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| 1 | Improvement of quantitative testing of liver function in patients with chronic hepatitis C after installment of antiviral therapy显示文摘AIM: To investigate if and to what extent antiviral therapy influenced a broad panel of quantitative testing of liver function (QTLF).METHODS: Fifty patients with chronic hepatitis C were either treated with interferon (n = 8), interferon/ribavirin (n = 19) or peg-interferon/ribavirin (n = 23). Quantitative testing of liver function, including aminopyrine breath test (ABT), galactose elimination capacity (GEC), sorbitol clearance (SCI) and indocyanine green clearance (ICG)was performed before and 3 mo after initiation of antiviral therapy.RESULTS: After 3 mo of antiviral treatment, 36 patients showed normal transaminases and were negative for HCV-RNA, 14 patients did not respond to therapy. ABT and GEC as parameters of microsomal and cytosolic liver function were reduced in all patients before therapy initiation and returned to normal values in the 36 therapy responders after 3 mo. Parameters of liver perfusion (SCI and ICG) were not affected by antiviral therapy. In the 14 non-responders,no changes in QTLF values were observed during the treatment period.CONCLUSION: ICG and SCI remained unaffected in patients with chronic hepatitis C, while ABT and GEC were significantly compromised. ABT and GEC normalized in responders to antiviral therapy. Early determination of ABT and GEC may differentiate responders from non-responders to antivJral treatment in hepatitis C. | Matthias Ocker Marion Ganslmayer Steffen Zopf Susanne Gahr Christopher Janson Eckhart G. Hahn Christoph Herold | 2005 | World Journal of Gastroenterology2005，11，35： | 8 |
| 2 | Advances in hepatitis C therapy: What is the current state-what come's next?显示文摘Chronic hepatitis C virus(HCV) infection affects 80-160 million people worldwide and is one of the leading causes of chronic liver disease.It is only a few years ago that standard treatment regimes were based on pegylated interferon alpha and ribavirin.However,treatment of HCV has undergone a revolutionary change in recent years.The admission of the nucleotide polymerase inhibitor Sofosbuvir enabled an interferon-free regimen with direct antiviral agents(DAA).Meanwhile seven DAAs are available and can be applied in several combinations for 8 to 24 wk depending on HCV genotype and patient characteristics such as cirrhosis and chronic renal failure.High rates of sustained virological response(SVR) rates can be achieved with these novel drugs.Even in difficult to treat populations such as patients with liver cirrhosis,HCV-human immunodeficiency virus co-infections,after liver transplantion,or with chronic kidney disease comparable high rates of SVR can be achieved.The anticipated 2nd generation DAAs are strikingly effective in patients so far classified as difficult to treat including decompensated liver cirrhosis or posttransplant patients.These 2nd generations DAAs will have higher resistance barriers,higher antiviral effects and a pan-genotypic spectrum.This review highlights the current state of the art of antiviral treatment in hepatitis Cand gives an outlook for upcoming therapies. | Steffen Zopf Andreas E Kremer Markus F Neurath Juergen Siebler | 2016 | World Journal of Hepatology2016，8，3： | 7 |
| 3 | Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn’s disease: a pilot study显示文摘 | Gian Tontini Jonas Mudter Michael Vieth Raja Atreya Claudia Günther Yurdagül Zopf Dane Wildner Ralf Kiesslich Maurizio Vecchi Markus Neurath Helmut Neumann | 2014 | Endoscopy2014，，： | 2 |
| 4 | Comparison of Hemospray~? and Endoclot? for the treatment of gastrointestinal bleeding显示文摘BACKGROUND Gastrointestinal(GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders(HP) represent 'touch-free' agents.AIM To analyze short term(ST-within 72 h-) and long-term(LT-within 30 d-) success for achieving hemostasis with HP and to directly compare the two agents Hemospray(HS) and Endoclot(EC).METHODS HP was applied in 154 consecutive patients(mean age 67 years) with GI bleeding.Patients were followed up for 1 mo(mean follow-up: 3.2 mo).RESULTS Majority of applications were in upper GI tract(89%) with following bleeding sources: peptic ulcer disease(35%), esophageal varices(7%), tumor bleeding(11.7%), reflux esophagitis(8.7%), diffuse bleeding and erosions(15.3%). Overall ST success was achieved in 125 patients(81%) and LT success in 81 patients(67%). Re-bleeding occurred in 27% of all patients. In 72 patients(47%), HP was applied as a salvage hemostatic therapy, here ST and LT success were 81% and64%, with re-bleeding in 32%. As a primary hemostatic therapy, ST and LT success were 82% and 69%, with re-bleeding occurring in 22%. HS was more frequently applied for upper GI bleeding(P = 0.04)CONCLUSION Both HP allow for effective hemostasis with no differences in ST, LT success and re-bleeding. | Francesco Vitali Andreas Naegel Raja Atreya Steffen Zopf Clemens Neufert Juergen Siebler Markus F Neurath Timo Rath | 2019 | World Journal of Gastroenterology2019，25，13： | 2 |
