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| 1 | Regulation of MYB and bHLH Transcription Factors: A Glance at the Protein Level显示文摘 | Marie Pireyre Meike Burow | 2015 | Molecular Plant2015，8，3： | 14 |
| 2 | Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy显示文摘Background:Progressive accumulation ofα-synuclein is a key step in the pathological development of Parkinson’s disease.Impaired protein degradation and increased levels ofα-synuclein may trigger a pathological aggregation in vitro and in vivo.The chaperone-mediated autophagy(CMA)pathway is involved in the intracellular degradation processes ofα-synuclein.Dysfunction of the CMA pathway impairsα-synuclein degradation and causes cytotoxicity.Results:In the present study,we investigated the effects on the CMA pathway andα-synuclein aggregation using bioactive ingredients(Dihydromyricetin(DHM)and Salvianolic acid B(Sal B))extracted from natural medicinal plants.In both cell-free and cellular models ofα-synuclein aggregation,after administration of DHM and Sal B,we observed significant inhibition ofα-synuclein accumulation and aggregation.Cells were co-transfected with a Cterminal modifiedα-synuclein(SynT)and synphilin-1,and then treated with DHM(10μM)and Sal B(50μM)16 hours after transfection;levels ofα-synuclein aggregation decreased significantly(68%for DHM and 75%for Sal B).Concomitantly,we detected increased levels of LAMP-1(a marker of lysosomal homeostasis)and LAMP-2A(a key marker of CMA).Immunofluorescence analyses showed increased colocalization between LAMP-1 and LAMP-2A withα-synuclein inclusions after treatment with DHM and Sal B.We also found increased levels of LAMP-1 and LAMP-2A both in vitro and in vivo,along with decreased levels ofα-synuclein.Moreover,DHM and Sal B treatments exhibited anti-inflammatory activities,preventing astroglia-and microglia-mediated neuroinflammation in BAC-α-syn-GFP transgenic mice.Conclusions:Our data indicate that DHM and Sal B are effective in modulatingα-synuclein accumulation and aggregate formation and augmenting activation of CMA,holding potential for the treatment of Parkinson’s disease. | Jia-Zhen Wu Mustafa Ardah Caroline Haikal Alexander Svanbergsson Meike Diepenbroek Nishant N.Vaikath Wen Li Zhan-You Wang Tiago F.Outeiro Omar M.El-Agnaf Jia-Yi Li | 2019 | Translational Neurodegeneration2019，8，1： | 11 |
| 3 | The Metabolic Response of Arabidopsis Roots to Oxidative Stress is Distinct from that of Heterotrophic Cells in Culture and Highlights a Complex Relationship between the Levels of Transcripts, Metabolites, and Flux显示文摘新陈代谢的调整是一重要,但是糟糕理解,到氧化应力的植物的反应的部分。在以前的研究(巴斯斯特等, 2007 ) ,在到由甲蔡醌的氧化应力的正式就职的文化的 Arabidopsis 房间的新陈代谢的反应被描绘。紧急情况幸存策略在 anabolism 的主要新陈代谢大部分在哪个是下面调整的赞成被揭开分解代谢并且抗氧化剂新陈代谢。在整个植物纸巾的反应可能是不同的,我们因此调查了 Arabidopsis 根的反应到甲蔡醌处理,分析有主要以及第二等的新陈代谢的焦点的 transcriptome, metabolome 和关键新陈代谢的流动。用氧化还原作用敏感的 GFP,甲蔡醌引起氧化还原作用不安,这也被显示出,不是就在线粒体,而且在根的 cytosol 和质体。在里面开始的 30 ? 处理的 min,反应类似于房间文化:在 TCA 周期和氨基酸生合成的代谢物有减少, transcriptomic 反应被 DNA 规章的蛋白质的起来规定统治。在 2 和 6 以后 ? 处理的 h,根的反应对房间文化不同。代谢物层次没仍然保持沮丧,但是相反恢复并且在 pyruvate 的情况中,一些氨基酸和脂肪族的 glucosinolates 在控制层次上面显示出稳定的增加。然而,在中央碳新陈代谢的流动的主要变化都没被观察,新陈代谢的抄本主要独立于相应代谢物变化了。一起,结果建议根纸巾能在氧化抑制以后恢复新陈代谢的活动并且为 glycolysis 和氧化戊糖磷酸盐小径加亮潜在地重要的角色。 | Martin Lehmann Markus Schwarzlander Toshihiro Obata Supaart Sirikantaramas Meike Burow Carl Erik Olsen Takayuki Tohge Mark D. Fricker Birger Lindberg Moiler Alisdair R. Fernie Lee J. Sweetlove Miriam Laxa | 2009 | Molecular Plant2009，2，3： | 8 |
