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| 1 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis显示文摘 | Richard Moreau Rajiv Jalan Pere Gines Marco Pavesi Paolo Angeli Juan Cordoba Francois Durand Thierry Gustot Faouzi Saliba Marco Domenicali Alexander Gerbes Julia Wendon Carlo Alessandria Wim Laleman Stefan Zeuzem Jonel Trebicka Mauro Bernardi Vicente Arro | 2013 | Gastroenterology2013，，7： | 12 |
| 2 | Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis显示文摘 | Jonel Trebicka Evrim Anadol Natalia Elfimova Ingo Strack Michael Roggendorf Sergei Viazov Inga Wedemeyer Uta Drebber Jürgen Rockstroh Tilman Sauerbruch Hans-Peter Dienes Margarete Odenthal | 2012 | Journal of Hepatology2012，，： | 2 |
| 3 | Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment显示文摘While stromal interactions are essential in cancer adaptation to hormonal therapies,the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood.Here,we tissue-engineered and validated an in vitro microtissue model of osteoblastic bone metastases,and used it to study the effects of androgen deprivation in this microenvironment.The model was established by culturing primary human osteoprogenitor cells on melt electrowritten polymer scaffolds,leading to a mineralized osteoblast-derived microtissue containing,in a 3D setting,viable osteoblastic cells,osteocytic cells,and appropriate expression of osteoblast/osteocyte-derived mRNA and proteins,and mineral content.Direct co-culture of androgen receptordependent/ independent cell lines (LNCaP,C4-2B,and PC3) led cancer cells to display functional and molecular features as observed in vivo.Co-cultured cancer cells showed increased affinity to the microtissues,as a function of their bone metastatic potential.Cocultures led to alkaline phosphatase and collagen-I upregulation and sclerostin downregulation,consistent with the clinical marker profile of osteoblastic bone metastases.LNCaP showed a significant adaptive response under androgen deprivation in the microtissues,with the notable appearance of neuroendocrine transdifferentiation features and increased expression of related markers (dopa decarboxylase,enolase 2).Androgen deprivation affected the biology of the metastatic microenvironment with stronger upregulation of androgen receptor,alkaline phosphatase,and dopa decarboxylase,as seen in the transition towards resistance.The unique microtissues engineered here represent a substantial asset to determine the involvement of the human bone microenvironment in prostate cancer progression and response to a therapeutic context in this microenvironment. | Nathalie Bock Ali Shokoohmand Thomas Kryza Joan Rohl Jonelle Meijer Phong A. Tran Colleen C. Nelson Judith A. Clements Dietmar W. Hutmacher | 2019 | Bone Research2019，7，2： | 2 |
| 4 | U-Pb dating of detrital zircon grains in the Paleocene Stumpata Formation,Tethyan Himalaya,Zanskar,India显示文摘 | CLIFT P D CARTER A JONELL T N | 2014 | Journal of Asian Earth Sciences2014，82，： | 1 |
| 5 | Evaluation of microbial systems in porous medium for EOR显示文摘 | Bryant R S Jonell D | 1998 | SPE Reservoir Engineering1998，3，2： | 1 |
| 6 | Defective RhoA/Rho-Kinase Signaling Contributes to Vascular Hypocontractility and Vasodilation in Cirrhotic Rats显示文摘 | Martin Hennenberg Erwin Biecker Jonel Trebicka Kerstin Jochem Qi Zhou Martina Schmidt Karl H. Jakobs Tilman Sauerbruch J?rg Heller | 2006 | Gastroenterology2006，，3： | 1 |
| 7 | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients显示文摘 | Hans Dieter Nischalke Cordula Berger Carolin Luda Tobias Müller Thomas Berg Martin Coenen Benjamin Kr?mer Christian K?rner Jonel Trebicka Frank Grünhage Frank Lammert Jacob Nattermann Tilman Sauerbruch Ulrich Spengler | 2011 | Journal of Hepatology2011，，4： | 1 |
| 8 | The Genome sequence of the SARS -associated coronavirus显示文摘 | Mara MA Jonel S J Astell CR | 2003 | Science2003，300，5624： | 1 |
