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| 1 | Is there an association of microscopic colitis and irritable bowel syndrome-A subgroup analysis of placebo-controlled trials显示文摘TO THE EDITOR
With great interest we read the recent retrospectice study by Barta et al (1) dealing with the clinical presentation of patients with microscopic colitis. They investigated in a cohort of 53 patients with microscopic colitis (46 with collagenous colitis, 7 with lymphocytic colitis)the relationship between microscopic colitis and both constipation and diarrhea. One of their mean finding was that abdominal pain, diarrhea and constipation was a common symptom complex of patients with microscopic colitis, thus the face of microcopic colitis resembles the subgroups of irritable bowel syndrome (IBS). | Ahmed Madisch Birgit Bethke Manfred Stolte Stephan Miehlke | 2005 | World Journal of Gastroenterology2005，11，41： | 4 |
| 2 | Strictures, diaphragms, erosions or ulcerations of ischemic type in the colon should always prompt consideration of nonsteroidal anti-inflammatory drug-induced lesions显示文摘AIM: To investigate whether NSAIDs/ASA lesions in the colon can histologically be diagnosed on the basis of ischemic necrosis similar to biopsy-based diagnosis of NSAIDs/ASA-induced erosions and ulcers of the stomach.METHODS: In the period between 1997 and 2002, we investigated biopsy materials obtained from 611 patients (415 women, 196 men, average age 60.5 years) with endoscopic focal erosions, ulcerations, strictures or diaphragms in the colon. In the biopsies obtained from these lesions, we always established the suspected diagnosis of NSAID-induced lesions whenever necroses of the ischemic type were found. Together with the histological report, we endosed a questionnaire to investigate the use of medication.The data provided by the questionnaire were then correlated with the endoscopic findings, the location, number and nature of the lesions, and the histological findings.RESULTS: At the time of their colonoscopy, 86.1% of the patients had indeed been taking NSAID/ASA medication for years (43.9%) or months (29.5%). The most common indication for the use of these drugs was pain (64.3%),and the most common indication for colonoscopy was bleeding (55.5%). Endoscopic inspection revealed multiple erosions and/or ulcers in 60.6%, strictures in 15.8%, and diaphragms in 3.0% of the patients. The lesions were located mainly in the right colon including the transverse colon (79.9%). A separate analysis of age and sex distribution,endoscopic and histological findings for NSAIDs alone,ASA alone, combined NSAID/ASA, and for patients denying the use of such drugs, revealed no significant differences among the groups.CONCLUSION: This uncontrolled retrospective study based on the histological finding of an ischemic necrosis shows that the histologically suspected diagnosis of NSAID-induced lesions in the colon is often correct. The true diagnostic validity of this finding and the differentiation from ischemic colitis should, however, be investigated in a prospective controlled study. | Manfred Stolte Diana Karimi Michael Vieth Hildegard Volkholz Klaus Dirschmid Sigrid Rappel Birgit Bethke | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 3 | Oral budesonide therapy improves quality of life in patients with collagenous colitis显示文摘 | Ahmed Madisch Peter Heymer Claudia Voss Bernd Wigginghaus Elke B?stlein Ekkehard Bayerd?rffer Eberhard Meier Wolfgang Schimming Birgit Bethke Manfred Stolte Stephan Miehlke | 2005 | International Journal of Colorectal Disease2005，，4： | 1 |
| 4 | Budesonide treatment for collagenous colitis: A randomized, double-blind, placebo-controlled, multicenter trial显示文摘 | Stephan Miehlke Peter Heymer Birgit Bethke Elke B?stlein Eberhard Meier Hans–peter Bartram Günther Wilhelms Norbert Lehn Gian Dorta Joachim Delarive Andreas Tromm Ekkehard Bayerd?rffer Manfred Stolte | 2002 | Gastroenterology2002，，4： | 1 |
| 5 | Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial显示文摘 | Ahmed Madisch Stephan Miehlke Otto Eichele Jenny Mrwa Birgit Bethke Eberhard Kuhlisch Elke B?stlein Georg Wilhelms Andrea Morgner Bernd Wigginghaus Manfred Stolte | 2007 | International Journal of Colorectal Disease2007，，12： | 1 |
| 6 | Colorectal de novo carcinoma: a review of its diagnosis, histopathology, molecular biology, and clinical relevance显示文摘 | James D. Mueller Birgit Bethke Manfred Stolte | 2002 | Virchows Archiv2002，，5： | 1 |
| 7 | Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial显示文摘 | Ahmed Madisch Stephan Miehlke Otto Eichele Jenny Mrwa Birgit Bethke Eberhard Kuhlisch Elke B?stlein Georg Wilhelms Andrea Morgner Bernd Wigginghaus Manfred Stolte | 2007 | International Journal of Colorectal Disease2007，，12： | 1 |
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