|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overlap syndromes among autoimmune liver diseases显示文摘The three major immune disorders of the liver are autoimmune hepatitis(AIH),primary biliary cirrhosis(PBC) and primary sclerosing cholangitis(PSC).Variant forms of these diseases are generally called overlap syndromes,although there has been no standardised definition.Patients with overlap syndromes present with both hepatitic and cholestatic serum liver tests and have histological features of AIH and PBC or PSC.The AIH-PBC overlap syndrome is the most common form,affecting almost 10% of adults with AIH or PBC.Single cases of AIH and autoimmune cholangitis(AMA-negative PBC) overlap syndrome have also been reported.The AIH-PSC overlap syndrome is predominantly found in children,adolescents and young adults with AIH or PSC.Interestingly,transitions from one autoimmune to another have also been reported in a minority of patients,especially transitions from PBC to AIH-PBC overlap syndrome.Overlap syndromes show a progressive course towards liver cirrhosis and liver failure without treatment.Therapy for overlap syndromes is empiric,since controlled trials are not available in these rare disorders.Anticholestatic therapy with ursodeoxycholic acid is usually combined with immunosuppressive therapy with corticosteroids and/or azathioprine in both AIH-PBC and AIH-PSC overlap syndromes.In end-stage disease,liver transplantation is the treatment of choice. | Christian Rust Ulrich Beuers | 2008 | World Journal of Gastroenterology2008，14，21： | 41 |
| 2 | Recent research and developments on wrought magnesium alloys显示文摘Wrought magnesium alloys attract special interests as lightweight structural material due to their homogeneous microstructure and enhanced mechanical properties compared to as-cast alloys.In this contribution,recent research and developments on wrought magnesium alloys are reviewed from the viewpoint of the alloy design,focusing on Mg-Al,Mg-Zn and Mg-rare earth(RE)systems.The effects of different alloying elements on the microstructure and mechanical properties are described considering their strengthening mechanisms,e.g.grain refinement,precipitation and texture hardening effect.Finally,the new alloy design and also the future research of wrought magnesium alloys to improve their mechanical properties are discussed. | Sihang You Yuanding Huang Karl Ulrich Kainer Norbert Hort | 2017 | Journal of Magnesium and Alloys2017，5，3： | 43 |
| 3 | Microbiota and the gut-liver axis:Bacterial translocation,inflammation and infection in cirrhosis显示文摘Liver disease is associated with qualitative and quantitative changes in the intestinal microbiota.In cirrhotic patients the alteration in gut microbiota is characterized by an overgrowth of potentially pathogenic bacteria(i.e.,gram negative species)and a decrease in autochthonous familiae.Here we summarize the available literature on the risk of gut dysbiosis in liver cirrhosis and its clinical consequences.We therefore described the features of the complex interaction between gut microbiota and cirrhotic host,the so called'gut-liver axis',with a particular attention to the acquired risk of bacterial translocation,systemic inflammation and the relationship with systemic infections in the cirrhotic patient.Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of gut dysbiosis and its complication in liver cirrhosis. | Valerio Giannelli Vincenza Di Gregorio Valerio Iebba Michela Giusto Serena Schippa Manuela Merli Ulrich Thalheimer | 2014 | World Journal of Gastroenterology2014，20，45： | 43 |