| 9 | Intraeardiac Thrombus and Pulmonai'y Embolism With Cavitation and Pneumomediastinum in a Patient With Pro-tein S Deficiency 显示文摘 | Pierre D Maldjian MD Jonelle M | 2006 | Thorac Imaging2006，21，： | 1 |
| 10 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis显示文摘 | Richard Moreau Rajiv Jalan Pere Gines Marco Pavesi Paolo Angeli Juan Cordoba Francois Durand Thierry Gustot Faouzi Saliba Marco Domenicali Alexander Gerbes Julia Wendon Carlo Alessandria Wim Laleman Stefan Zeuzem Jonel Trebicka Mauro Bernardi Vicente Arro | 2013 | Gastroenterology2013，，7： | 1 |
| 11 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis显示文摘 | Richard Moreau Rajiv Jalan Pere Gines Marco Pavesi Paolo Angeli Juan Cordoba Francois Durand Thierry Gustot Faouzi Saliba Marco Domenicali Alexander Gerbes Julia Wendon Carlo Alessandria Wim Laleman Stefan Zeuzem Jonel Trebicka Mauro Bernardi Vicente Arro | | Gastroenterology0，，： | 1 |
| 12 | Activation of the Mas Receptor by Angiotensin-(1–7) in the Renin–Angiotensin System Mediates Mesenteric Vasodilation in Cirrhosis显示文摘 | Josephine A. Grace Sabine Klein Chandana B. Herath Michaela Granzow Robert Schierwagen Noemi Masing Thomas Walther Tilman Sauerbruch Louise M. Burrell Peter W. Angus Jonel Trebicka | 2013 | Gastroenterology2013，，： | 1 |
| 13 | Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure显示文摘 | Rajiv Jalan Faouzi Saliba Marco Pavesi Alex Amoros Richard Moreau Pere Ginès Eric Levesque Francois Durand Paolo Angeli Paolo Caraceni Corinna Hopf Carlo Alessandria Ezequiel Rodriguez Pablo Solis-Mu?oz Wim Laleman Jonel Trebicka Stefan Zeuzem Thierry Gus | 2014 | Journal of Hepatology2014，，： | 1 |
| 14 | Good long‐term outcome of Budd‐Chiari syndrome with a step‐wise management显示文摘 | Susana Seijo Aurelie Plessier Jildou Hoekstra Alessandra Dell’Era Dalvinder Mandair Kinan Rifai Jonel Trebicka Isabelle Morard Luc Lasser Juan G. Abraldes Sarwa Darwish Murad J?rg Heller Antoine Hadengue Massimo Primignani Elwyn Elias Harry L.A. Janssen D | 2013 | Hepatology2013，，5： | 1 |
| 15 | Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats显示文摘 | Jonel Trebicka Ludger Leifeld Martin Hennenberg Erwin Biecker Andreas Eckhardt Nicolas Fischer Andrea Schulze Pr?bsting Christoph Clemens Frank Lammert Tilman Sauerbruch J?rg Heller | 2008 | Hepatology2008，，4： | 1 |
| 16 | Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis显示文摘 | Jonel Trebicka Evrim Anadol Natalia Elfimova Ingo Strack Michael Roggendorf Sergei Viazov Inga Wedemeyer Uta Drebber Jürgen Rockstroh Tilman Sauerbruch Hans-Peter Dienes Margarete Odenthal | 2012 | Journal of Hepatology2012，，： | 1 |
| 17 | CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt显示文摘 | Marie-Luise Berres Sonja Asmacher Jennifer Lehmann Christian Jansen Jan G?rtzen Sabine Klein Carsten Meyer Holger M. Strunk Rolf Fimmers Frank Tacke Christian P. Strassburg Christian Trautwein Tilman Sauerbruch Hermann Elard Wasmuth Jonel Trebicka | 2014 | Journal of Hepatology2014，，： | 1 |
| 18 | Defective RhoA/Rho-Kinase Signaling Contributes to Vascular Hypocontractility and Vasodilation in Cirrhotic Rats显示文摘 | Martin Hennenberg Erwin Biecker Jonel Trebicka Kerstin Jochem Qi Zhou Martina Schmidt Karl H. Jakobs Tilman Sauerbruch J?rg Heller | 2006 | Gastroenterology2006，，3： | 1 |
| 19 | HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects显示文摘 | Sabine Klein Marike Marjolijn Van Beuge Michaela Granzow Leonie Beljaars Robert Schierwagen Sibel Kilic Iren Heidari Sebastian Huss Tilman Sauerbruch Klaas Poelstra Jonel Trebicka | 2012 | Journal of Hepatology2012，，6： | 1 |
| 20 | 研究:暴露于空气污染导致动脉中的钙加速累积显示文摘科学家多年来已知长期暴露于空气污染中会提高心脏疾病风险。一项备受瞩目、由华盛顿大学环境健康专家带领的研究,终于为我们揭示了其中原因。
审慎研究
乔尔·考夫曼博士在这项长达10年、对象涵盖6个州6000多人的分析中发现,住在户外污染较严重地区的人,心脏动脉钙累积的速度高于住在其他地方的人。 | JoNel Aleccia | 2016 | 空中英语教室(高级版.彭蒙惠英语)2016，，11： | 0 |
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