|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 组织承诺影响因素的模拟实验研究显示文摘与传统问卷调查的研究方法不同 ,本研究采用情景模拟实验的方法来探讨影响组织承诺的各种因素 ,以及组织承诺对离职等各种结果变量的影响。本研究的结果和方法进一步加深了人们对组织承诺以及情景模拟实验的理解。 | 刘小平 王重鸣 Brigitte Charle-Pauvers | 2002 | 中国管理科学2002，10，6： | 62 |
| 2 | Regulation of hepatic blood flow:The hepatic arterial buffer response revisited显示文摘The interest in the liver dates back to ancient times when it was considered to be the seat of life processes. The liver is indeed essential to life,not only due to its complex functions in biosynthesis,metabolism and clearance,but also its dramatic role as the blood volume reservoir. Among parenchymal organs,blood flow to the liver is unique due to the dual supply from the portal vein and the hepatic artery. Knowledge of the mutual communication of both the hepatic artery and the portal vein is essential to understand hepatic physiology and pathophysiology. To distinguish the individual importance of each of these inflows in normal and abnormal states is still a challenging task and the subject of on-going research. A central mechanism that controls and allows constancy of hepatic blood flow is the hepatic arterial buffer response. The current paper reviews the relevance of this intimate hepatic blood flow regulatory system in health and disease. We exclusively focus on the endogenous interrelationship between the hepatic arterial and portal venous inflow circuits in liver resection and transplantation,as well as inflammatory and chronic liver diseases. We do not consider the hepatic microvascular anatomy,as this has been the subject of another recent review. | Christian Eipel Kerstin Abshagen Brigitte Vollmar | 2010 | World Journal of Gastroenterology2010，16，48： | 49 |
| 3 | Obesity leads to higher risk of sperm DNA damage in infertile patients显示文摘在在富饶上的男营养的影响的过去几年有成长兴趣。不孕被连接了到男过重或肥胖,并且常规精液参数值似乎在高身体团索引(BMI ) 的情况下被改变。在精子 DNA 正直上估计 BMI 的影响的一些研究被出版了,但是他们没导致强壮的一致。我们的目的是进一步探索在精子 DNA 正直和 BMI 之间的关系,通过 3 年的 multicentre 研究。在 subfertile 夫妇的 330 个男搭挡被包括。用标记的终端 uridine 刻痕结束(TUNEL ) 试金,我们在肥胖的人观察了精子 DNA 损坏的增加的率(机会比率(95 %信心间隔) :2.5 (1.2-5.1 )) 。 | Charlotte Dupont Celine Fauret Nathalie Sermondade Marouane Boubaya Florence Eustache Patrice Clement Pascal Briot Isabelle Berthaut Vincent Levy Isabelle Cedrin-Durnerin Brigitte Benzacken Pascale Chavatte-Palmer Rachel Levy | 2013 | Asian Journal of Andrology2013，15，5： | 27 |
| 4 | The Simultaneous Repression Of CCR and CAD, Two Enzymes of the Lignin Biosynthetic Pathway, Results in Sterility and Dwarfism in Arabidopsis thaliana显示文摘Cinnamoyl CoA reductase (CCR ) 和 cinnamyl 白酒脱氢酶(CAD ) 催化 monolignol 生合成的最后步骤。在 Arabidopsis,一 CCR 基因(CCR1, At1g15950 ) 并且二 CAD 基因(CAD C At3g19450 和 CAD D At4g34230 ) 涉及这条小径。三倍的恶棍 c 恶棍 d ccr1 变异的、命名 ccc,被获得。这异种显示严格的矮子显型和男绝育。在 ccc 的木质素内容成熟的茎被归结为 50% 野类型的水平。另外,茎木质素结构严重地被影响,在抵抗内部单位的契约和加入由戏剧的丰富出现进象 coniferaldehyde 那样的 monolignol 先锋的聚合物 sinapaldehyde,和 ferulic 酸。男绝育由于在花药内层的木质化的缺乏,它引起花药裂开并且花粉版本的失败。ccc hypolignified 茎积累黄酮醇 glycosides, sinapoyl malate 和 feruloyl malate 的更高的数量,它建议酉分的小径的重定向。因此, CAD 和 CCR 的缺席, monolignol 小径的关键酶,比他们中的每的单个缺席在显型上有更严重的后果。另一 CCR 感应(CCR2, At1g80820 ) 并且另一 CAD (CAD1, At4g39330 ) 不补偿主要 CCR 和 CAD 活动的缺席。CCR 和 CAD 活动的这缺乏不仅影响木质化,而且严重地影响植物的发展。当试着减少植物的木质素内容以便便于 lignocellulose-to-bioethanol 变换过程时,这些后果必须小心地被考虑。 | Johanne Thevenin Brigitte Pollet Bruno Letarnec Luc Saulnier Lionel Gissot Alessandra Maia-Grondard Catherine Lapierre Lise Jouanin | 2011 | Molecular Plant2011，4，1： | 18 |
