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| 1 | Differential diagnosis in inflammatory bowel disease colitis:State of the art and future perspectives显示文摘Distinction between Crohn's disease of the colonrectum and ulcerative colitis or inflammatory bowel disease(IBD) type unclassified can be of pivotal importance for a tailored clinical management,as each entity often involves specific therapeutic strategies and prognosis.Nonetheless,no gold standard is available and the uncertainty of diagnosis may frequently lead to misclassification or repeated examinations.Hence,we have performed a literature search to address the problem of differential diagnosis in IBD colitis,revised current and emerging diagnostic tools and refined disease classification strategies.Nowadays,the differential diagnosis is an untangled issue,and the proper diagnosis cannot be reached in up to 10% of patients presenting with IBD colitis.This topic is receiving emerging attention,as medical therapies,surgical approaches and leading prognostic outcomes require more and more disease-specific strategies in IBD patients.The optimization of standard diagnostic approaches based on clinical features,biomarkers,radiology,endoscopy and histopathology appears to provide only marginal benefits.Conversely,emerging diagnostic techniques in the field of gastrointestinal endoscopy,molecular pathology,genetics,epigenetics,metabolomics and proteomics have already shown promising results.Novel advanced endoscopic imaging techniques and biomarkers can shed new light for the differential diagnosis of IBD,better reflecting diverse disease behaviors based on specific pathogenic pathways. | Gian Eugenio Tontini Maurizio Vecchi Luca Pastorelli Markus F Neurath Helmut Neumann | 2015 | World Journal of Gastroenterology2015，21，1： | 13 |
| 2 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 3 | New endoscopic approaches in IBD显示文摘Recent advances in endoscopic imaging techniques have revolutionized the diagnostic approach of patients with inflammatory bowel disease(IBD).New,emerging endoscopic imaging techniques visualized a plethora of new mucosal details even at the cellular and subcellular level.This review offers an overview about new endoscopic techniques,including chromoendoscopy,magnification endoscopy,spectroscopy,confocal laser endomicroscopy and endocytoscopy in the face of IBD. | Helmut Neumann Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 4 | Probe based confocal laser endomicroscopy of the pancreatobiliary system显示文摘AIM:To review applications of confocal laser endomicroscopy(CLE) in pancreatobiliary lesions and studies that assessed training and interpretation of images. METHODS: A computerized literature search was performed using OVID MEDLINE, EMBASE, Cochrane library, and the ISI Web of Knowledge from 1980 to October 2014. We also searched abstracts from major meetings that included the Digestive Disease Week, Canadian Digestive Disease Week and the United European Gastroenterology Week using a combination of controlled vocabulary and text words related to p CLE, confocal, endomicroscopy, probe-based confocal laser endomicroscopy, and bile duct to identify reports of trials. In addition, recursive searches and crossreferencing was performed, and manual searches of articles identified after the initial search was also completed. We included fully published articles and those in abstract form. Given the relatively recent introduction of CLE we included randomized trials and cohort studies.R E S U LT S : In the evaluation of indeterminate pancreatobiliary strictures CLE with ERCP compared to ERCP alone can increase the detection of cancerous strictures with a sensitivity of(98% vs 45%) andhas a negative predictive value(97% vs 69%), but decreased the specificity(67% vs 100%) and the positive predictive value(71% vs 100%) when compared to