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| 1 | Heat shock induction of a 65 kDa ATP-binding proteinase in rat C6 glioma cells显示文摘The 45, 55, 65 and 100 kDa ATP-binding proteinases (ATP-BPases) of the heat-shocked (44 ℃ for 30 min, recovery for 12h) rat C6 glioma cells were purified by DEAE-ionexchange and ATP-affinity chromatography. Their molecular masses, isoelectric points (pI), pH-optima and other properties were analyzed by native proteinase gels.It was shown that the 65 kDa ATP-BPase is specifically induced by heat shock and not detectable in control cells.Its N-terminal 1-9 amino acid sequence was determined by Edman degradation, but no homologies to other proteins in the protein data bases were found. 30 and 31 kDa proteinases can be cleaved from the 45, 55 and 65 kDa proteinases to which they are linked. A possible relationship of the heat-induced 65 kDa ATP-BPase with the ATP-dependent proteinases (ATP-DPases) in prokaryotes and eukaryotes is discussed. | XU CUN SHUAN WEI MING ZHANG DIETER TECHEL MARCO MEYER YAN ZHANG LI LUDGER RENSING (Department of Biology, Henan Normal University,Xinxiang 453002)(Institute of Cell Biology, Bremen University, D-28359 Bremen, Germany) | 1999 | Cell Research1999，9，2： | 8 |
| 2 | Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma显示文摘AIM: To investigate the role of tumor inf iltrating lym-phocytes (TIL) in primary hepatocellular and cholangio-lar carcinomas of the liver.METHODS: Immunohistochemical analysis was per-formed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-f ixed and paraff in-embed-ded tissue of 35 liver resection specimens of hepatocel-lular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver interface.RESULTS: All hepatocellular carcinomas showed in-filtration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power f ields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPF) and of CD4+ cells in the interface region (223.1/10 HPF). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells indepen-dent of histogenetic origin. Different functions of lym-phocytes in these regions seem possible. | Hans-Udo Kasper Uta Drebber Dirk Ludger Stippel Hans Peter Dienes Anton Gillessen | 2009 | World Journal of Gastroenterology2009，15，40： | 8 |
| 3 | 采用计量型扫描力显微镜校准微纳米标准样板显示文摘为了建立质量保证体系,微米和纳米样板至今仍被广泛地应用于校准微纳米尺度的测量仪器中.介绍了应用由德国联邦物理研究所开发研究的、测量范围为25 mm×25 mm×5 mm的计量型扫描力显微镜(M-LRSFM)的校准方法.上述计量型扫描力显微镜配置有三个零拍的激光干涉仪,可分别测量沿x、y、z三条轴线方向的位移,因而其测量值可直接溯源于“米”定义.此种M-LRSFM能够校准横向的微纳尺度的结构尺寸,诸如阶梯高度、一维和二维光栅、镀层厚度、线宽、微纳尺度的表面粗糙度等.作为实例,介绍了一种横向样板的校准程序及获得的校准结果.研究表明这种方法适合于校验扫描电子显微镜(SEM)的放大倍率. | 戴高良 KOENDERS Ludger DANZEBRINK Ulrich WILKENING Günter 周健雄 陈振宇 | 2006 | 纳米技术与精密工程2006，4，1： | 8 |
| 4 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
| 5 | The Long Noncoding MALAT-1 RNA Indicates a Poor Prognosis in Non-small Cell Lung Cancer and Induces Migration and Tumor Growth显示文摘 | Lars Henning Schmidt Tilmann Spieker Steffen Koschmieder Julia Humberg Dominik Jungen Etmar Bulk Antje Hascher Danielle Wittmer Alessandro Marra Ludger Hillejan Karsten Wiebe Wolfgang E. Berdel Rainer Wiewrodt Carsten Muller-Tidow | 2011 | Journal of Thoracic Oncology2011，，12： | 6 |
