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| 1 | Disruption of the Sugar Transporters AtSWEET11 and AtSWEET12 Affects Vascular Development and Freezing Tolerance in Arabidopsis显示文摘Dear Editor, In plants,the transport of sugars from the site of biosynthesis to the site of utilization or storage relies on sugar transporters located in different subcellular compartments and different vascular cell types.The SWEET sugar transporter family is one such class and is represented by 17 members in Arabidopsis.AtSWEET1 was the first plant SWEET transporter to be characterized;it acts as a glucose uniporter in multiple systems (Chen et al.,2010). | Rozenn Le Hir Lara Spinner Patrick A. W. Klemens Dipankar Chakraborti Federica de Marco Francoise Vilaine Nelly Wolff Remi Lemoine Benoit Porcheron Carine Gery Evelyne Teoule Salem Chabout Gregory Mouille H. Ekkehard Neuhaus Sylvie Dinant Catherine Bellini | 2015 | Molecular Plant2015，8，11： | 16 |
| 2 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus. | Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 3 | Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature显示文摘Xanthogranulomatous 胆汁(XGC ) 是胆囊的破坏煽动性的疾病,很少包含邻近的机关并且模仿国王先进胆囊癌。诊断在病理学的检查以后仅仅通常是可能的。46 42 岁的女人被指我们包含肝核,正确的肝脑叶,恰好结肠的弯曲,和十二指肠的怀疑的胆囊癌症的中心。刷细胞学获得了由内视镜后退胆管造影术(ERC ) 出现了高级发育异常。病人经历了团的在团体切除术,由正确叶切除术,正确的半结肠切除术,和部分十二指肠的切除术组成。出人意料地揭示的病理学的检查一 XGC.Only,为有邻近的机关的直接参与的 XGC 的扩大外科的切除术的六个案例到目前为止被报导了。在这些情况中,与癌给 XGC 的可能的共存,恶意不能被排除,甚至在细胞学和 intraoperative 冰冻切片调查以后。在结论,由于源于在另外的方面上包围机关的高度好攻击的煽动性的侵略的一个方面和可能的复杂并发症上的胆囊癌的差的预后,它似乎这些案例应该被当作恶性瘤直到不那样证明。临床医生们应该包括 XGC 在之中可能微分在肝核群众诊断。 | Antonino Spinelli Guido Schumacher Andreas Pascher Enrique Lopez-Hanninen Hussain Al-Abadi Christoph Benckert Igor M Sauer Johann Pratschke Ulf P Neumann Sven Jonas Jan M Langrehr Peter Neuhaus | 2006 | World Journal of Gastroenterology2006，12，14： | 13 |
| 4 | Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)显示文摘 | René Adam Vincent Karam Valérie Delvart John O’Grady Darius Mirza Jurgen Klempnauer Denis Castaing Peter Neuhaus Neville Jamieson Mauro Salizzoni Stephen Pollard Jan Lerut Andreas Paul Juan Carlos Garcia-Valdecasas Fernando San Juan Rodríguez Andrew Burro | 2012 | Journal of Hepatology2012，，3： | 6 |
| 5 | The Rice RMR1 Associates with a Distinct Prevacuolar Compartment for the Protein Storage Vacuole Pathway显示文摘从到液泡的 Golgi 仪器或 trans-Golgi 网络(TGN ) 的 vacuolar 蛋白质的运输在植物房间是经由中间的膜界限 prevacuolar 分隔空间(PVC ) 的一个调停受体的过程。排序受体(VSR ) 和受体相同 region-transmembrane domain-RING-H2 (RMR ) 蛋白质的两 vacuolar 被显示了在把存储蛋白质搬运到蛋白质存储液泡(PSV ) 工作,但是很少为 PSV 小径对 PVC 的性质被知道。这里,我们把米饭 RMR1 (OsRMR1 ) 用作一根探针在植物学习 PSV 小径。有特定的 OsRMR1 抗体的 Immunogold 电子显微镜学(他们)证明 OsRMR1 蛋白质在两个大米文化房间和发展中的大米种子与 PVC 的特征在 Golgi 仪器, TGN ,和一个不同细胞器被发现,象蛋白质身体类型 II ( PBII )或在开发大米种子的 PSV 一样。这个细胞器,也在烟草 BY-2 和 Arabidopsis 暂停发现有教养的房间,从 VSR 积极的 multivesicular 是词法上不同的 lysin 的 PVC 或 multivesicular 身体(MVB ) 并且因此为我们说出存储 PVC (sPVC ) 的 PSV 小径代表 PVC。进一步,在 vivo 并且在 vitro,相互作用用蛋白质分泌了进暂停房间表明了的转基因的 BY-2 的文化媒介的截断的 OsRMR1 学习那 OsRMR1 在搬运象 vicilin 一样存储蛋白质作为排序的受体工作。 | Yun Shen Junqi Wang Yu Ding Sze Wan Lo Guillaume Gouzerh Jean-Marc Neuhau Liwen Jiang | 2011 | Molecular Plant2011，4，5： | 5 |
| 6 | Biliary Complications After Liver Transplantation: Old Problems and New Challenges显示文摘 | D. Seehofer D. Eurich W. Veltzke‐Schlieker P. Neuhaus | 2013 | American Journal of Transplantation2013，，2： | 5 |
