 autophagic 的可能的贡献的简短概述。 | Ellen Wirawan Tom Vanden Berghe Saskia Lippens Patrizia Agostinis Peter Vandenabeele | 2012 | Cell Research2012，22，1： | 70 |
| 3 | Neutrophil extracellular trap cell death requires both autophagy and superoxide generation显示文摘嗜中性的细胞外的陷井(网) 是能套住并且降级的细胞外的染色质结构微生物。他们从激活称为网络房间死亡,或 NETosis 的一个房间死亡程序的 neutrophils 产生。NETosis 的激活被显示了包含 NADPH oxidase 活动,原子信封的崩溃和大多数小粒膜,网的原子染色质和形成的 decondensation。我们报导在 phorbol,十四酸盐醋酸盐(PMA ) 刺激了 neutrophils,细胞内部的染色质 decondensation 和网形成跟随 autophagy 和 superoxide 生产,哪个被要求调停导致 PMA 的 NETosis 并且独立于对方发生。从有长期的 granulomatous 疾病的病人的 Neutrophils,缺乏 NADPH oxidase 活动,仍然展出导致 PMA 的 autophagy。相反地,导致 PMA 的 NADPH oxidase 活动没被 autophagy 的药理学抑制影响。有趣地,任何一个 autophagy 的抑制或 NADPH oxidase 阻止细胞内部的染色质 decondensation,它为 NETosis 和网形成是必要的,并且导致 apoptosis 的特点描绘的房间死亡。当 autophagy 或 NADPH oxidase 活动被阻止时,这些结果显示 apoptosis 可能为 NETosis 作为一个备份节目工作。 | Quinten Remij sen Tom Vanden Berghe Ellen Wirawan Bob Asselbergh Eef Parthoens Riet De Rycke Sam Noppen Michel Delforge Jean Wlllems Peter Vandenabeele | 2011 | Cell Research2011，21，2： | 46 |
| 4 | Tissue factor in predicted severe acute pancreatitis显示文摘AIM: To study tissue factor (TF) in acute pancreatitis and evaluate the role of TF as a predictive marker of severity. METHODS: Forty-nine consecutive patients admitted to Lund University Hospital, fulfilling the criteria of predicted severe acute pancreatitis (AP), were recruited prospectively between 2002 and 2004. Blood samples for TF analyses were drawn at inclusion in the study and 12 h, 1 d and 3 d later. RESULTS: Twenty-seven patients developed mild AP, and 22 patients severe AP. At inclusion in the study, the groups were comparable with respect to gender, aetiology, Acute Physiology and Chronic Health Evaluation Ⅱ score, and duration of pain. At inclusion in the study and at 12 h, TF was higher in the severe AP group (P = 0.035 and P = 0.049, respectively). After 1 and 3 d, no differences in TF levels were noted. Interleukin (IL)-6 was significantly higher in the severe AP group at all of the studied time points. C-reactive protein (CRP) was significantly higher in the AP group at 1 and 3 d. In receiver operating characteristic-curves, the area under the curve (AUC) for TF was 0.679 (P = 0.035) at inclusion in the study, and a cut off level for TF of 40 pg/mL showed a sensitivity of 71% and a specificity of 67%, whereas corresponding AUC for IL-6 was 0.775, P = 0.001, and for CRP was 0.653. IL-6 showed better AUC-values than TF at all time points studied. CONCLUSION: TF-levels are raised early in severe AP. TF as an early predictive marker of severe AP is superior to CRP, but inferior to IL-6. | Ellen Andersson Jakob Axelsson Gunilla Eckerwall Daniel Ansari Roland Andersson | 2010 | World Journal of Gastroenterology2010，16，48： | 26 |
| 5 | Systemic air embolism after transthoracic lung biopsy: A case report and review of literature显示文摘Computed tomography (CT)-guided lung biopsy is a common diagnostic procedure that is associated with various complications, including pneumothorax, hemoptysis and parenchymal hemorrhage. Systemic air embolism is a very rare (0.07%) but potentially lifethreatening complication. We report a fatal case of air embolism to the cerebral and coronary arteries confirmed by head and chest CT, followed by a review of the literature. | Wessam Bou-Assaly Perry Pernicano Ellen Hoeffner | 2010 | World Journal of Radiology2010，2，5： | 20 |
