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| 1 | Solid pseudopapillary tumor of the pancreas:A review of 553 cases in Chinese literature显示文摘AIM:To sum up the clinical and pathological characte- ristics of solid pseudopapillary tumor (SPT) and the experience with it.METHODS: A total of 553 SPT patients reported in Chinese literature between January 1996 and January 2009 were retrospectively reviewed and analyzed. RESULTS: The mean age of the 553 SPT patients included in this review was 27.2 years, and the male to female ratio was 1:8.37. Their symptoms were non-specific, and nearly one third of the patients were asymptomatic. Computed tomography and ultraso-nography were performed to show the nature and location of SPT. Most of the tumors were distributed in the pancreatic head (39.8%), tail (24.1%), body andtail (19.5%). Forty-five patients (9.2%) were diagnosed as malignant SPT with metastasis or invasion. None of the clinical factors was closely related to the malignant potential of SPT. Surgery was the main therapeutic modality for SPT. Local resection, distal pancreatectomy and pancreatoduodenectomy were the most common surgical procedures. Local recurrence and hepatic metastasis were found in 11 and 2 patients, respectively, after radical resection. Four patients died of tumor progression within 4 years after palliative resection of SPT. The prognosis of SPT patients was good with a 5-year survival rate of 96.9%.CONCLUSION: SPT of the pancreas is a rare indolent neoplasm that typically occurs in young females. It is a low-grade malignancy and can be cured with extended resection. The prognosis of such patients is good although the tumor may recur and metastasize. | Yu, Peng-Fei Hu, Zhen-Hua Wang, Xin-Bao Guo, Jian-Min Cheng, Xiang-Dong Zhang, Yun-Li Xu, Qi | 2010 | World Journal of Gastroenterology2010，16，10： | 121 |
| 2 | Active tectonic blocks and strong earthquakes in the continent of China显示文摘The primary pattern of the late Cenozoic to the present tectonic deformation of China is characterized by relative movements and interactions of tectonic blocks. Active tectonic blocks are geological units that have been separated from each other by active tectonic zones. Boundaries between blocks are the highest gradient of differential movement. Most of tectonic activity occurs on boundaries of the blocks. Earthquakes are results of abrupt releases of accumulated strain energy that reaches the threshold of strength of the earth's crust. Boundaries of tectonic blocks are the locations of most discontinuous deformation and highest gradient of stress accumulation, thus are the most likely places for strain energy accumulation and releases, and in turn, devastating earthquakes. Almost all earthquakes of magnitude greater than 8 and 80%-90% of earthquakes of magnitude over 7 occur along boundaries of active tectonic blocks. This fact indicates that differential movements and interactions of active tectonic blocks are the primary mechanism for the occurrences of devastating earthquakes. | ZHANG Peizhen (张培震) DENG Qidong (邓起东) ZHANG Guomin (张国民) MA Jin (马 瑾) GAN Weijun (甘卫军) MIN Wei (闵 伟) MAO Fengying (毛凤英) WANG Qi (王 琪) | 2003 | Science China Earth Sciences2003，46，z2： | 239 |
