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| 1 | Long-term follow-up after complete ablation of Barrett's esophagus with argon plasma coagulation显示文摘AIM: To report the long-term outcome of patients after complete ablation of non-neoplastic Barrett's esophagus (BE) with respect to BE relapse and development of intraepithelial neoplasia or esophageal adenocarcinoma.METHODS: In 70 patients with histologically proven nonneoplastic BE, complete BE ablation was achieved by argon plasma coagulation (APC) and high-dose proton pump inhibitor therapy (120 mg omeprazole daily). Sixty-six patients (94.4%) underwent further surveillance endoscopy. At each surveillance endoscopy four-quadrant biopsies were taken from the neo-squamous epithelium at 2 cm intervals depending on the pre-treatment length of BE mucosa beginning at the neo-Z-line, and from any endoscopically suspicious lesion.RESULTS: The median follow-up of 66 patients was 51 mo (range 9-85 mo) giving a total of 280.5 patient years.A mean of 6 biopsies were taken during surveillance endoscopies. In 13 patients (19.7%) tongues or islands suspicious for BE were found during endoscopy. In 8 of these patients (12.1%) non-neoplastic BE relapse was confirmed histologically giving a histological relapse rate of 3% per year. In none of the patients, intraepithelial neoplasia nor an esophageal adenocarcinoma was detected.Logistic regression analysis identified endoscopic detection of islands or tongues as the only positive predictor of BE relapse (P = 0.0004).CONCLUSION: The long-term relapse rate of nonneoplastic BE following complete ablation with high-power APC is low (3% per year). | Ahmed Madisch Stephan Miehike Ekkehard Bayerdoerffer Birgit Wiedemann David Antos Anke Sievert Michael Vieth Manfred Stolte Heinrich Schulz | 2005 | World Journal of Gastroenterology2005，11，8： | 14 |
| 2 | Elevated risk for gastric adenocarcinoma can be predicted from histomorphology显示文摘The number of patients with gastric cancer has more than doubled since 1985 in developing countries. Thus, the questions of whether it can be predicted from gastritis morphology, who is at risk and who has a lower risk of developing gastric carcinoma are raised. H pylori-infection leads to erosions, ulcerations, carcinoma, mucosa associated lymphoid tissue (MALT)- lymphoma and extragastric diseases only in some individuals. The frequency of ulcerations among H pylori-infected individuals is estimated to be 13%, gastric cancer about 1% and MALT lymphoma around 0.1%. In the literature a multistep model from chronic active H pylori -infection through multifocal atrophy, intestinal metaplasia, dysplasia (intraepithelial neoplasia) and carcinoma has been described. But this model cannot be applied to all routine cases. Since risk factors such as metaplasia and atrophy are paracancerous rather than precancerous conditions, this raises the question whether there is a better morphological marker. Differences in topography, grade and activity of Helicobacter gastritis in the antrum and corpus might be good markers for identifying those who are at risk of developing gastric cancer. It is known that the so-called corpus dominant H pylori gastritis is found more frequently among individuals with early and advanced gastric cancer and within high risk populations. This is valid both for first- degree relatives of gastric cancer patients and for patients with gastric adenoma and hyperplastic polyps. In conclusion, corpus-dominant H pylori gastritis is significantly more common in patients with advanced and early gastric cancer, first-degree relatives of patients with gastric cancer, patients with gastric adenoma and gastric hyperplastic polyps. Therefore, all these patients are at risk of developing gastric cancer. Next, the question of who is at risk of developing corpus-dominant gastritis is raised. It appears that patients with a low acid output more frequently develop gastric cancer. Eradication therapy is never performed too early but probably sometimes too late after the patients pass a “point of no return”. Large prospective long term studiesare necessary to prove this and identify new reliable markers for gastric cancer development. | Michael Vieth Mandred Stolte | 2006 | World Journal of Gastroenterology2006，12，38： | 8 |