| 6 | H pylori and host interactions that influence pathogenesis显示文摘H pylori is probably the most prevalent human patho- gen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I car- cinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduo- denal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory re- sponse that becomes chronic, along with a detectable adaptive immune response, these responses are ineffec- tive in clearing the infection. H pylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they inter- act with the host epithelium to influence pathogenesis. | Ellen J Beswick Giovanni Suarez Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，35： | 20 |
| 7 | 乳腺癌患者配偶夫妻沟通干预方案的修订与实施显示文摘不良的沟通方式会影响乳腺癌夫妻关系的调适。本文详细介绍了乳腺癌患者配偶夫妻沟通干预方案的本土化修订过程、内容、实施方法及效果的初步评价,旨在帮助配偶学会良好的夫妻沟通方法,为乳腺癌家庭支持研究提供参考。 | 李智 刘均娥 陈双琴 Frances Marcus Lewis Ellen H.Zahlis | 2016 | 中国护理管理2016，16，2： | 19 |
| 8 | Acute complications of spinal cord injuries显示文摘The aim of this paper is to give an overview of acute complications of spinal cord injury(SCI). Along with motor and sensory deficits, instabilities of the cardiovascular, thermoregulatory and broncho-pulmonary system are common after a SCI. Disturbances of the urinary and gastrointestinal systems are typical as well as sexual dysfunction. Frequent complications of cervical and high thoracic SCI are neurogenic shock, bradyarrhythmias, hypotension, ectopic beats, abnormal temperaturecontrol and disturbance of sweating, vasodilatation and autonomic dysreflexia. Autonomic dysreflexia is an abrupt, uncontrolled sympathetic response, elicited by stimuli below the level of injury. The symptoms may be mild like skin rash or slight headache, but can cause severe hypertension, cerebral haemorrhage and death. All personnel caring for the patient should be able to recognize the symptoms and be able to intervene promptly. Disturbance of respiratory function are frequent in tetraplegia and a primary cause of both short and long-term morbidity and mortality is pulmonary complications. Due to physical inactivity and altered haemostasis, patients with SCI have a higher risk of venous thromboembolism and pressure ulcers. Spasticity and pain are frequent complications which need to be addressed. The psychological stress associated with SCI may lead to anxiety and depression. Knowledge of possible complications during the acute phase is important because they may be life threatening and/ or may lead to prolonged rehabilitation. | Ellen Merete Hagen | 2015 | World Journal of Orthopedics2015，6，1： | 19 |
| 9 | 一种新肿瘤生长相关生物标志物胸苷激酶1临床应用进展显示文摘胸苷激酶1(TK1)是一种嘧啶补救途径的激酶,能催化脱氧胸苷磷酸化为一腺胸苷酸,与细胞周期调控和细胞增殖密切相关。多项实验证明,TK1可用于健康体检、肿瘤早期筛查、常规检测、疗效监视和预后等方面,是一种灵敏有效地评估人体肿瘤增长的标志物。本综述概述了近年关于TK1临床应用的新进展。 | 刘秀菊 周际 李远 刘森波 方聪 宇莉君 Ellen HE Sven SKOG | 2011 | 中国药理学与毒理学杂志2011，25，1： | 16 |
| 10 | 血清胸苷激酶1检测对恶性肿瘤诊断及疗效评估的意义显示文摘目的探讨血清胸苷激酶1(TK1)作为肿瘤细胞增殖标志物对恶性肿瘤诊断及疗效评估的意义。方法应用免疫印迹-增强化学发光法检测恶性肿瘤组(53例)治疗前后、体格检查组(49例)以及健康对照组(18名)的血清TK1水平。治疗前与治疗后比较用配对t检验,治疗前和后分别与健康对照组、体格检查组比较采用两独立样本均数比较t检验。结果恶性肿瘤组治疗前STK1为0.3—11.3(2.4±2.0)pmol/L;恶性肿瘤组治疗后STK1为0.3~5.0(0.9±0.8)pmol/L;体格检查组STK1为0.1~2.1(0.8±0.3)pmol/L;健康对照组STK1为0.5~1.2(0.7±0.2)pmol/L。恶性肿瘤组治疗前与治疗后之间STK1水平差异有统计学意义(t=5.257,P〈0.0001)。恶性肿瘤组治疗前与健康对照组和体格检查组STK1水平比较,差异均有统计学意义(t=3.568和5.460,P=0.001和〈0.0001),而恶性肿瘤组治疗后与健康对照组和体格检查组STK1水平比较,差异均无统计学意义(t=1.056和0.715,P均〉0.05)。结论血清TK1检测细胞增殖有较高的特异性和灵敏度,对临床监测恶性肿瘤疗效和在体格检查中进行恶性肿瘤风险筛查具有重要意义。 | 李清茹 桑士标 袁航 苏成海 吴翼伟 张旻 周际 Ellen He Sven Skog 赵久涛 | 2009 | 中华核医学杂志2009，29，4： | 16 |