| 4 | Predictors of premature delivery in patients with intrahepatic cholestasis of pregnancy显示文摘瞄准:在怀孕(ICP ) 的肝内胆汁郁积为早熟评估临床的症状和生物化学的参数的预兆的价值。方法:有 ICP 的六十个征兆的病人在这回顾的分析被包括。Preterm 交货在 37 wk 怀孕期前被定义为交货。preterm 交货的预言者被二进制代码多揭示变量逻辑回归分析。结果:交货的吝啬的时间是 38.1 +/- 1.7 wk。没有死胎发生了。早产在八被观察(13.3%) 病人。全部的禁食浆液胆汁酸更高(47.8 +/- 15.2 对 41.0 +/- 10.0 mumol/L, P <
0.05 ) ,并且瘙痒趋于更早开始(29.0 +/- 3.9 对 31.6 +/- 3.3 wk, P = 0.057 ) 在有早产的病人什么时候与那些相比与术语交货。二进制多逻辑回归分析揭示了的变量瘙痒的那早发作(或 1.70, 95% CI 1.23-2.95, P = 0.038 ) 并且浆液胆汁酸(或 2.13, 95% CI 1.13-3.25, P = 0.013 ) 是 preterm 的独立预言者交货。结论:瘙痒的早发作和浆液胆汁酸的高水平在 ICP 预言 preterm 交货,并且为穷人在风险定义病人的亚群新生的结果。 | Jurate Kondrackiene Ulrich Beuers Rimantas Zalinkevicius Horst-Dietmar Tauschel Vladas Gintautas Limas Kupcinskas | 2007 | World Journal of Gastroenterology2007，13，46： | 39 |
| 5 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 6 | The Change of North China Climate in Transient Simulations Using the IPCC SRES A2 and B2 Scenarios with a Coupled Atmosphere-Ocean General Circulation Model显示文摘This paper applies the newest emission scenarios of the sulfur and greenhouse gases, namely IPCCSRES A2 and B2 scenarios, to investigate the change of the North China climate with an atmosphere-oceancoupled general circulation nodel. In the last three decades of the 21st century, the global warming enlargesthe land-sea thermal contrast, and hence, causes the East Asian summer (winter) monsoon circulation tobe strengthened (weakened). The rainfall seasonality strengthens and the summer precipitation increasessignificantly in North China. It is suggested that the East Asian rainy area would expand northward toNorth China in the last three decades of the 21st century. In addition, the North China precipitationwould increase significantly in September. In July, August, and September, the interannual variability ofthe precipitation enlarges evidently over North China, implying a risk of flooding in the future. | 布和朝鲁 Ulrich CUBASCH 林永辉 纪立人 | 2003 | Advances in Atmospheric Sciences2003，20，5： | 31 |
| 7 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 8 | Erectile dysfunction after transurethral prostatectomy for lower urinary tract symptoms:results from a center with over 500 patients显示文摘瞄准:为良性的职业人员静电干扰增生(BPH ) 在前列腺(TURP ) 的经尿道切除术以后为可勃起的机能障碍(编辑) 识别可能的风险因素。方法:在 1999 年 3 月和 2004 年 3 月之间, 629 个病人为征兆的 BPH 的治疗在我们的部门经历了 TURP。所有病人经历了 transrectal 超声检查。另外,流动率,尿残余,国际前列腺症状分数(IPSS ) 和生命(QOL ) 的质量为没有一根导管,介绍了的那些被记录。最后,病人的可勃起的功能根据可勃起的功能仪器(IIEF-5 ) 问询表的国际索引被评估。在哪儿有不到 21 的一个全部的分数,被决定编辑存在。流动率, IPSS 和 QOL 评价在 3 和 6 个月被执行处理以后。IIEF-5 评价在 6 月的后续被重复。逻辑回归分析被用来鉴别潜力为编辑结果冒因素的风险:在基线, 522 (83%) 病人们回答了 IIEF-5 问询表。吝啬的耐心的年龄是(63.7+/-9.7 ) 年。编辑率是 65% 。在 6 个月以后,(88%) 459 从 522 个病人归还了 IIEF 问询表。这个组的其余部分从统计分析被排除。在 TURP 以后的六个月,报导编辑的病人的率增加了到 77% 。统计分析表明在 TURP 以后与最新报导的编辑联系的唯一的重要因素是糖尿病(P = 0.003, r = 3.67 ) 并且观察 intraoperative 胶囊的穿孔(P = 0.02, r = 1.12 ) 。结论:在 TURP 以后的手术后的、最新报导的编辑的发生是 12% 。为它的出现的风险因素是糖尿病和 intraoperative 胶囊的穿孔。 | Vassilis Poulakis Nikolaos Ferakis Ulrich Witzsch Rachelle de Vries Eduard Becht | 2006 | Asian Journal of Andrology2006，8，1： | 21 |
