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| 1 | Therapeutic and clinical aspects of portal vein thrombosis in patients with cirrhosis显示文摘Portal vein thrombosis(PVT) is a frequent complication in cirrhosis, particularly in advanced stages of the disease. As for general venous thromboembolism, risk factors for PVT are slow blood flow, vessel wall damage and hypercoagulability, all features of advanced cirrhosis. Actually, the old dogma of a hemorrhagic tendency in cirrhosis has been challenged by new laboratory tools and the clinical evidence that venous thrombosis also occurs in cirrhosis. The impaired hepatic synthesis of both pro- and anticoagulants leads to a rebalanced hemostasis, more liable to be tipped towards thrombosis or even bleeding. Conventional anticoagulant drugs(low molecular weight heparin or vitamin K antagonists) may be used in cirrhosis patients with PVT, particularly in those eligible for liver transplantation, to prevent thrombosis progression thus permitting/facilitating liver transplant. However, several doubts exist on the level of anticoagulation achieved as estimated by coagulation tests, on the efficacy of treatment monitoring and on the correct timing for discontinuation in non-transplant candidates, while in transplant candidates there is expert consensus on continuing anticoagulation until transplantation. The recent introduction of direct acting oral anticoagulant drugs(DOACs) in other clinical settings generates much interest on their possible application in patients with cirrhosis and PVT. However, DOACs were not evaluated yet in patients with liver disease and cannot be recommended for the present time. | Massimo Primignani Giulia Tosetti Vincenzo La Mura | 2015 | World Journal of Hepatology2015，7，29： | 13 |
| 2 | Cirrhosis and portal hypertension: The importance of risk stratification, the role of hepatic venous pressure gradient measurement显示文摘Portal hypertension is the main prognostic factor in cirrhosis. The recent emergence of potent antiviral drugs and new algorithm of treatment for the management of complications due to portal hypertension have sensibly changed our perception of cirrhosis that can be now considered as a multistage liver disease whose mortality risk can be reduced by a tailored approachfor any stage of risk. Experts recommend to move toward a pathophysiological classification of cirrhosis that considers both structural and functional changes. The hepatic venous pressure gradient HVPG, is the reference gold standard to estimate the severity of portal hypertension in cirrhosis. It correlates with both structural and functional changes that occur in cirrhosis and carries valuable prognostic information to stratify the mortality risk. This article provides a general overview of the pathophysiology and natural course of cirrhosis and portal hypertension. We propose a simplified classification of cirrhosis based on low, intermediate and high mortality stage. The prognostic information provided by HVPG is presented according to each stage. A comparison with prognostic models based on clinical and endoscopic variables is discussed in order to evidence the additional contribute given by HVPG on top of other clinical and instrumental variables widely used in clinical practice. | Vincenzo La Mura Antonio Nicolini Giulia Tosetti Massimo Primignani | 2015 | World Journal of Hepatology2015，7，4： | 10 |
| 3 | 非选择性β受体阻滞剂可能促进肝硬化患者门静脉血栓的进展显示文摘【据《Adv Ther》2020年2月报道】题:非选择性β受体阻滞剂可能加重肝硬化患者门静脉血栓的进展:一项回顾性观察性研究(作者Xu XB等)阻塞性门静脉血栓(PVT)显著影响肝硬化患者预后。非选择性β受体阻滞剂(NSBBs)可能与PVT形成有关,但目前尚不清楚NSBBs是否会加重PVT进展。来自北部战区总医院的Xu等纳入了43例既往曾行两次增强CT和/或MRI且具有服用NSBBs详细信息的患者。其中,NSBBs组包括16例患者,非NSBBs组包括27例患者。血栓进展的定义为一个复合性终点,包括既往无PVT的患者发生PVT和既往有PVT的患者PVT加重。采用logistic回归分析明确NSBBs对PVT进展的影响。 | 许向波 祁兴顺 XU SX PRIMIGNANI M | 2020 | 临床肝胆病杂志2020，36，5： | 6 |
| 4 | Use of non-selective beta blockers in cirrhosis:The evidence we need before closing(or not) the window显示文摘Non selective beta blockers(NSBBs)are used in primary and secondary prophylaxis of portal hypertensionrelated bleeding in patients with cirrhosis.The efficacy of NSBBs treatment is predicted by hemodynamic response in term of reduction of the hepatic venouspressure gradient(HVPG)below 12 mm Hg or at least20%of the basal value.Nevertheless a relevant number of patients who do not achieve this HVPG reduction during NSBBs therapy do not bleed during follow up;this evidence suggests an additional non-hemodynamic advantage of NSBBs treatment to modify the natural history of cirrhosis.Recent studies have questioned the efficacy and safety of NSBBs in patients with advanced stage of liver disease characterized by refractory ascites and/or spontaneous bacterial peritonitis.These studies have suggested the existence of a defined and limited period to modify the natural history of cirrhosis by NSBBs:the'window hypothesis'.According with this hypothesis,patients with cirrhosis benefit from the use of NSBBs from the appearance of varices up to the development of an advanced stage of cirrhosis.Indeed,in patients with refractory ascites and/or spontaneous bacterial peritonitis the hemodynamic effects of NSBBs may expose to a high risk of further complications such as renal insufficiency and/or death.Methodological concerns and contrasting results counterbalance the evidence produced up to now on this issue and are the main topic of this editorial. | Vincenzo La Mura Giulia Tosetti Massimo Primignani Francesco Salerno | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 5 | TIPS for Budd-Chiari Syndrome: Long-Term Results and Prognostics Factors in 124 Patients显示文摘 | Juan Carlos Garcia–Pagán Mathis Heydtmann Sebastian Raffa Aurélie Plessier Sarwa Murad Federica Fabris Giovanni Vizzini Juan Gonzales Abraldes Simon Olliff Antonio Nicolini Angelo Luca Massimo Primignani Harry L.A. Janssen Dominique Valla Elwyn Elias Jaum | 2008 | Gastroenterology2008，，3： | 3 |
| 6 | The coagulopathy of cirrhosis assessed by thromboelastometry and its correlation with conventional coagulation parameters显示文摘 | Tripodi A Primignani M Chantarangkul V | 2009 | Thromb Res2009，124，1： | 1 |
| 7 | Thrombin generation in patients with cirrhosis: The role of platelets 显示文摘 | Tripodi A Primignani M Chantarangkul V | 2006 | Hepatology2006，44，2： | 1 |
| 8 | An imbalance of pro versus anti-coagulation factors in plasma from patients with cirrhosis显示文摘 | Tripodi A Primignani M Chantarangkul V | 2009 | Gasthoenterology2009，137，6： | 1 |
| 9 | Diagnosis and monitoring of portal hypertension显示文摘 | de Franchis R Dell'Era A Primignani M | 2008 | Dig Liver Dis2008，40，5： | 1 |
| 10 | A novel mutation withinthe miR 96 gene causes non-syndromic inherited hearing loss in anItalian family by altering pre-miRNA processing 显示文摘 | Solda G Hobusto M Primignani P | 2012 | Hum MolGenet2012，21，3： | 1 |
| 11 | Diagnosis and monitoring of portal hypertension显示文摘 | DE FRANCHIS R DELL'ERA A PRIMIGNANI M | 2008 | Dig Liver Dis2008，40，5： | 1 |
| 12 | A novel mutation within the MIR96 gene causes non- syndromic inherited hearing 10ss in an Italian family by altering pre--miRNA pro- cessing显示文摘 | Soldd G Robusto M Primignani P | 2012 | Hum Mol Genet2012，21，： | 1 |
| 13 | Diagnosis and moni- toring of portal hypertension显示文摘 | de Franchis R Dell'Era A Primignani M | 2008 | Dig Liver Dis2008，40，5： | 1 |
| 14 | Procoagulant Imbalance in Patients with Nonalcoholic Fatty Liver Disease显示文摘 | Armando Tripodi Anna L. Fracanzani Massimo Primignani Veena Chantarangkul Marigrazia Clerici Pier Mannuccio Mannucci Flora Peyvandi Cristina Bertelli Luca Valenti Silvia Fargion | 2014 | Journal of Hepatology2014，，： | 1 |
| 15 | Natural history of portal hypertensive gastropathy in patients with liver cirrhosis 显示文摘 | Carpinelli L Preatoni P | 2000 | Gastroenterology2000，119，1： | 1 |
| 16 | Thrumbin generation in patients with cirrhosis:the role of platelets显示文摘 | Tripodi A Primignani M Chantarangkul V | 2006 | Hepatology2006，44，2： | 1 |
| 17 | An imbalance of pro-vs anti-coagalation factors in plasma from patients with cirrhosis 显示文摘 | Tripodi A Primignani M Chantarangkul V | 2009 | Gastroenterology2009，137，6： | 1 |
| 18 | Endoscopic treatments for portal hypertension 显示文摘 | Franclfis R D Primignani M | 1999 | Sere Liver Disease1999，19，4： | 1 |
| 19 | Natural history of portal hypertensive gastropathy in patients with liver cirrhosis显示文摘 | Primignani M Carpinelli L Preatoni P | 2000 | Gastroenterology2000，119，1： | 1 |
| 20 | A novel mutation within the miR-96 gene causes non-syndromlc inherited hearing loss in an Italian family by altering pre-miRNA processing显示文摘 | Solda G Robusto M Primignani P | 2012 | Hum Mol Gen- et2012，21，3： | 1 |
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