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| 1 | 炎症与癌症:肿瘤的发生、进展和转移以及中药植物药(英文)显示文摘古往今来,癌症都被视为一个炎症过程。过去20多年的研究已经从分子水平证实大部分慢性疾病包括癌症都是由炎症反应失调所引起的。转录因子如核因子κB与信号转导和转录激活因子3以及它们的基因产物如肿瘤坏死因子、白细胞介素1、白细胞介素6、趋化因子、环氧合酶2、血管内皮生长因子、黏附分子等的发现为阐释炎症在癌症过程中的作用提供了分子基础。肿瘤的发生、发展和转移以及机体无法对其产生免疫抑制都可以部分地用慢性全身炎症反应来解释。中药用于治疗癌症及炎症具有悠久的历史。本文介绍了近期有关癌症与炎症的研究进展以及用于治疗癌症的中药和中药复方。 | Daniel Weber Janelle M Wheat Geoffrey M Currie | 2010 | 中西医结合学报2010，8，11： | 10 |
| 2 | High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging显示文摘Progress in neuroscience relies on new techniques for investigating the complex dynamics of neuronal networks.An ongoing challenge is to achieve minimally invasive and high-resolution observations of neuronal activity in vivo inside deep brain areas.Recently introduced methods for holographic control of light propagation in complex media enable the use of a hair-thin multimode optical fibre as an ultranarrow imaging tool.Compared to endoscopes based on graded-index lenses or fibre bundles,this new approach offers a footprint reduction exceeding an order of magnitude,combined with a significant enhancement in resolution.We designed a compact and high-speed system for fluorescent imaging at the tip of a fibre,achieving a resolution of 1.18±0.04μm across a 50-μm field of view,yielding 7-kilopixel images at a rate of 3.5 frames/s.Furthermore,we demonstrate in vivo observations of cell bodies and processes of inhibitory neurons within deep layers of the visual cortex and hippocampus of anaesthetised mice.This study paves the way for modern microscopy to be applied deep inside tissues of living animal models while exerting a minimal impact on their structural and functional properties. | Sergey Turtaev Ivo T.Leite Tristan Altwegg-Boussac Janelle M.P.Pakan Nathalie L.Rochefort Tomáš Čižmár | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 3 | 肿瘤干细胞及中草药提取物和其他补充医学植物药的作用研究综述(英文)显示文摘本文目的在于阐明某些癌症的起源与干细胞、肿瘤干细胞、干细胞微环境、肿瘤微环境之间的联系,并探讨中草药及其提取物治疗癌症的作用。本文从相关文献中筛选出8篇有关中草药防治癌症复发的研究,并对它们进行分析和评价。一些中草药中的有效成分,如大豆黄酮类、人参皂苷 Rg3、小白菊内酯、小檗胺、姜黄色素等,可通过干预肿瘤干细胞及与其相关的肿瘤发生机制而起到有效的抗癌作用。中草药成分可以针对肿瘤微环境和慢性系统性炎症反应进行联合治疗,这或许比其他药物单一的治疗方案更为有效。许多研究表明,在治疗癌症时运用补充替代医学与常规医学治疗相结合的方法可以取得更好的疗效。 | Daniel A.Weber Janelle M.Wheat Geoffrey M.Currie | 2012 | 中西医结合学报2012，10，5： | 7 |
| 4 | Clinical Performance of an Automated Stool DNA Assay for Detection of Colorectal Neoplasia显示文摘 | Graham P. Lidgard Michael J. Domanico Janelle J. Bruinsma James Light Zubin D. Gagrat Rebecca L. Oldham-Haltom Keith D. Fourrier Hatim Allawi Tracy C. Yab Julie A. Simonson Mary Devens Russell I. Heigh David A. Ahlquist Barry M. Berger | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 5 |
| 5 | Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo显示文摘 | Ralf Kiesslich Juergen Burg Michael Vieth Janina Gnaendiger Meike Enders Peter Delaney Adrian Polglase Wendy McLaren Daniela Janell Steven Thomas Bernhard Nafe Peter R. Galle Markus F. Neurath | 2004 | Gastroenterology2004，，3： | 3 |
| 6 | 基于足底模型的痉挛性脑性瘫痪儿童步态生物力学特征分析显示文摘目的:基于足底模型分析尖足步态、蹲伏步态痉挛性脑性瘫痪(CP)儿童步态生物力学特征,探讨其与正常发育儿童步态生物力学特征的差异。方法:选择新西兰奥克兰大学生物力学实验室收集的60例CP儿童步态数据,按步态情况分为正常发育组、尖足步态组、蹲伏步态组,每组20例。采用三维步态采集与分析系统采集步态运动学数据。测试前先完成静态试验,校准计算机模型的物理标记点。每次测试时,研究对象以正常步速在指定区域内向前行进10 m,重复测量3次,取其平均值。比较3组足底压力中心前后侧(AP)位移、内外侧(ML)位移和中心位移斜率;踝关节最大推进力时足底压力中心与足底坐标系原点的水平距离(COP-AJC_(0));踝关节/膝关节AP、ML方向的杠杆臂和外力矩的差异。结果:(1)足底压力中心轨迹特征:与正常发育组比较,尖足步态组和蹲伏步态组COP-AJC_(0)均明显升高,差异均具有统计学意义(P<0.05)。与尖足步态组比较,蹲伏步态组COP-AJC_(0)、足底压力中心前后侧位移明显更大,足底压力中心位移斜率明显更小,差异均具有统计学意义(P<0.05)。(2)踝关节、膝关节杠杆臂和外力矩:与正常发育组比较,尖足步态组和蹲伏步态组踝关节AP杠杆臂、膝关节AP杠杆臂均明显更长,差异具有统计学意义(P<0.05)。与尖足步态组比较,蹲伏步态组踝关节AP杠杆臂明显更长,差异具有统计学意义(P<0.05)。3组踝关节/膝关节AP、ML外力矩差异均无统计学意义(P>0.05)。结论:基于改良足底模型的足底压力中心轨迹和下肢关节杠杆臂特征分析能够精确、客观地反映痉挛性脑瘫儿童步态生物力学特征,值得临床推广应用。 | 张琪 TOLENTINO Janel 孙成彦 盛博 张彦新 | 2022 | 康复学报2022，32，6： | 3 |