| 5 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 6 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 7 | 高效抗病毒治疗促使艾滋病患者免疫功能重建显示文摘The characteristics of AIDS is that HIV infection induces CD4+ T cell defects that includes a quantitave CD4+ T cells depletion and a loss of T helper cells function leading to a progressive immune deficiency. Early report indicated that this immune deficiency was irreversible, even with the antiretroviral therapies. More recently, however, clinical benifits of hightly active antiretroviral therapies (HAART) are increasingly evidenced by resolving opportunistic infections and malignancies, as well as declining hospitalization and mortality rates. This suggests that potent and sustained suppression of viral replication, at least to some extent, is associated with reconstitution of the immune system even in adult patients treated at advanced stages of the disease. Such immune reconstitution which was demonstrated firstly by a French reseach group includes (the group leader is Pr Brigitte Autran)(1) a rapid rise in CD4+ and CD8+ T cells followed by a slower CD4+ T cell increase; (2) a rapid rise in memory CD4+ T cells during the first three months of treatment by late increase in naive T cells coexpressing CD45RA and CD62L molecules after 3 months of efficient antiviral treatment;(3) a significant reduction of CD4 and CD8 activation markers in parallel to plasma virus load reduction;(4) a restoration in CD4+ T cell reactivity to recall antigens. These observations open new perspectives for the understanding of CD4+ T cells deficiency and therapeutic strategies of HIV infection. In the present review we will address some of the questions raised by immune restoration with HAART when administered at advanced stages of the disease. | 李太生 Guislaine Carcelaine Patrice Debre Brigitte Autran | 2001 | 基础医学与临床2001，21，1： | 14 |
| 8 | Turning rice meiosis into mitosis显示文摘通过在庄稼的种子(单性生殖) 的同种细胞的复制的介绍有潜力由允许任何精英变化的自我繁殖革命化农业,特别地 F1 混血儿。在性模型植物 Arabidopsis thaliana,通过种子的合成同种细胞的复制能被联合三个变化把成熟分裂变成有丝分裂(笑剧) 并且(的(i) 人工地实现 ii ) 穿过获得的同种细胞的配偶子,一根线表示修改了 CENH3 并且其染色体在接合子被消除。这里,我们证明变化的另外的联合能把 Arabidopsis 成熟分裂变成有丝分裂并且在米饭(Oryza sativa ) 的三个变化的联合高效地把成熟分裂变成有丝分裂,导致在这主要庄稼的男、女的同种细胞的双配偶子的生产。在种系发生地远的 eudicot Arabidopsis 和 monocot 米饭的笑剧技术的成功的实现为它的申请打开门到任何 flowering 植物并且为在庄稼种类介绍单性生殖铺平道路。 | Delphine Mieulet Sylvie Jolivet Maud Rivard Laurence Cromer Aurore Vemet Pauline Mayonove Lucie Pereira Gaetan Droc Brigitte Courtois Emmanuel Guiderdoni Raphael Mercier | 2016 | Cell Research2016，26，11： | 14 |
| 9 | Arbuscular mycorrhizal fungal colonization of Glycyrrhiza glabra roots enhances plant biomass,phosphorus uptake and concentration of root secondary metabolites显示文摘Arbuscular mycorrhizal(AM)fungi penetrate the cortical cells of the roots of vascular plants,and are widely distributed in soil.The formation of these symbiotic bodies accelerates the absorption and utilization of mineral elements,enhances plant resistance to stress,boosts the growth of plants,and increases the survival rate of transplanted seedlings.We studied the effects of various arbuscular mycorrhizae fungi on the growth and development of licorice(Glycyrrhiza glabra).Several species of AM,such as Glomus mosseae,Glomus intraradices,and a mixture of