| 6 | Open cellular magnesium alloys for biodegradable orthopaedic implants显示文摘Replication processing using NaCl spaceholders offers the possibility to produce cellular structures for a range of Mg alloys. Four Mg alloys (AZ63, M2, ZM21 and MZX211) were processed into open cellular structures with a pore size near 500 μm and a porosity of 75% using an optimized NaCl leaching procedure. The production method was found to be robust and yielded samples of acceptable strength and stiffness. Their dissolution rate (by H2 release in simulated body fluid) and mechanical properties (by cyclic compression) were measured. For all 4 alloys the initial mechanical properties mimic those of cancellous bone;however, the dissolution rate is too high for direct use in the human body, leading to excessive hydrogen evolution and overly rapid degradation of mechanical properties. Further post-processing of the material is thus required. | Karel Lietaert Ludger Weber Jan Van Humbeeck Andreas Mortensen Jan Luyten Jan Schrooten | 2013 | Journal of Magnesium and Alloys2013，1，4： | 3 |
| 7 | 动态^(18)F-FDG PET定量分析用于骨病变鉴别诊断显示文摘目的 评价18F 脱氧葡萄糖 (FDG)PET在骨骼病变中的诊断价值。方法 研究对象为40例原发性骨骼病变患者。所有患者在注射示踪剂后立即开始动态PET采集 ,持续 6 0min。对动态PET图像进行半定量分析 ,分别计算平均和最大标准摄取值 (SUVaver和SUVmax) ,病灶SUV/肌肉SUV比值 (T/M) ,病灶 6 0minSUV/ 30minSUV比值 (SUVaver 60 /3 0min和SUVmax 60 /3 0min)等。采用Patlak作图分析法对动态图像数据进行拟合计算 ,得出摄入常数 (Ki) ,计算FDG代谢率 (MRFDG)。根据接受器工作特性曲线 (ROC)确定各定量指标的诊断阈值 ,并比较其鉴别良恶性病变的灵敏度和特异性。结果 经病理检查证实恶性病变 2 1例 ,良性病变 19例。恶性病变的MRFDG和SUV值高于良性病变 ,但各种指标的数值分布均存在交叉重叠。SUVaver与MRFDG呈正相关 (r=0 6 7)。以SUV值≥ 1 8作为阈值时 ,鉴别良恶性病变的灵敏度和特异性分别为 85 0 %和 82 4% ,以MRFDG(1 1)为阈值时的灵敏度 (82 4% )与SUV相近 ,而特异性 (92 9% )较高。同时采用SUV(1 8)和SUVaver 60 /3 0min(1 1)作为鉴别标准时 ,较之单独采用SUV特异性可改善为 93 3% ,灵敏度略有降低 (81 3% )。结论 骨骼良恶性病变之间存在葡萄糖代谢率差异。单用静态FDGPET获取SUV值不能很好鉴? | 吴华 Antonia Dimitrakopoulou-Strauss Thomas O-Heichel Burkhard Lehner Ludger Bernd Volker Ewerbeck Cyrill Burger Ludwig G Strauss | 2002 | 中华核医学杂志2002，22，2： | 3 |
| 8 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 9 | Cloud Computing Based Optimal Driving for a Parallel Hybrid Electric Vehicle显示文摘A cloud computing based optimal driving method is proposed and its feasibility is validated through a real-world scenario simulation.Based on principles of vehicle dynamics,the driving optimization problem has been formulated into an optimal control problem constrained by traffic rules,directed at achieving lower equivalent fuel consumption and shorter travel time.In order to conveniently specify the constraints and facilitate the application of the dynamic programming(DP)algorithm,the driving optimization problem is transformed into spatial domain and discretized properly.Considering the heavy computational costs of the DP algorithm,a cloud computing based platform structure is proposed to solve the optimal driving problem in real-time.A case study is simulated based on a real-world traffic scenario in Matlab.Simulation results demonstrate that the cloud computing framework is promising toward realizing the real-time energy management for hybrid electric vehicles. | Jie Fan Yuan Zou Zehui Kong Ludger Heide | 2019 | Journal of Beijing Institute of Technology2019，28，1： | 2 |
| 10 | 学历与一生的收入:德国最新的有关调查统计(上)显示文摘教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的居民年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,对不同受教育程度人群进行分类并计算他们之间终生收入的差异。研究结果表明,在整个职业生涯中,每一个较高的学历都会带来多出22%到64%的收入。但是,地域、性别,特别是职业培训和大学教育的不同专业也是影响收入差距的重要因素,例如医学和社会工作之间的差异就很大。 | Marc Piopiunik Franziska Kugler Ludger Wβmann 陈颖 | 2017 | 应用型高等教育研究2017，2，4： | 2 |
| 11 | 妊娠与乳腺癌显示文摘妊娠期乳腺癌与非妊娠期乳腺癌的预后相似终止妊娠改麦乳腺癌预后的证据不足罹患乳腺癌后妊娠不影响治疗的结果乳腺癌治疗后与再次妊娠之间理想的时间同隔尚不清楚 | Ludger Barthelmes Louise A Davidson Christopher Gaffney Christopher A Gateley 赵卫红 | 2005 | 英国医学杂志中文版2005，8，6： | 2 |
