|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma显示文摘Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. Most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ERCP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ERCP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ERCP is a useful tool to differentiate extraductal from intraductal obstruction. | Deha Erdogan Olivier RC Busch Erik AJ Rauws Otto M van Delden Dirk J Gouma Thomas M van Gulik | 2006 | World Journal of Gastroenterology2006，12，35： | 26 |
| 2 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 3 | Heat Shock Factors HsfB 1 and HsfB2b Are Involved in the Regulation of Pdf1.2 Expression and Pathogen Resistance in Arabidopsis显示文摘以便估计热的功能的角色在 Arabidopsis 的导致压力的班 B 热吃惊因素,我们调查了 AtHsfB1 和 AtHsfB2b 的 T-DNA 猛烈异种。在异种的 defensin 基因 Pdf1.2a/b 的基础 mRNA 水平的一条起来规定种的作为强壮揭示的两倍猛烈 hsfB1/hsfB2b 植物的 Micorarray 分析。Pdf 表示被 jasmonic 酸处理或感染进一步与 necrotrophic 真菌 Alternaria brassicicola 提高。单个变异的 hsfB2b 和双变异的 hsfB1/B2b 显著地在 A 以后在疾病抵抗被改进。brassicicola 感染。为和 Pdf1.2 的倡导者的 Hsf 的一个直接相互作用没有指示,它缺乏完美的 HSE 一致 Hsf 有约束力的序列。然而,在形成变化近来 HsfA2 依赖的 HSE 绑定在 hsfB1/B2b 植物被检测。这建议 HsfB1/B2b 可以在调整热吃惊反应的用以遮闭之物与班 A-Hsf 交往。Pdf 基因的鉴定作为 Hsf 依赖的否定规定的目标是为在关於生命、不能生活的回答的规定的 Hsf 的互联的第一条证据。 | Mukesh Kumar Wolfgang Busch Hannah Birke Birgit Kemmerling Thorsten Nurnberger Friedrich Schoffl | 2009 | Molecular Plant2009，2，1： | 15 |
| 4 | Cholesterol crystal binding of biliary immunoglobulin A: visualization by fluorescence light microscopy显示文摘AIM To assess potential contributions of biliary IgA for crystal agglomeration into gallstones, we visualized cholesterol crystal binding of biliary IgA.METHODS Crystal-binding biliary proteins were extracted from human gallbladder bile using lectin affinity chromatography. Biliary IgA was isolated from the bound protein fraction by immunoaffinity chromatography. Pure cholesterol monohydrate crystals were incubated with biliary IgA and fluoresceine isothiocyanate (FITC)-conjugated anti-lgA at 37C. Samples were examined under polarizing and fluorescence light microscopy with digital image processing.RESULTS Binding of biliary IgA to cholesterol monohydrate crystals could be visualized with FITC-conjugated anti-lgA antibodies. Peak fluorescence occurred at crystal edges and dislocations. Controls without biliary IgA or with biliary IgG showed no significant fluorescence.CONCLUSION Fluorescence light microscopy provided evidence for cholesterol crystal binding of biliary IgA. Cholesterol crystalbinding proteins like IgA might be important mediators of crystal agglomeration and growth of cholesterol gallstones by modifying the evolving crystal structures in vivo. | Frank Lammert Stefan Südfeld Norbert Busch Siegfried Matern | 2001 | World Journal of Gastroenterology2001，7，2： | 6 |
| 5 | Cast iron-a predictable material显示文摘High strength compacted graphite iron (CGI) or alloyed cast iron components are substituting previously used non-ferrous castings in automotive power train applications.The mechanical engineering industry has recognized the value in substituting forged or welded structures with stiff and light-weight cast iron castings.New products such as wind turbines have opened new markets for an entire suite of highly reliable ductile iron cast components.During the last 20 years,casting process simulation has developed from predicting hot spots and solidification to an integral assessment tool for foundries for the entire manufacturing route of castings.The support of the feeding related layout of the casting is still one of the most important duties for casting process simulation.Depending on the alloy poured,different feeding behaviors and self-feeding capabilities need to be considered to provide a defect free casting.Therefore,it is not enough to base the prediction of shrinkage defects solely on hot spots derived from temperature fields.To be able to quantitatively predict these defects,solidification simulation had to be combined with density and mass transport calculations,in order to evaluate the impact of the solidification morphology on the feeding behavior as well as to