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| 1 | 乳腺癌患者的心身症状与生活质量显示文摘目的:探讨乳腺癌患者抑郁、焦虑的心理症状与躯体症状之间的关系,心身症状与生活质量的关系以及心身症状和生活质量与患者所接受过的治疗和生存期的关系。方法:本研究采用横断面设计,对北京市315例符合入组标准的乳腺癌患者进行调查,所使用的调查工具包括病人健康问卷(PHQ-15)、病人健康问卷抑郁量表(PHQ-9)、广泛性焦虑量表(GAD-7)及癌症患者生命质量测定量表(QLQ-C30),并对255份有效数据进行了分析。结果:乳腺癌患者躯体症状的严重程度与抑郁、焦虑均呈正相关(r=0.44,0.56;均P<0.01);在重度躯体症状的患者中,抑郁的发生率为42.3%,焦虑的发生率为50%;抑郁、焦虑与乳腺癌患者总体健康状况相关(β=-0.22,-0.30;均P<0.01);接受化疗的患者其躯体症状和抑郁、焦虑得分高于未接受化疗的患者[(9.0±5.0)vs.(6.0±4.1),(8.3±6.0)vs.(4.0±3.5),(5.4±5.0)vs.(3.1±3.7);均P<0.01];生存期5年以上的乳腺癌患者只有焦虑分数低于5年以内的患者[(5.8±5.0)vs.(4.3±4.5),P<0.05],在躯体症状、抑郁和生活质量方面差异无统计学意义。结论:乳腺癌患者抑郁、焦虑的心理症状与其躯体症状和总体健康状况相关,接受化疗患者的心身症状和生活质量可能会更差一些,生存期5年以上的患者焦虑水平低于5年以内的患者,但躯体症状、抑郁以及生活质量与生存期的延长未见相关。 | 庞英 FISCHER Irmela KOCH Maike FRITZSCHE Kurt 唐丽丽 | 2013 | 中国心理卫生杂志2013，27，4： | 109 |
| 2 | 大别造山带壳幔界面的断错结构和壳内低速体显示文摘2001年4月~2002年3月, 北起河南兰考附近的崔林(34°40′N, 114°49′E), 南到江西大冶附近的大箕铺(30°20′N, 115°03′E), 横跨大别造山带, 布设了总长度约500 km, 由34台宽频带流动地震仪组成的二维地震台阵观测剖面. 台站采用不等间距布设. 在大别造山带范围内, 台站间距为3~8 km, 其他地区为15~20 km. 利用台阵记录的远震P波波形数据和接收函数方法, 获得了横穿大别造山带的接收函数剖面和各台站下方100 km深度范围内地壳上地幔的S波速度结构. 研究结果表明: 大别造山带地壳在垂直山体走向的方向上具有明显的非对称分块结构; 地壳最大厚度为42 km; 壳幔界面具有与地壳分块结构相应的断错结构, 最大断距达到8 km; 在造山带核部, 存在壳内横波低速体; 壳内低速体分为两部分, 分别对应南大别和北大别; 在垂向上两者可能曾有差异运动; 其下方地壳速度具有随深度增加的梯度结构, 上地幔顶部直到70 km深度范围内速度异常偏低, 而其下方70~100 km的深度上有高速异常体. | 刘启元 Rainer Kind 陈九辉 Yuan Xiaohui 李顺成 郭飚 Kurt Wylegalla 赖院根 | 2005 | 中国科学(D辑)2005，35，4： | 31 |
| 3 | 清洗、消毒在医院感染控制中的重要性显示文摘 | Kurt Voboril 李东兵 | 2006 | 中国感染控制杂志2006，5，1： | 33 |
| 4 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 5 | 塔河油田奥陶系碳酸盐岩裂缝成因研究显示文摘塔河油田碳酸盐岩储集层主要为岩溶作用、多期构造叠加及构造变形作用形成的缝洞型储集层,裂缝具有连通有效储存空间的桥梁作用。区分构造裂缝与非构造裂缝,结合塔河油田构造特征,并对碳酸盐岩储层裂缝特征、分类及其成因进行了分析。研究表明:构造裂缝为塔河油田岩溶储层发育提供了流体运移通道,为油气的运移,特别是垂向运移提供了条件;非构造裂缝的存在改善了储层储渗性能,扩大了储层泄油面积。构造裂缝和非构造裂缝的存在作为储层的有利影响因素,对其进行深入研究可以为碳酸盐岩储层开发提供有益参考,并可增加储层预测产量。 | 艾合买提江.阿不都热和曼 钟建华 Kurt Bucher Ingrid Stober | 2009 | 特种油气藏2009，16，4： | 20 |
| 6 | 综合医院不同科室门诊多躯体症状患者抑郁、焦虑障碍的检出率及症状分布特点--一项多中心横断面研究显示文摘目的:描述综合医院不同科室门诊中多躯体症状患者的躯体、抑郁和焦虑症状分布特点及抑郁障碍、焦虑障碍检出率。方法:对国内6个综合医院中医科、西医内科和精神/心理科门诊候诊患者连续筛查,并完成简明国际神经精神障碍访谈(MINI)。结果:本研究共纳入491例受试者,其中多躯体症状组(SOM+)237例(48.3%)。SOM+患者最常受困扰的抑郁症状为疲劳和睡眠问题等;其抑郁或焦虑障碍的检出率为50.4%。此外,尽管躯体症状严重程度相似,在心理科就诊的SOM+患者抑郁或焦虑障碍的检出率更高(34.6%,43.9%,76.2%;χ~2=17.1,P<0.01)。结论:综合医院门诊多躯体症状患者中抑郁或焦虑障碍的检出率较高;疲劳和睡眠问题是多躯体症状患者中最常见症状。 | 熊娜娜 魏镜 洪霞 李涛 蒋静 朱丽明 田国庆 赵旭东 张岚 Kurt Fritzsche | 2017 | 临床精神医学杂志2017，27，2： | 16 |