| 12 | Seasonal Variability of Soil Organic Carbon Fractions Under Arable Land显示文摘Carbon fractions in soils apparently vary not only in space, but also over time. A lack of knowledge on the seasonal variability of labile carbon fractions under arable land hampers the reliability and comparability of soil organic carbon(SOC) surveys from different studies. Therefore, we studied the seasonal variability of two SOC fractions, particulate organic matter(POM) and dissolved organic carbon(DOC), under maize cropping: POM was determined as the SOC content in particle-size fractions, and DOC was measured as the water-extractable SOC(WESOC) of air-dried soil. Ammonium, nitrate, and water-extractable nitrogen were measured as potential regulating factors of WESOC formation because carbon and nitrogen cycles in soils are strongly connected. There was a significant annual variation of WESOC(coefficient of variation(CV) = 30%). Temporal variations of SOC in particle-size fractions were smaller than those of WESOC. The stocks of SOC in particle-size fractions decreased with decreasing particle sizes, exhibiting a CV of 20%for the coarse sand-size fraction(250–2 000 μm), of 9% for the fine sand-size fraction(50–250 μm), and of 5% for the silt-size fraction(20–50 μm). The WESOC and SOC in particle-size fractions both peaked in March and reached the minimum in May/June and August, respectively. These results indicate the importance of the time of soil sampling during the course of a year, especially when investigating WESOC. | Henning SCHIEDUNG Ludger BORNEMANN Gerhard WELP | 2017 | Pedosphere2017，27，2： | 2 |
| 13 | Influence of heart rate on vessel visibility in noninvasive coronary angiography using new multislice computed tomography显示文摘 | Stephen Schroeder Andreas F Kopp Axel Kuettner Christof Burgstahler Christian Herdeg Martin Heuschmid Andreas Baumbach Claus D Claussen Karl R Karsch Ludger Seipel | 2002 | Clinical Imaging2002，，2： | 2 |
| 14 | Was Weber Wrong?A Human Capital Theory of Protestant Economic History显示文摘 | Becker Sascha Ludger Woessmann | 2009 | Quarterly Journal of Economics2009，124，2： | 1 |
| 15 | Raman spectra of BN nanotubes:Ab initio and bond-polarizability model calculations显示文摘 | Ludger W Michele L Francesco M | 2005 | Phys Rev B2005，71，24： | 1 |
| 16 | Lacunary Interpolation by Antiperiodic Trigonometric Polynomials 显示文摘 | FRANZ-JURGEN Delvos LUDGER Knoche | 1999 | BIT1999，39，3： | 1 |
| 17 | Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2′-deoxycytidine显示文摘 | Jie Chen Christoph R?cken Ludger Klein-Hitpass Tobias G?tze Andreas Leodolter Peter Malfertheiner Matthias P.A. Ebert | 2004 | Clinical & Experimental Metastasis2004，，5： | 1 |
| 18 | Estrogenic and antiestrogenic regulation of MMP-2 and MMP-13 mRNA in RUCA-I endometrial tumor cells in vitro and in vivo显示文摘 | Ludger Tüshaus Anne-Christine Hopert Elisabeth Strunck Christine Schubert Winfried Wünsche Günter Vollmer | 2003 | Cancer Letters2003，，： | 1 |
| 19 | The kinetic separation of protein mixtures using reversed micelles显示文摘 | LUDGER H P | 2000 | September Science and Technology2000，35，6： | 1 |
| 20 | Autosomal dominant cerebellar ataxias:clinical features genetics and pathogenesis显示文摘 | Ludger S Peter B Thorsten S | 2004 | Lancet Neurol2004，3，： | 1 |
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