| 7 | Different cava reconstruction techniques in liver transplantation:piggyback versus cava resection显示文摘BACKGROUND: Originally, cava reconstruction(CR) in liver transplantation meant complete resection and reinsertion of the donor cava. Alternatively, preservation of the recipients inferior vena cava(IVC) with side-to-side anastomosis(known as 'piggyback') can be performed. Here, partial clamping maintains blood flow of the IVC, which may improve cardiovascular stability, reduce blood loss and stabilize kidney function. The aim of this study was to compare both techniques with particular focus on kidney function.METHODS: A series of 414 patients who had had adult liver transplantations(2006-2009) were included. Among them,176(42.5%) patients had piggyback and 238 had classical CR operation, 112(27.1%) of the patients underwent CR accompanied with veno-venous bypass(CR-B) and 126(30.4%)without a bypass. The choice of either technique was based on the surgeons' individual preference. Kidney function [serum creatinine, calculated glomerular filtration rate(GFR), RIFLE stages] was assessed over 14 days.RESULTS: Lab-MELD scores were significantly higher in CR-B(22.5±11.0) than in CR(17.3±9.0) and piggyback(18.8±10.0)(P=0.008). Unexpectedly, the incidences of arterial stenoses(P=0.045) and biliary leaks(P=0.042) were significantly increased in piggyback. Preoperative serum creatinine levels were the highest in CR-B [1.45±1.17 vs 1.25±0.85(piggyback)and 1.13±0.60 mg/dL(CR); P=0.033]. Although a worsening of postoperative kidney function was observed among all groups,this was most pronounced in CR-B [creatinine day 14: 1.67±1.40 vs 1.35±0.96(piggyback) and 1.45±1.03 mg/dL(CR); P=0.102].Accordingly, the proportion of patients displaying RIFLE stages≥2 was the highest in CR/CR-B(26%/19%) when compared to piggyback(18%).CONCLUSIONS: Piggyback revealed a shorter warm ischemic time, a reduced blood loss, and a decreased risk of acute kidney failure. Thus, piggyback is a useful technique, which should be applied in standard procedures. When piggyback is unfeasible,cava replacement, which displayed a lower incidence of vascular and biliary complications in our study, remains as a safe alternative. | Volker Schmitz Wenzel Schoening Ines Jelkmann Brigitta Globke Andreas Pascher Marcus Bahra Peter Neuhaus Gero Puhl | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 5 |
| 8 | Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis显示文摘 | Vincenzo Mazzaferro Josep M Llovet Rosalba Miceli Sherrie Bhoori Marcello Schiavo Luigi Mariani Tiziana Camerini Sasan Roayaie Myron E Schwartz Gian Luca Grazi René Adam Peter Neuhaus Mauro Salizzoni Jordi Bruix Alejandro Forner Luciano De Carlis Umberto | 2009 | Lancet Oncology2009，，1： | 4 |
| 9 | Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis显示文摘 | Sven Jonas Wolf O. Bechstein Thomas Steinmüller Martin Herrmann Cornelia Radke Thomas Berg Utz Settmacher Peter Neuhaus | 2001 | Hepatology2001，，5： | 4 |
| 10 | The Plastid-Localized NAD-Dependent Malate Dehydrogenase Is Crucial for Energy Homeostasis in Developing Arabidopsis thaliana Seeds显示文摘当光合作用不在时, ATP 被 ATP/ADP transporters 进口进叶绿体和非绿的质体或在 glycolysis 期间形成了,要求 NAD+ 的连续新生的后者,由 NADMDH 的 plastidial isoform 供应了。在在 Arabidopsis 的 plNADMDH 基因为 T-DNA 插入异种屏蔽期间,仅仅异质接合的植物能被孤立,同型结合的猛烈异种仅仅在互补以后成长了。这些异质接合的植物显示出其他的改革 NAD+ 酶的更高的抄本层次, NADHGOGAT,并且,显著地,当铵是唯一的 N 来源时,改进了生长。在 situ,杂交并且 GUS 组织化学的染色表明 plNADMDH 特别地充满男、女的配偶体。猛烈 plNADMDH 花粉展览在 vitro 损害了试管生长,它能被增加 NADHGOGAT 的底层克服。在 vivo,猛烈花粉能使肥沃卵房间。异质接合的植物包含的 selfed 的年轻 siliques 相应于 wild-type/heterozygous (绿色) 和同型结合的猛烈异种(白色) 在的绿、白的种子一(1:2 ): 1 比率。同型结合的猛烈种子的胚胎仅仅到达了球状的阶段,绿,并且发展了到微小的起皱的种子。有在本国的倡导者下面的基因的互补救了作为野类型开发的这个缺点,和所有种子。这建议在 plNADMDH 异种的一个堵住的主要生理的过程停止胚胎和内乳开发,因此避免在损害后代吸收投资。 | Jennifer Selinski Nicolas Konig Benedikt Wellmeyer Guy T. Hanke Vera Linke H. Ekkehard Neuhaus Renate Scheibe | 2014 | Molecular Plant2014，7，1： | 4 |
| 11 | Normalised intrinsic mortality risk in liver transplantation: European Liver Transplant Registry study显示文摘 | René Adam Valérie Cailliez Pietro Majno Vincent Karam Paul McMaster Roy Y Calne John O’Grady Rudolf Pichlmayr Peter Neuhaus Jean-Bernard Otte Krister Hoeckerstedt Henri Bismuth | 2000 | The Lancet . 2000 (9230)2000，，9230： | 3 |
| 12 | Einteilung und Behandlung von Gallengangverletzungen nach laparoskopischer Cholecystektomie显示文摘 | P. Neuhaus S. C. Schmidt R. E. Hintze A. Adler W. Veltzke R. Raakow J. M. Langrehr W. O. Bechstein | 2000 | Der Chirurg2000，，2： | 3 |
