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| 1 | Lymph node staging in colorectal cancer:Old controversies and recent advances显示文摘Outcome prediction based on tumor stage reflected by the American Joint Committee on Cancer(AJCC)/Union for International Cancer Control(UICC)tumor node metastasis(TNM)system is currently regarded as the strongest prognostic parameter for patients with colorectal cancer.For affected patients,the indication for adjuvant therapy is mainly guided by the presence of regional lymph node metastasis.In addition to the extent of surgical lymph node removal and the thoroughness of the pathologist in dissecting the resection specimen,several parameters that are related to the pathological work-up of the dissected nodes may affect the clinical significance of lymph node staging.These include changing definitions of lymph nodes,involved lymph nodes,and tumor deposits in different editions of the AJCC/UICC TNM system as well as the minimum number of nodes to be dissected.Methods to increase the lymph node yield in the fatty tissue include methylene blue injection and acetone compression.Outcome prediction based on the lymph node ratio,defined as the number of positive lymph nodes divided by the total number of retrieved nodes,may be superior to the absolute numbers of involved nodes.Extracapsular invasion has been identified as additional prognostic factor.Adding step sectioning and immunohistochemistry to the pathological work-up may result in higher accuracy of histological diagnosis.The clinical value of more recent technical advances,such as sentinel lymph node biopsy and molecular analysis of lymph nodes tissue still remains to be defined. | Annika Resch Cord Langner | 2013 | World Journal of Gastroenterology2013，19，46： | 14 |
| 2 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 3 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 4 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 5 | 蒂森克虏伯公司高炉的喷煤操作显示文摘在高炉炼铁工艺中。喷吹煤粉是普遍采用的措施。氧一煤喷吹技术在前面已经介绍过。对气相输煤条件进行改进后,在煤枪的前端便可依靠煤粉的自燃烧直接进行氧化反应。蒂森克虏伯钢铁公司的所有高炉已全部采用了这种工艺.在保证高炉高利用系数的条件下,达到了焦比300kg/t、煤比175kg/t的水平。为促进氧化反应.煤粉在进入风口之前进行了预热,2000年Schwelgern公司1号高炉第20~40号风口的煤粉喷吹采用了这种煤粉预热技术,其余的20个风口的煤粉喷吹于2004年底也采用了该技术。 | Karl Langner 孙永方 | 2006 | 鞍钢技术2006，，2： | 6 |
| 6 | Dual Targeting of a Mitochondrial Protein: The Case Study of Cytochrome C1显示文摘由于 endosymbiotic 基因转移,线粒体和叶绿体的蛋白质的多数被编码为原子核并且作为为运输带 N 终端运输肽进各自的目标细胞器的先锋分子在 cytosol 综合了。在大多数例子,运输发生进线粒体或叶绿体,尽管进两个细胞器的双指向的一些例子被描述了。这里,我们由三不同试验性的策略的联合出现另外土豆的细胞色素 c1,呼吸电子运输链的一个部件,线粒体被进口进不仅,而且进质体。在有孤立的线粒体和叶绿体,它在单个、混合的细胞器试金被分析的 organello 进口实验,证明在二个 endosymbiotic 细胞器以内在进口以后积累的处理产品在尺寸是不同的。细胞色素 c1 的双指向在 vivo 也被观察,在叶的 biolistic 转变以后有合适的记者构造的表皮的房间。最后,西方的分析采用细胞色素 c1 特定的抗血清提供蛋白质在豌豆和菠菜的线粒体和叶绿体在重要数量积累的证据。我们双指向现象的关联上的调查结果的可能的后果被讨论。 | Anja Rodiger Bianca Baudisch Uwe Langner Ralf Bernd Klosgen | 2011 | Molecular Plant2011，4，4： | 3 |
