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| 1 | Present and future possibilities for early diagnosis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) represents the fifth most common cancer in the world,and the third most frequent oncological cause of death.The incidence of HCC is on the increase.HCC typically develops in patients with chronic liver diseases,and cirrhosis,usually with viral etiology,is the strongest predisposing factor.Nowadays HCC diagnosis is a multistage process including clinical,laboratory,imaging and pathological examinations.The prognosis of HCC is mostly poor,because of detection at an advanced,non-resectable stage.Potentially curative treatment(surgery) is limited and really possible only for cases with small HCC malignancies.For this reason,more effective surveillance strategies should be used to screen for early occurrence of HCC targeted to the population at risk.So far,the generally accepted serological marker is α-fetoprotein(AFP).Its diagnostic accuracy is unsatisfactory and questionable because of low sensitivity,therefore there is a strong demand by clinicians for new HCC-specific biomarkers.In this review,we will focus on other biomarkers that seem to improve HCC diagnosis,such as AFP-L3,des-γ-carboxyprothrombin,α-l-fucosidase,,γ-glutamyl transferase,glypican-3,squamous cell carcinoma antigen,a new generation of immunoglobulin M-immunocomplexes,and very promising geneexpression profiling. | Piotr Stefaniuk Janusz Cianciara Alicja Wiercinska-Drapalo | 2010 | World Journal of Gastroenterology2010，16，4： | 109 |
| 2 | 白龙江流域滑坡泥石流灾害研究进展与展望显示文摘白龙江流域地处青藏高原、黄土高原、四川盆地交接处,我国东西南北向地震带从此交汇通过,此处构造复杂、山高坡陡、沟谷深切、软岩广布,且多暴雨,是我国四大滑坡、泥石流灾害高发区之一。基于实地调查研究、并结合现有资料和研究成果,总结分析了白龙江流域滑坡、泥石流的分布特征、形成条件、成因机理、监测预警、防治措施等多方面进展及不足,推进该流域地质灾害研究,支持当地防灾减灾建设。 | 孟兴民 陈冠 郭鹏 熊木齐 Janusz Wasowski | 2013 | 海洋地质与第四纪地质2013，33，4： | 78 |
| 3 | Expression of p53,Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease显示文摘AIM: To analyze the protein expression essential for apoptosis in liver steatosis. METHODS: The expression of proapoptotic proteins p53, Bax, and antiapoptotic Bcl-2 in hepatocytes with steatosis (SH) and without steatosis (NSH) was evaluated in 84 patients at various stages of non-alcoholic fatty liver disease (NAFLD). RESULTS: Immunohistochemical staining of liver tissue showed the activation of p53 protein in SH and NSH with increased liver steatosis, diminished Bcl-2 and slightly decreased Bax protein. Positive correlation was found between the stage of liver steatosis with p53 expression in SH (r = 0.54, P < 0.01) and NSH (r = 0.49, P < 0.01). The antiapoptotic protein Bcl-2 was diminished together with the advancement of liver steatosis, especially in non-steatosed hepatocytes (r =0.43, P < 001). CONCLUSION: Apoptosis is one of the most important mechanisms leading to hepatocyte elimination in NAFLD. The intensification of inflammation in NAFLD induces proapoptotic protein p53 with the inhibition of antiapoptotic Bcl-2. | Anatol Panasiuk Janusz Dzieciol Bozena Panasiuk Danuta Prokopowicz | 2006 | World Journal of Gastroenterology2006，12，38： | 46 |
| 4 | 电弧炉粉尘的治理显示文摘电弧炉粉尘含有某些重金属元素 ,堆放填埋对环境造成污染。至今已有约 2 0种方法处理这类粉尘回收有价金属 ,尤其是近几年来出现的 Ausmelt,Met Wool,Enviroplas,All Met,IBDR- ZIPP,Modified ZINCEX,Cashman,Rezada和 Rerra Gaia等技术正逐步趋于成熟。不锈钢和特种钢电弧炉粉尘中有价金属的综合回收虽未标准化 ,但越来越受到人们的关注。 | 彭兵 张传福 彭及 Jonathan Lobel Janusz A.Kozinski | 2000 | 矿产综合利用2000，，4： | 16 |
| 5 | 有源滤波器空间矢量脉宽调制电流跟踪算法的优化显示文摘为提高有源滤波器的电流跟踪性能,针对传统空间矢量脉宽调制(SVPWM)电流跟踪算法的不足,提出了一种用于并联有源滤波器的SVPWM电流跟踪算法的优化方法。该跟踪算法利用三相相间误差电流的正负来判断空间指令电压矢量所在的区域。与传统SVPWM电流跟踪算法相比,省略了三相电网电压的检测环节,即省略了判断空间指令电压矢量所在区域的复杂运算,从而简化了硬件电路,同时也简化了算法。针对以三相不可控整流阻感负载为谐波源的电路模型,分别采用传统SVPWM电流跟踪算法和所设计的SVPWM电流跟踪算法作为有源滤波器的电流控制方法,进行了滤除谐波电流的实验。 | 许晓彦 杨才建 Janusz MINDYKOWSKI | 2012 | 电力系统自动化2012，36，4： | 14 |
