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| 1 | Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline显示文摘 | Michael F. Holick Neil C. Binkley Heike A. Bischoff-Ferrari Catherine M. Gordon David A. Hanley Robert P. Heaney M. Hassan Murad Connie M. Weaver | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，7： | 5 |
| 2 | 正相-反相两步高效液相色谱法制备毫克量级维生素D_3异构体显示文摘利用正相半制备柱和反相分析柱的两步高效液相色谱法,在实验室规模制备了毫克是级维生素D_3的三个重要异构体——维生素D_3前体、光甾醇_3和速甾醇_3·维生素D_3原体,7-去氢胆固醇的光照是在一个装有UVB荧光灯的光治疗室中进行。采用紫外分光光度法和高效液相色谱法对制得的三个异构体进行了定性定量分析。在这三个异构体检测极限下,除了维生素D_3前体中有不超过0.25%的维生素D_3杂质外,三个产品中均没有发现任何除它本身之外的其他异构体杂质。 | 陆志仁 TC Chen MF Holick | 1992 | 药学学报1992，27，5： | 5 |
| 3 | High Prevalence of Vitamin D Inadequacy and Implications for Health显示文摘 | Michael F. Holick | 2006 | Mayo Clinic Proceedings2006，，3： | 3 |
| 4 | Estimates of optimal vitamin D status显示文摘 | Bess Dawson-Hughes Robert P. Heaney Michael F. Holick Paul Lips Pierre J. Meunier Reinhold Vieth | 2005 | Osteoporosis International2005，，7： | 2 |
| 5 | Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths:An ecological integrative approach显示文摘BACKGROUND Vitamin D population status may have possible unappreciated consequences to the coronavirus disease 2019(COVID-19)pandemic.Αsignificant association between vitamin D sufficiency and reduction in clinical severity and inpatient mortality from COVID-19 disease has recently been shown,while a recent study has claimed lower COVID-19 cases in European countries with a better vitamin D status.Low serum 25-hydroxyvitamin-D[25(OH)D]was identified as an independent risk factor for COVID-19 infection and hospitalization,and administration of 0.532 mg(21280 IU)of calcifediol or 25(OH)D,followed by 0.266 mg on days 3 and 7 and then weekly until discharge or intensive care unit admission significantly reduced the need for intensive care unit treatment.AIM To elucidate the role of vitamin D European population status in the COVID-19 pandemic,data from the Worldometer were analyzed.METHODS Linear regression explored the correlation between published representativestandardized population vitamin D concentrations and the number of total cases/million(M),recovered/M,deaths/M and serious-critically ill/M from COVID-19 for 26 European countries populated>4 M(Worldometer).Life expectancy was analyzed with semi-parametric regression.Weighted analysis of variance/analysis of covariance evaluated serious-critical/M and deaths/M by the vitamin D population status:Deficient<50,insufficient:50-62.5,mildly insufficient>62.5-75 and sufficient>75 nmol/L,while controlling for life expectancy for deaths/M.Statistical analyses were performed in XLSTAT LIFE SCIENCE and R(SemiPar Library).RESULTS Linear regression found no correlation between population vitamin D concentrations and the total cases-recovered/M,but negative correlations predicting a reduction of 47%-64%-80%in serious-critical illnesses/M and of 61%-82%-102.4%in deaths/M further enhanced when adapting for life expectancy by 133-177-221%if 25(OH)D concentrations reach 100-125-150 nmol/L,sustained on August 15,2020,indicating a truthful association.Weighted analysis of variance was performed to evaluate serious-critical/M(r2=0.22)by the vitamin D population status and analysis of covariance the deaths/M(r2=0.629)controlling for life expectancy(r2=0.47).Serious-critical showed a decreasing trend(P<0.001)from population status deficient(P<0.001)to insufficient by 9.2%(P<0.001),to mildly insufficient by 47.6%(P<0.044)and to sufficient by 100%(reference,P<0.001).For deaths/M the respective decreasing trend(P<0.001)was 62.9%from deficient(P<0.001)to insufficient(P<0.001),65.15%to mildly insufficient(P<0.001)and 78.8%to sufficient(P=0.041).CONCLUSION Achieving serum 25(OH)D 100-150 nmol/L(40-60 ng/mL)(upper tolerable daily doses followed by maintenance proposed doses not requiring medical supervision,Endocrine Society)may protect from serious-critical illness/death from COVID-19 disease. | Dimitrios T Papadimitriou Alexandros K Vassaras Michael F Holick | 2021 | World Journal of Virology2021，10，3： | 2 |
| 6 | Vitamin D and prevention of colorectal cancer显示文摘 | Edward D. Gorham Cedric F. Garland Frank C. Garland William B. Grant Sharif B. Mohr Martin Lipkin Harold L. Newmark Edward Giovannucci Melissa Wei Michael F. Holick | 2005 | Journal of Steroid Biochemistry and Molecular Biology2005，，1： | 2 |
| 7 | Vitamin D deficiency 显示文摘 | Holick MF | 2007 | N Engl J Med2007，357，： | 1 |
| 8 | Resurrection of vitamin D deficiency and rickets显示文摘 | Holick MF | 2006 | J Clin Invest2006，116，8： | 1 |
| 9 | Treatment of psoriatic arthritis with oral 1,25-dihydroxyvitamin D3 : a pilot study 显示文摘 | Huckins D Felson DT Holick M | 1990 | Arthritis Rheum1990，33，11： | 1 |
| 10 | Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline 显示文摘 | Holick MF Binkley NC Bisehoff-Ferrari HA | 2011 | J Clin Endocrinol Metab2011，96，： | 1 |
| 11 | Estimates of optimal vitamin d status显示文摘 | DAWSON-HUGHES B HEANEY R P HOLICK M F | 2005 | Osteoporos Int2005，16，7： | 1 |
| 12 | VitaminD deficiency显示文摘 | Holick MF | 2007 | N Engl J Med2007，357，3： | 1 |
| 13 | Vitamin D deficiency显示文摘 | Holick MF | | 0，，3： | 1 |
| 14 | Vitamin D deficiency显示文摘 | Holick MF | 2007 | N Engl J Med2007，357，3： | 1 |
| 15 | McCollum Award Lecture, 1994: vitamin D--new horizons for the 21st century显示文摘 | Holick MF | 1994 | Am J Clin Nutr1994，60，： | 1 |
| 16 | Vitamin D deficiency: a worldwide problem with health consequences 显示文摘 | HOLICK M F CHEN T C | 2008 | Am J Clin Nutr2008，，： | 1 |
| 17 | Vitamin D:importance in the prevention of cancers,type 1 diabetes,heart disease,and osteoporosis显示文摘 | Michael F Holick | 2004 | American Society for Clinical Nutrition2004，79，： | 1 |
| 18 | Vitamin D: importance in the prevention of cancers, type 1 diabetes,heart disease, and osteoporosis 显示文摘 | Holick MF | 2004 | Am J Clin Nutr2004，79，3： | 1 |
| 19 | Vitamin D deficiency:a worldwide problem with health consequences显示文摘 | Holick MF Chen TC | 2008 | Am J Clin Nutr2008，87，4： | 1 |
| 20 | Vitamin D:evolutionary,physiological and health perspectives显示文摘 | HOLICK M F | 2011 | Curr Drug Targets2011，12，1： | 1 |
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