| 7 | MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice显示文摘 | Callis Thomas E Pandya Kumar Seok Hee Young Tang Ru-Hang Tatsuguchi Mariko Huang Zhan-Peng Chen Jian-Fu Deng Zhongliang Gunn Bronwyn Shumate Janelle Willis Monte S Selzman Craig H Wang Da-Zhi | 2009 | Journal of Clinical Investigation2009，，9： | 3 |
| 8 | Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma显示文摘 | Janel L. Kopp Guido von Figura Erin Mayes Fen-Fen Liu Claire L. Dubois John P. Morris Fong Cheng Pan Haruhiko Akiyama Christopher V.E. Wright Kristin Jensen Matthias Hebrok Maike Sander | 2012 | Cancer Cell2012，，6： | 2 |
| 9 | Recognition of Bacteria by Inflammasomes显示文摘 | Jakob von Moltke Janelle S. Ayres Eric M. Kofoed Joseph Chavarría-Smith Russell E. Vance | 2013 | Annual Review of Immunology2013，，： | 2 |
| 10 | 瑞舒伐它汀一周一次治疗过去对它汀不耐受患者的疗效显示文摘它汀类药标准的一天一次应用,具有良好的安全性,一般能很好耐受。但有少数患者因不良事件停药,如像肌痛。作者报告8例过去对它汀不耐受患者对一周一次瑞舒伐它汀(rosuvastatin)治疗的效果。结论:一周一次瑞舒伐它汀对过去不耐受一天一次它汀的患者可能是可行并且有效的选择. | James M. Patrick M. Janelle F. 罗雪琚(节译) | 2007 | 实用心脑肺血管病杂志2007，15，10： | 2 |
| 11 | Cystathionine β Synthase Deficiency Promotes Oxidative Stress, Fibrosis, and Steatosis in Mice Liver显示文摘 | Karine Robert Johnny Nehmé Emmanuel Bourdon Gérard Pivert Bertrand Friguet Claude Delcayre Jean–Maurice Delabar Nathalie Janel | 2005 | Gastroenterology2005，，5： | 2 |
| 12 | Charac-terization of human pre-elafin mutants: full anti- peptidase activity is essential to preserve lung tis- sue integrity in experimental emphysema显示文摘 | Doucet A Bouchard D Janelle MF | 2007 | Bio- chem J2007，405，3： | 1 |
| 13 | Entry trajectory and aeroheating environment definition for capsule-shaped vehicles显示文摘 | Jeffrey S Kathryn E Janelle C | 2009 | Journal of Spacecraft and Rockets2009，46，1： | 1 |
| 14 | Staff Walking Program:a Quasi-Experimental Trial of M aintenance New sletters to M aintain Walking Follow ing a Pedometer Program显示文摘 | Janelle B Dafna M Chris R | 2010 | Health Promotion Journal of Austria2010，21，： | 1 |
| 15 | Optical organophosphate/ phosphonate sensor based upon gold nanoparticle functionalized quartz 显示文摘 | Janelle D S Newmanl John M | 2007 | Analytica Chimica Acta2007，602，1： | 1 |
| 16 | Accessibility in space and time: A theme on spatially integrated social science显示文摘 | Kwan M P Janelle D G Goodchild M F | 2003 | Journal of Geographical systems2003，5，： | 1 |
| 17 | Social Enterprise in the United States and Europe: Understanding and Learning from the Differences显示文摘 | Janelle A. Kerlin | 2006 | VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations2006，，3： | 1 |
| 18 | Solid-phase microextraction of N -nitrosamines显示文摘 | Janel E. Grebel Connie C. Young I.H. (Mel) Suffet | 2006 | Journal of Chromatography A2006，，1： | 1 |
| 19 | Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq显示文摘 | Jihee K Janelle RK Andrea D | 2006 | Cell Signall2006，18，10： | 1 |
| 20 | Measuring Human Extensibility in a Shrinking World显示文摘 | Janelle D G | 1973 | The Journal of Geography1973，72，5： | 1 |
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