| 6 | Blood platelet and monocyte activations and relation to stages of liver cirrhosis显示文摘AIM: Blood platelets (plt) and monocytes are the cells that play a crucial role in the pathogenesis of liver damage and liver cirrhosis (LC). In this paper, the analysis of mutual relationship between platelets and monocytes activation in LC was conducted.METHODS: Immunofluorescent flow cytometry was usedto measure the percentage of activated platelet populations(CD62P, CD63), the percentage of plt-monocyte aggregates (pma) (CD41/CD45), and activated monocytes (CD11b, CD14, CD16) in the blood of 20 volunteers and 40 patientswith LC. Platelet activation markers: sP-selectin, platelet factor 4 (PF4), beta-thromboglobulin (βTG) and monocyte chemotactic peptide-1 (MCP-1) were measured and compared in different stages of LC.RESULTS: Platelet activation with the increase in bothβTG serum concentration and elevation of plt population(CD62P and CD63 as well as MIF CD62P and CD63) is elevated as LC develops and thrombocytopenia rises. There is a positive correlation between medial intensityof fluorescence (MIF) CD62P and MIF CD63 in LC. We did not show any relationship between monocyte activation and pma level. SP-selectin concentration correlates positively with plt count and pma, and negatively with stage of plt activation and MIF CD62P and MIF CD63. There was no correlation between MCP-1 concentration andpit, monocyte activation as well as pma level in LC. CD16 monocytes and MIF CD16 populations are significantlyhigher in the end stage of LC. A positive correlation occurs between the value of CD11b monocyte population andMIF CD14 and MIF CD16 on monocytes in LC.CONCLUSION: Platelet and monocyte activation plays an important role in LC. Platelet activation stage does not influence monocyte activation and production of plt aggregates with monocytes in LC. With LC development, thrombocytopenia may be the result of plt consumption in platelet-monocyte aggregates. | Anatol Panasiuk Janusz Zak Edwina Kasprzycka Katarzyna Janicka Danuta Prokopowicz | 2005 | World Journal of Gastroenterology2005，11，18： | 11 |
| 7 | 一种基于信息熵的金融数据神经网络分类方法显示文摘讨论一种基于信息熵的神经网络数据分类方法,通过所有神经元的统计权重信息对输入数据进行投票分类.这种多层网络结构以及基于信息量的分割算法,使得它在数据分类问题上比现有的多数神经网络具有更好的表现.其并行的可扩展结构适合硬件实现,能够提高实际运算速度,适合用来处理金融方面高维度、复杂的海量数据问题. | 冯建 Starzyk Janusz 邱菀华 | 2012 | 控制与决策2012，27，2： | 10 |
| 8 | N-acetylcysteine does not prevent post-endoscopic retrograde cholangiopancreatography hyperamylasemia and acute pancreatitis显示文摘瞄准:尖锐胰腺炎(AP ) 是最普通、经常严重的复杂并发症内视镜后退 cholangiopancreatography (ERCP ) 。在尖锐胰腺炎的致病的早步可能是毛状的内皮损害由导出氧的自由基调停了。N-acetylcysteine - 自由基 scavenger 可能在阻止尖锐胰腺炎和它是的 post-ERCP 是潜在地有效的也知道那个 N-acetylcysteine (ACC ) 罐头在 AP 的试验性的模型减少疾病的严厉。方法:106 个病人随机被分配到二个组。55 个病人被给 N-acetylcysteine (口头上地,在 ERCP 和 600 mg 前的 24 和 12 h 被给 iv 的二 600 mg 剂量,两次为在 ERCP 以后的二天的一天) 。控制组由被给 iv 的 51 个病人组成了。等渗盐两次为在 ERCP 以后的二天的一天。浆液和尿淀粉酶活动在过程以后在 ERCP 和 8 和 24 h 前被测量。主要结果参数是尖锐胰腺炎和第二等的结果参数是的 post-ERCP 在浆液和尿淀粉酶活动的组之间的差别。结果:处于在二个组之间的 post-ERCP 胰腺炎的率没有有效差量(10 病人外套, 4 在 ACC 组织, 6 在控制组织) 。也在在 ACC 组和控制组之间的基线和 post-ERCP 浆液和尿淀粉酶活动没有有效差量。结论:N-acetylcysteine 没能在 post-ERCP 胰腺炎上,以及在浆液和尿淀粉酶活动上表明任何重要预防效果。 | Janusz Milewski Grazyna Rydzewska Malgorzata Degowska Maciej Kierzkiewicz Andrzej Rydzewski | 2006 | World Journal of Gastroenterology2006，12，23： | 10 |
| 9 | Preoperative high level of D-dimers predicts unresectability of pancreatic head cancer显示文摘AIM: To assess the value of D-dimer level in determining resectability of pancreatic cancer. METHODS: Preoperative prediction of pancreatic head cancer resectability remains inaccurate. The use of hemostatic factors may be of potential help, since D-dimers correlate with tumor stage. Single center clinical trial study comprised patients with potentially resectable pancreatic head tumor and without detectable venous thrombosis(n = 64). Resectability was defined as no evidence of nodal involvement, distant spread