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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis显示文摘 | Jonel Trebicka Evrim Anadol Natalia Elfimova Ingo Strack Michael Roggendorf Sergei Viazov Inga Wedemeyer Uta Drebber Jürgen Rockstroh Tilman Sauerbruch Hans-Peter Dienes Margarete Odenthal | 2012 | Journal of Hepatology2012，，： | 2 |
| 3 | Orthotopic Liver Transplantation in Human-Immunodeficiency-Virus-Positive Patients in Germany显示文摘 | E. Anadol S. Beckebaum K. Radecke A. Paul A. Zoufaly M. Bickel F. Hitzenbichler T. Ganten J. Kittner M. Stoll C. Berg S. Manekeller J. C. Kalff T. Sauerbruch J. K. Rockstroh U. Spengler Raffaele Bruno | 2012 | AIDS Research and Treatment2012，，： | 2 |
| 4 | Immediate effects of speed-dependent treadmill training on gait parameters in early Parkinson's disease显示文摘 | Pohl M Rockstroh G Ruckriem S | 2003 | Arch Phys Med Rehabil2003，84，： | 1 |
| 5 | Does hepatitis C viremia or genotype predict the risk of mortality in individuals co-infected with HIV?显示文摘 | Rockstroh JK Peters L Grint D | 2013 | J Hepatol2013，59，2： | 1 |
| 6 | Hepatitis C virus treatment in the real world: optimising treatment and access to therapies显示文摘 | Zoulim Fabien Liang T Jake Gerbes Alexander L Aghemo Alessio Deuffic-Burban Sylvie Dusheiko Geoffrey Fried Michael W Pol Stanislas Rockstroh Ju?rgen Kurt Terrault Norah A Wiktor Stefan | 2015 | Gut2015，，11： | 1 |
| 7 | State-of-the-art clas- sification and muhimodality treatment of' malignant thymoma 显示文摘 | Koppitz H Rockstroh JK Schiiller H | 2012 | Cancer Treat Rev2012，38，5： | 1 |
| 8 | Influence of hepati- tis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy 显示文摘 | Rockstroh JK Mocroft A Soriano V | 2005 | J Infect Dis2005，192，6： | 1 |
| 9 | Peginterferon alfa-2a plus fibavirin for chronic hepatitis C vires infection in HIV-infected patients显示文摘 | Torriani FJ Rodriguez-Torres M Rockstroh J | 2004 | N Engl J Med2004，351，5： | 1 |
| 10 | Impaired CD4 + T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients<!-- Doctopic: VH -->显示文摘 | Andreas Gl?ssner Marianne Eisenhardt Pavlos Kokordelis Benjamin Kr?mer Franziska Wolter Hans Dieter Nischalke Christoph Boesecke Tilman Sauerbruch Jürgen K. Rockstroh Ulrich Spengler Jacob Nattermann | 2013 | Journal of Hepatology2013，，： | 1 |
| 11 | Investigation of liquid gun propellants: Electrical ignition of LGP1846 显示文摘 | Klingenberg G Rockstroh H Knapton J D | 1990 | Journal of Propellants Explosives Pyrotechnics1990，15，3： | 1 |
| 12 | Natural history and management of hepatitis C: does sex play a role? 显示文摘 | Baden R Rockstroh JK Buti M | 2014 | J Infect Dis2014，209，3： | 1 |
| 13 | Increased corti cal representation of the left hand in string players显示文摘 | Elbert T Pantev C Wienbruch C Rockstroh B | 1995 | Science1995，270，： | 1 |
| 14 | Reduced interhemispheric transmission on schizophrenia patients:evidence from eventrelated potentials显示文摘 | Endrass T Mohr B Rockstroh B | 2003 | Neuroscience Letters2003，320，： | 1 |
| 15 | Benzopyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism显示文摘 | Murugaiyan J Rockstroh M Wagner J | 2013 | Toxicol Appl Pharmacol2013，269，3： | 1 |
| 16 | Increased incidence of antiretroviral drug discontinuation among patients with viremic hepatitis C virus coinfection and high hyaluronic acid,a marker of liver fibrosis显示文摘 | Grint D Peters L Rockstroh J K | 2014 | AIDS2014，28，4： | 1 |
| 17 | Efficacy and safety of grazoprevir (MK-5172) and elbasvir (MK-8742) in patients with hepatitis C virus and HIV co-infection (C-EDGE CO-INFECTION): a non-randomised, open-label trial 显示文摘 | Rockstroh JK Nelson M Katlama C | 2015 | Lancet Hiv2015，2，： | 1 |
| 18 | Serum selenium versus lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection显示文摘 | Look MP Rockstroh JK Rao GS | 1997 | Biol Trace Elem Res1997，56，1： | 1 |
| 19 | HIV and hepatitis C virus co-infection显示文摘 | Rockstroh JK Spengler U | 2004 | Lancet Infect Dis2004，4，7： | 1 |
| 20 | Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepatitis C virus coinfection显示文摘 | Naztfa Qurishi Christina Kreuzberg Guido Lüchters Wolfgang Effenberger Bernd Kupfer Tilman Sauerbruch Jürgen K Rockstroh Ulrich Spengler | 2003 | The Lancet2003，，9397： | 1 |
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