index pathology. Modifications in the classification systems in indeterminate biliary strictures have increased the specificity of p CLE from 67% to 73%. In pancreatic cystic lesions there is a need to develop similar systems to interpret and characterize lesions based on CLE images obtained. The presence of superficial vascular network predicts serous cystadenomas accurately. Also training in acquiring and interpretation of images is feasible in those without any prior knowledge in CLE in a relatively simple manner and computer-aided diagnosis software is a promising innovation. CONCLUSION: The role of p CLE in the evaluation of pancreatobiliary disorders might be better suited for those with an intermediate and low probability. | Majid A Almadi Helmut Neumann | 2015 | World Journal of Gastroenterology2015，21，44： | 6 |
| 5 | First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy显示文摘We present the case of a 53-year-old woman with long-standing ulcerative colitis and severe, steroid-dependent disease course unresponsive to treatment with azathioprine, methotrexate, anti-TNF antibodies(infliximab, adalimumab) and tacrolimus, who refused colectomy as a therapeutic option. As the pro-inflammatory cytokine interleukin-6(IL-6) had been identified as a crucial regulator in the immunopathogenesis of inflammatory bowel diseases, we treated the patient with biweekly intravenous infusions of an anti-IL-6R antibody(tocilizumab) for 12 wk. However, no clinical improvement of disease activity was noted. In fact, endoscopic, histological and endomicroscopic assessment demonstrated exacerbation of mucosal inflammation and ulcer formation upon anti-IL-6R therapy. Mechanistic studies revealed that tocilizumab treatment failed to suppress intestinal IL-6 production, impaired epithelial barrier function and induced production of pro-inflammatory cytokines such as TNF, IL-21 and IFN-γ. Inhibition of IL-6 by tocilizumab had no clinical benefit in this patient with intractable ulcerative colitis and even led to exacerbation of mucosal inflammation. Our findings suggest that anti-IL-6R antibody therapy may leadto aggravation of anti-TNF resistant ulcerative colitis. When targeting IL-6, the differential responsiveness of target cells has to be taken into account, as IL-6 on the one side promotes acute and chronic mucosal inflammation via soluble IL-6R signaling but on the other side also strongly contributes to epithelial cell survival via membrane bound IL-6R signaling. | Raja Atreya Ulrike Billmeier Timo Rath Jonas Mudter Michael Vieth Helmut Neumann Markus F Neurath | 2015 | World Journal of Gastroenterology2015，21，45： | 5 |
| 6 | Advanced gastrointestinal endoscopic imaging forinflammatory bowel diseases显示文摘Gastrointestinal luminal endoscopy is of paramount importance for diagnosis, monitoring and dysplasia surveillance in patients with both, Crohn's disease and ulcerative colitis. Moreover, with the recent recognition that mucosal healing is directly linked to the clinical outcome of patients with inflammatory bowel disorders, a growing demand exists for the precise, timely and detailed endoscopic assessment of superficial mucosal layer. Further, the novel field of molecular imaging has tremendously expanded the clinical utility and applications of modern endoscopy, now encompassing not only diagnosis, surveillance, and treatment but also the prediction of individual therapeutic responses. Within this review, we describe how novel endoscopic approaches and advanced endoscopic imaging methods such as high definition and high magnification endoscopy, dye-based and dye-less chromoendoscopy, confocal laser endomicroscopy, endocytoscopy and molecular imaging now allow for the precise and ultrastructural assessment of mucosal inflammation and describe the potential of these techniques for dysplasia detection. | Gian Eugenio Tontini Timo Rath Helmut Neumann | 2016 | World Journal of Gastroenterology2016，22，3： | 3 |