| 7 | Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?显示文摘AIM: To determine the association between the neutrophil to lymphocyte(N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B(CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the 'no/minimal liver fibrosis' group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the 'advanced liver fibrosis' group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant.RESULTS: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the 'no/minimal fibrosis' group included 79 individuals, while the 'advanced fibrosis' group included 50 individuals. Mean(N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis.CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB. | Murat Kekilli Alpaslan Tanoglu Yusuf Serdar Sakin Mevlut Kurt Serkan Ocal Sait Bagci | 2015 | World Journal of Gastroenterology2015，21，18： | 15 |
| 8 | 高温合金的发展与选择显示文摘 | Kurt P.Rohrbach | 2005 | 宇航材料工艺2005，35，1： | 13 |
| 9 | 荧光显像技术在消化外科中的应用进展显示文摘近红外荧光显像技术可运用特殊分子的荧光特性增强显示人体重要解剖结构和组织血流灌注。笔者总结荧光显像技术原理、常用荧光分子特性和荧光显像设备特点,探讨荧光显像技术在胃食管外科、肝胆外科、结直肠外科及腹膜恶性肿瘤等外科实践中的应用价值。笔者认为:通过特异性抗体偶联荧光分子探针检出肿瘤转移灶是荧光显像技术应用于消化外科的未来发展方向。 | Lucas Willian Thornblade Kurt Allan Melstrom Ali Zhumkhawala Yuman Fong | 2021 | 中华消化外科杂志2021，20，2： | 13 |
| 10 | Feedstock choice,pyrolysis temperature and type influence biochar characteristics:a comprehensive meta-data analysis review显示文摘Various studies have established that feedstock choice,pyrolysis temperature,and pyrolysis type influence final biochar physicochemical characteristics.However,overarching analyses of pre-biochar creation choices and correlations to biochar characteristics are severely lacking.Thus,the objective of this work was to help researchers,biochar-stakeholders,and practitioners make more well-informed choices in terms of how these three major parameters influence the final biochar product.Utilizing approximately 5400 peer-reviewed journal articles and over 50,800 individual data points,herein we elucidate the selections that influence final biochar physical and chemical properties,total nutrient content,and perhaps more importantly tools one can use to predict biochar’s nutrient availability.Based on the large dataset collected,it appears that pyrolysis type(fast or slow)plays a minor role in biochar physico-(inorganic)chemical characteristics;few differences were evident between production styles.Pyrolysis temperature,however,affects biochar’s longevity,with pyrolysis temperatures>500℃ generally leading to longer-term(i.e.,>1000 years)half-lives.Greater pyrolysis temperatures also led to biochars containing greater