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| 1 | HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice显示文摘HER2 is overexpressed in approximately 10%-20% of gastric and gastroesophageal junction carcinomas. In these types of cancer, accurate assessment of HER2 status is mandatory, for selecting patients who may benefit from targeted therapies with anti-HER2 drugs such as Trastuzumab. This manuscript focuses on HER2 in gastric carcinogenesis, on optimal evaluation of HER2 and on the possible causes which may contribute to inaccurate HER2 evaluation. Similarly to breast cancer HER2 evaluation, standardization of HER2 testing in gastric cancer is necessary in diagnostic practice. The three principle aspects which require consideration are:(1) the choice of sample with regards to cancer morphology- intestinal vs diffuse areas;(2) the choice of scoring criteria- use of HER2 scoring criteria specific for gastric cancer; and(3) the choice of HER2 evaluation methods- use of an algorithm in which both immunohistochemistry and in situ hybridization play a role. Problematic issues include:(1) pre-analytic variables with particular emphasis on fixation;(2) recommended methodology for HER2 assessment(immunohistochemistry vs in situ hybridization);(3) HER2 heterogeneity both within the primary tumor and between primary tumor and metastases;(4) reliability of biopsies in HER 2 evaluation; and(5) quantity of sample(FFPE blocks from surgical specimens or endoscopic biopsies) necessary for an adequate assessment. | Federica Grillo Matteo Fassan Francesca Sarocchi Roberto Fiocca Luca Mastracci | 2016 | World Journal of Gastroenterology2016，22，26： | 3 |
| 2 | OLGA staging for gastritis: A tutorial显示文摘 | M. Rugge P. Correa F. Di Mario E. El-Omar R. Fiocca K. Geboes R.M. Genta D.Y. Graham T. Hattori P. Malfertheiner S. Nakajima P. Sipponen J. Sung W. Weinstein M. Vieth | 2008 | Digestive and Liver Disease2008，，8： | 2 |
| 3 | Intracellular, Intercellular, and Stromal Invasion of Gastric Mucosa, Preneoplastic Lesions, and Cancer by Helicobacter pylori显示文摘 | Vittorio Necchi Maria Elena Candusso Francesca Tava Ombretta Luinetti Ulderico Ventura Roberto Fiocca Vittorio Ricci Enrico Solcia | 2007 | Gastroenterology2007，，3： | 2 |
| 4 | Magnetic resonance angiography in an adult with aortic coarctation associated with subclavian stenosis显示文摘 | L Fiocca F Zumbo AS Montenero | 2004 | Heart2004，90，4： | 1 |
| 5 | Kinetic and catalytic aspects of the formation of poly( ethylene tereph- thalate) (PET) investigated with model molecules 显示文摘 | APICELLA B DI SERIO M FIOCCA L | 1998 | J App Polymer Sci1998，69，12： | 1 |
| 6 | Comparison 1and 2 weeks of omeprazole,amoxicillin and clarithromycin treatment for Helicobacter pylori eradication:the HYPER Study显示文摘 | Zagari R M Bianchi-Porro G Fiocca R | 2007 | Gut2007，56，4： | 1 |
| 7 | Intestinal and diffuse gastric cancers arise in a different gene involvement显示文摘 | Solcia E Fiocca R Luinetti O | 1996 | Am J Surg Pathol1996，20，1： | 1 |
| 8 | A randomized, double-blind trial of the efficacy and safety of 10 or 20 mg rabeprazole compared with 20 rag omeprazole in the maintenance of gastro-oesophageal reflux diseases over 5 years 显示文摘 | Thjodleifsson B Rindi G Fiocca R | 2003 | Aliment Pharmacol Ther2003，17，： | 1 |
| 9 | Hyrospadias surgery:a 10-year review显示文摘 | Marrocoo G Vallasciani S Fiocca G | | 0，，03： | 1 |
| 10 | ERCP and acute pancreatitis显示文摘 | Fiocca E Santagati A Ceci V | 2002 | Eur Rev Med Pharmacol Sci2002，6，： | 1 |
| 11 | Characteristics and outcomes of patients with st-segment elevation myocardial infarction excluded from the harmonizing outcomes with re- vascularization and stents in acute myocardial infarction (HORIZONS-AMI) trial显示文摘 | Fiocca L Guagliumi G Rossini R | 2013 | Am J Cardiol2013，111，2： | 1 |
| 12 | The contribution of cell phenotype to the behavior of gastric cancer显示文摘 | Enrico Solcia Catherine Klersy Alessandro Vanoli Federica Grillo Rachele Manca Francesca Tava Ombretta Luinetti Roberto Fiocca | 2013 | Gastric Cancer2013，，4： | 1 |
| 13 | Long-term outcome ofmicroscopic esophagitis in chronic GERD patients treated withesomeprazole or laparoscopic antireflux surgery in the LOTUS trial显示文摘 | Fiocca R Mastracci L Engstrom C | 2010 | Am J Gastroenterol2010，105，5： | 1 |
| 14 | Microscopic esophagitisand Barrett 's esophagus : the histology report 显示文摘 | Fiocca R Mastracci L Milione M | 2011 | Dig Liver Dis2011，434，： | 1 |
| 15 | Stent implantation without predilatation in patients with a single, noncalcifled coronary artery lesion显示文摘 | Danzi GB Capuano C Fiocca L | 1999 | Am J Cardiol1999，84，5： | 1 |
| 16 | Development of consensusguidelines for the histologic recognition of microscopic esophagitisin patients with gastroesophageal reflux disease:the Esohisto project显示文摘 | Fiocca R Mastracci L Riddell R | 2010 | Hum Pathol2010，41，2： | 1 |
| 17 | Oxazoline-containing phosphazene derivatives(Part Ⅱ)Polymer preparation and modification through the reactivity of oxazoline moieties on cyclophosphazenes显示文摘 | BERTANI Roberta FAMBRI Luca FIOCCA Luisa | | 0，，02： | 1 |
| 18 | Early HER2 dysregulation in gastric and oesophageal carcinogenesis显示文摘 | Matteo Fassan Luca Mastracci Federica Grillo Vittorina Zagonel Sara Bruno Giorgio Battaglia Francesca Pitto Donato Nitti Tiziana Celiento Giovanni Zaninotto Roberto Fiocca Massimo Rugge | 2012 | Histopathology2012，，5： | 1 |
| 19 | Risk indicators of organic diseases inuninvestigated dyspepsia: a one - week survey in 246 Italian endoscopyunits 显示文摘 | Stanghellini V Anti M Porro GB Corinaldesi R Gasbarrini G Giacosa A Fiocca R LaVecchia C Maconi G Negri E | 1999 | Eur J Gas- troenterol Hepatol1999，11，： | 1 |
| 20 | Localization of bombesin and GRP (gastrin releasing peptide) sequences in gut nerves or endocrine cells显示文摘 | Buffa R Solovieva I Fiocca R | 1982 | Histochemistry and Cell Biology1982，76，4： | 1 |
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