| 11 | Effect of Helicobacter pylori on gastric epithelial cells显示文摘The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori(H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori. | Shatha Alzahrani Taslima T Lina Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 15 |
| 12 | 青光眼视网膜神经纤维层厚度的光学相干断层扫描纵向评估显示文摘目的:纵向评估光学相干断层扫描(OCT)视盘周围神经纤维层厚度测量,并将这些检查与临床状态和自动视野计检查作横向比较。
方法:对参与前瞻性纵向研究的青光眼或疑似青光眼患者64只眼(37例)作回顾性评估。所有参与者每6个月作一次全面的临床评估、视野检查和OCT。视野进展按可重复性测量的视野平均偏差至少比基线降低2dB,OCT进展按可重复性测量视网膜神经纤维层平均厚度至少变薄20pro。
结果:每个患者在中位值为4.7年的随访中有5个可使用的OCT扫描。青光眼和疑似青光眼患者之间视网膜神经纤维层厚度线性回归斜度的差异对所有变量均不显著;然而,Kaplan-Meier生存曲线分析显示视野比OCT测量有较高的进展率。在随访期间66%的眼是稳定的。22%只有OCT进展,9%单有视野平均偏差进展。3%视野和OCT都有进展。
结论:OCT比全自动视野计对辨别青光眼进展有更大的可能性。这可能反映OCT的敏感性或在常规方法发现之前其真实损害就能被OCT发现。 | Gadi Wollstein Joel S. Schuman Lori L. Price Ali Aydin Paul C. Stark Ellen Hertzmark Edward Lai Hiroshi Ishikawa Cynthia Mattox James G. Fujimoto Lelia A. Paunescu 刘春(译) 朱志忠(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，4： | 14 |
| 13 | 卵巢浆液性腺癌组织中TK1和Ki-67表达的意义显示文摘目的探讨细胞质胸苷激酶1(cytoplasmic thymidinekinas-1,TK1)、Ki-67在卵巢浆液性腺癌中表达的意义。方法回顾性研究55例经手术治疗的卵巢浆液性腺癌患者的临床病理资料,并运用免疫组化技术观察TK1、Ki-67在卵巢浆液性腺癌中的表达情况及与临床病理参数之间的意义。结果 TK1阳性表达定位于细胞质,阳性率为72.7%。TK1的表达与肿瘤的最大径、复发、pTNM分期、病理分级密切相关(P<0.05)。Ki-67阳性表达定位于细胞核,阳性率为80.0%,Ki-67的表达与肿瘤的复发、pTNM分期、病理分级有关(P<0.05)。Kappa检验显示TK1的表达与卵巢浆液性腺癌复发较一致(k=0.559,P=0.000),且判断复发比Ki-67更为优越。Kaplan-Meier检验显示pTNM分期、肿瘤复发、MDACC分级、Ki-67、TK1表达分别与预后有关(P<0.05)。COX回归多因素分析显示:肿瘤复发是影响卵巢浆液性腺癌患者的独立性预后因素。结论卵巢浆液性腺癌的复发影响患者的预后,TK1对判断卵巢浆液性腺癌是否有复发倾向具有参考价值,且优于Ki-67,初次手术后肿瘤组织免疫组化TK1高表达预示患者存在高复发的风险,提示临床要加强术后的治疗方案,并提高随访频数。 | 刘冲 郭庆 石群立 余波 马恒辉 Staffan Eriksson Ellen He Sven Skog | 2011 | 临床与实验病理学杂志2011，27，12： | 12 |
| 14 | 形成性评价(Formative Assessment)的本质及其对教与学的影响显示文摘长期以来,很多学者一直倡导指导教学的评价,即通过评估学生需求和监测其学习进展,适当地设计学习顺序,调整教学策略,改良学习计划,以便有效地促进学习目标的完成。本研究调查了形成性评价在美国中学科学课中的实施情况,并分析其对学生学习进步的影响。研究表明,教师都在努力使用形成性评价来指导教学,而学生取得的成绩各不相同。 | Joan L.Herman Ellen Osmundson Carlos Ayala Stephen Schneider Mike Timms 杜承达 | 2010 | 考试研究2010，6，1： | 12 |
| 15 | 血清胸苷激酶1对癌前疾病的癌变风险筛查的意义显示文摘目的研究血清胸苷激酶1(STK1)对癌前疾病癌变风险筛查的意义。方法吉林油田总医院对8869例不同工种人群进行常规健康体检,包括平行检测STK1。该项目检测方法是采用高灵敏度点印迹免疫增强发光检测系统来检测STK1的浓度。依据STK1检测结果将人群分类讨论。结果正常绀8355例,STK1≤2pmol/L,平均值(0.6±0.5)pmol/L;其中仅124例每项体检项目都正常占1.4%。风险组514例,STK1〉2pmol/L,平均值(3.8±2.2)pmol/L,风险率为5.8%。癌前相关疾病可能恶变风险人数为85.2%(包括胆/肾息肉样病变增生,疑肝或肺恶瘤病灶,贫血疾病,肥胖,胆/肝/肺良性肿瘤,脂肪肝和乙肝阳性并伴有肝功能异常)。发现STK1风险率升降与职业有一定相关性,第一类是长期、直接进行油田操作(钻井,运输,地质),总人数4333例,风险率7.8%;第二类是钻井前技术准备和服务(钻服,物探,钻技和测井),总人数4536例,风险率为3.9%,两类比较,第一类人群风险率有明显的升高(x^2=55.53,P〈0.05),特别是息肉样病变增生和疑恶瘤病灶者主要发现在第一类,可能与直接、长期接触油田污染物有关。结论胸苷激酶1是很有前景的血清标志物之一,它真实地反映了细胞异常增殖状况,使早期评估癌前疾病的癌变风险成为可能。 | 张兴华 杨金荣 付筱英 秦蕾 刘海燕 汪海霞 云霞 宋波 张旻 Ellen He Sven Skog | 2010 | 中华健康管理学杂志2010，4，1： | 10 |
| 16 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 17 | Challenges and prospects for consumer acceptance of cultured meat显示文摘Consumer acceptance of cultured meat is expected to depend on a wide diversity of determinants ranging from technologyrelated perceptions to product-specific expectations, and including wider contextual factors like media coverage, public involvement, and trust in science, policy and society. This paper discusses the case of cultured meat against this multitude of possible determinants shaping