| 3 | Petrogenesis of the Neopro-terozoic bimodal volcanic rocks along the western margin of the Yangtze Block:New constraints from Hf isotopes and Fe/Mn ratios显示文摘High-precision major element and Hf isotope data are reported for the Neoproterozoic Suxiong volcanic rocks along the western margin of the Yangtze Block. These volcanic rocks have variable εHf(T) values and Fe/Mn ratios. The relatively primitive basalts have high Fe/Mn ratios and high Hf-Nd isotopic compositions, indicating that they were generated by partial melting of garnet clinopyroxene in mantle plume at high pressure. Thus, the Suxiong basalts are genetically related to the proposed Neoproterozoic super-plume. On the contrary, a few differentiated basalts have low Fe/Mn ratios and low Hf-Nd isotopic compositions. They are likely to experience assimilation-fractional crystallization process. The Suxiong rhyolites have consistent Hf and Nd model ages of 1.3―1.4 Ga. They are likely generated by shallow dehydration melting of pre-existing young arc igne-ous rocks associated with the basaltic underplating/intrusion in a continental rift. | LI Xianhua QI Changshi LIU Ying LIANG Xirong TU Xianglin XlE Liewen YANG Yueheng | 2005 | Chinese Science Bulletin2005，50，21： | 91 |
| 4 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 5 | The novel quantitative trait locus GL3.1 controls rice grain size and yield by regulating Cyclin-T1;3显示文摘增加的庄稼收益被要求支持世界范围的快速的人口生长。谷物重量是米饭产量的一个关键部件,但是控制它的内在的分子的机制留下逃犯。这里,我们报导为米饭谷物长度,重量和产量的控制克隆和一个新量的特点地点(QTL ) 的描述。这个地点, GL3.1,编码蛋白质磷酸酶 kelch (PPKL ) 家庭 —Ser/Thr 磷酸酶。GL3.1 是大谷物 WY3 变化的一个成员,它比小谷物 FAZ1 变化与更弱的 dephosphorylation 活动被联系。GL3.1-WY3 在小穗状花小穗影响蛋白质 phosphorylation 加速房间分割,从而导致更长的谷物和更高的收益。进一步的研究直接显示出那 GL3.1 dephosphorylates 它的底层, Cyclin-T1; 3,它很少仅仅在植物被学习了。Cyclin-T1 的 downregulation; 3 在更短的谷物导致了米饭,它在房间周期规定为 Cyclin-T 显示新奇功能。我们的调查结果为通过影响 Cyclin-T1 的 phosphorylation 的新奇调停磷酸酶的进程被驾驶的谷物尺寸和产量的规定建议新机制; 3 在房间周期前进期间,并且这样提供新卓见进位于庄稼种子开发下面的机制。我们引起了包含表明了增加的谷物产量的自然 GL3.1 等位基因的一个新变化,它显示 GL3.1 是为引起产量很高的庄稼的一个强大的工具。 | Peng Qi You-Shun Lin Xian-Jun Song Jin-Bo Shen Wei Huang Jun-Xiang Shan Mei-Zhen Zhu Liwen Jiang Ji-Ping Gao Hong-Xuan Lin | 2012 | Cell Research2012，22，12： | 132 |
| 6 | One-step generation of knockout pigs by zygote injection of CRISPR/Cas system显示文摘 | Tang Hai Fei Teng Runfa Guo Wei Li Qi Zhou | 2014 | Cell Research2014，24，3： | 131 |
| 7 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 8 | Two Faces of One Seed: Hormonal Regulation of Dormancy and Germination显示文摘种子植物演变维持刚成熟的种子的休眠直到萌芽的适当时间。种子休眠和萌芽是不同生理的过程,并且到萌芽的从休眠的转变是在植物的生命周期的关键发展的步,但是为农业生产也是重要的不仅。这些过程被多样的内长的荷尔蒙和环境暗示精确调整。尽管骆驼毛的织物(abscisic 酸) 和气体(赤霉素) 被知道是反对地调整种子休眠的主要植物激素,最近的调查结果表明那另外一个植物激素,植物生长素,为导致并且维持也是批评的播种休眠,可能因此充当种子休眠的一个关键保护者。在这评论,我们总结我们在调整种子休眠和萌芽包含植物激素的关键角色的复杂分子的网络的当前的理解,在里面它 AP2-domain-containing 抄写因素 playkey 角色。我们也在种子休眠和萌芽讨论多样的神经质的信号的相互作用(串音) ,集中于组成中央节点的 ABA/GA 平衡。 | Kai Shu Xiao-dong Liu Qi Xie Zu-hua He | 2016 | Molecular Plant2016，9，1： | 95 |
| 9 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 10 | Digital Twins and Cyber Physical Systems toward Smart Manufacturing and Industry 4.0:Correlation and Comparison显示文摘State-of-the-art technologies such as the Internet of Things(IoT),cloud computing(CC),big data analytics(BDA),and artificial intelligence(AI)have greatly stimulated the development of smart manufacturing.An important prerequisite for smart manufacturing is cyber-physical integration,which is increasingly being embraced by manufacturers.As the preferred means of such integration,cyber-physical systems(CPS)and digital twins(DTs)have gained extensive attention from researchers and practitioners in industry.With feedback loops in which physical processes affect cyber parts and vice versa,CPS and DTs can endow manufacturing systems with greater efficiency,resilience,and intelligence.CPS and DTs share the same essential concepts of an intensive cyber-physical connection,real-time interaction,organization integration,and in-depth collaboration.However,CPS and DTs are not identical from many perspectives,including their origin,development,engineering practices,cyber-physical mapping,and core elements.In order to highlight the differences and correlation between them,this paper reviews and analyzes CPS and DTs from multiple perspectives. | Fei Tao Qinglin Qi Lihui Wang A.Y.C.Nee | 2019 | Engineering2019，5，4： | 84 |