consider alloy dependent feeding ranges.For cast iron foundries,the use of casting process simulation has become an important instrument to predict the robustness and reliability of their processes,especially since the influence of alloying elements,melting practice and metallurgy need to be considered to quantify the special shrinkage and solidification behavior of cast iron.This allows the prediction of local structures,phases and ultimately the local mechanical properties of cast irons,to asses casting quality in the foundry but also to make use of this quantitative information during design of the casting.Casting quality issues related to thermally driven stresses in castings are also gaining increasing attention.State-of-the-art tools allow the prediction of residual stresses and iron casting distortion quantitatively.Cracks in castings can be assessed,as well as the reduction of casting stresses during heat treatment.As the property requirements for cast iron as a material in design strongly increase,new alloys and materials such as ADI might become more attractive,where latest software developments allow the modeling of the required heat treatment.Phases can be predicted and parametric studies can be performed to optimize the alloy dependent heat treatment conditions during austenitization,quenching and ausferritization.All this quantitative information about the material's performance is most valuable if it can be used during casting design.The transfer of local properties into the designer's world,to predict fatigue and durability as a function of the entire manufacturing route,will increase the trust in this old but highly innovative material and will open new opportunities for cast iron in the future.The paper will give an overview on current capabilities to quantitatively predict cast iron specific defects and casting performance and will highlight latest developments in modeling the manufacture of cast iron and ADI as well as the prediction of iron casting stresses. | Jrg C.Sturm Guido Busch | 2011 | China Foundry2011，8，1： | 4 |
| 6 | 腹部手术后是否应用鼻胃管?——近期文献的分析显示文摘在许多医疗中心,腹部手术后在胃肠(GI)功能尚未完全恢复前预防性使用鼻胃管(NGI)已是一个诊疗常规。在腹部手术中使用鼻胃管可使术野有更好显露也已成为广泛共识。但在二十世纪80—90年代,许多临床试验却对是否常规使用鼻胃管提出了新的争议。1995年,Cheatham等在对截止到1993年所公开发表的文献所做的分析中显示: | 刘军麟 Vermeulen H Storm-Versloot MN Busch OR | 2008 | 中华普通外科学文献(电子版)2008，2，2： | 4 |
| 7 | 唐氏综合征动物模型肠神经系发育的动态观察显示文摘目的通过研究唐氏综合征动物模型16三体鼠肠神经系发育,揭示16三体鼠是否伴有先天性巨结肠。方法通过免疫组织化学方法测定16三体胎鼠及同龄胎鼠蛋白基因产物9.5(PGP9.5),并观察了肠神经系的形态学特征。结果16三体胎鼠肠神经系发育异常,肠肌间神经丛发育迟缓,肠粘膜下神经丛缺如,盲肠末端有5mm的无神经节区。但肠道外源性神经支配正常,肠系膜神经系发育良好。结论唐氏综合征动物模型16三体鼠伴有先天性巨结肠,这种动物模型可用于研究先天性巨结肠病。 | 李继承 Busch,LC | 1999 | 中华医学杂志1999，79，6： | 3 |
| 8 | The development of colon innervation in trisomy mice and Hirschsprungs disease显示文摘AIM To study the colon innervation of trisomy16 mouse, an animal model for Downssyndrome, and the expression of protein geneproduct 9.5 ( PGP 9.5) in the stenosed segmentof colon in Hirschsprungs disease (HD).METHODS Trisomy 16 mouse breeding;cytogenetic analysis of trisomy 16 mice; andPGP 9.5 immunohistochemistry of colons oftrisomy 16 mice and HD were carried out.RESULTS Compared with their normalIittermates, the nervous system of colon intrisomy 16 mice was abnormally developed.There existed developmental delay of muscularplexuses of colon, no submucosal plexus wasfound in the colon, and there was 5mmaganglionic bowel aparting from the anus intrisomy 16 mice. The mesentery nerve fiberswere as well developed as shown in their normallittermates. Abundant proliferation of PGP 9.5positive nerve fibers was revealed in thestenosed segment of HD colon.CONCLUSION Trisomy 16 mice could serve asaganglionic bowel in the distal part of colon.Abundant proliferation of PGP 9.5 positive fibersresulted from extrinsic nerve compensation,since no ganglionic cells were observed in thestenosed segment of the colon in HD. HD has agenetic tendency. | LC Busch W Kuhnel | 2001 | World Journal of Gastroenterology2001，7，1： | 3 |
| 9 | Functional significance of cell volume regulatory mechanisms显示文摘 | Lang F Busch GL Ritter M | 1998 | Physiol Rev1998，78，1： | 3 |