| 3 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 4 | First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy显示文摘We present the case of a 53-year-old woman with long-standing ulcerative colitis and severe, steroid-dependent disease course unresponsive to treatment with azathioprine, methotrexate, anti-TNF antibodies(infliximab, adalimumab) and tacrolimus, who refused colectomy as a therapeutic option. As the pro-inflammatory cytokine interleukin-6(IL-6) had been identified as a crucial regulator in the immunopathogenesis of inflammatory bowel diseases, we treated the patient with biweekly intravenous infusions of an anti-IL-6R antibody(tocilizumab) for 12 wk. However, no clinical improvement of disease activity was noted. In fact, endoscopic, histological and endomicroscopic assessment demonstrated exacerbation of mucosal inflammation and ulcer formation upon anti-IL-6R therapy. Mechanistic studies revealed that tocilizumab treatment failed to suppress intestinal IL-6 production, impaired epithelial barrier function and induced production of pro-inflammatory cytokines such as TNF, IL-21 and IFN-γ. Inhibition of IL-6 by tocilizumab had no clinical benefit in this patient with intractable ulcerative colitis and even led to exacerbation of mucosal inflammation. Our findings suggest that anti-IL-6R antibody therapy may leadto aggravation of anti-TNF resistant ulcerative colitis. When targeting IL-6, the differential responsiveness of target cells has to be taken into account, as IL-6 on the one side promotes acute and chronic mucosal inflammation via soluble IL-6R signaling but on the other side also strongly contributes to epithelial cell survival via membrane bound IL-6R signaling. | Raja Atreya Ulrike Billmeier Timo Rath Jonas Mudter Michael Vieth Helmut Neumann Markus F Neurath | 2015 | World Journal of Gastroenterology2015，21，45： | 5 |
| 5 | Accuracy of the AAST organ injury scale for CT evaluation of traumatic liver and spleen injuries显示文摘腹的损害的 ObjectiveDetection 是在损伤管理的一个很重要的部件因此对包括他们的严厉度的肝和脾损害的一个精确评价是必要的。有一个好盒子处于紧急情况状况相信那 radiologists’性能可以用获得系统建立从一条系统的途径获利。因为损伤的外科的美国协会起草的机关损害规模(OIS ) 是为客观损伤评价的珍贵指导,获得系统。这研究的目的是回顾地评估用 OIS 的一条结构化的途径是否可以帮助改进损伤 assessmentMethodsFifty -- 在腹的损伤在这被包括以后,经历了 CT 和剖腹术的三个病人, 38 男性和 15 女性学习。剖腹术被富有经验的外科医生与 6 的最小的经验执行;年。当原来的 CT 报告被不同放射线学者与最小写时, 3 经历 有 4 的经验的年,然后一个放射线学者;年考察了一样的原来的 CT 图画,导致结构化的报告。肝和怒气损害上的原版和结构化的 CT 结果被变成 OIS 等级。最后,起始、组织的 CT 结果与调查结果从外科 report.ResultsRegarding 收集了的 intraoperative 相比我们发现了 0.68 的吝啬的分叉的原来的 CT 报告; ± ; 0.8 ( r ; = ; 0.45 )到为肝损害在外科报告发现的 OIS ( 0.69 ; ± ; 1.17 为怒气损害;r = 0.69 ) 。与结构化的途径比较,在我们检测了 0.8 的分叉的地方; ± 0.68;r = 0.63 (0.47 ± 0.77 为怒气损害;r = 0.91 ) ,没有重要差别。然而,我们在结构化的 approaches.ConclusionOur 学习表演检测了在诊断上的更低的率用一张成像清单的腹的损伤不导致的 triage 的一条结构化的途径显著地更高的察觉率,而是一个不重要的趋势到减少 overdiagnoses 的率,因此在分级严厉是更精确的分级。有关由回顾的学习设计的偏爱,进一步未来的调查被需要在组织了报导系统是在另外的放射学的学科的珍贵指导的紧急情况部门过程在工作流上评估损伤分数的影响。 | Georg Homann Christina Toschke Peter Gassmann Volker Vieth | 2014 | Chinese Journal of Traumatology2014，17，1： | 5 |
| 6 | Prevalence of H pylori associated 'high risk gastritis' for development of gastric cancer in patients with normal endoscopic findings显示文摘AIM: To investigate the prevalence of H pylori associated corpus-predominant gastritis (CPG) or pangastritis, severe atrophy, and intestinal metaplasia (IM) in patients without any signifi cant abnormal fi ndings during upper- GI endoscopy. METHODS: Gastric biopsies from 3548 patients were obtained during upper GI-endoscopy in a 4-year period. Two biopsies from antrum and corpus were histologically assessed according to the updated Sydney-System. Eight hundred and forty-fi ve patients (mean age 54.8 ± 2.8 years) with H pylori infection and no peptic ulcer or abnormal gross fi ndings in the stomach were identifi ed and analyzed according to gastritis phenotypes using different scoring systems. RESULTS: The prevalence of severe H pylori associated changes like pangastritis, CPG, IM, and severe atrophy increased with age, reaching a level of 20% in patients of the age group over 45 years. No differences in frequencies between genders were observed. The