future consumer acceptance or rejection. The paper also presents insights from a primary exploratory study performed in April 2013 with consumers from Flanders(Belgium)(n=180). The concept of cultured meat was only known(unaided) by 13% of the study participants. After receiving basic information about what cultured meat is, participants expressed favorable expectations about the concept. Only 9% rejected the idea of trying cultured meat, while two thirds hesitated and about quarter indicated to be willing to try it. The provision of additional information about the environmental benefits of cultured meat compared to traditional meat resulted in 43% of the participants indicating to be willing to try this novel food, while another 51% indicated to be ‘maybe' willing to do so. Price and sensory expectations emerged as major obstacles. Consumers eating mostly vegetarian meals were less convinced that cultured meat might be healthy, suggesting that vegetarians may not be the ideal primary target group for this novel meat substitute. Although exploratory rather than conclusive, the findings generally underscore doubts among consumers about trying this product when it would become available, and therefore also the challenge for cultured meat to mimic traditional meat in terms of sensory quality at an affordable price in order to become acceptable for future consumers. | Wim Verbeke Pierre Sans Ellen J Van Loo | 2015 | Journal of Integrative Agriculture2015，14，2： | 10 |
| 18 | CD74 in antigen presentation,inflammation,and cancers of the gastrointestinal tract显示文摘CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract. | Ellen J Beswick Victor E Reyes | 2009 | World Journal of Gastroenterology2009，15，23： | 10 |
| 19 | Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses显示文摘Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease. Fusobacteria showed a statistically significantly higher number of transcripts at tumour sites and tumour-adjacent sites of cancer patients compared to the healthy controls analysed. Regardless of the community composition, specific metabolic signatures were consistently found in disease. Activities such as iron ion transport, tryptophanase activity, peptidase activities and superoxide dismutase were over-represented in tumour and tumour-adjacent samples when compared to the healthy controls. The expression of putative virulence factors in the oral communities associated with OSCC showed that activities related to capsule biosynthesis, flagellum synthesis and assembly, chemotaxis, iron transport, haemolysins and adhesins were upregulated at tumour sites. Moreover, activities associated with protection against reactive nitrogen intermediates, chemotaxis, flagellar and capsule biosynthesis were also upregulated in non-tumour sites of cancer patients. Although they are preliminary, our results further suggest that Fusobacteria may be the leading phylogenetic group responsible for the increase in expression of virulence factors in the oral microbiome of OSCC patients. | Susan Yost Philip Stashenko Yoonhee Choi Maria Kukuruzinska Caroline A.Genco Andrew Salama Ellen O.Weinberg Carolyn D.Kramer Jorge Frias-Lopez | 2018 | International Journal of Oral Science2018，10，4： | 9 |
| 20 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
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