| 4 | The Glucosinolate Biosynthetic Gene A OP2 Mediates Feed-back Regulation of Jasmonic Acid Signaling in Arabidopsis显示文摘在改变并且质问环境的幸存要求一个有机体高效地获得并且使用它的资源。由于他们的无柄的性质,植物动态地优化他们的新陈代谢是特别地批评的。在植物主要新陈代谢,新陈代谢的调整包含一条小径的输出控制它的输入产生精确、柔韧的回答到环境变化的反馈机制。由对比,很少研究为第二等的新陈代谢的反馈规定探讨了潜力。在 Arabidopsis,防卫混合物 glucosinolates 的累积以前在 glucosinolate biosynthetic 基因 AOP2 被连接了到基因变化。AOP2 表示能增加小径的二个已知的管理者(MYB28 和 MYB29 ) 的抄本层次,建议 AOP2 起在控制 glucosinolate 生合成的积极反馈规定的一个作用。我们产生了影响 AOP2, MYB28/29,或两个的异种。这些异种的 Transcriptome 分析识别了在表明 MYB28 和 MYB29 的独立人士的 AOP2 和 jasmonic 酸(JA ) 之间的一个到目前为止未被认出的连接。因此, AOP2 是连接 glucosinolate 生合成并且 JA 发信号的一个规章的反馈环的部分并且从而允许 glucosinolate 小径影响 JA 敏感。这个规章的反馈环的发现提供植物怎么为防御代谢物优化资源的使用的卓见。 | Meike Burow Susanna Atwell Marta Francisco Rachel E. Kerwin Barbara A. Halkier Daniel J. Kliebenstein | 2015 | Molecular Plant2015，8，8： | 6 |
| 5 | Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson's Disease显示文摘The enteric nervous system(ENS) controls the function of the gastrointestinal tract and has been implicated in various diseases, including Parkinson's disease(PD). PD is a neurodegenerative disease with Lewy bodies(LBs) and Lewy neurites(LNs) as the main pathological features. In addition to the typical motor symptoms in PD,attention has been drawn to non-motor symptoms, such as constipation, implying dysfunction of the ENS. In the present study, we characterized the age-dependent morphological alterations and aggregation of a-synuclein(asyn), the primary protein component in LBs and LNs, in the ENS in an a-syn transgenic mouse model. We found that the expression and accumulation of a-syn increased gradually in neurons of Meissner's and Auerbach's plexuses of the gastrointestinal tract with age(from 1 week to 2 years). In addition, a-syn was increasingly phosphorylated at the serine 129 residue, reflecting pathological alterations of the protein over time. Furthermore, asyn was present in different subtypes of neurons expressing vasoactive intestinal polypeptide, neuronal nitric oxide synthase, or calretinin. The results indicated that BAC-aSyn-GFP transgenic mice provide a unique model in which to study the relationship between ENS and PD pathogenesis. | Chong-Bin Zhong Qian-Qian Chen Caroline Haikal Wen Li Alexander Svanbergssona Meike Diepenbroek Jia-Yi Li | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 6 | Microstructural evolution of a PM TiAl alloy during heat treatment in α+γ phase field显示文摘In this study, the effect of temperatures and cooling rates of heat treatment on the microstructure of a powder metallurgy (PM) Ti-46Al-2Cr-2Nb-(B,W) (at.%) alloy was studied. Depending on the cooling rate and temperature, the different structures were obtained from the initial near-γ (NG) microstructures by heat treatment in the α+γ field. The results show that the microstructures of samples after furnace cooling (FC) consist primarily of equiaxed γ and α 2 grains, with a few grains containing lamellae. Duplex microstructures consist mainly of γ grains and lamellar colonies were obtained in the quenching into another furnace at 900°C (QFC) samples. However, further in- creasing of the cooling rate to air cooling (AC) induces the transformation of α→α_2 and results in a microstructure with equiaxed γ and α_2 grains, and no lamellar colonies are found. | SU Meike ZHENG Lijing LANG Zebao YAN Jie ZHANG Hu | 2012 | Rare Metals2012，31，5： | 5 |
| 7 | The dynamics of color signals in male threespine sticklebacks Gasterosteus aculeatus显示文摘 | Meike HIERMES Ingolf P. RICK Marion MEHLIS Theo C. M. BAKKER | 2016 | Current Zoology2016，62，1： | 4 |
| 8 | Product and environmental social performance: Varying effect on firm performance显示文摘 | Satish Jayachandran Kartik Kalaignanam Meike Eilert | 2013 | Strat. Mgmt. J2013，，10： | 3 |
| 9 | Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo显示文摘 | Ralf Kiesslich Juergen Burg Michael Vieth Janina Gnaendiger Meike Enders Peter Delaney Adrian Polglase Wendy McLaren Daniela Janell Steven Thomas Bernhard Nafe Peter R. Galle Markus F. Neurath | 2004 | Gastroenterology2004，，3： | 3 |