prevalence of IM had the highest increase, being 4-fold higher at the age of 65 years versus in individuals less than 45 years. CONCLUSION: The prevalence of gastritis featuring at risk for cancer development increases with age. These findings reinforce the necessity for the histological assessment, even in subjects with normal endoscopic appearance. The age-dependent increase in prevalence of severe histopathological changes in gastric mucosa, however, does not allow estimating the individual risk forgastric cancer development-only a proper follow-up can provide this information. | Andreas Leodolter Matthias P Ebert Ulrich Peitz Kathlen Wolle Stefan Kahl Michael Vieth Peter Malfertheiner | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 7 | Strictures, diaphragms, erosions or ulcerations of ischemic type in the colon should always prompt consideration of nonsteroidal anti-inflammatory drug-induced lesions显示文摘AIM: To investigate whether NSAIDs/ASA lesions in the colon can histologically be diagnosed on the basis of ischemic necrosis similar to biopsy-based diagnosis of NSAIDs/ASA-induced erosions and ulcers of the stomach.METHODS: In the period between 1997 and 2002, we investigated biopsy materials obtained from 611 patients (415 women, 196 men, average age 60.5 years) with endoscopic focal erosions, ulcerations, strictures or diaphragms in the colon. In the biopsies obtained from these lesions, we always established the suspected diagnosis of NSAID-induced lesions whenever necroses of the ischemic type were found. Together with the histological report, we endosed a questionnaire to investigate the use of medication.The data provided by the questionnaire were then correlated with the endoscopic findings, the location, number and nature of the lesions, and the histological findings.RESULTS: At the time of their colonoscopy, 86.1% of the patients had indeed been taking NSAID/ASA medication for years (43.9%) or months (29.5%). The most common indication for the use of these drugs was pain (64.3%),and the most common indication for colonoscopy was bleeding (55.5%). Endoscopic inspection revealed multiple erosions and/or ulcers in 60.6%, strictures in 15.8%, and diaphragms in 3.0% of the patients. The lesions were located mainly in the right colon including the transverse colon (79.9%). A separate analysis of age and sex distribution,endoscopic and histological findings for NSAIDs alone,ASA alone, combined NSAID/ASA, and for patients denying the use of such drugs, revealed no significant differences among the groups.CONCLUSION: This uncontrolled retrospective study based on the histological finding of an ischemic necrosis shows that the histologically suspected diagnosis of NSAID-induced lesions in the colon is often correct. The true diagnostic validity of this finding and the differentiation from ischemic colitis should, however, be investigated in a prospective controlled study. | Manfred Stolte Diana Karimi Michael Vieth Hildegard Volkholz Klaus Dirschmid Sigrid Rappel Birgit Bethke | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 8 | Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo显示文摘 | Ralf Kiesslich Juergen Burg Michael Vieth Janina Gnaendiger Meike Enders Peter Delaney Adrian Polglase Wendy McLaren Daniela Janell Steven Thomas Bernhard Nafe Peter R. Galle Markus F. Neurath | 2004 | Gastroenterology2004，，3： | 3 |
| 9 | Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus显示文摘AIM To determine the impact of upwards titration of proton pump inhibition(PPI) on acid reflux, symptom scores and histology, compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett's esophagus(BE) patients were studied. In group 1(n = 24), increasing doses of PPI were administered in 8-wk intervals until acid reflux normalization. At each assessment, ambulatory 24 h p H recording, endoscopy with biopsies and symptom scoring(by a gastroesophageal reflux disease health related quality of life questionnaire, GERD/HRLQ) were performed. Group 2(n = 30) consisted of patients with a previous fundoplication. RESULTS In group 1, acid reflux normalized in 23 of 24 patients, resulting in improved GERD/HRQL scores(P = 0.001), which were most