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| 1 | Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation:Effects on virus replication and recurrent hepatitis显示文摘瞄准:决定 calcineurin 禁止者, cyclosporine 和 tacrolimus 的效果,在丙肝上,在病人的周期性的丙肝的病毒(HCV ) 复制和活动张贴肝移植。方法:在我们的中心为在 1999 和 2003 之间的联系 HCV 的肝肝硬化收到了肝移植的 107 个病人的一个队的数据回顾地被分析。浆液 HCV-RNA 的水平和周期性的肝炎的活动在作为主要抑制免疫力的代理人和没在移植以后在开始的 12 瞬间以内导致胆汁的复杂并发症的不那样类似的抑制免疫力的政体收到了 cyclosporine 或 tacrolimus 的 47 个病人之间被比较。结果:HCV-RNA 在移植以后在 3 瞬间以内增加了,但是 cyclosporine 组和 tacrolimus 组之间的差别是不足道的(在 12 瞬间的 P=0.49 ) 。另外,由浆液 transaminases 决定了的周期性的肝炎并且门发炎和纤维变性的组织学的分级没在 12 瞬间(P=0.34 ) 以后显示出有效差量。结论:一个主要抑制免疫力的代理人不在肝移植以后在感染 HCV 的病人影响周期性的肝炎的正式就职或严厉的 Cyclosporine 或 tacrolimus。 | Philip Hilgard Alisan Kahraman Nils Lehmann Cornelia Seltmann Susanne Beckebaum R Stefan Ross Hideo A Baba Massimo Malago Christoph E Broelsch Guido Gerken | 2006 | World Journal of Gastroenterology2006，12，5： | 235 |
| 2 | 湖南芙蓉锡矿床锡矿石和有关花岗岩的^(40)Ar-^(39)Ar年龄及其地球动力学意义显示文摘在研究和介绍湖南芙蓉锡矿矿床地质特征的基础上 ,对云英岩型锡矿石中的白云母和与成矿有关的骑田岭角闪黑云花岗岩中的黑云母进行了40 Ar_3 9Ar年龄测定 ,获得角闪黑云花岗岩的坪年龄为 (1 5 7.5± 0 .3)Ma;三门云英岩锡矿石的坪年龄为 (1 5 6 .1± 0 .4 )Ma ;淘洗窝云英岩锡矿石的坪年龄 (1 6 0 .1± 0 .9)Ma。这 3组测年数据很一致 ,不仅精确地反应出成岩成矿的时间限制 ,而且表明了花岗岩成岩与锡矿成矿的密切关系。此外 ,三组数据坪年龄一致显示出 ,在成岩成矿之后矿体未受到后期热事件的扰动。芙蓉锡矿床是湘南大型钨锡多金属矿集区的组成部分 ,也是华南地区中生代钨锡成矿两大高峰期之一的 1 6 0~ 1 35Ma期间形成的代表性矿床 。 | 毛景文 李晓峰 Bernd Lehmann 陈文 蓝晓明 魏绍六 | 2004 | 矿床地质2004，23，2： | 138 |
| 3 | 云南昆阳磷矿黑色页岩微量元素特征及其地质意义显示文摘昆阳磷矿是我国下寒武统黑色页岩中赋存的最大的磷块岩矿床。为了探讨磷块岩及上覆黑色页岩的源区性质及古海洋的氧化还原环境,本文对梅树村组中谊村段的磷块岩、石岩头段的黑色页岩以及筇竹寺组玉案山段的砂质黑色页岩的地层剖面进行了岩石地球化学研究。发现昆阳剖面磷矿区的下寒武统黑色页岩Th-Zr和Th-Y/Ho比值以及Y-Y/Ho比值与陆源碎屑物质更为接近,石岩头段黑色页岩样品的稀土元素总量平均为174×10-6,与大陆壳稀土总量的平均丰度基本一致。稀土配分模式也十分类似,说明陆源碎屑物质来源比海水自生来源占的比重更大。受陆源碎屑物质的影响,Ni/Co,V/Cr和V/(V+Ni)等氧化还原敏感元素比值并不能很好的指示古海洋的沉积环境。但石岩头段黑色页岩的氧化还原敏感元素相对大陆壳具有一定程度的富集,并且富集程度不强烈,Ce具有轻微的负异常,反映了黑色页岩可能形成于次氧化环境。 | 徐林刚 Bernd LEHMANN 张锡贵 郑伟 孟庆田 | 2014 | 岩石学报2014，30，6： | 30 |
| 4 | 绿色城市规划法则及中国绿色城市未来展望显示文摘当今时代最大的环境挑战是城市和建筑对化石燃料的依赖,以及对能源、土地、水和食品安全日益增长的需求。在这一背景下,城市需向更可持续的城镇化模式转变,建筑和城市规划在这一过程中发挥主要作用。为此提出了15项绿色城市法则,以应对现存街区、区域和城市转型的挑战,并对中国低碳或无碳的未来进行了展望。 | Steffen Lehmann 胡先福 | 2014 | 建筑技术2014，45，10： | 18 |
| 5 | 基于中子成像的水泥基材料毛细吸水动力学研究显示文摘总结了国内外有关水泥基材料毛细吸水的动力学机理及其现有模型,应用中子成像技术对其毛细吸水过程进行了可视化再现,对水分侵入的空间分布规律进行了定量分析。结果表明,在毛细孔吸附力作用下,水分前锋不断向水泥基材料内部推进,在吸水初期速度较快,后趋于平缓直至稳定;水分侵入曲线在深度和含量上同时增长,可以由线性+反S形模型来描述其空间分布特点,并与实测结果吻合良好;现有的'时间开方'及其修正模型对毛细吸水的后期预测不太合理,本文提出的渗透系数双曲线衰减模型更符合真实结果。 | 张鹏 赵铁军 Wittmann F.H. Lehmann E. | 2011 | 水利学报2011，42，1： | 17 |
| 6 | 硅烷化聚氨酯技术在汽车工业中的应用显示文摘选择合适的硅烷,与聚氨酯预聚体中的异氰酸酯反应可以形成硅烷封端的聚氨酯(SPUR)。它作为汽车密封剂,具有优良的耐化学介质和耐候性等诸多优点,在汽车及交通运输等行业具有广泛的应用前景。 | 黄未雨 Patrice Lehmann 杨宇润 | 2005 | 粘接2005，26，2： | 14 |