fungi(G.mosseae,G.intraradices,G.cladoideum,G.microagregatum,G.caledonium and G.etunicatum)were used in our study.Licorice growth rates were determined by measuring the colonization rate of the plants by the fungi,plant dry biomass,phosphorus concentration and concentration of secondary metabolites.We established two cloned strains of licorice,clone 3(C3)and clone 6(C6)to exclude the effect of genotypic variations.Our results showed that the AM fungi could in fact increase the leaf and root biomass,as well as the phosphorus concentration in each clone.Furthermore,AM fungi significantly increased the yield of certain secondary metabolites in clone 3.Our study clearly demonstrated that AM fungi play an important role in the enhancement of growth and development of licorice plants.There was also a significant improvement in the secondary metabolite content and yield of medicinal compounds from the roots. | HongLing LIU Yong TAN Monika NELL Karin ZITTER-EGLSEER Chris WAWSCRAH Brigitte KOPP ShaoMing WANG Johannes NOVAK | 2014 | Journal of Arid Land2014，6，2： | 13 |
| 10 | 南运河生态修复水体有机污染物的污染特征显示文摘通过向水体投加高效微生物净水剂和生物复合酶生态修复南运河受污染水体.为研究南运河生态修复水体中持久性有机氯农药(Organochlorine pesticides,OCPs)、多环芳烃(Polycyclic aromatic hydrocarbons,PAHs)和有机磷农药(Organophosphorus pesticide,OPPs)污染特征,监测了南运河及生态修复试验河道水体中15种OCPs、17种PAHs和18种OPPs的含量.结果表明,南运河水体及试验河道表层水体中共检测出3种六六六类(Hexachlorocyclohexanes,HCHs)污染物,分别是α-六氯环己烷(α-HCH)、β-六氯环己烷(β-HCH)和林丹(γ-HCH),OCPs总量变化范围是1.11—1.78 ng·L^(-1);共检测出萘(Naphthalene,Nap)、苊(Acenaphthene,Ac P)、苊烯(Acenaphthylene,Ac Py)等11种PAHs,PAHs总量变化范围是52.76—60.28 ng·L^(-1);共检测出3种OPPs,分别是甲胺磷(Methamidophos,MTP)、敌敌畏(Dichlorvos,DDVP)、和甲基异柳磷(Isofenphos-methyl,IPM),OPPs总量变化范围是6.51—17.50 ng·L^(-1).微生物净水剂和生物复合酶的投加基本上不能降解水体中的OCPs和PAHs,而对水体中OPPs的降解有一定作用,降解率在19.6%—62.8%之间,平均降解率为35.2%.高效微生物净水剂和生物复合酶降解河道水体中持久性OCPs、PAHs和OPPs的机理有待进一步研究,该技术对河流、湖泊有机污染物生态修复实际应用具有一定的借鉴作用. | 王乙震 周绪申 林超 张宇 韩朝光 张淼 Brigitte Vincon-Leite | 2016 | 环境化学2016，35，2： | 13 |
| 11 | Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C显示文摘 | Laurent Castéra Julien Vergniol Juliette Foucher Brigitte Le Bail Elise Chanteloup Maud Haaser Monique Darriet Patrice Couzigou Victor de Lédinghen | 2005 | Gastroenterology2005，，2： | 8 |
| 12 | Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism显示文摘 | Jiang-Feng Mao Zhao-Xiang Liu Min Nie Xi Wang Hong-Li Xu Bing-Kun Huang Jun-Jie Zheng Le Min Ursula Brigitte Kaiser Xue-Yan Wu | 2017 | Asian Journal of Andrology2017，19，6： | 8 |
| 13 | The ATAF1 transcription factor: At the convergence point of ABA-dependent plant defense against biotic and abiotic stresses显示文摘 | Brigitte Mauch-Mani Victor Flors | 2009 | Cell Research2009，19，12： | 7 |
| 14 | Successful photodynamic therapy for biliary papillomatosis:A case report显示文摘Papillomatosis of the bile duct is a rare disease with a high risk of malignant transformation. Therapeutical options include partial hepatectomy and liver transplantation. A previously healthy 65-years old male developed jaundice and right upper abdominal quadrant pain in 1996. A villous adenoma of the distal bile duct was diagnosed. A Whipple procedure was performed. In 2002 the patient turned symptomatic again. Another adenoma was found in the right hepatic duct resulting in a right hepatectomy. Two years later the patient again developed cholestasis. After drainage of the left hepatic duct with a percutaneous transhepatic