| 7 | European consensus on the histopathology of inflammatory bowel disease显示文摘 | F. Magro C. Langner A. Driessen A. Ensari K. Geboes G.J. Mantzaris V. Villanacci G. Becheanu P. Borralho Nunes G. Cathomas W. Fries A. Jouret-Mourin C. Mescoli G. de Petris C.A. Rubio N.A. Shepherd M. Vieth R. Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 8 | Furazolidone-based triple therapy for H pylori gastritis in children显示文摘AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients with upper digestive symptoms suffi ciently severe to warrant endoscopic investigation. H pylori status was defined based both on histology and on positive 13C-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and 13C-urea breath test. Further clinical evaluation was performed 7 d, 2 and 6 mo after the treatment. RESULTS: Thirty-eight patients (24 females, 14 males) were included. Their age ranged from 4 to 17.8 (mean 10.9 ± 3.7) years. On intent-to-treat analysis (n = 38), the eradication rate of H pylori was 73.7% (95% CI, 65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI, 78.5%-91%). All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate effi cacy in H pylori treatment. The eradicationrate seems to be higher in patients with duodenal ulcer. | Elisabete Kawakami Rodrigo Strehl Machado Silvio Kazuo Ogata Marini Langner Erika Fukushima Anna Paula Carelli Vania Cláudia Guimares Bonucci Francy Reis Silva Patrício | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 9 | Whole-body CT trauma imaging with adapted and optimized CT angiography of the craniocervical ves- sels: do we need an extra screening examination? 显示文摘 | Langner S Fleck S Kirsch M | 2008 | AJNR Am J Neuroradiol2008，29，10： | 1 |
| 10 | Comparison of parameter threshold combinations for diffusion tensor trac- tography in chronic stroke patients and healthy subjects 显示文摘 | Domin M Langner S Hosten N | 2014 | PLoS One2014，9，98： | 1 |
| 11 | Microbial reduction of arsenate in the presence of ferrihydrite 显示文摘 | Langner H W Inskeep W P | 2000 | Environmental Science Technology2000，34，15： | 1 |
| 12 | Hypermethylation ofhMLHl,HPP1, pl4(ARF),pl6( INK4A) and APC in primary ade-nocarcinomas of the small bowel 显示文摘 | Bricher BLDM Geddert H Langner C | 2006 | Int J Cancer2006，119，6： | 1 |
| 13 | CD13 -not just a marker in leukemia typing显示文摘 | Riemann D Kehlen A Langner J | 1999 | Immunol Today1999，20，2： | 1 |
| 14 | Identification of the causes of intrauterine death during 310 consecutive autopsies显示文摘 | Horn LC Langner A Stiehl P | | 0，，02： | 1 |
| 15 | Klebsiella oxytoca as a causative organism of antibiotic-associated hemonrhagic colitis显示文摘 | Hogenauer C Langner C Beubler E | | 0，，23： | 1 |
| 16 | Telecentric beam position for advanced E-beam lithography显示文摘 | Stickel W Langner G O | 1992 | Microcircuit Eng1992，17，4： | 1 |
| 17 | Cosmic radiation and Cancer mortalitgy among airline pilots; results from a European cohort study (ESCAPE) 显示文摘 | Langner L Blettner M Gundenstrup M | 2004 | Radial Environ Biophys2004，42，4： | 1 |
| 18 | Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 ( Abcb4 ) knockout mice显示文摘 | Peter Fickert Andrea Fuchsbichler Martin Wagner Gernot Zollner Arthur Kaser Herbert Tilg Robert Krause Frank Lammert Cord Langner Kurt Zatloukal Hanns-Ulrich Marschall Helmut Denk Michael Trauner | 2004 | Gastroenterology2004，，1： | 1 |
| 19 | IGF-1 R, IGF-1 and 1GF-2 expression as potential prognostic and predictive markers in colorectal - cancer 显示文摘 | Peters G Gongoll S Langner C | 2003 | Virchows Arch2003，44，3： | 1 |
| 20 | Elevated retinal zeaxanthin and prevention of light-induced photoreceptor cell death in quail显示文摘 | Thomson LR Toyoda Y Langner A | 2002 | Invest Ophthalmol Vis Sci2002，43，： | 1 |
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