| 7 | Advanced colonoscopic imaging using endocytoscopy显示文摘 | Helmut Neumann Shin‐Ei Kudo Ralf Kiesslich Markus F. Neurath | 2015 | Digestive Endoscopy2015，，2： | 2 |
| 8 | Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn’s disease: a pilot study显示文摘 | Gian Tontini Jonas Mudter Michael Vieth Raja Atreya Claudia Günther Yurdagül Zopf Dane Wildner Ralf Kiesslich Maurizio Vecchi Markus Neurath Helmut Neumann | 2014 | Endoscopy2014，，： | 2 |
| 9 | Assessment of Crohn’s disease activity by confocal laser endomicroscopy显示文摘 | Helmut Neumann Michael Vieth Raja Atreya Martin Grauer Jürgen Siebler Thomas Bernatik Markus F. Neurath Jonas Mudter | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 10 | Confocal Laser Endomicroscopy: Technical Advances and Clinical Applications显示文摘 | Helmut Neumann Ralf Kiesslich Michael B. Wallace Markus F. Neurath | 2010 | Gastroenterology2010，，2： | 1 |
| 11 | Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14 + Macrophages显示文摘 | Raja Atreya Michael Zimmer Brigitte Bartsch Maximilian J. Waldner Imke Atreya Helmut Neumann Kai Hildner Arthur Hoffman Ralf Kiesslich Andreas D. Rink Tilman T. Rau Stefan Rose–John Hermann Kessler Jan Schmidt Markus F. Neurath | 2011 | Gastroenterology2011，，6： | 1 |
| 12 | Quantitative evaluation of myocardial blush to assess tissue level reperfusion in patients with acute ST-elevation myocardial infarction显示文摘 | Grigorios Korosoglou Andreas Haars Gick Michael Markus Erbacher Stefan Hardt Evangelos Giannitsis Kerstin Kurz Neumann Franz-Josef Helmut Dickhaus Hugo A. Katus Helmut Kuecherer | 2007 | American Heart Journal2007，，4： | 1 |
| 13 | Assessment of Crohn’s disease activity by confocal laser endomicroscopy显示文摘 | Helmut Neumann Michael Vieth Raja Atreya Martin Grauer Jürgen Siebler Thomas Bernatik Markus F. Neurath Jonas Mudter | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 14 | Su1143 The Role of Confocal Laser Endomicroscopy in the Management of Patients With Biliary Strictures: A Consensus Report Based on Clinical Evidence显示文摘 | David L. Carr-Locke Razvan Arsenescu Helga Bertani Fabrice Caillol Guido Costamagna S. Ian Gan Marc Giovannini Frank G. Gress Oleh Haluszka Khek-Yu Ho Helmut Neumann Frederic Prat Raj J. Shah Prateek Sharma Satish K. Singh Kenneth K. Wang | 2014 | Gastroenterology2014，，5： | 1 |
| 15 | Label-Free Imaging of Inflammatory Bowel Disease Using Multiphoton Microscopy显示文摘 | Sebastian Schürmann Sebastian Foersch Raja Atreya Helmut Neumann Oliver Friedrich Markus F. Neurath Maximilian J. Waldner | 2013 | Gastroenterology2013，，3： | 1 |
| 16 | Schlieren visualization of ultrasonic wave fields with high spatial resolution显示文摘 | Thorsten Neumann Helmut Ermert | 2006 | Ultrasonics2006，，： | 1 |
| 17 | Learning curve of virtual chromoendoscopy for the prediction of hyperplastic and adenomatous colorectal lesions: a prospective 2-center study显示文摘 | Helmut Neumann Michael Vieth Lucía C. Fry Claudia Günther Raja Atreya Markus F. Neurath Klaus M?nkemüller | 2013 | Gastrointestinal Endoscopy2013，，1： | 1 |
| 18 | Comparison of heroin by capillary gas chromatography in Germany显示文摘 | Helmut Neumann | 1994 | Forensic Science International1994，69，： | 1 |
| 19 | Inflammation and Long-Term Mortality After Non-ST Elevation Acute Coronary Syndrome Treated With a Very Early Invasive Strategy in 1042 Consecutive Patients显示文摘 | Christian Mueller Heinz J. Buettner John M. Hodgson Stephan Marsch André P. Perruchoud Helmut Roskamm Franz-Josef Neumann | 2002 | Circulation: Journal of the American Heart Association2002，，12： | 1 |
| 20 | Confocal Laser Endomicroscopy: Technical Advances and Clinical Applications显示文摘 | Helmut Neumann Ralf Kiesslich Michael B. Wallace Markus F. Neurath | 2010 | Gastroenterology2010，，2： | 1 |
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