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| 1 | 中国细菌耐药监测研究显示文摘目的 了解我国不同地区院内感染 (HI)和社区获得感染 (CAI)病人中致病菌的耐药趋势。方法 按 1998年美国临床实验标准委员会指导原则采用标准的平皿稀释法 ,对 1998~ 1999年从13家医院分离的 2 0 81株致病菌进行敏感试验。以MIC50 、MIC90 表示抗菌药物的抗菌活性 ,R %、I%、S %代表细菌对所测药物的耐药率、中介率与敏感率。结果 从CAI与HI病人中分别分离到金黄色葡萄球菌 87株与 11株 ,共 98株。甲氧西林耐药金黄色葡萄球菌 (MRSA)检出率为 2 7.5 5 % (2 7/ 98) ,HI病人中MRSA检出率为 81.82 % (9/ 11) ,显著高于CAI病人的MRSA检出率 2 1.84% (19/ 87)。青霉素耐药肺炎链球菌 (PRSP)的检出率 (R % +I% )为 2 2 5 0 % (9/ 40 ) ,其中R(MIC≥ 2mg/L)仅为 2 .5 %(1/ 40 ) ,I占 2 0 % (8/ 40 )。未发现万古霉素耐药金黄色葡萄球菌和万古霉素耐药肠球菌 (VRE) ,万古霉素中介粪肠球菌和屎肠球菌分别为 3 .2 3% (9/ 2 79)和 3.77% (2 / 5 3)。大肠杆菌对各种喹诺酮类呈交叉耐药 ,耐药率超过 6 0 %。结论 中国也存在严重的多重耐药问题 ,如多重耐药的MRSA、PRSP、肠杆菌属等 ,特别是大肠杆菌对喹诺酮类的耐药率 。 | 李家泰 AllanJ Weinstein 杨敏 中国细菌耐药监测研究组 | 2001 | 中华医学杂志2001，81，1： | 376 |
| 2 | Reversible Middle Cerebral Artery Occlusion Without Craniectomy in Rats显示文摘 | Enrique Zea Longa Philip R. Weinstein Sara Carlson Robert Cummins | 1989 | Stroke1989，，1： | 27 |
| 3 | Reversible Middle Cerebral Artery Occlusion Without Craniectomy in Rats显示文摘 | Enrique Zea Longa Philip R. Weinstein Sara Carlson Robert Cummins | 1989 | Stroke1989，，1： | 9 |
| 4 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 5 | Mayo临床中心肺癌CT筛查的长期效果评价显示文摘目的分析Mayo临床中心肺癌CT筛查研究受试者的单组个体数据,评价筛查的长期效果,同时对比评价已知肺癌模拟模型和应用相同数据建立的不同模型之间的差别。方法本研究经伦理审查委员会批准,并且符合HIPPA。在Mayo临床中心,由1520例肺癌筛查受试者(年龄50~85岁,吸烟或有吸烟史)的匿名资料组成肺癌政策模型.包括微观的肺癌发展模拟模型、CT筛查所见、治疗结果和长期结果。模型用于预测单位研究小组内(包括连续5a肺癌年筛查和不进行肺癌筛查)肺癌的诊断和死亡。 | P.M. McMahon C.Y. Kong B.E. Johnson M.C. Weinstein J.C. Weeks K.M.Kuntz 高莉(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 5 |
| 6 | Market access, economic geography and comparative advantage: an empirical test显示文摘 | Donald R. Davis David E. Weinstein | 2002 | Journal of International Economics2002，，1： | 3 |
| 7 | Reversible middle cerebral artery occlusion without craniectomy in rats 显示文摘 | Zea Longa EL Weinstein PR Canson S | 1989 | Stroke1989，20，1： | 2 |
| 8 | Fecal Incontinence in US Adults: Epidemiology and Risk Factors显示文摘 | William E. Whitehead Lori Borrud Patricia S. Goode Susan Meikle Elizabeth R. Mueller Ashok Tuteja Alison Weidner Milena Weinstein Wen Ye | 2009 | Gastroenterology2009，，2： | 2 |
| 9 | EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells显示文摘 | Masahito Shimizu Atsuko Deguchi Yukihiko Hara Hisataka Moriwaki I. Bernard Weinstein | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 2 |
| 10 | Economic geography and regional production structure: An empirical investigation显示文摘 | Donald R. Davis David E. Weinstein | 1999 | European Economic Review1999，，2： | 2 |
| 11 | New criteria for blind deconvolution of nonminimum phase systems(channels)显示文摘 | SHALVI O WEINSTEIN E | 1990 | IEEE Trans Inform Theory1990，36，： | 2 |
| 12 | Evaluation of operative cholangiography in 2043 patients undergoing laparoscopic cholecystectomy显示文摘 | L. L. Snow L. S. Weinstein J. K. Hannon D. R. Lane | 2001 | Surgical Endoscopy2001，，1： | 2 |
| 13 | Periodic orbits for convex Hamiltonian systems显示文摘 | Weinstein A | 1978 | Ann Math1978，108，4： | 2 |