| 5 | Acoustic Radiation Force Impulse (ARFI) zur Messung der Leberelastizit?t: Eine alternative nicht invasive Methode zur Bestimmung des Leberfibrosegrades bei viraler Hepatitis显示文摘 | R. Goertz Y. Zopf V. Jugl R. Heide C. Janson D. Strobel T. Bernatik T. Haendl | 2010 | Ultraschall in Med2010，，02： | 2 |
| 6 | Analysis of sialyllactones in blood and urine by high-Performance liquid chromatography 显示文摘 | Daotian F David Zopf | 1999 | Analytical Biochemistry1999，269，： | 1 |
| 7 | Water- soluble calix resorcarenes as enantiosclective NMR shift rcasents for aromatic compounds 显示文摘 | Dignam C F Zopf J J Richards C J | 2005 | Journal of Organic Chemistry2005，70，20： | 1 |
| 8 | The versatility of the tempor-oparietal fascia flap in head and neck reconstruction 显示文摘 | Collar RM Zopf D Brown D | 2012 | J Plast Reconstr Aesthet Surg2012，65，2： | 1 |
| 9 | Strategies for training in diagnostic upper endoscopy: a prospective, randomized trial显示文摘 | Anke Ende Yurdaguel Zopf Peter Konturek Andreas Naegel Eckhart G. Hahn Kai Matthes Juergen Maiss | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 10 | Strain tunable quantum dot based non-classical photon sources显示文摘Semiconductor quantum dots are leading candidates for the on-demand generation of single photons and entangled photon pairs.High photon quality and indistinguishability of photons from different sources are critical for quantum information applications.The inability to grow perfectly identical quantum dots with ideal optical properties necessitates the application of post-growth tuning techniques via e.g.temperature,electric,magnetic or strain fields.In this review,we summarize the state-of-the-art and highlight the advantages of strain tunable non-classical photon sources based on epitaxial quantum dots.Using piezoelectric crystals like PMN-PT,the wavelength of single photons and entangled photon pairs emitted by InGaAs/GaAs quantum dots can be tuned reversibly.Combining with quantum light-emitting diodes simultaneously allows for electrical triggering and the tuning of wavelength or exciton fine structure.Emission from light hole exciton can be tuned,and quantum dot containing nanostructure such as nanowires have been piezo-integrated.To ensure the indistinguishability of photons from distant emitters,the wavelength drift caused by piezo creep can be compensated by frequency feedback,which is verified by two-photon interference with photons from two stabilized sources.Therefore,strain tuning proves to be a flexible and reliable tool for the development of scalable quantum dots-based non-classical photon sources. | Jingzhong Yang Michael Zopf Fei Ding | 2020 | Journal of Semiconductors2020，41，1： | 1 |
| 11 | Mast cell tryptase levels in gut mucosa in patients with gastrointestinal symptoms caused by food allergy显示文摘 | Hagel AF deRossi T Zopf Y | 2013 | Int Arch Allergy Immunol2013，160，4： | 1 |
| 12 | LOH and copy neutral LOH act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability 显示文摘 | Melcher R Hartmann E Zopf W | 2011 | Carcinogenesis2011，32，4： | 1 |
| 13 | Exercise intervention studies in patients with peripheral neuropa thy: a systematic review显示文摘 | Streckmann F Zopf E M Lehmann H C | 2014 | Sports Med2014，44，9： | 1 |
| 14 | Measurement of liver elasticity with acoustic radiation force impulse (ARFI) technology: an alternative noninvasive method for staging liver fibrosis in viral hepatitis显示文摘 | Goertz R S Zopf Y Jugl V -t al | 2010 | Ultraschall Med2010，31，2： | 1 |
| 15 | A multi-objective op- timization approach with consideration of fuzzy variables ap- plied to structural tire design显示文摘 | Serafinska A Kaliske M Zopf C | 2013 | Computers & Structures2013，116，： | 1 |
| 16 | Experimental characterization and constitutive modeling of the mechanical properties of uncured rubber显示文摘 | Kaliske M Zopf C and Brüggemann C | 2010 | Rubber Chemistry and Technology2010，83，1： | 1 |
| 17 | Oligosaccharides interfere with the establishment and progression of experimental pneumococcal pneumonia显示文摘 | Idanpaan-Heikkila I Simon PM Zopf D | 1997 | J Inject Dis1997，176，3： | 1 |
| 18 | C-122, a novel antagonist of serotonin receptor 5-HT2B, prevents monocrotaline-inducedpulmonary arterial hypertension in rats 显示文摘 | Zopf D A das Neves L A Nikula K J | 2011 | EurJPharmacol2011，670，1： | 1 |
| 19 | The differential diagnosis of food intolerance 显示文摘 | Zopf Y Bacnkler H W Silbermann A | 2009 | Dtseh Arztebl lnt2009，106，21： | 1 |
| 20 | Biosynthesis of the cancer-associated sialyl-Lea antigen显示文摘 | l-lansson GC Zopf D | 1985 | J Biol Chem1985，260，16： | 1 |
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