| 10 | 采用净能方法配制猪日粮显示文摘二十世纪初在美国出现了以净能(NE)确定动物日粮中能量的方法,起初该方法仅被应用于牛.然而,实践证明它对于大部分商业日粮配方特别是单胃动物(尤其是猪)的配方并不实用.对于猪的日粮,普遍使用消化能(DE)的方法.但是,如今合成氨基酸很容易可得到以及人们追求低日粮粗蛋白,导致消化能方法逐渐被废弃.同欧洲和其它地区一样,北美洲在配制猪日粮时也开始以净能方法取代消化能方法. | Jonathan Goodson Meike Rademacher 林月霞 | 2005 | 国外畜牧学(猪与禽)2005，，6： | 2 |
| 11 | Determination of basal ileal endogenous losses and standardized ileal digestibility of amino acids in barley fed to growing pigs显示文摘Background: Basal ileal endogenous amino acid(AA) losses(IAA_(end)) and standardized ileal digestibility(SID) values of cereal grains, such as barley, are apparently underestimated when determined according to the nitrogen(N)-free method. Regression analysis between the dietary apparent ileal digestible content(c AID) and total crude protein(CP) and AA can be considered as alternative approach to obtain more accurate values for IAA_(end)and SID of AA in cereal grains.Methods: Eight hulled barley genotypes were used, with barley being the only source of CP and AA in the assay diets. The diets contained 95 % as-fed of these eight barley genotypes each, ranging in CP content between 109.1 and 123.8 g/kg dry matter(DM). Nine ileally T-cannulated barrows, average body weight(BW) 30 ± 2 kg, were allotted to a row-column design comprising eight periods with 6 d each and nine pigs. On d 5 and the night of d 6 of every period, ileal digesta were collected for a total of 12 h. The IAA_(end) and the SID were determined by linear regression analysis between c AID and total dietary CP and AA.Results: There exist linear relationships between cA ID and total CP and AA(P < 0.001). The IAA_(end) of CP, Lys, Met, Thr and Trp amounted to 35.34, 1.08, 0.25, 1.02 and 0.38 g/kg DM intake(DMI), respectively, which are greater compared to average IAA_(end) determined previously under N-free feeding conditions. The SID of CP, Lys, Met, Thr and Trp was 90,79, 85, 79 and 86 %, respectively, and was greater when compared to tabulated values. Moreover, these SID values were greater than those reported in literature, based on correction of apparent ileal digestibility(AID) of CP and AA for their IAA_(end)values. Summarized, the results of the present regression analysis indicate greater IAA_(end)in barley-based diets compared to those obtained by N-free feeding.Conclusions: For low-protein feed ingredients like barley the regression method may be preferred over correction of AID values for their IAA_(end)determined under N-free feeding conditions, as intercepts and slopes of the linear regression equations between cA ID and total dietary CP and AA provide direct estimates of IAA_(end)and SID of CP and AA in the presence of the assay feed ingredient. | Hanna Katharina Spindler Rainer Mosenthin Pia Rosenfelder Henry J?rgensen Knud Erik Bach Knudsen Meike Eklund | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 2 |
| 12 | Inspection of the human stomach using remote-controlled capsule endoscopy: a feasibility study in healthy volunteers (with videos)显示文摘 | Jutta Keller Christiane Fibbe Frank Volke Jeremy Gerber Alexander C. Mosse Meike Reimann-Zawadzki Elisha Rabinovitz Peter Layer Daniel Schmitt Viola Andresen Ulrich Rosien Paul Swain | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 13 | 大数据与物联网——移动通信行业将如何迎接挑战显示文摘介绍了一种LTE信号功率稳幅系统,采用有效值检波技术实现高速实时采样,数字脉冲稳幅技术进行功率控制。根据LTE脉冲调制信号的特点,利用FPGA高精度计数器测量通道延迟时间,计算出实时采样时刻;给出了基于FPGA处理控制,包含电调衰减器、放大器、耦合器、检波器及调制器在内的环路设计方案,设计出针对脉冲调制信号稳幅的软件算法系统。实验表明:该系统在2~3 GHz宽频带内,实现了功率稳定控制,误差在0.5 d Bm以内,保证了平坦的功率特性,满足宽频带、高精度、功率稳定输出的要求。 | Meik Kottkamp 汤日波 | 2016 | 国外电子测量技术2016，35，7： | 2 |