| 11 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 12 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 13 | The Chinese Society of Clinical Oncology(CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer显示文摘China is one of the countries with the highest incidence of gastric cancer.There are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selection between gastric cancer patients from the Eastern and Western countries.Non-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer patients.The Chinese Society of Clinical Oncology(CSCO)arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile,discuss,and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and abroad.By referring to the opinions of industry experts,taking into account of regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted experts’consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes.This guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis,comprehensive treatment,and follow-up visits for gastric cancer. | Feng-Hua Wang Lin Shen Jin Li Zhi-Wei Zhou Han Liang Xiao-Tian Zhang Lei Tang Yan Xin Jing Jin Yu-Jing Zhang Xiang-Lin Yuan Tian-Shu Liu Guo-Xin Li Qi Wu Hui-Mian Xu Jia-Fu Ji Yuan-Fang Li Xin Wang Shan Yu Hao Liu Wen-Long Guan Rui-Hua Xu | 2019 | Cancer Communications2019，39，1： | 127 |
| 14 | Coding metamaterials, digital metamaterials and programmable metamaterials显示文摘Metamaterials are artificial structures that are usually described by effective medium parameters on the macroscopic scale,and these metamaterials are referred to as‘analog metamaterials’.Here,we propose‘digital metamaterials’through two steps.First,we present‘coding metamaterials’that are composed of only two types of unit cells,with 0 and p phase responses,which we name‘0’and‘1’elements,respectively.By coding‘0’and‘1’elements with controlled sequences(i.e.,1-bit coding),we can manipulate electromagnetic(EM)waves and realize different functionalities.The concept of coding metamaterials can be extended from 1-bit coding to 2-bit coding or higher.In 2-bit coding,four types of unit cells,with phase responses of 0,p/2,p,and 3p/2,are required to mimic the‘00’,‘01’,‘10’and‘11’elements,respectively.The 2-bit coding has greater freedom than 1-bit coding for controlling EM waves.Second,we propose a unique metamaterial particle that has either a‘0’or‘1’response controlled by a biased diode.Based on this particle,we present‘digital metamaterials’with unit cells that possess either a‘0’or‘1’state.Using a field-programmable gate array,we realize digital control over the digital metamaterial.By programming different coding sequences,a single digital metamaterial has the ability to manipulate EM waves in different manners,thereby realizing‘programmable metamaterials’.The above concepts and physical phenomena are confirmed through numerical simulations and experiments using metasurfaces. | Tie Jun Cui Mei Qing Qi Xiang Wan Jie Zhao Qiang Cheng | 2014 | Light(Science & Applications)2014，3，1： | 130 |