overall C and specific surface area(SSA),which could promote soil physico-chemical improvements.However,based on the collected data,it appears that feedstock selection has the largest influence on biochar properties.Specific surface area is greatest in wood-based biochars,which in combination with pyrolysis temperature could likely promote greater changes in soil physical characteristics over other feedstock-based biochars.Crop-and other grass-based biochars appear to have cation exchange capacities greater than other biochars,which in combination with pyrolysis temperature could potentially lead to longer-term changes in soil nutrient retention.The collected data also suggest that one can reasonably predict the availability of various biochar nutrients(e.g.,N,P,K,Ca,Mg,Fe,and Cu)based on feedstock choice and total nutrient content.Results can be used to create designer biochars to help solve environmental issues and supply a variety of plant-available nutrients for crop growth. | James A.Ippolito Liqiang Cui Claudia Kammann Nicole Wrage‑Mönnig Jose MEstavillo Teresa Fuertes‑Mendizabal Maria Luz Cayuela Gilbert Sigua Jeff Novak Kurt Spokas Nils Borchard | 2020 | Biochar2020，2，4： | 13 |
| 11 | 传统DNA疫苗载体与Semliki森林病毒复制子对HIV-1 Pr55^(gag)表达与体液免疫原性的比较性研究显示文摘为探索Semliki森林病毒 (SFV)衍生的复制型DNA载体可否用于HIV疫苗的候选载体 ,对该载体与传统DNA疫苗载体对HIV - 1Pr5 5 gag的表达与体液免疫原性进行了系统比较研究。将野生型 (wtgag)及密码子改造(syngag)的HIV - 1ⅢBgag 基因分别克隆于SFVDNA载体及传统DNA疫苗载体 [pCDNA3 1(+) ],对其Pr5 5 gag细胞内表达水平、Pr5 5 gag病毒样颗粒释放、以及在BALB/c鼠的体液免疫原性进行了比较。在 2 93T、H12 99、C2C12和BHK细胞系中 ,SFV -wtgag可以Rev非依赖方式有效表达Pr5 5 gag ,而 pC -wtgag转染的细胞不能有效表达Pr5 5 gag,从而不能诱导小鼠产生免疫反应。虽然SFV质粒的细胞转化效率明显低于pCDNA载体 ,SFV -wtgag和SFV -syngag在细胞内Pr5 5 gag的表达量与 pC -syngag相似 ,而Pr5 5 gag病毒样颗粒的释放明显低于 pC -syngag。在肌内注射免疫的小鼠中 ,低剂量 (0 1和 1 0 μg)的SFV及 pCDNAgag表达质粒均未诱导出GAG特异性免疫反应。在高剂量 (10 ,30 ,10 0 μg)免疫组中 ,与SFVgag表达质粒相比 ,pC -syngag可诱导出较高水平的TH1型GAG特异性抗体。SFV -syngag较SFV -wtgag可诱导出高水平的体液免疫反应。结果提示 ,SFV衍生的复制子单独使用不能在小鼠诱导出优于传统DNA疫苗载体的HIV - 1GAG特异性? | 张健慧 Jens Wild Kurt Bieler Marcus Graf Ludwig Deml Hans Wolf PeterLiljestrm Ralf Wagner 邵一鸣 | 2002 | 病毒学报2002，18，1： | 13 |
| 12 | 躯体形式障碍与躯体症状障碍患者临床特征比较显示文摘目的探索三甲综合医院门诊躯体形式障碍(somatoform disorder,SFD)和躯体症状障碍(somatic symptom disorder,SSD)患者临床特征的差异。方法采用方便取样法纳入消化内科、神经内科、中医科、精神科门诊候诊患者,完成患者健康问卷躯体症状群量表(Patient Health Questionnaire-15,PHQ-15),患者健康问卷抑郁量表(Patient Health Questionnare-9,PHQ-9),广泛性焦虑障碍量表(General Anxiey Disorder Scale,GAD-7),躯体症状障碍诊断B标准量表(Somatic Symptom Disorder-B Criteria Scale,SSD-12),世界卫生组织残疾评定方案2.0(WHO Disability Assessment Schedule 2.0,WHO DAS 2.0)等自评问卷,并经结构化访谈得出SSD和SFD诊断,采用独立样本t检验分析并比较SSD和SFD患者的临床特征及差异。结果699例受访者中,236例(33.8%)和431例(61.7%)分别被诊断为SSD和SFD,二者诊断一致性较低(Cohenκ=0.291 P<0.01)。SSD患者在PHQ-15[(12.01±5.54)分比(10.38±5.53)分,t=3.624]、PHQ-9[(11.84±6.76)分比(9.40±6.57)分,t=4.546]、GAD-7[(9.70±6.08)分比(7.34±5.92)分,t=4.871]、SSD-12[(23.60±11.43)分比(16.52±12.64)分,t=7.154]和WHO DAS 2.0[(22.65±8.52)分比(19.96±7.77)分,t=4.128]量表得分显著高于SFD患者,均P<0.01。结论SSD和SFD诊断一致性较低;相对于SFD患者,SSD患者在躯体症状负荷、焦虑抑郁情绪、与症状相关情绪、思维和行为问题、社会功能损害更严重。 | 姜忆南 魏镜 李涛 马希权 张岚 张耀尹 陈华 吴珩 李闻天 卢伟 任洁 Kurt Fritzsche | 2020 | 中华精神科杂志2020，53，1： | 13 |
| 13 | Dislocation structure of the crust-mantle boundary and low-velocity body within the crust beneath the Dabie Shan collision orogen显示文摘From April of 2001 to March of 2002, a passive seismic array experiment was car- ried out in the Dabie Shan and its adjacent region. In this experiment, totally 34 broadband seismic stations were deployed along a profile across the Dabie Shan orogen and North-China platform. This profile is about 500 km long from Cuilin (34°40′N, 114°49′E), Henan Province, to Dajipu (30°20′N, 115°03′E), Hubei Province. The space between stations is about 3?8 km in the Dabie Shan orogenic belt and about 15?20 km in other area. The receiver function profile and S-wave velocity structure of the crust and upper mantle down to 100 km depth along the profile are investigated in terms of the receiver function techniques (Liu et al., 1996, 2000). Our results show that the crust beneath the Dabie Shan orogen has an obviously asymmetric blocked structure in the direction perpendicular to the mountain strike. The maximal crustal thickness reaches to 42 km. The crust-mantle boundary has a dislocation structure correlated to the crustal blocks and the largest offset reaches to 8 km. In the kernel of the orogen exists a low-velocity body inside the crust, which is separated into two parts corresponding to the South Dabie and North Dabie on the surface, respectively. Probably a vertical divergent movement between both took place in history. The crust below this low-velocity area has a positive gradient velocity structure with the depth, and the upper mantle down to the depth of 70 km has the lower S-wave velocity than its both sides. Beneath the Dabie Shan, however, a high-velocity anomaly exists in the upper mantle below 70 km. | LIU Qiyuan1, Rainer Kind2, CHEN Jiuhui1, YUAN Xiaohui2, LI Shuncheng1, GUO Biao1, Kurt Wylegalla2 & LAI Yuangen1 1. State Key Laboratory of Earthquake Dynamics, Institute of Geology, China Earthquake Administration, Beijing 100029, China 2. GeoForschungZentrum Potsdam, Telegrafenburg A17, Potsdam, D-14473, Germany | 2005 | Science China Earth Sciences2005，48，7： | 12 |
| 14 | Cell Wall Lignin is Polymerised by Class Ⅲ Secretable Plant Peroxidases in Norway Spruce显示文摘Class Ⅲ secretable plant peroxidases occur as a large family of genes in plants with many functions and probable redundancy. In this review we are concentrating on the evidence we have on the catalysis of lignin polymerization by class Ⅲ plant peroxidases present in the apoplastic space in the xylem of trees. Some evidence exists on the specificity of peroxidase isozymes in lignin polymerization through substrate specificity studies, from antisense mutants in tobacco and poplar and from tissue and cell culture lines of Norway spruce (Picea abies) and Zinnia elegans. In addition, real time (RT-)PCR results have pointed out that many peroxidases have tissue specific expression patterns in Norway spruce. Through combining information on catalytic properties of the enzymes, on the expression patterns of the corresponding genes, and on the presence of monolignols and hydrogen peroxide in the apoplastic space, we can show that specific peroxidases catalyze lignin polymerization in the apoplastic space of Norway spruce xylem. | Kurt V.Fagerstedt Eija M.Kukkola Ville V.T.Koistinen Junko Takahashi Kaisa Marjamaa | 2010 | Journal of Integrative Plant Biology2010，52，2： | 12 |
| 15 | Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis: retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction显示文摘我们以前在范畴 II 长期的细菌的前列腺炎(CBP ) 表明了 fluoroquinolone-macrolide 联合治疗的安全和功效。这研究的目的是回顾地基于 azithromycin 的联合为 CBP 比较 microbiological 和二个处理计划的临床的调查结果(500 mg,三次每周) 与一次每日的 500-mg 或 ciprofloxacin 的 750-mg 剂量(Cipro-500 或 Cipro-750 队,分别地) 。azithromycin 的联合管理(1500 有以 750 的率的 ciprofloxacin 的 mg 星期 −1) ;为 4 个星期而非在 500 的 mg 天 −1 ;为 6 个星期的 mg 天 −1 从 62.35 % 增加了根除率;到 77.32 %并且从 71.76 % 的全部的细菌学的成功;到 85.57 %。在煽动性的白血球计数和浆液的疼痛和 voiding 症状 / 症状和重要减小地的重要减少前列腺特定的抗原(PSA ) 在两个组在整个 18 月的后续经期被支撑。射精的疼痛, haemospermia 和早泄显著地在两个组在 microbiological 根除上被稀释,但是后者在 Cipro-750 队更即时减退了。总共, 59 个 Cipro-750 病人显示出 mild-to-severe 在基线的可勃起的机能障碍(编辑) ,当 22 个病人没在 microbiological 根除上并且在整个后续时期有编辑时。在结论 fluoroquinolone-macrolide,治疗在病原体根除和 CBP 症状变细导致了,包括疼痛, voiding 骚乱和性机能障碍。为 4 个星期的 ciprofloxacin 的一次每日的 750-mg 剂量与 500-mg 剂量相比显示出提高的根除率和更低的煽动性的白血房间计数 6 个星期。我们的结果是开的推进未来的确认。 | Vittorio Magri Emanuele Montanari Visnja Skerk Alemka Markotic Emanuela Marras Antonella Restelli Kurt G Naber Gianpaolo Perletti | 2011 | Asian Journal of Andrology2011，13，6： | 12 |