| 7 | 钼及钼同位素地球化学--同位素体系、测试技术及在地质中的应用显示文摘多接收电感耦合等离子体质谱(MC-ICP-MS)的广泛应用使过渡金属元素同位素地球化学的研究近年来获得蓬勃发展。利用元素双稀释剂法对钼同位素值进行校正,目前可以获得±0.1‰(2σ)的测试精度。自然界中钼同位素分馏δ98/95Mo可达~3‰,其分馏机制与环境的氧化-还原状态有关。在氧化环境下钼以MoO24-的形式与锰的氧化物和氢氧化物共存,并以富集轻钼同位素为特征。在还原环境下由于水体中H2S的存在使MoO24-转换为MoOxS42--x的形式,钼同位素在这一化学过程中分馏作用明显,静水还原环境沉积物(比如黑色页岩)富集重钼同位素。由于具有对氧化-还原环境敏感的特性,钼同位素被认为是反演全球范围内古海洋及古大气氧化环境变化最有效的手段之一。基于最近几年的研究成果,文章对钼同位素体系做了详细论述,包括钼及钼同位素地球化学行为、钼同位素分析测试技术、同位素分馏机理、钼同位素在各种储库中的特征以及应用钼同位素反演古海洋氧化-还原环境和约束矿床成因等,以推动过渡金属元素同位素特别是钼同位素在地球科学领域的研究和应用。 | 徐林刚 Bernd Lehmann | 2011 | 矿床地质2011，30，1： | 13 |
| 8 | DNA methylation,microRNAs,and their crosstalk as potential biomarkers in hepatocellular carcinoma显示文摘Epigenetic alterations have been identified as a major characteristic in human cancers.Advances in the field of epigenetics have contributed significantly in refining our knowledge of molecular mechanisms underlying malignant transformation.DNA methylation and microRNA expression are epigenetic mechanisms that are widely altered in human cancers including hepatocellular carcinoma(HCC),the third leading cause of cancer related mortality worldwide.Both DNA methylation and microRNA expression patterns are regulated in developmental stage specific-,cell type specific-and tissue-specific manner.The aberrations are inferred in the maintenance of cancer stem cells and in clonal cell evolution during carcinogenesis.The availability of genome-wide technologies for DNA methylation and microRNA profiling has revolutionized the field of epigenetics and led to the discovery of a number of epigenetically silenced microRNAs in cancerous cells and primary tissues.Dysregulation of these microRNAs affects several key signalling pathways in hepatocarcinogenesis suggesting that modulation of DNA methylation and/or microRNA expression can serve as new therapeutic targets for HCC.Accumulative evidence shows that aberrant DNA methylation of certain microRNA genes is an event specifically found in HCC which correlates with unfavorable outcomes.Therefore,it can potentially serve as a biomarker for detection as well as for prognosis,monitoring and predicting therapeutic responses in HCC. | Sumadi Lukman Anwar Ulrich Lehmann | 2014 | World Journal of Gastroenterology2014，20，24： | 11 |
| 9 | Acupuncture in ancient China: How important was it really?显示文摘Although acupuncture theory is a fundamental part of the Huangdi Neijing, the clinical application of the needle therapy in ancient China was always a limited one. From early times there have been warnings that acupuncture might do harm. In books like Zhang Zhongjing's Shanghanlun it plays only a marginal role. Among the 400 emperors in Chinese history, acupuncture was hardly ever applied. After Xu Dachun called acupuncture a 'lost tradition' in 1757, the abolition of acupuncture and