| 14 | 蛋氨酸和蛋氨酸羟基类似物对猪的生物学效价显示文摘蛋氨酸缺乏日粮中添加DL-蛋氨酸和液体蛋氨酸羟基类似物增加了仔猪和生长猪的氮沉积,明显改善了仔猪的生产性能,这表明试验结果是在蛋氨酸敏感区域内测得。液体蛋氨酸羟基类似物对猪的相对生物学效价只有DL-蛋氨酸的65%,远低于液体蛋氨酸羟基类似物88%的商业含量。这些结果再次验证在家禽的研究结果,即液体蛋氨酸羟基类似物相对DL-蛋氨酸的效价只有65%。因此,液体蛋氨酸羟基类似物对猪的生物学效价只有65%。 | Meike Rademacher 张维军 黄军儿 | 2001 | 四川畜牧兽医2001，28，3： | 2 |
| 15 | Influence of lighting environment on social preferences in sticklebacks from two different photic habitats.I.mate preferences of wild-caught females显示文摘Ultraviolet(UV)A signals(320-400 nm)are important in mate choice in numerous species.The sensitivity for UV signals is not only assumed to be costly,but also expected to be a function of the prevailing ecological conditions.Generally,those signals are favored by selection that efficiently reach the receiver.A decisive factor for color signaling is the lighting environment,especially in aquatic habitats,as the visibility of signals,and thus costs and benefits,are instantaneously influenced by it.Although ecological aspects of color signal evolution are relatively well-studied,there is little data on specific effects of environmental UV-light conditions on signaling at these shorter wavelengths.We studied wild-caught gravid female 3-spined sticklebacks Gasterosteus aculeatus of 2 photic habitat types(tea-stained and clear-water lakes),possessing great variation in their UV transmission.In 2 treatments,tea-stained and clear-water,preferences for males viewed under UV-present(UV-1-)and UV-absent(UV-)conditions were tested.A preference for males under UV+conditions was found for females from both habitat types,thus stressing the significance of UV signals in stickleback's mate choice decisions.However,females from both habitat types showed the most pronounced preferences for males under UV-h conditions under clear-water test conditions.Moreover,reflectance measurements revealed that the carotenoid-based orange-red breeding coloration in wild-caught males of both habitat types differed significantly in color intensity(higher in clear-water males)and hue(more red shifted in clear-water males)while no significant differences in UV coloration were found.The differential reflection patterns in longer wavelengths suggest that sticklebacks of both habitat types have adapted to the respective water conditions.Adaptations of UV signals in a sexual context to ambient light conditions in both behavior and coloration seem less evident. | Meike Hiermes Stephanie REHER Ingolf P.RICK Theo C.M.Bakker | 2021 | Current Zoology2021，67，3： | 2 |
| 16 | Active at night, sleepy all day – Sleep disturbances in patients with hepatitis C virus infection显示文摘 | Meike Heeren Faina Sojref Ramona Schuppner Hans Worthmann Henning Pflugrad Anita B. Tryc Thomas Pasedag Karin Weissenborn | 2013 | Journal of Hepatology2013，，： | 2 |
| 17 | Hepatitis C virus infection and the brain显示文摘 | Karin Weissenborn Anita B. Tryc Meike Heeren Hans Worthmann Henning Pflugrad Georg Berding Martin Bokemeyer Hans L. Tillmann Annemarie Goldbecker | 2009 | Metabolic Brain Disease2009，，1： | 2 |
| 18 | H eritability of head size in dutch and Australian twin families at ages 0-50 Years 显示文摘 | Dirk J AS Michelle L Meike B | 2010 | Twin Research And Human Genetics2010，13，4： | 1 |
| 19 | Clopidogrel Use Is Associated With an Increased Prevalence of Cerebral Microbleeds in a Stroke‐Free Population: The Rotterdam Study显示文摘 | Sirwan K.L. Darweesh Maarten J.G. Leening Saloua Akoudad Daan W. Loth Albert Hofman M. Arfan Ikram Meike W. Vernooij Bruno H. Stricker | 2013 | Journal of the American Heart Association2013，，5： | 1 |
| 20 | Enteral nutritional support in prevention and treatment of pressure ulcers:A systematic review and meta-analysis 显示文摘 | Rebecca J Stracton Anna-Christina EK Meike Engfer | 2005 | Ageing Research Reviews2005，4，： | 1 |
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