| 16 | Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum显示文摘Colorectal cancer(CRC) is the third most common cancer and the fourth most common cause of cancerrelated death worldwide. Besides the lymphatic and haematogenous routes of dissemination,CRC frequently gives rise to transcoelomic spread of tumor cells in the peritoneal cavity,which ultimately leads to peritoneal carcinomatosis(PC). PC is associated with a poor prognosis and bad quality of life for these patients in their terminal stages of disease. A loco-regional treatment modality for PC combining cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy has resulted in promising clinical results. However,this novel approach is associated with significant morbidity and mortality. A comprehensive understanding of the molecular events involved in peritoneal disease spread is paramount in avoiding unnecessary toxicity. The emergence of PC is the result of a molecular crosstalk between cancer cells and host elements,involving several well-defined steps,together known as the peritoneal metastatic cascade. Individual or clumps of tumor cells detach from the primary tumor,gain access to the peritoneal cavity and become susceptible to the regular peritoneal transport. They attach to the distant peritoneum,subsequently invade the subperitoneal space,where angiogenesis sustains proliferation and enables further metastatic growth. These molecular events are not isolated events but rather a continuous and interdependent process. In this manuscript,we review current data regarding the molecular mechanisms underlying the development of colorectal PC,with a special focus on the peritoneum and the role of the surgeon in peritoneal disease spread. | Lieselotte Lemoine Paul Sugarbaker Kurt Van der Speeten | 2016 | World Journal of Gastroenterology2016，22，34： | 12 |
| 17 | 躯体症状障碍患者临床特征分析显示文摘目的探索躯体症状障碍(SSD)患者的临床特征。方法采用方便取样法选取北京协和医院精神科、中医科和消化科门诊患者作为研究对象。根据入排标准,共纳入210名被试完成自评问卷,并经过结构化诊断访谈得出SSD的诊断。分析SSD患者的临床特征,并与非SSD患者比较,同时比较来自3个科室SSD患者的临床特征。结果(1)被试中有27.1%(57/210)被诊断为SSD;患者年龄(43±13)岁,其中女性占61.4%(35/57),与非SSD患者各项人口学资料的对比差异均无统计学意义。(2)45.6%(26/57)的SSD患者躯体症状持续时间超过2年,29.9%(17/57)报告近1年就诊次数超过20次。过去6个月接受过治疗的SSD患者有46.8%(22/47)治疗满意度3~5分,44.7%(21/47)对治疗效果评分3~5分。(3)SSD患者较各科室非SSD患者各项自评量表得分差异均有统计学意义(P<0.05);与精神科非SSD相比,在躯体症状、焦虑相关量表及12项健康调查简表(SF-12)亚量表精神健康总评(MCS)间差异有统计学意义(P<0.05)。三个科室的SSD患者在诊治情况和各项自评量表得分的比较差异均无统计学意义。结论SSD患者的身心受疾病影响较为严重,应得到积极治疗。综合医院精神科,尤其会诊联络精神医学亚专科工作应重点关注该类患者并开展更深入研究。 | 赵晓晖 魏镜 李涛 曹锦亚 姜忆南 Kurt Fritzsche | 2019 | 中华精神科杂志2019，52，4： | 10 |