moxibustion from the Imperial Medical Academy in 1822 was a radical, but consequent act. When traditional Chinese medicine was revived after 1954, the 'New Acupuncture' was completely different from what it had been in ancient China. The conclusion, however, is a positive one: The best time acupuncture ever had was not the Song dynasty or Yuan dynasty, but is now - and the future of acupuncture does not lie in old scripts, but in ourselves. | Hanjo Lehmann | 2013 | Journal of Integrative Medicine2013，11，1： | 10 |
| 10 | Design,delivery and efficacy testing of therapeutic nucleic acids used to inhibit hepatitis C virus gene expression in vitro and in vivo显示文摘Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are | Wolfgang H.Caselmann Matthias Serwe Thomas Lehmann János Ludwig Brian S.Sproat Joachim W.Engels | 2000 | World Journal of Gastroenterology2000，6，5： | 9 |
| 11 | 纳米SiO_2/聚丙烯复合材料的微观结构显示文摘利用原子力显微镜和透射电镜分析了聚苯乙烯辐射接枝纳米二氧化硅粒子(SiO2-g-PS)填充聚丙烯(PP)的微观结构,并与该复合材料的拉伸和冲击强度相关联,为探讨纳米粒子的增强增韧作用机制提供了直观证据。利用原子力显微镜进行的微划痕和纳米压痕实验,通过与显微硬度和动态力学性能测试结果的比较,证实了接枝改性后的纳米粒子团聚体具有承载能力,而这些团聚体对复合材料的局部和整体力学响应不同,揭示了团聚体增强效应的内在原因,即在纳米粒子团聚体内部以及团聚体之间形成了特定的应力双逾渗结构。 | FRIEDRICH Klaus SREEKALA Meyyarappallil Sadasivan LEHMANN Bjoern 容敏智 章明秋 | 2006 | 复合材料学报2006，23，1： | 9 |
| 12 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 13 | The Metabolic Response of Arabidopsis Roots to Oxidative Stress is Distinct from that of Heterotrophic Cells in Culture and Highlights a Complex Relationship between the Levels of Transcripts, Metabolites, and Flux显示文摘新陈代谢的调整是一重要,但是糟糕理解,到氧化应力的植物的反应的部分。在以前的研究(巴斯斯特等, 2007 ) ,在到由甲蔡醌的氧化应力的正式就职的文化的 Arabidopsis 房间的新陈代谢的反应被描绘。紧急情况幸存策略在 anabolism 的主要新陈代谢大部分在哪个是下面调整的赞成被揭开分解代谢并且抗氧化剂新陈代谢。在整个植物纸巾的反应可能是不同的,我们因此调查了 Arabidopsis 根的反应到甲蔡醌处理,分析有主要以及第二等的新陈代谢的焦点的 transcriptome, metabolome 和关键新陈代谢的流动。用氧化还原作用敏感的 GFP,甲蔡醌引起氧化还原作用不安,这也被显示出,不是就在线粒体,而且在根的 cytosol 和质体。在里面开始的 30 ? 处理的 min,反应类似于房间文化:在 TCA 周期和氨基酸生合成的代谢物有减少, transcriptomic 反应被 DNA 规章的蛋白质的起来规定统治。在 2 和 6 以后 ? 处理的 h,根的反应对房间文化不同。代谢物层次没仍然保持沮丧,但是相反恢复并且在 pyruvate 的情况中,一些氨基酸和脂肪族的 glucosinolates 在控制层次上面显示出稳定的增加。然而,在中央碳新陈代谢的流动的主要变化都没被观察,新陈代谢的抄本主要独立于相应代谢物变化了。一起,结果建议根纸巾能在氧化抑制以后恢复新陈代谢的活动并且为 glycolysis 和氧化戊糖磷酸盐小径加亮潜在地重要的角色。 | Martin Lehmann Markus Schwarzlander Toshihiro Obata Supaart Sirikantaramas Meike Burow Carl Erik Olsen Takayuki Tohge Mark D. Fricker Birger Lindberg Moiler Alisdair R. Fernie Lee J. Sweetlove Miriam Laxa | 2009 | Molecular Plant2009，2，3： | 8 |
| 14 | Nutrient availability and leaching in an archaeological Anthrosol and a Ferralsol of the Central Amazon basin: fertilizer, manure and charcoal amendments显示文摘 | Johannes Lehmann Jose Pereira da Silva Christoph Steiner Thomas Nehls Wolfgang Zech Bruno Glaser | 2003 | