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| 1 | Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies显示文摘The role of enteric glial cells has somewhat changed from that of mere mechanical support elements, gluing together the various components of the enteric nervous system, to that of active participants in the complex interrelationships of the gut motor and inflammatory events. Due to their multiple functions, spanning from supporting elements in the myenteric plexuses to neurotransmitters, to neuronal homeostasis, to antigen presenting cells, this cell population has probably more intriguing abilities than previously thought. Recently, some evidence has been accumulating that shows how these cells may be involved in the pathophysiological aspects of some diseases. This review will deal with the properties of the enteric glial cells more strictly related to gastrointestinal motor function and the human pathological conditions in which these cells may play a role, suggesting the possibility of enteric neuro- gliopathies. | Gabrio Bassotti Vincenzo Villanacci Simona Fisogni Elisa Rossi Paola Baronio Carlo Clerici Christoph A Maurer Gieri Cathomas Elisabetta Antonelli | 2007 | World Journal of Gastroenterology2007，13，30： | 16 |
| 2 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
| 3 | β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection显示文摘 | Huatao Huang Hideki Fujii Anna Sankila Betania M. Mahler-Araujo Masanori Matsuda Gieri Cathomas Hiroko Ohgaki | 1999 | The American Journal of Pathology1999，，6： | 2 |
| 4 | European consensus on the histopathology of inflammatory bowel disease显示文摘 | F. Magro C. Langner A. Driessen A. Ensari K. Geboes G.J. Mantzaris V. Villanacci G. Becheanu P. Borralho Nunes G. Cathomas W. Fries A. Jouret-Mourin C. Mescoli G. de Petris C.A. Rubio N.A. Shepherd M. Vieth R. Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 5 | Langerhans cell histiocytosis of the stomach with a typical morphological features显示文摘 | Terracciano L Kocher T Cathomas G | 1999 | Pathol Int1999，49，6： | 1 |
| 6 | Multi-target fluoresceuce in situ hybridization ~n bradder washings for prediction of recurrent bladder cancer显示文摘 | Tobias Zellwegerl Gabriel Benzl Gieri Cathomas | 2006 | Int J Cancer2006，，119： | 1 |
| 7 | Molecular detection and characterization of yellow fever virus in blood and liver specimens of a non-vaccinated fatal human case显示文摘 | Deubel V Huerre M Cathomas G | 1997 | J Meal Viroi1997，53，3： | 1 |
| 8 | Enteric neuropathology of the terminal ileum in patients with intractable slow-transit constipation 显示文摘 | Bassotti G Villanacci V Cathomas G | 2006 | Hum Pathol2006，37，10： | 1 |
| 9 | Isehemic Colitis: Clinical Presentation, localization in Relation to Risk Factors, and Long-Term Results显示文摘 | Glauser PM Wermuth P Cathomas G | 2011 | World J Surg2011，35，11： | 1 |
| 10 | Enteric neuropathology of the terminal ileum in pa- tients with intractable slow-transit constipation显示文摘 | BASSOTTI G VILLANACCI V CATHOMAS G | 2006 | Hum Pathol2006，37，： | 1 |
| 11 | Human herpes virus 8:a new virus disclosesits face显示文摘 | Cathomas G | 2000 | Virchows Arch2000，436，3： | 1 |
| 12 | Cytomegalovirus infection and graft rejection in renal transplantation显示文摘 | Dickenmann M J Cathomas G Steiger J | 2001 | Transplantation2001，71，6： | 1 |
| 13 | 查看详情显示文摘 | Dickenmann MJ Cathomas G Steiger J | | 0，，： | 1 |
| 14 | Severe hyponatremia in apatient with mantle cell lymphoma treated with bortezomib: a case reportand review of the literature显示文摘 | S Brodmann EG Klaas R Cathomas | 2007 | Onkologie2007，30，12： | 1 |
| 15 | Effect of buffered formalin on amplification of DNA from paraffin wax embed- ded small biopsies using real-time PCR 显示文摘 | Zsikla V Baumann M Cathomas G | 2004 | Clin Pathol2004，57，6： | 1 |
| 16 | Severe hyponatremia in a patient with mantle cell lymphoma treated with bortezomib:a case report and review of the literature显示文摘 | Brodmann S K laas EG Cathomas R | 2007 | Oncologie2007，30，12： | 1 |
| 17 | Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver显示文摘 | Burri E Steuerwald M Cathomas G | 2006 | Eur J Gastroenterol Hepatol2006，18，4： | 1 |
| 18 | Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver显示文摘 | Burri E Steuerwald M Cathomas G | 2006 | Eur J Gastroenterol Hepatol2006，18，4： | 1 |
| 19 | Effect of buffered formalin on amplification of DNA from paraffin wax em- bedded small biopsies using real-time PCR显示文摘 | Zsikla V Baumann M Cathomas G | 2004 | J Clin Pathol2004，57，6： | 1 |
| 20 | Cytomegalovirus infection and graft rejection in renal transplantation 显示文摘 | Dickenmann M J Cathomas G Steiger J | 2001 | Transplantation2001，71，6： | 1 |
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