pronounced after the starting dose of PPI(P < 0.001). PPI treatment reached the same level of GERD/HRQL scores as after a clinically successful fundoplication(P = 0.5). Normalization of acid reflux in both groups was associated with reduction in papillary length, basal cell layer thickness, intercellular space dilatation, and acute and chronic inflammation of squamous epithelium. CONCLUSION This study shows that acid reflux and symptom scores co-vary throughout PPI increments in long-segment BE patients, especially after the first dose of PPI, reaching the same level as after a successful fundoplication. Minor changes were found among GERD markers at the morphological level. | Francisco Baldaque-Silva Michael Vieth Mumen Debel Bengt Hakanson Anders Thorell Nuno Lunet Huan Song Miguel Mascarenhas-Saraiva Gisela Pereira Lars Lundell Hanns-Ulrich Marschall | 2017 | World Journal of Gastroenterology2017，23，17： | 3 |
| 10 | The Development and Validation of an Endoscopic Grading System for Barrett’s Esophagus: The Prague C & M Criteria显示文摘 | Prateek Sharma John Dent David Armstrong Jacques J.G.H.M. Bergman Liebwin Gossner Yoshio Hoshihara Janusz A. Jankowski Ola Junghard Lars Lundell Guido N.J. Tytgat Michael Vieth | 2006 | Gastroenterology2006，，5： | 3 |
| 11 | Consensus Statements for Management of Barrett’s Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process显示文摘 | Cathy Bennett Nimish Vakil Jacques Bergman Rebecca Harrison Robert Odze Michael Vieth Scott Sanders Laura Gay Oliver Pech Gaius Longcroft–Wheaton Yvonne Romero John Inadomi Jan Tack Douglas A. Corley Hendrik Manner Susi Green David Al Dulaimi Haythem Ali | 2012 | Gastroenterology2012，，2： | 2 |
| 12 | A Novel Line Immunoassay Based on Recombinant Virulence Factors Enables Highly Specific and Sensitive Serologic Diagnosis of Helicobacter pylori Infection显示文摘 | Luca Formichella Laura Romberg Christian Bolz Michael Vieth Michael Geppert Gereon G?ttner Christina N?lting Dirk Walter Wolfgang Schepp Arne Schneider Kurt Ulm Petra Wolf Dirk H. Busch Erwin Soutschek Markus Gerhard | 2013 | Clinical and Vaccine Immunology2013，，11： | 2 |
| 13 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 14 | Prevalence of Barrett’s Esophagus in the General Population: An Endoscopic Study显示文摘 | Jukka Ronkainen Pertti Aro Tom Storskrubb Sven–Erik Johansson Tore Lind Elisabeth Bolling–Sternevald Michael Vieth Manfred Stolte Nicholas J. Talley Lars Agréus | 2005 | Gastroenterology2005，，： | 2 |
| 15 | Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn’s disease: a pilot study显示文摘 | Gian Tontini Jonas Mudter Michael Vieth Raja Atreya Claudia Günther Yurdagül Zopf Dane Wildner Ralf Kiesslich Maurizio Vecchi Markus Neurath Helmut Neumann | 2014 | Endoscopy2014，，： | 2 |
| 16 | Curative endoscopic resection of early esophageal adenocarcinomas (Barrett’s cancer)显示文摘 | Christian Ell Andrea May Oliver Pech Liebwin Gossner Erwin Guenter Angelika Behrens Lars Nachbar Josephus Huijsmans Michael Vieth Manfred Stolte | 2007 | Gastrointestinal Endoscopy2007，，1： | 2 |
| 17 | European consensus on the histopathology of inflammatory bowel disease显示文摘 | F. Magro C. Langner A. Driessen A. Ensari K. Geboes G.J. Mantzaris V. Villanacci G. Becheanu P. Borralho Nunes G. Cathomas W. Fries A. Jouret-Mourin C. Mescoli G. de Petris C.A. Rubio N.A. Shepherd M. Vieth R. Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 18 | OLGA staging for gastritis: A tutorial显示文摘 | M. Rugge P. Correa F. Di Mario E. El-Omar R. Fiocca K. Geboes R.M. Genta D.Y. Graham T. Hattori P. Malfertheiner S. Nakajima P. Sipponen J. Sung W. Weinstein M. Vieth | 2008 | Digestive and Liver Disease2008，，8： | 2 |
| 19 | Endoscopic submucosal dissection of early gastric neoplasia with a water jet–assisted knife: a Western, single-center experience显示文摘 | Brigitte Schumacher Jean-Pierre Charton Thomas Nordmann Michael Vieth Markus Enderle Horst Neuhaus | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 20 | Estimates of optimal vitamin D status显示文摘 | Bess Dawson-Hughes Robert P. Heaney Michael F. Holick Paul Lips Pierre J. Meunier Reinhold Vieth | 2005 | Osteoporosis International2005，，7： | 2 |
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