| 10 | Endoscopic and Percutaneous Preoperative Biliary Drainage in Patients with Suspected Hilar Cholangiocarcinoma显示文摘 | Jaap J. Kloek Niels A. Gaag Yalda Aziz Erik A. J. Rauws Otto M. Delden Johan S. Lameris Olivier R. C. Busch Dirk J. Gouma Thomas M. Gulik | 2010 | Journal of Gastrointestinal Surgery2010，，1： | 3 |
| 11 | Collaboration for success:the value of strategic collaborations for precision medicine and biomarker discovery显示文摘Precision medicine aims to provide the precise treatment for the patient with the right dose at the right point of time.Biomarkers(BM)are vital for the identification of patients who would benefit the most from individualized treatment.In addition,they help to enable the prediction of prognosis,the detection of early therapeutic and adverse effects,and may serve as surrogate endpoints in clinical trials.BM are becoming essential tools to increase productivity in drug discovery and impressively enhance the way medicine is practiced.However,the identification,sufficient validation and implementation of such BM are challenging.This process requires expertise from different areas and high resource investments.Collaborations of different partners may be helpful to overcome these challenges.In the past decade,collaborations between diagnostics and pharmaceutical companies as well as industrial–academic collaborations have been increasingly pursued.Moreover,public funding may offer support and open new opportunities to form such consortia.Herein we give an overview of the different types of collaborations,their opportunities and challenges,and describe experiences in forming strategic partnerships with other companies. | Lilla Landeck Monika Lessl Joachim Reischl Andreas Busch Patricia Carrigan Matthias Gottwald Petra Reinke Khusru Asadullah | 2016 | Advances in Precision Medicine2016，1，1： | 3 |
| 12 | Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study显示文摘 | Katja Ott Andreas Sendler Karen Becker Hans-Joachim Dittler Hermann Helmberger Raimonde Busch Christian Kollmannsberger J. Rüdiger Siewert Ulrich Fink | 2003 | Gastric Cancer2003，，3： | 3 |
| 13 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 14 | A Novel Line Immunoassay Based on Recombinant Virulence Factors Enables Highly Specific and Sensitive Serologic Diagnosis of Helicobacter pylori Infection显示文摘 | Luca Formichella Laura Romberg Christian Bolz Michael Vieth Michael Geppert Gereon G?ttner Christina N?lting Dirk Walter Wolfgang Schepp Arne Schneider Kurt Ulm Petra Wolf Dirk H. Busch Erwin Soutschek Markus Gerhard | 2013 | Clinical and Vaccine Immunology2013，，11： | 2 |
| 15 | Improved Outcome of Resection of Hilar Cholangiocarcinoma (Klatskin Tumor)显示文摘 | Sander Dinant Michael F. Gerhards E. A. J. Rauws Olivier R. C. Busch Dirk J. Gouma Thomas M. Gulik | 2006 | Annals of Surgical Oncology2006，，： | 2 |
| 16 | Intraindividual Comparison of 123I-mIBG SPECT/MRI, 123I-mIBG SPECT/CT, and MRI for the Detection of Adrenal Pheochromocytoma in Patients With Elevated Urine or Plasma Catecholamines显示文摘 | Thorsten Derlin Jasmin D. Busch Christian Wisotzki Bjoern P. Schoennagel Peter Bannas László Papp Susanne Klutmann Christian R. Habermann | 2013 | Clinical Nuclear Medicine2013，，： | 2 |
| 17 | CBM and CO2-ECBM related sorption processes in coal: A review显示文摘 | Andreas Busch Yves Gensterblum | 2011 | International Journal of Coal Geology2011，，2： | 2 |
| 18 | Development of an event-specific Real-time PCR detection method for the transgenic Bt rice line KMD1显示文摘 | Ruzha Babekova Tristan Funk Sven Pecoraro Karl-Heinz Engel Ulrich Busch | 2009 | European Food Research and Technology2009，，5： | 2 |
| 19 | Family coverage expansions: Impact on insurance coverage and health care utilization of parents显示文摘 | Susan H. Busch Noelia Duchovny | 2005 | Journal of Health Economics2005，，5： | 2 |
| 20 | Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarction显示文摘 | Andreas H. Mahnken Ralf Koos Marcus Katoh Elmar Spuentrup Petra Busch Joachim E. Wildberger Harald P. Kühl Rolf W. Günther | 2005 | European Radiology2005，，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员