| 14 | OLGA staging for gastritis: A tutorial显示文摘 | M. Rugge P. Correa F. Di Mario E. El-Omar R. Fiocca K. Geboes R.M. Genta D.Y. Graham T. Hattori P. Malfertheiner S. Nakajima P. Sipponen J. Sung W. Weinstein M. Vieth | 2008 | Digestive and Liver Disease2008，，8： | 2 |
| 15 | The effects of large interference on thetracking capability of digitally implemented echo cancellers显示文摘 | Gitlin R D Weinstein S D | 1978 | IEEE Trans on COM1978，，6： | 2 |
| 16 | 模拟游戏:潜力巨大的员工培训媒介显示文摘多数培训师都曾听说过运用严肃游戏和模拟来进行员工培训,但多数人依然没有意识到这一媒介的巨大潜力。实际上,对市场触觉敏感的培训师来说,方案游戏化与多人在线游戏技术革命性的发展大大激发了组织学习兴趣以及学习者参与的热情。精心设计的培训游戏和模拟使学员以深入参与的方式来学习新技能并在虚拟的环境下安全进行实践。 | Margery Weinstein | 2013 | 职业2013，，7： | 2 |
| 17 | Ankle Fractures in the Elderly: What You Get Depends on Where You Live and Who You See显示文摘 | Kenneth J Koval Jon Lurie Weiping Zhou Michael B Sparks Robert V Cantu Scott M Sporer James Weinstein | 2005 | Journal of Orthopaedic Trauma2005，，9： | 2 |
| 18 | Reyersible Middle Cerebral Artery Occlusion without Craniectomy in rats 显示文摘 | Zea Longa EL Weinstein PR Carlson S | 1989 | Stroke1989，20，： | 2 |
| 19 | Reversible middle cerebral artery occlusion without craniectomy in rats显示文摘 | Longa E Z Weinstein P R Carlson S | 1989 | Stroke1989，20，1： | 2 |
| 20 | 在男吸烟者之中的白血球 DNA methylation 和 colorectal 癌症显示文摘 AIM: To explore the association between methylation in leukocyte DNA and colorectal cancer (CRC) risk in male smokers using the α-tocopherol, β-carotene cancer prevention study. METHODS: About 221 incident CRC cases, and 219controls, frequency-matched on age and smoking intensity were included. DNA methylation of 1505 CpG sites selected from 807 genes were evaluated using Il-lumina GoldenGate Methylation Cancer Panel I in prediagnostic blood leukocytes of study subjects. Tertiles of methylation level classified according to the distribution in controls for each CpG site were used to analyze the association between methylation level and CRC risk with logistic regression. The time between blood draw to cancer diagnosis (classifying cases according to latency) was incorporated in further analyses using proportional odds regression. RESULTS: We found that methylation changes of 31 CpG sites were associated with CRC risk at P<0.01 level. Though none of these 31 sites remained statistically significant after Bonferroni correction, the most statistically significant CpG site associated with CRC risk achieved a Pvalue of 1.0×10-4 . The CpG site is located in DSP gene, and the risk estimate was 1.52 (95% CI: 0.91-2.53) and 2.62 (95% CI: 1.65-4.17) for the second and third tertile comparing with the lowest tertile respectively. Taking the latency information into account strengthened some associations, suggesting that the methylation levels of corresponding sites might change over time with tumor progression. CONCLUSION: The results suggest that the methylation level of some genes were associated with cancer susceptibility and some were related to tumor development over time. Further studies are warranted to confirm and refine our results. | Keith Killian Stephanie Weinstein Jarmo Virtamo Margaret Tucker Philip Taylor Demetrius Albanes Paul Meltzer Neil Caporaso | 2012 | World Journal of Gastrointestinal Oncology2012，4，8： | 2 |
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