| 15 | Detection and parameter estimation of multicomponent LFM signal based on the fractional Fourier transform显示文摘This paper presents a new method for the detection and parameter estimation of multicomponent LFM signals based on the fractional Fourier transform. For the optimization in the fractional Fourier domain, an algorithm based on Quasi-Newton method is proposed which consists of two steps of searching, leading to a reduction in computation without loss of accuracy. And for multicomponent signals, we further propose a signal separation technique in the fractional Fourier domain which can effectively suppress the interferences on the detection of the weak components brought by the stronger components. The statistical analysis of the estimate errors is also performed which perfects the method theoretically, and finally, simulation results are provided to show the validity of our method. | QI Lin1, 2, TAO Ran1, ZHOU Siyong1 & WANG Yue1 1. Department of Electronic Engineering, Beijing Institute of Technology, Beijing 100081, China 2. School of Information Engineering, Zhengzhou University, Zhengzhou 450052, China Correspondence should be addressed to QI Lin (email: qilin@bit.edu.cn) | 2004 | Science in China(Series F)2004，47，2： | 143 |
| 16 | Attribute reduction theory and approach to concept lattice显示文摘The theory of the concept lattice is an efficient tool for knowledge representation and knowledge discovery, and is applied to many fields successfully. One focus of knowledge discovery is knowledge reduction. This paper proposes the theory of attribute reduction in the concept lattice, which extends the theory of the concept lattice. In this paper, the judgment theorems of consistent sets are examined, and the discernibility matrix of a formal context is introduced, by which we present an approach to attribute reduction in the concept lattice. The characteristics of three types of attributes are analyzed. | ZHANG Wenxiu WEI Ling QI Jianjun | 2005 | Science in China(Series F)2005，48，6： | 70 |
| 17 | Abrupt Holocene changes of the Asian monsoon at millen-nial-and centennial-scales: Evidence from lake sediment document in Minqin Basin, NW China显示文摘Considerable research is now focusing on abrupt Holocene changes at millennial- and centennial-scales all over the world. This study shows that the changes in theHolocene summer monsoon can be divided into two main periods, based on climatic proxy records of lake sediments from the Sanjiaocheng section located at the NW boundary of the summer monsoon, Gansu Province. The early and middle Holocene was humid with stronger summer monsoon, while the late Holocene is dry with weak summer monsoon. Detailed results also show a series of millennial- and centennial-scale changes in the intensity of the summer monsoon, with a periodicity of 1600 years during the whole Holocene, and with a periodicity of 800 years during the early Holocene. Ten dry events during the Holocene are associated with the weakening of the summer monsoon. These rapid climatic changes may be representative of a global climatic change pattern during the Holocene. | CHEN Fahu ZHU Yan LI Jijun SHI Qi JIN Liya B.Wunemann | 2001 | Chinese Science Bulletin2001，46，23： | 61 |
| 18 | 近50年来长江与鄱阳湖水文相互作用的变化显示文摘通过分析1957-2008年长江与鄱阳湖相互作用的基本特征及其与长江中游、鄱阳湖流域的径流量和气候变化的关系,并用2004-2006年三峡水库蓄水、放水量的数据,定量地计算和比较了三峡水库运行和区域气候变化对长江与鄱阳湖相互作用的影响程度,得出如下主要结论:1)从年际、年代际尺度上来看,鄱阳湖流域的气候变化和五河入湖流量是鄱阳湖水位和水量变化的主要因素,同时也在很大程度上决定了长江与鄱阳湖相互作用关系及其强弱变化。2)长江与鄱阳湖的相互作用强度是此消彼长的关系。从季节来看,鄱阳湖对长江的较强作用主要在4-6月,而长江对鄱阳湖的较强作用主要发生在7-9月。3)三峡水库运行并没有改变长江与鄱阳湖作用的基本特征,在多数季节三峡水库的影响不足以解释长江径流量变化的10%,但是水库在不同季节的蓄水或放水在一定程度上影响了江湖作用的季节变化和鄱阳湖流域的旱涝机率。4-6月的放水加强了长江作用,由于此时正值鄱阳湖流域的雨季,增强的长江作用在湿润气候的环境下可能增加初夏鄱阳湖流域发生洪涝的概率;7-9月的少量蓄水则减弱长江对鄱阳湖的作用,降低了湖区洪涝的概率;而10月份三峡水库的大量蓄水可能增加鄱阳湖流域的旱季干旱发生率。 | 郭华 HU Qi 张奇 | 2011 | 地理学报2011，66，5： | 73 |