| 9 | 脑干海绵状血管瘤手术入路选择显示文摘目的探讨脑干海绵状血管瘤手术适应证和手术入路的选择。方法回顾分析70例手术治疗的脑干海绵状血管瘤,其中位于:中脑15例、中脑-桥脑交界8例、桥脑34例、桥脑-延髓交界5例、延髓8例。我们共采用8种手术入路:经菱形窝27例、颞下或颞-枕入路14例、远外侧经髁7例、外侧小脑上幕下7例、中线小脑上幕下8例、枕经天幕4例、乳突后2例,以及眶颧1例。结果本组病例的年出血率为2.9%(77/2364),占同期颅内海绵状血管瘤的44%(70/159);97%的病例手术选择在亚急性或慢性期、且所有患者均有颅神经症状和(或)运动功能障碍、感觉障碍、共济失调(包括失平衡)。中脑病变手术入路选择以中线小脑上(46.7%,7/15)、颞下或颞-枕(26.7%,4/15)为主;桥脑病变多选择菱形窝(58.8%,20/34)、颞下或颞-枕(23.5%,8/34);而病变位于延髓者以远外侧经髁(62.5%,5/8)和菱形窝入路(37.5%,3/8)为主。结论脑干海绵状血管瘤表现为进行性神经功能缺失、具有占位效应、接近脑干表面者可考虑手术治疗;个体化地选择手术入路、术中神经电生理监测以及直接的电刺激是手术成功的关键。 | 卞留贯 Helmut Bertalanffy 孙青芳 沈建康 Ulrich Sure Wuttipong Tirakotai 赵卫国 | 2007 | 中华神经外科疾病研究杂志2007，6，1： | 20 |
| 10 | 大气污染物与呼吸系统疾病急诊就诊关系的病例交叉研究显示文摘目的 分析大气污染急性暴露对呼吸系统疾病急诊人次的影响.方法 收集2004年1月1日至2005年12月31日北京大学第三医院急诊科呼吸系统疾病急诊资料和北京市环境监测中心大气污染物数据,应用时间分层的病例交叉设计研究方法进行数据分析,同时比较单向回顾性对照设计和双向对照设计研究结果的差异.结果 在调整气象因素并采用单向回顾性(多污染物)模型中,无滞后大气可吸入颗粒物(PM10)、二氧化硫(SO2)、滞后2 d二氧化氮(NO2)日平均浓度每增加10 μg/m^3,呼吸系统疾病总急诊的OR值(95%CI)分别为1.010(1.005~1.014)、1.010(1.001~1.018)、0.996(0.983~1.009);双向对称性(多污染物)模型中,其相应OR值(95%CI)分别为1.002(0.998~1.005)、1.011(1.003~1.018)、1.012(1.001~1.022).采用不同对照选择方案,病例交叉设计的研究结果有变化.结论 区域内大气污染物暴露对居民呼吸系统疾病急诊人次有急性效应. | 苏畅 郭玉明 Ulrich Franck 潘小川 | 2010 | 中华流行病学杂志2010，31，8： | 20 |
| 11 | Role of multi-microalloying by rare earth elements in ductilization of magnesium alloys显示文摘The present work investigates the influences of microalloying with rare earths on the mechanical properties of magnesium alloys.The amount of each rare earth element is controlled below 0.4 wt.%in order not to increase the cost of alloy largely.The synergic effects from the multi-microalloying with rare earths on the mechanical properties are explored.The obtained results show that the as-cast magnesium alloys multi-microalloying with rare earths possesses a quite high ductility with a tensile strain up to 25-30%at room temperature.Moreover,these alloys exhibit much better corrosion resistance than AZ31 alloy.The preliminary in situ neutron diffractions on the deformation of these alloys indicate that the multi-microalloying with rare earths seems to be beneficial for the activation of more slip systems.The deformation becomes more homogeneous and the resultant textures after deformation are weakened. | Yuanding Huang Weimin Gan Karl Ulrich Kainer Norbert Hort | 2014 | Journal of Magnesium and Alloys2014，2，1： | 19 |
| 12 | Ursodeoxycholic acid treatment of vanishing bile duct syndromes显示文摘消失的胆汁管症候群(VBDS ) 被从肝失败导致长期的胆汁郁积,肝硬化,和早熟的死亡的许多不同疾病引起的小肝内管的进步损失描绘。有 VBDS 的成年病人的多数受不了主要胆汁性肝硬变(PBC ) 和主要致硬化的胆管炎(PSC ) 。Ursodeoxycholic 酸(UDCA ) ,吸水的 dihydroxy 胆汁酸,唯一的药当前被同意因为有 PBC 的病人的治疗,和 anticholestatic 效果为几另外的胆汁郁积的症候群被报导了。UDCA 的行动的几潜在的机制包括肝胆管分泌物的刺激被建议了, apoptosis 的抑制和对恐水病的胆汁酸的有毒的效果的 cholangiocytes 的保护。 | Thomas Pusi Ulrich Beuers | 2006 | World Journal of Gastroenterology2006，12，22： | 18 |