| 13 | Megacolon in adulthood after surgical treatment of Hirschsprung's disease in early childhood显示文摘Hirschsprung's disease (HD) is a disorder associated with congenital malformation of the enteric nervous system with segmental aganglionosis. Prevailing therapy includes a resection of the affected part of the bowel. However, patients often do not obtain complete functional improvement after surgical treatment. We present the case of a 25-year-old woman who had surgical treatment of HD in early childhood. After that procedure she had clinical features of constipation for years in the end,passing of stool once a week, requiring laxatives and enemas. We diagnosed an incomplete resection of the aganglionic bowel via rectal biopsy and resected the remaining aganglionic segment. Two months after surgery the patient's bowel function improved to a frequency of 1-4 stools per day. We conclude that regular follow-up is required to identify HD patients with persistent alterations of bowel function after surgery. In patients presenting with constipation, recognition of a remaining aganglionic segment or other alterations of the enteric nervous system should be aimed at in an early stage. | Christoph R.Werner Gisela Stoltenburg-Didinger Henning Weidemann Christoph Benckert Marco Schmidtmann Ivo R.van der Voort Viola Andresen Burghard F.Klapp Peter Neuhaus Bertram Wiedenmann Hubert Mnnikes | 2005 | World Journal of Gastroenterology2005，11，36： | 3 |
| 14 | Surgical management of proximal bile duct cancer: extended right lobe resection increases resectability and radicality显示文摘 | Peter Neuhaus Sven Jonas Utz Settmacher Armin Thelen Christoph Benckert Enrique Lopez-H?nninen Rainer E. Hintze | 2003 | Langenbeck’s Archives of Surgery2003，，3： | 2 |
| 15 | Hydroxyethylstarch revisited for acute brain injury treatment显示文摘Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss.In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients.Because of the serious risk for critically ill patients, the administration of hydroxyethylstarch was restricted for clinical use.Animal studies and recently published in vitro experiments showed that hydroxyethylstarch might exert protective effects on the blood-brain barrier.Since the prevention of blood-brain barrier disruption was shown to go along with the reduction of brain damage after several kinds of insults, we revisit the topic hydroxyethylstarch and discuss a possible niche for the application of hydroxyethylstarch in acute brain injury treatment. | Martin A.Schick Malgorzata Burek Carola Y.Forster Michiaki Nagai Christian Wunder Winfried Neuhaus | 2021 | Neural Regeneration Research2021，16，7： | 2 |
| 16 | Diagnostic criteria and severity assessment of acute cholangitis: Tokyo Guidelines显示文摘 | Keita Wada Tadahiro Takada Yoshifumi Kawarada Yuji Nimura Fumihiko Miura Masahiro Yoshida Toshihiko Mayumi Steven Strasberg Henry A. Pitt Thomas R. Gadacz Markus W. Büchler Jacques Belghiti Eduardo de Santibanes Dirk J. Gouma Horst Neuhaus Christos Derven | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，1： | 2 |
| 17 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
| 18 | Oncological Superiority of Hilar En Bloc Resection for the Treatment of Hilar Cholangiocarcinoma显示文摘 | Peter Neuhaus Armin Thelen Sven Jonas Gero Puhl Timm Denecke Wilfried Veltzke-Schlieker Daniel Seehofer | 2012 | Annals of Surgical Oncology2012，，5： | 2 |
| 19 | Liver transplantation for HBV-related cirrhosis in Europe: An ELTR study on evolution and outcomes显示文摘 | Patrizia Burra Giacomo Germani Renè Adam Vincent Karam Alfredo Marzano Pietro Lampertico Mauro Salizzoni Franco Filipponi Jurgen L. Klempnauer Denis Castaing Murat Kilic Luciano De Carlis Peter Neuhaus Sezai Yilmaz Andreas Paul Antonio D. Pinna Andrew K. | 2012 | Journal of Hepatology2012，，： | 2 |
| 20 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
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