cholangial drainage (PTCD) catheter, a recurrent biliary adenomatosis was diagnosed by cholangioscopy. As there was no surgical option left, the patient received photodynamic therapy (PDT) for the recurrent biliary papillomatosis. Three mo after he received further photodynamic therapies, the bile duct epithelium appeared normal and the patient had no signs of adenomatosis, both macroscopically and histologically. The follow-up cholangioscopy in late 2005 revealed only a small papilloma without the need for intervention. In early 2006, the patient died of multi organ failure without signs of extrahepatic cholestasis or cholangitis at the age of 75, 10 years after the diagnosis of biliary papillomatosis was established. The patient exceeded the average life expectancy of patients with biliary papillomatosis by far. Thus, PDT might be a sufficient therapeutic option for recurrent papillomatosis patients with no significant side effects. | Lars P Bechmann Philip Hilgard Andrea Frilling Brigitte Schumacher Hideo A Baba Guido Gerken Thomas Zoepf | 2008 | World Journal of Gastroenterology2008，14，26： | 7 |
| 15 | 局部进展期乳腺癌新辅助化疗后的保乳治疗显示文摘目的观察不具备保乳治疗的局部晚期乳腺癌(LABC)经过4个CEF100序贯4个多西紫杉醇新辅助化疗(NCT)后实施保乳治疗的疗效。方法 45例均有组织学诊断证实的局部晚期乳腺癌给以行新辅助化疗,化疗方案为4个周期的CEF100,序贯4个周期的多西紫杉醇。化疗结束后3~4周手术,26例行保乳手术,19例做了改良根治手术。手术后3~4周行放射治疗,选用6 MV-X射线,采用乳房切线野(保乳术后)或者胸壁切线野(根治术后)照射,每次2 Gy,每周照射5次,至DT 50 Gy/25 f/35 d,保乳手术患者瘤床区加量照射根据乳房腺体的厚度采用9~12 MeV电子线,每次2 Gy,每周1次,共5次,DT 10 Gy。有腋窝淋巴结转移者,给以同时行内乳区+锁骨上区预防性照射DT 50 Gy/25 f/35 d。结果 NCT后保乳率为57.8%,病理完全缓解16例(36%)。经过中位随访73个月,5年生存率为92.3%,局部控制率为88.5%。结论蒽环类药物为基础序贯多西紫杉醇的新辅助化疗可以提高保乳率,术后放疗降低局部复发率。 | 温凤云 马特 于洪 DELAFONTAN Brigitte | 2012 | 山东医药2012，52，24： | 7 |
| 16 | 应用ELISPOT试验测定重组卡介苗诱导的T细胞应答显示文摘应用免疫磁性分离技术去除免疫小鼠脾脏细胞中CD4+或CD8+T细胞后 ,在酶联免疫斑点试验中证实表达大肠杆菌MalE蛋白的重组卡介苗 (rBCG·MalE)诱导的T细胞应答是CD4+T细胞依赖的。对MalE、PPD特异T细胞应答的动态分析结果表明 ,rBCG·MalE、BCG诱导的特异CD4+T细胞应答存在Th1/Th2平衡转换现象 ,即起始阶段为Th1应答 ,一段时间后出现Th2应答 ,并逐步形成Th1/Th2混合应答。这些结果 ,为分枝杆菌T细胞应答规律提供了新的认识 ,同时 ,亦表明BCG是优良的外源抗原表达与运送载体。 | 焦新安 RichardLo-man EdithD’eriaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2001 | 中国预防兽医学报2001，23，1： | 7 |
| 17 | Aortic Stiffness Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Patients显示文摘 | Stéphane Laurent Pierre Boutouyrie Roland Asmar Isabelle Gautier Brigitte Laloux Louis Guize Pierre Ducimetiere Athanase Benetos | 2001 | Hypertension: Journal of the American Heart Association2001，，5： | 6 |
| 18 | Post-Translational Regulation of AtFER2 Ferritin in Response to Intracellular Iron Trafficking during Fruit Development in Arabidopsis显示文摘Ferritins 是在植物铁动态平衡的主要播放器。令人惊讶地,他们在转基因的植物的 overexpression 仅仅带了到种子铁内容的中等增加,建议为装载的铁和在种子的存储的控制检查点的存在。这个工作报导二个这些检查点的鉴定。首先,在在 Arabidopsis thaliana 的水果开发期间满意的种子金属的测量揭示一类似为 Fe, Mn, Cu,和 Zn 装载动态。控制金属装进种子的步从壳由运输的规定发生到种子。第二,金属装载和 ferritin 丰富在在 vacuolar 铁运输影响的不同基因背景被监视(AtVIT1, AtNRAMP3, AtNRAMP4 ) 或质体铁存储(到 4 的 AtFER1 ) 。揭示的这条途径(1 ) 在种子的 ferritin 累积的一条 translational 以后规定,并且(2 ) 那 ferritin 稳定性取决于在液泡和质体之间的铁分配的平衡。因此,为铁 biofortification 的 ferritin overexpression 策略的成功,在开发国家,将强烈得益于鉴定并且启用高度的 translocation 的机制设计减少铁缺乏贫血症的一条有希望的途径铁总计进种子质体。 | Karl Ravet Brigitte Touraine Sun A. Kim Francoise Cellier Sebastien Thomine Mary Lou Guerinot Jean-Francois Briat Frederic Gaymard | 2009 | Molecular Plant2009，2，5： | 5 |
| 19 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 20 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员