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| 1 | Recent results of laparoscopic surgery in inflammatory bowel disease显示文摘Inflammatory bowel diseases are an ideal indication for the laparoscopic surgical approach as they are basically benign diseases not requiring lymphadenectomy and extended mesenteric excision;well-established surgical procedures are available for the conventional approach.Inflammatory alterations and fragility of the bowel and mesentery,however,may demand a high level of laparoscopic experience.A broad spectrum of operations from the rather easy enterostomy formation for anal Crohn’s disease(CD)to restorative proctocolectomies for ulcerative colitis(UC)may be managed laparoscopically.The current evidence base for the use of laparoscopic techniques in the surgical therapy of inflammatory bowel diseases is presented.CD limited to the terminal ileum has become a common indication for laparoscopic surgical therapy.In severe anal CD, laparoscopic stoma formation is a standard procedure with low morbidity and short operative time.Studies comparing conventional and laparoscopic bowel resections,have found shorter times to first postoperative bowel movements and shorter hospital stays as well as lower complication rates in favour of the laparoscopic approach.Even complicated cases with previous surgery,abscess formation and enteric fistulas may be op-erated on laparoscopically with a low morbidity.In UC, restorative proctocolectomy is the standard procedure in elective surgery.The demanding laparoscopic approach is increasingly used,however,mainly in major centers; its feasibility has been proven in various studies.An increased body mass index and acute inflammation of the bowel may be relative contraindications.Short and longterm outcomes like quality of life seem to be equivalent for open and laparoscopic surgery.Multiple studies have proven that the laparoscopic approach to CD and UC is a safe and successful alternative for selected patients. The appropriate selection criteria are still under investigation.Technical considerations are playing an important role for the complexity of both diseases. | Hermann Kessler Jonas Mudter Werner Hohenberger | 2011 | World Journal of Gastroenterology2011，17，9： | 7 |
| 2 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 3 | New endoscopic approaches in IBD显示文摘Recent advances in endoscopic imaging techniques have revolutionized the diagnostic approach of patients with inflammatory bowel disease(IBD).New,emerging endoscopic imaging techniques visualized a plethora of new mucosal details even at the cellular and subcellular level.This review offers an overview about new endoscopic techniques,including chromoendoscopy,magnification endoscopy,spectroscopy,confocal laser endomicroscopy and endocytoscopy in the face of IBD. | Helmut Neumann Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 4 | First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy显示文摘We present the case of a 53-year-old woman with long-standing ulcerative colitis and severe, steroid-dependent disease course unresponsive to treatment with azathioprine, methotrexate, anti-TNF antibodies(infliximab, adalimumab) and tacrolimus, who refused colectomy as a therapeutic option. As the pro-inflammatory cytokine interleukin-6(IL-6) had been identified as a crucial regulator in the immunopathogenesis of inflammatory bowel diseases, we treated the patient with biweekly intravenous infusions of an anti-IL-6R antibody(tocilizumab) for 12 wk. However, no clinical improvement of disease activity was noted. In fact, endoscopic, histological and endomicroscopic assessment demonstrated exacerbation of mucosal inflammation and ulcer formation upon anti-IL-6R therapy. Mechanistic studies revealed that tocilizumab treatment failed to suppress intestinal IL-6 production, impaired epithelial barrier function and induced production of pro-inflammatory cytokines such as TNF, IL-21 and IFN-γ. Inhibition of IL-6 by tocilizumab had no clinical benefit in this patient with intractable ulcerative colitis and even led to exacerbation of mucosal inflammation. Our findings suggest that anti-IL-6R antibody therapy may leadto aggravation of anti-TNF resistant ulcerative colitis. When targeting IL-6, the differential responsiveness of target cells has to be taken into account, as IL-6 on the one side promotes acute and chronic mucosal inflammation via soluble IL-6R signaling but on the other side also strongly contributes to epithelial cell survival via membrane bound IL-6R signaling. | Raja Atreya Ulrike Billmeier Timo Rath Jonas Mudter Michael Vieth Helmut Neumann Markus F Neurath | 2015 | World Journal of Gastroenterology2015，21，45： | 5 |
