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| 1 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis显示文摘 | Richard Moreau Rajiv Jalan Pere Gines Marco Pavesi Paolo Angeli Juan Cordoba Francois Durand Thierry Gustot Faouzi Saliba Marco Domenicali Alexander Gerbes Julia Wendon Carlo Alessandria Wim Laleman Stefan Zeuzem Jonel Trebicka Mauro Bernardi Vicente Arro | 2013 | Gastroenterology2013，，7： | 12 |
| 2 | N-acetylcysteine and glycyrrhizin combination:Benefit outcome in a murine model of acetaminophen-induced liver failure显示文摘BACKGROUND Acetaminophen overdose is the most frequent cause of drug-induced liver failure in developed countries.Substantial progress has been made in understanding the mechanism of hepatocellular injury,but N-acetylcysteine remains the only effective treatment despite its short therapeutic window.Thus,other hepatoprotective drugs are needed for the delayed treatment of acetaminopheninduced hepatotoxicity.Our interest focused on glycyrrhizin for its role as an inhibitor of high mobility group box 1(HMGB1)protein,a member of the family of damage-associated molecular pattern,known to play an important pathological role in various diseases.AIM To investigate the efficacy of the N-acetylcysteine/glycyrrhizin combination compared to N-acetylcysteine alone in the prevention of liver toxicity.METHODS Eight-week-old C57BL/6J wild-type female mice were used for all our experiments.Mice fasted for 15 h were treated with acetaminophen(500 mg/kg)or vehicle(phosphate-buffered saline)by intraperitoneal injection and separated into the following groups:Glycyrrhizin(200 mg/kg);N-acetylcysteine(150 mg/kg);and N-acetylcysteine/glycyrrhizin.In all groups,mice were sacrificed 12 h following acetaminophen administration.The assessment of hepatotoxicity was performed by measuring plasma levels of alanine aminotransferase,aspartate aminotransferase and lactate dehydrogenase.Hepatotoxicity was also evaluated by histological examination of hematoxylin and eosin-stained tissues sections.Survival rates were compared between various groups using Kaplan-Meier curves.RESULTS Consistent with data published in the literature,we confirmed that intraperitoneal administration of acetaminophen(500 mg/kg)in mice induced severe liver injury as evidenced by increases in alanine aminotransferase,aspartate aminotransferase and lactate dehydrogenase but also by liver necrosis score.Glycyrrhizin administration was shown to reduce the release of HMGB1 and significantly decreased the severity of liver injury.Thus,the co-administration of glycyrrhizin and N-acetylcysteine was investigated.Administered concomitantly with acetaminophen,the combination significantly reduced the severity of liver injury.Delayed administration of the combination of drugs,2 h or 6 h after acetaminophen,also induced a significant decrease in hepatocyte necrosis compared to mice treated with N-acetylcysteine alone.In addition,administration of N-acetylcysteine/glycyrrhizin combination was associated with an improved survival rate compared to mice treated with only N-acetylcysteine.CONCLUSION We demonstrate that,compared to N-acetylcysteine alone,co-administration of glycyrrhizin decreases the liver necrosis score and improves survival in a murine model of acetaminophen-induced liver injury.Our study opens a potential new therapeutic pathway in the prevention of acetaminophen hepatotoxicity. | Charlotte Minsart Sandrine Rorive Arnaud Lemmers Eric Quertinmont Thierry Gustot | 2020 | World Journal of Hepatology2020，12，9： | 4 |
| 3 | Management of bacterial infections in cirrhosis显示文摘 | Javier Fernández Thierry Gustot | 2012 | Journal of Hepatology2012，，： | 3 |
| 4 | Common polymorphism in the PNPLA3 /adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease显示文摘 | Eric Trépo Thierry Gustot Delphine Degré Arnaud Lemmers Laurine Verset Pieter Demetter Romy Ouziel Eric Quertinmont Vincent Vercruysse Leila Amininejad Pierre Deltenre Olivier Le Moine Jacques Devière Denis Franchimont Christophe Moreno | 2011 | Journal of Hepatology2011，，4： | 2 |
| 5 | Inflammation and Portal Hypertension – The Undiscovered Country显示文摘 | Gautam Mehta Thierry Gustot Rajeshwar P. Mookerjee Juan Carlos Garcia-Pagan Michael B. Fallon Vijay H. Shah Richard Moreau Rajiv Jalan | 2014 | Journal of Hepatology2014，，： | 2 |
| 6 | An inhibitor of interleukin-6 trans-signalling,sgp130,eontributes to impaired acute phase response in human chronic liver disease显示文摘 | Lemmers A Gustot T Durnez A | 2009 | Clin Exp Immunol2009，156，3： | 1 |
| 7 | Impact of infec-tion on the prognosis of critically ill cirrhotic patients: results from alarge worldwide study显示文摘 | GUSTOT T FELLEITER P PICKKERS P | 2014 | Liver Int2014，34，10： | 1 |
| 8 | Invasive aspergillosisin patients with severe alcoholic hepatitis显示文摘 | GUSTOT T MAILLART E BOCCI M | 2014 | J Hepatol2014，60，2： | 1 |
| 9 | Multiple organ failure in sepsis: prognosis and role of systemic inflammatory response 显示文摘 | Gustot T | 2011 | Curr Opin Crit Care2011，17，2： | 1 |
| 10 | Management of bacterial infections in cirrhosis显示文摘 | Fernandez J Gustot T | 2012 | J Hepatol2012，561，： | 1 |
| 11 | Severe hyponatremia is a better predictor of mortality than MELDNa in patients with cirrhosis and refractory ascites显示文摘 | Serst6 T Gustot T Rautou PE | 2012 | J Hepatol2012，57，2： | 1 |
| 12 | CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice 显示文摘 | Moreno C Gustot T Nicaise C | 2005 | Hepology2005，42，4： | 1 |
| 13 | The inter- leukin - 17 pathway is inv - olved in human alcoholic liv- er disease 显示文摘 | Lemmers A M C Gustot T Mar' chal R | 2009 | Hepatology2009，49，2： | 1 |
| 14 | The interleukin-17pathway is involved in human alcoholic liver disease 显示文摘 | Lemmers A Moreno C Gustot T | 2009 | Hepatology2009，49，2： | 1 |
| 15 | The ST2 pathway is involved in acute panereatitis:a translational study in humans and mice显示文摘 | Ouziel R Gustot T Moreno C | 2012 | Am J Patho12012，180，6： | 1 |
| 16 | The interleukin-17 pathway is involved in human alcoholic liver disease 显示文摘 | Lemmers A Moreno C Gustot T | 2009 | Hepatology2009，49，2： | 1 |
| 17 | Common polymorphism in the PNPLA3/adiponutrin gcnc confers higher risk of cirrhosis and liver damage in alcoholic liver disease显示文摘 | Trdpo E Gustot T Dear6 D | 2011 | J Hcpatol2011，55，4： | 1 |
| 18 | Management of bacterial infections in cirrhosis显示文摘 | Fernandez J Gustot T | 2012 | J Hepatol2012，561，： | 1 |
| 19 | Correlation between ECL2 (MCP-1),neutrophils recruitment and disease severity in alcoholic hepatitis: a potential IL-17 dependent pathway显示文摘 | DEGRFI D LEMMERS A GUSTOT T | 2010 | Hepatology2010，52，1： | 1 |
| 20 | Common polymorphism in the PNPLA3/adiponutrin gone confers higher risk of cirrhosis and liver damage in alcoholic liver disease显示文摘 | Tr6po E Gustot T Dcgre D | 2011 | J Hepatol2011，55，： | 1 |
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