and no invasion of mesenteric vessels. Final decision of resectability was confirmed intraoperatively. Experienced pancreatic surgeon performed all surgeries. Following the dissection of hepatoduodenal ligament, samples of portal blood and bile were taken. Peripheral blood via central line and urine via Foley catheter were sampled. D-dimer levels were further measured.RESULTS: At laparotomy only 29(45.3%) tumors were found to be resectable. Our analysis showed higher by 57.5%(P < 0.001) mean D-dimer values in peripheral and 43.7%(P = 0.035) in portal blood of patients with unresectable pancreatic cancer. Significant differences were not observed when analyzing D-dimer levels in bile and urine. Peripheral D-dimer level correlated with pancreatic cancer resectability. When cut-off D-dimer value of 570.6 μg/L was used, the sensitivity for assessment of tumor unresectability was 82.8%. Furthermore, D-dimer level in peripheral blood of metastatic disease(n = 15) was significantly higher when compared to locally advanced(n = 20) pancreatic cancer(2470 vs 1168, P = 0.029). The area under ROC curve for this subgroup of patients was 0.87; for determination of unresectable disease when threshold of 769.8 μg/L was used, sensitivity and specificity was 86.6% and 80%, respectively.CONCLUSION: Patients with resectable pancreatic head cancer based on preoperative imaging studies and high D-dimer level may be considered unresectable due to occult hepatic metastases. These patients may benefit from diagnostic laparoscopy to avoid exploratory laparotomy. | Adam Durczynski Anna Kumor Piotr Hogendorf Dariusz Szymanski Piotr Grzelak Janusz Strzelczyk | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 10 | Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation显示文摘AIM:To investigate large tumor suppressor 1 (LATS1 ) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC).METHODS:RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized to expression of the ACTB and RPL32 housekeeping genes. To analyze hypermethylation, genomic DNA was isolated from 44 tumor CRC biopsies, and methylation-specific PCR was performed. Microsatellite instability (MSI) status was checked with PCR using BAT26, BAT25, and BAT40 markers in the genomic DNA of 84 CRC patients, followed by denaturing gel electrophoresis. RESULTS:Decreased LATS1 expression was found in 127/142 (89.4%) CRC cases with the average ratio of the LATS1 level 10.33 ± 32.64 in CRC patients vs 32.85 ± 33.56 in healthy controls. The lowest expression was found in Dukes' B stage tumors and G1 (welldifferentiated) cells. Hypermethylation of the LATS1 promoter was present in 25/44 (57%) CRC cases analyzed. LATS1 promoter hypermethylation was strongly associated with decreased gene expression; methylated cases showed 162× lower expression of LATS1 than unmethylated cases. Although high-grade MSI (mutation in all three markers) was found in 14/84 (17%) cases and low-grade MSI (mutation in 1-2 markers) was found in 30/84 (36%) cases, we found no association with LATS1 expression. CONCLUSION:Decreased expression of LATS1 in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC. | Piotr M Wierzbicki Krystian Adrych Dorota Kartanowicz Marcin Stanislawowski Anna Kowalczyk Janusz Godlewski Iwona Skwierz-Bogdanska Krzysztof Celinski Tomasz Gach Jan Kulig Bartlomiej Korybalski Zbigniew Kmiec | 2013 | World Journal of Gastroenterology2013，19，27： | 8 |
| 11 | Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia显示文摘AIM:To evaluate blood concentration of melatonin and urinary excretion of its metabolite,6-sulfatoxymelatonin(6-OHMS),in functional dyspepsia(FD).METHODS:Ninety individuals were enrolled in the study:30 in each study group:patients with postprandial distress syndrome(PDS),epigastric pain syndrome(EPS),and controls.Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed.Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay.RESULTS:Serum melatonin concentration at night and in the morning was significantly(P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL,quartile range(QR):79.8-116.2;at 09.00 h-14.3 pg/mL,QR:7.06-19.0] than in EPS(57.2 pg/mL,QR:42.6-73.1;8.1 pg/mL,QR:4.1-9.3) and control patients(57.7 pg/mL,QR:51.2-62.5;8.1 pg/mL,QR:5.4-10.3).A similar relationship was observed for urinary 6-OHMS excretion.Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes,whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms.CONCLUSION:Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD. | Cezary Chojnacki Tomasz Poplawski Grazyna Klupinska Janusz Blasiak Jan Chojnacki Russel J Reiter | 2011 | World Journal of Gastroenterology2011，17，21： | 8 |
| 12 | Method of Characteristic for Functional Equations in Polynomial Form | Janusz Matkowski (Department of Mathematics,Technical University of Bielsko-Biala 43-309 Bielsko-Biala,Poland)Zhang Weinian (Department of Mathematics,Sichung Union University,East Area,Chengdu 610041,China) | 1997 | Acta Mathematica Sinica,English Series1997，13，3： | 8 |
| 13 | Thermodynamic calculation on the smelting slag of direct recycling of electric arc furnace stainless steelmaking dust显示文摘Thermodynamic calculation on the smelting slag of direct recycling of electric arc furnace stainless steelmaking dust was presented. An induction furnace was used to simulate electric arc furnace smelting to recover the metals from the dust. The elements of iron, chromium and nickel in the ingot and the components of metal oxides in the slag were analyzed. The thermodynamic model for FeO Cr 2O 3 MgO SiO 2 slag was set up and the active concentrations of substances in the slag at 1 550 ℃ were determined by thermodynamic calculation according to the experimental data. The results show that the apparent equilibrium constant and quantitative distribution of chromium between slag and steel are unstable and affected by the mass ratios of pellets to start iron and metal reducing agent to the pellets. In order to get satisfactory chromium recovery from the direct recycling of electric arc furnace stainless steelmaking dust, it is important to ensure the mass ratio of pellets to the steel below 0.20 and the mass ratio of metal reducing agent to pellets over 0.18 in practical smelting runs. | 彭兵 彭及 Janusz A.Kozinski Jonathan Lobel 柴立元 张传福 陈为亮 | 2003 | Journal of Central South University of Technology2003，10，1： | 6 |
| 14 | Thermodynamics calculation on the oxidation and sulfur removal abilities of slag in EAF dust pellet reduction process显示文摘The valuable metals in the dust can be recycled by mixing it with reducing agent carbon and lignosulfonate as the binder to make pellets, then returning the pellets to electric arc furnace (EAF) and adding ferro silicon. Part of valuable metals in the dust is reduced by carbon and part of them reduced by ferro silicon for the economical consideration. The reduced metals get into the steel in the stainless steel or special steel production. But the sulfur in the lignosulfonate may affect the quality of produced steel, which is dependent on the status of the smelting slag. The experiments were conducted in the way of changing the ratio of start iron, pellets, ferro silicon and lime. The content of the slag was checked by XRF for the calculation thermodynamics study. The active concentrations of materials in the slag, the slag abilities of oxidation and sulfur removal in EAF dust reduction process were determined by thermodynamics calculation study on CaO MgO FeO Fe 2O 3 SiO 2 S slag at 1 550 ℃. The oxidation ability of slag can be expressed as N (FetO)= N (FeO)+6 N (Fe 2O 3)+8 N (Fe 3O 4). The sulfur removal ability is dependent on the amount of added ferro silicon and the basicity of the slag. The calculation thermodynamics model was set up and it could be applied to the practical production. | PENG Bing 1,PENG Ji 1,ZHANG Chuan fu 1,Jonathan Lobel 2,Janusz A. Kozinski 2 (1 Department of Metallurgical Science and Engineering, Central South University, Changsha 410083, China 2 Department of Metallurgical Engineering, McGill University | 2001 | Journal of Central South University of Technology2001，8，1： | 6 |
| 15 | Dietary and socio-economic factors in relation to Helicobacter pylori re-infection显示文摘AIM:To examine if dietary and socio-economic factors contribute to Helicobacter pylori(H pylori)re-infection. METHODS:The population of patients consisted of subjects in whom H pylori infection had been successfully treated in the past.Patients were divided into two groups:Ⅰ-examined group(111 persons with H pylori re-infection)andⅡ-control group(175 persons who had not been re-infected).The respondents were interviewed retrospectively on their dietary habits and socio-economic factors. RESULTS:A statistically significant lower frequency of fermented dairy products(P<0.0001),vegetables (P=0.02),and fruit(P=0.008)consumption was noted among patients with H pylori re-infection as compared to those who had not been re-infected. CONCLUSION:High dietary intake of probiotic bacteria,mainly Lactobacillus,and antioxidants,mainly vitamin C(contained in fruit and vegetables),might decrease the risk of H pylori re-infection. | Mirosaw Jarosz Ewa Rychlik Magdalena Siuba Wioleta Respondek Magorzata Ryzko-Skiba Iwona Sajór Sylwia Gugaa Tomasz Bazejczyk Janusz Ciok | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 16 | Zn-Ca-Fe氧化物催化水解微晶纤维素显示文摘以尿素为沉淀剂制备了一系列复合金属沉淀物,将其在高温条件下煅烧获得一系列复合金属氧化物固体催化剂,并将其用于催化微晶纤维素的水解反应;考察了反应温度、反应时间、搅拌转速、催化剂用量和微晶纤维素用量对反应的影响。实验结果表明,在反应温度160℃、反应时间20 h、搅拌转速400 r/mnin、微晶纤维素2.0 g、Zn-Ca-Fe氧化物0.9 g和H_2O 200 mL的条件下,微晶纤维素的转化率高达42.56%,葡萄糖的收率为69.20%,且微晶纤维素水解液为中性溶液。在相同反应条件下,Zn-Ca-Fe氧化物可重复使用5次,其催化活性无明显降低。 | 张帆 邓欣 方真 曾虹燕 田霄飞 Janusz A.Kozinski | 2011 | 石油化工2011，40，1： | 6 |
| 17 | Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients显示文摘Disturbances in the metabolism of lipoprotein profiles and oxidative stress in hemodialyzed(HD) and post-renal transplant(Tx) patients are proatherogenic,but elevated concentrations of plasma high-density lipoprotein(HDL) reduce the risk of cardiovascular disease.We investigated the concentrations of lipid,lipoprotein,HDL particle,oxidized low-density lipoprotein(ox-LDL) and anti-ox-LDL,and paraoxonase-1(PON-1) activity in HD(n=33) and Tx(n=71) patients who were non-smokers without active inflammatory disease,liver disease,diabetes,or malignancy.HD patients had moderate hypertriglyceridemia,normocholesterolemia,low HDL-C,apolipoprotein A-I(apoA-I) and HDL particle concentrations as well as PON-1 activity,and increased ox-LDL and anti-ox-LDL levels.Tx patients had hypertriglyceridemia,hypercholesterolemia,moderately decreased HDL-C and HDL particle concentrations and PON-1 activity,and moderately increased ox-LDL and anti-ox-LDL levels as compared to the reference,but ox-LDL and anti-ox-LDL levels and PON-1 activity were more disturbed in HD patients.However,in both patient groups,lipid and lipoprotein ratios(total cholesterol(TC)/HDL-C,LDL-C/HDL-C,triglyceride(TG)/HDL-C,HDL-C/non-HDL-C,apoA-I/apoB,HDL-C/apoA-I,TG/HDL) were atherogenic.The Spearman's rank coefficient test showed that the con-centration of ox-LDL correlated positively with HDL particle level(R=0.363,P=0.004),and negatively with TC(R=?0.306,P=0.012),LDL-C(R=?0.283,P=0.020),and non-HDL-C(R=?0.263,P=0.030) levels in Tx patients.Mul-tiple stepwise forward regression analysis in Tx patients demonstrated that ox-LDL concentration,as an independent variable,was associated significantly positively with HDL particle level.The results indicated that ox-LDL and de-creased PON-1 activity in Tx patients may give rise to more mildly-oxidized HDLs,which are less stable,easily un-dergo metabolic remodeling,generate a greater number of smaller pre-β-HDL particles,and thus accelerate reverse cholesterol transport,which may be beneficial for Tx patients.Further studies are necessary to confirm this. | Elzbieta KIMAK Magdalena HALABI Iwona BARANOWICZ-GASZCZYK Janusz SOLSKI Andrzej KSIAZEK | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，5： | 5 |
| 18 | Major complications following exenteration in cases of pelvic malignancy:A 10-year experience显示文摘瞄准:在妇产科、直肠的恶意的取出肚肠以后分析主要复杂并发症。方法:有妇产科的恶意的 22 个病人并且 6 与直肠的恶意经历了在 1996 和 2005 之间的盆腔脏器除去术(PE ) 。 PE 在71.4%盒子中为主要恶意被执行(在 13 的外阴癌症,在 5 直肠的癌症,在 1 的颈的癌症和 Bartholin 分别地是在 1 种情况中的腺癌症并且在28.6%盒子中的周期性的恶意(在 5 的颈的癌症,在 1 的卵巢的癌症,在 1 的子宫的肉瘤和在 1 种情况中的直肠的癌症分别地)。以后的 PE,全部的 PE 和前面的 PE 最经常被执行。结果:包含泌尿道感染或伤口裂开的起作用的领域里的主要复杂并发症发生在 12 个病人(42.9%) 。早复杂并发症包括了从骶的丛,成年呼吸窘迫症候群(ARDS ) ,血栓静脉炎,尖锐肾衰竭,膀胱机能障碍,输尿管损坏,重新操作和肺的栓子的巨大的流血。尿失禁作为迟了的复杂并发症在 2 个女人被观察。在 1 个病人,肾造口术由于有的复杂并发症与胃肠道连接了的广泛的肾盂积水膨出和 1 个病人在 1 个病人被执行。死亡率是 7% ,哪个内部起作用的死亡占了 3.5% 。主要复杂并发症经常在与周期性的恶意影响那些的先进主要外阴癌症发生了。结论:PE 比到有周期性的癌症的那些对有主要外阴、直肠的癌症的病人更有益。固有的复杂并发症的知识和 PE 的病态是必要的。 | Dariusz Wydra Janusz Emerich Sambor Sawicki Katarzyna Ciach Andrzej Marciniak | 2006 | World Journal of Gastroenterology2006，12，7： | 5 |
| 19 | Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src显示文摘Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium, leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes. Preventing or mitigating EC senescence might serve as a promising therapeutic paradigm for these diseases. Recent studies showed that small extracellular vesicles (sEV) have the potential to transfer bioactive molecules into recipient cells and induce phenotypic changes. Since mesenchymal stem cells (MSCs) have long been postulated as an important source cell in regenerative medicine, herein we investigated the role and mechanism of MSC-derived sEV (MSC-sEV) on EC senescence. In vitro results showed that MSC-sEV reduced senescent biomarkers, decreased senescence-associated secretory phenotype (SASP), rescued angiogenesis, migration and other dysfunctions in senescent EC induced by oxidative stress. In the In vivo natural aging and type-2 diabetes mouse wound-healing models (both of which have senescent ECs), MSC-sEV promoted wound closure and new blood vessel formation. Mechanically, miRNA microarray showed that miR-146a was highly expressed in MSC-sEV and also upregulated in EC after MSC-sEV treatment. miR-146a inhibitors abolished the stimulatory effects of MSC-sEV on senescence. Moreover, we found miR-146a could suppress Src phosphorylation and downstream targets VE-cadherin and Caveolin-1. Collectively, our data indicate that MSC-sEV mitigated endothelial cell senescence and stimulate angiogenesis through miR-146a/Src. | Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li Janusz Rak Shihua Wang Robert Chunhua Zhao | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 5 |
| 20 | Biomass gasification and Polish coal-fired boilers for process of reburning in small boilers显示文摘Reburning was applied to Polish automatic coal-fired retort boiler (25 kW).The use of bio-syngas reduced NOx emissions from the boiler by over 25%,below the significant level of 200 mg/m3 .Reburning was carried out using an integrated system consisting of the boiler and a fixed-bed 60 kW (GazEla) gasification reactor.The process gas was continuously introduced above the coal burner of the boiler.The process parameters of the boiler and the gasifier were also measured and compared with the other units.Characteristic NOx emissions from automatic and manually operated boilers were also presented. | Hrycko Piotr Lasek Janusz Matuszek Katarzyna | 2013 | Journal of Central South University2013，20，6： | 5 |
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