| 5 | Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn’s disease: a pilot study显示文摘 | Gian Tontini Jonas Mudter Michael Vieth Raja Atreya Claudia Günther Yurdagül Zopf Dane Wildner Ralf Kiesslich Maurizio Vecchi Markus Neurath Helmut Neumann | 2014 | Endoscopy2014，，： | 2 |
| 6 | Recognition and characterization of small colonic neoplasia with high-definition colonoscopy using i-Scan is as precise as chromoendoscopy显示文摘 | A. Hoffman C. Kagel M. Goetz A. Tresch J. Mudter S. Biesterfeld P.R. Galle M.F. Neurath R. Kiesslich | 2009 | Digestive and Liver Disease2009，，1： | 2 |
| 7 | Recognition and characterization of small colonic neoplasia with high-definition colonoscopy using i-Scan is as precise as chromoendoscopy显示文摘 | A. Hoffman C. Kagel M. Goetz A. Tresch J. Mudter S. Biesterfeld P.R. Galle M.F. Neurath R. Kiesslich | 2009 | Digestive and Liver Disease2009，，1： | 1 |
| 8 | High-definition endoscopy with i-Scan and Lugol’s solution for more precise detection of mucosal breaks in patients with reflux symptoms显示文摘 | A. Hoffman N. Basting M. Goetz A. Tresch J. Mudter S. Biesterfeld P. Galle M. Neurath R. Kiesslich | 2009 | Endoscopy2009，，02： | 1 |
| 9 | Functional rele- vance of T helper 17 (Thl7) cells and the IL-17 cy- tokine family in inflammatory bowel disease 显示文摘 | Hundorfean G Neurath MF Mudter J | 2012 | Inflamm Bowel Dis2012，18，1： | 1 |
| 10 | Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo显示文摘 | Atreya R Mudter J Finotto S | 2000 | Nat Med2000，6，5： | 1 |
| 11 | IL-6 signaling in inflammatory boweldisease : Pathophysiological role and clinical,relevance 显示文摘 | Mudter J Neurath MF | 2007 | Inflamm Bowel Dis2007，13，8： | 1 |
| 12 | Insight into Crohn’s disease pathomorphology显示文摘 | Jonas Mudter Markus F. Neurath | 2012 | Abdominal Imaging2012，，6： | 1 |
| 13 | Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory diseases显示文摘 | Mudter J Weigmann B Bartsch B | 2005 | Am J Gastroenterol2005，100，1： | 1 |
| 14 | Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflanunation:evidence in Crohn's disease and expefimential colitis in vivo 显示文摘 | Aterya R Mudter J Finotto S | 2000 | Nat Med2000，6，5： | 1 |
| 15 | Assessment of Crohn’s disease activity by confocal laser endomicroscopy显示文摘 | Helmut Neumann Michael Vieth Raja Atreya Martin Grauer Jürgen Siebler Thomas Bernatik Markus F. Neurath Jonas Mudter | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 16 | IRF4 regulates IL-17A pro- moter activity and controls RORct dependent ThlTcolitis in vivo显示文摘 | MUDTER J YU J L ZUFFEREY C | 2011 | Inflamm Bowel Dis2011，17，6： | 1 |
| 17 | Blockade ofinterleukin 6 transsighaling suppresses T-cell resistance against apoptosis in chronic in testinal inflammation: evidence in crohn disease and experimental colitis in vivo显示文摘 | Atreya R Mudter J Finotto S | 2000 | Nat Med2000，6，5： | 1 |
| 18 | Blockade of interleukin 6 transsignaling suppresses t-cell resistance against apoptosis in chronicintestinal inflammation;evidence in crohn disease and experimentialcolitis in vivo显示文摘 | Atreya R Mudter J Finotto S | | Nat Med0，6，5： | 1 |
| 19 | Il-6 signaling in inflammatory bowel disease:pathophysiological role and clinical relevance显示文摘 | Mudter J Neurath MF | 2007 | Inflamm Bowel Dis2007，13，8： | 1 |
| 20 | High definition colonoscopy combined with i-Scan is superior in the detection of colorectal neoplasias compared with standard video colonoscopy: a prospective randomized controlled trial显示文摘 | A. Hoffman F. Sar M. Goetz A. Tresch J. Mudter S. Biesterfeld P. Galle M. Neurath R. Kiesslich | 2010 | Endoscopy2010，，10： | 1 |
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