| 18 | A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells显示文摘CCL5 是响应压力信号在有免疫力、非有免疫力的房间的一个宽数组表示的 CC chemokine 家庭的一个成员。有先进人的乳癌的 CCL5 表示相互关联。然而,它行动的功能的意义和模式没被建立。这里,我们证明 CCL5 缺乏的老鼠对高度好攻击的、三元组否定的乳房的肿瘤生长抵抗。造血的 CCL5 在这显型是主导的。造血的 CCL5 的缺席由积累 Ly6C +/Gr-1+, 的异常产生导出 myeloid 的 suppressor 房间(MDSC )> 嗨有损害能力到的 和 Ly6G + MDSC 压制 CD8 + T 房间的 cytotoxicity。CCL5 的这些性质在 orthotopic 和自发的乳房的肿瘤被观察。CCL5 的调停抗体的全身的封锁禁止肿瘤前进并且对非产生免疫性的肿瘤提高治疗学的种痘的功效。CCL5 也帮助维持人的 MDSC 的抑制免疫力的能力。我们的学习揭开经由与导出肿瘤的刺激殖民地的因素在合作在骨头髓产生 MDSC 支持乳房的肿瘤前进的造血地导出的 CCL5 的一项新奇、 chemokine 独立的活动。学习在在造血的分隔空间和肿瘤壁龛之间的相互影响上打开可观的灯。因为在正常生理学的这个分子的明显的非必需的性质, CCL5 可以象有 MDSC 渗入的重要数量的大量稳固的肿瘤一样为乳癌在免疫疗法代表一个优秀治疗学的目标。 | Yan Zhang Dandan Lv Ha-Jeong Kim Robert A Kurt Wen Bu Yi Li Xiaojing Ma | 2013 | Cell Research2013，23，3： | 9 |
| 19 | 综合医院门诊躯体形式障碍患者功能损害及相关影响因素显示文摘目的探讨影响躯体形式障碍(SFD)患者功能损害的影响因素。方法采用多中心横断面研究,从5个城市9家综合医院的神经内科、消化内科、中医科以及心理(心身医学)科招募被试者,采用自编社会人口学问卷、世界卫生组织残疾评定量表12项目自评版(WHO-DASII)、患者健康问卷抑郁症状群量表(PHQ-9)、广泛性焦虑量表(GAD-7)对被试者的情绪及功能损害情况进行评估,采用简明国际神经精神访谈进行精神障碍诊断分类。分别应用t检验和Pearson χ^2检验对社会人口学及临床中的计量和计数资料进行比较,用多元线性回归分析探索SFD功能损害的影响因素。结果招募有效被试者446例,SFD患者327例,有明确躯体疾病但不符合SFD及其他精神障碍诊断患者(躯体疾病患者)119例。SFD患者和躯体疾病患者女性比例[63.9%(209/327)比52.9%(63/119);χ^2=4.53,P=0.03]、过去12个月就诊次数>10次(χ^2=31.55,P<0.01)、病程>6个月(χ^2=44.71,P<0.01)均高于躯体疾病患者,SFD患者中抑郁和焦虑的阳性比例与躯体疾病患者比较差异无统计学意义(P>0.05);SFD患者PHQ-9得分高于躯体疾病患者[(8.5±6.4)分比(6.9±5.9)分;t=2.33,P=0.02]。相关分析显示,居住地(r=0.12,P=0.01)、拥有医疗保险的情况(r=0.12,P<0.01)、婚姻状况(r=0.14,P=0.04)、冬夏季是否锻炼(r=0.12、0.11,P<0.01、0.05)以及焦虑(r=0.59,P<0.01)、抑郁(r=0.65,P<0.01)状况与患者的功能残疾存在显著相关。回归分析显示,居住地、焦虑、抑郁情绪对患者的功能损害有显著影响,方程模型可以解释功能损害49.3%(F=77.76,P<0.01)的变异。结论SFD患者较躯体疾病患者的情绪损害严重;居住地及焦虑、抑郁状态是SFD患者功能损害的影响因素。 | 马希权 张岚 张耀尹 陈华 吴珩 李闻天 任洁 卢伟 魏镜 Kurt Fritzsche | 2019 | 中华精神科杂志2019，52，4： | 9 |
| 20 | 紫杉醇对MDA-MB-435人乳腺癌高转移细胞粘附,侵袭及迁移能力的影响显示文摘观察紫杉醇对人乳腺癌高转移细胞粘附 ,侵袭和迁移能力的影响 .采用重组基底膜侵袭模型 ,三维空间胶原小室培养 ,时间推移摄像和计算机辅助细胞跟踪系统研究紫杉醇对MDA MB 4 35人乳腺癌高转移细胞粘附 ,侵袭和迁移能力的影响 .紫杉醇在 0 .0 1~ 0 .1mg·L- 1范围内可明显抑制MDA MB 4 35细胞与纤维粘连蛋白或层粘连蛋白的粘附 ,抑制率分别为 9.9%~ 51.2 %和 35.0 %~ 4 9.8% ;紫杉醇 0 .0 1和 0 .0 3mg·L- 1对MDA MB 4 35细胞侵袭重组基底膜抑制率为 66.7%和 74 .4 % ;0 .0 2和 0 .1mg·L- 1时可明显抑制MDA MB 4 35细胞在三维胶原中的迁移 .结果表明紫杉醇具有较强的抑制MDA MB 4 35细胞粘附 ,侵袭和迁移的作用 。 | 周龙恩 刘红岩 徐少锋 付招娣 KurtS ZAENKER 韩锐 | 2001 | 中国药理学与毒理学杂志2001，15，1： | 9 |
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