| 13 | 黄连素对P-糖蛋白底物在Caco-2和L-MDR1细胞跨膜转运的影响显示文摘目的研究黄连素(berberine,Ber)对P-糖蛋白底物环孢素(cyclosporine A,CsA)和地高辛在Caco-2和L-MDR1细胞跨膜转运的影响。方法以Caco-2、L-MDR1细胞为模型,在50μmol·L-1~5mmol·L-1Ber作用后,测定地高辛和CsA跨膜转运的转运率和表观渗透系数。结果Ber在50μmol·L-1~5mmol·L-1范围内可剂量依赖性地降低地高辛在Caco-2和L-MDR1细胞单层底端(B侧)至顶端(A侧)的转运。对于CsA在Caco-2细胞的转运,50μmol·L-1~5mmol·L-1的Ber不但剂量依赖性地降低CsA从B→A方向的转运,而且也明显增加其在A→B方向的转运。在Caco-2和L-MDR1细胞,Ber抑制地高辛B→A方向转运的IC50值分别为1.44mmol·L-1和1.24mmol·L-1。Ber抑制CsA在Caco-2细胞转运的IC50值为607μmol·L-1。结论Ber和CsA相互作用的机制可能涉及P-gp功能的抑制和饱和。 | 辛华雯 吴笑春 李罄 余爱荣 Ulrich Klotz | 2007 | 中国药理学通报2007，23，6： | 16 |
| 14 | 应用GPV VP3基因重组原核表达产物建立检测抗体的ELISA方法研究显示文摘利用鹅细小病毒(GPV)VP3基因的原核表达蛋白作为包被抗原建立了检测GPV抗体的间接ELISA及Dot-ELISA方法。经确定两种方法的抗原包被浓度为125μg/mL,其中间接-ELISA 100μL/孔、Dot-ELISA 5μL/点。间接-ELISA中HRP标记的兔抗鹅IgG的工作浓度是1:200,检测血清的最适稀释度是1:400,阳性判定标准为OD492≥0.20,且P/N≥2.0。用此方法检测弱毒疫苗免疫血清,其抗体滴度在1:400~1:51200。Dot-ELISA的结果与间接-ELISA的结果一致。 | 布日额 李宝臣 马波 王君伟 Ulrich Neumann | 2006 | 畜牧兽医学报2006，37，2： | 15 |
| 15 | HCV-specific cytokine induction in monocytes of patients with different outcomes of hepatitis C显示文摘AIM:Cytokine release by macrophages critically determines the type of immune response to an antigen Therefore.we studied hepatitis C virus (HCV0-Specific induction of interleukins-1β,-10,-12(IL-1β,il-10,IL-12),and tumor necrosis factor-α(TNF-α) in monocytes.METHODS:Intracellular cytokine expression was studied by flow cytometry in 23 patients with chronic hepatitis C,14 anti-HCV seropositives without viremia and 11 controls after stimulation of peripheral blood mononuclear cells with recombinant core,NS3,NS4 NS5a and NS5b proteins .RESULTS:Patients with HCV viremia revealed greater spontaneous exprssion of IL-1β,TNF-α,and IL-10,Furthermore,greater than twofold higher IL-10 epression was induced by the HCV antigens in chronic hepatitis C than in the other two groups (P<0.05) In contrast,neither IL-12 noir TNF-α was induced preferentially.CONCLUSION:In chonic hepatitis C antigen-specific cytokine induction in monocytes is apparently shifted towards predominant IL-10 induction-not counterbalanced by antiviral type 1 cytokines,This may contribute to persistent viral replication. | Rainer P.Woitas Uwe Petersen Dirk Moshage Hans H.Brackmann Bertfried Matz Tilman Sauerbruch Ulrich Spengler | 2002 | World Journal of Gastroenterology2002，8，3： | 15 |
| 16 | 硅油填充术后眼组织病理改变显示文摘目的 探讨硅油对人眼内组织毒副作用的发生时间及机制。 方法 对19例因硅油填充术后严重并发症而摘除的眼球进行组织病理学观察。 结果 在感觉层视网膜、视网膜色素上皮(retinalpigm entepithelium ,RPE)细胞、视神经、视网膜前膜和下膜、虹膜、前房角、以及角膜内皮中均可见硅油小泡或小滴。在硅油填充短于9个月的眼中,硅油小泡仅见于视网膜表面(视网膜前膜及巨噬细胞内);硅油填充9个月以上的眼中,硅油小泡进入感觉层视网膜内。1例硅油填充39个月的眼中,视神经间质和蛛网膜下间隙受到硅油小泡弥漫性浸润。 结论 眼内硅油填充术后的并发症与硅油在眼内存留的时间长短有关。 | 马景学 Gisbert Richard Ulrich Schaudig Alexander A.Bialasiewicz | 1999 | 中华眼底病杂志1999，15，4： | 15 |
| 17 | Antibacterial approaches in tissue engineering using metal ions and nanoparticles:From mechanisms to applications显示文摘Bacterial infection of implanted scaffolds may have fatal consequences and,in combination with the emergence of multidrug bacterial resistance,the development of advanced antibacterial biomaterials and constructs is of great interest.Since decades ago,metals and their ions had been used to minimize bacterial infection risk and,more recently,metal-based nanomaterials,with improved antimicrobial properties,have been advocated as a novel and tunable alternative.A comprehensive review is provided on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria.Antibacterial mechanisms such as