| 19 | Surveillance of Hand,Foot,and Mouth Disease in China's Mainland (2008-2009)显示文摘Objective Since HFMD was designated as a class C communicable disease in May 2008,18 months surveillance data have been accumulated to December 2009.This article was to describe the distribution of HFMD for age,sex,area,and time between 2008 and 2009,to reveal the characteristics of the epidemic.Methods We analyzed weekly reported cases of HFMD from May 2008 to December 2009,and presented data on the distribution of age,sex,area and time.A discrete Poisson model was used to detect spatial-temporal clusters of HFMD.Results More than 1 065 000 cases of HFMD were reported in China's Mainland from May 2008 to December 2009 (total incidence:12.47 per 10 000).Male incidence was higher than female for all ages and 91.9% of patients were <5 years old.The incidence was highest in Beijing,Shanghai,Zhejiang and Hainan.The highest peak of HFMD cases was in April and the number of cases remained high from April to August.The spatial-temporal distribution detected four clusters.Conclusion Children <5 years old were susceptible to HFMD and we should be aware of their vulnerability.The incidence was higher in urban than rural areas,and an annual pandemic usually starts in April. | ZHU Qi HAO YuanTao MA JiaQi YU ShiCheng WANG Yu | 2011 | Biomedical and Environmental Sciences2011，24，4： | 73 |
| 20 | A meta-analysis of lamivudine for interruption of mother-to-child transmission of hepatitis B virus显示文摘AIM:To determine the therapeutic effect of lamivudine in late pregnancy for the interruption of motherto-child transmission(MTCT) of hepatitis B virus(HBV).METHODS:Studies were identified by searching available databases up to January 2011.Inclusive criteria were HBV-carrier mothers who had been involved in randomized controlled clinical trials(RCTs) with lamivudine treatment in late pregnancy,and newborns or infants whose serum hepatitis B surface antigen(HBsAg),hepatitis B e antigen(HBeAg) or HBV DNA had been documented.The relative risks(RRs) for interruption of MTCT as indicated by HBsAg,HBV DNA or HBeAg of newborns or infants were calculated with 95% confidence interval(CI) to estimate the efficacy of lamivudine treatment.RESULTS:Fifteen RCTs including 1693 HBV-carrier mothers were included in this meta-analysis.The overall RR was 0.43(95% CI,0.25-0.76;8 RCTs;Pheterogeneity = 0.04) and 0.33(95% CI,0.23-0.47;6 RCTs;Pheterogeneity = 0.93) indicated by newborn HBsAg or HBV DNA.The RR was 0.33(95% CI,0.21-0.50;6 RCTs;Pheterogeneity = 0.46) and 0.32(95% CI,0.20-0.50;4 RCTs;Pheterogeneity = 0.33) indicated by serum HBsAg or HBV DNA of infants 6-12 mo after birth.The RR(lamivudine vs hepatitis B immunoglobulin) was 0.27(95% CI,0.16-0.46;5 RCTs;Pheterogeneity = 0.94) and 0.24(95% CI,0.07-0.79;3 RCTs;P heterogeneity = 0.60) indicated by newborn HBsAg or HBV DNA,respectively.In the mothers with viral load < 106 copies/mL after lamivudine treatment,the efficacy(RR,95% CI) was 0.33,0.21-0.53(5 RCTs;Pheterogeneity = 0.82) for the interruption of MTCT,however,this value was not significant if maternal viral load was > 106 copies/mL after lamivudine treatment(P = 0.45,2 RCTs),as indicated by newborn serum HBsAg.The RR(lamivudine initiated from 28 wk of gestation vs control) was 0.34(95% CI,0.22-0.52;7 RCTs;Pheterogeneity = 0.92) and 0.33(95% CI,0.22-0.50;5 RCTs;Pheterogeneity = 0.86) indicated by newborn HBsAg or HBV DNA.The incidence of adverse effects of lamivudine was not higher in the mothers than in controls(P = 0.97).Only one study reported side effects of lamivudine in newborns.CONCLUSION:Lamivudine treatment in HBV carriermothers from 28 wk of gestation may interrupt MTCT of HBV efficiently.Lamivudine is safe and more efficient than hepatitis B immunoglobulin in interrupting MTCT.HBV MTCT might be interrupted efficiently if maternal viral load is reduced to < 106 copies/mL by lamivudine treatment. | Lei Han Hong-Wei Zhang Jia-Xin Xie Qi Zhang Hong-Yang Wang Guang- Wen Cao | 2011 | World Journal of Gastroenterology2011，17，38： | 61 |
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