oxidative stress induction,ion release and disruption of biomolecules are currently well accepted.However,the exact antimicrobial mechanisms of the discussed metal compounds remain poorly understood.The combination of different metal ions and surface decorations of nanoparticles will lead to synergistic effects and improved microbial killing,and allow to mitigate potential side effects to the host.Starting with a general overview of antibacterial mechanisms,we subsequently focus on specific metal ions such as silver,zinc,copper,iron and gold,and outline their distinct modes of action.Finally,we discuss the use of these metal ions and nanoparticles in tissue engineering to prevent implant failure. | Maria Godoy-Gallardo Ulrich Eckhard Luis M.Delgado Yolanda J.D.de Roo Puente Mireia Hoyos-Nogués F.Javier Gil Roman A.Perez | 2021 | Bioactive Materials2021，6，12： | 14 |
| 18 | 用地高辛标记核酸探针检测鹅细小病毒的研究显示文摘从带有鹅细小病毒(GPV)NS1基因的重组质粒pMD18T NS1用限制性内切酶EcoRI和BamHI双酶切回收1880bp大小片段,并制备出地高辛标记的GPV核酸探针。其标记效率达到0 01pg/μl。特异性检测结果表明,该探针能与GPV不同毒株核酸发生特异性杂交,而与对照的DPV、GPPV等病毒的核酸杂交反应均为阴性;敏感性检测结果表明,该探针对GPV的最低检出量为0 0224pg。该探针对不同方法处理的GPV感染病料进行检测,均出现杂交阳性。表明所研制的标记探针用于GPV的检测是可行的。 | 布日额 王君伟 吴金花 孙红梅 Ulrich Neumann | 2004 | 畜牧兽医学报2004，35，1： | 14 |
| 19 | Management of early gastrointestinal neuroendocrine neoplasms显示文摘Neuroendocrine neoplasms (NENs) of the stomach, duo- denum, appendix or rectum that are small (≤ 1 cm) and well differentiated can be considered 'early' tumors, since they generally have a (very) good prognosis. In the new WHO classification of 2010, these neoplasms are called neuroendocrine tumors/ carcinoids (NETs), grade (G) 1 or 2, and distinguished from poorly differentiated neuroendocrine carcinomas (NECs), G3. NETs are increasing, with a rise in the age-adjusted incidence in the U.S.A. by about 700 % in the last 35 years. Improved early detection seems to be the main reason for these epidemiological changes. Both the better generalavailability of endoscopy, and imaging techniques, have led to a shift in the discovery of smaller-sized (≤ 10-20 mm) intestinal NETs/carcinoids and earlier tumor stages at diagnosis. Endoscopic screening is therefore effective in the early diagnosis, not only of colorectal adenocarcinomas, but also of NETs/carcinoids. Endoscopic removal, followed up with endoscopic surveillance is the treatment of choice in NETs/carcinoids of the stomach, duodenum and rectum that are ≤ 10 mm in size, have a low proliferative activity (G1), do not infiltrate the muscular layer and show no angioinvasion. In all the other intestinal NENs, optimal treatment generally needs surgery and/or medical therapy depending on type, biology and stage of the tumor, as well as the individual situation of the patient. | Hans Scherübl Robert T Jensen Guillaume Cadiot Ulrich Stlzel Günter Klppel | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，7： | 13 |
| 20 | 基于热传导逆问题方法预测材料热物性参数显示文摘建立了一种应用LevenbergMarquardt迭代过程求解非线性热传导逆问题用于预测材料热物性的方法.以平板内的一维非稳态热传导为研究对象,在准确的数值计算结果上施加非均匀随机误差来模拟瞬态温度实验数据,应用该方法分别对热传导系数为常数、热传导系数和容积比热容为常数以及热传导系数和容积比热容为温度的函数3种情况进行了预测.参数预测结果表明,方法对基于瞬态实验方法进行热物性预测具有良好的适应性,并适用于分析多类热传导逆问题,该方法还能为优化实验提供有效信息. | 杨晨 Ulrich Gross | 2005 | 化工学报2005，56，12： | 13 |
您所在的机构暂未开通此部分的功能，请联系管理员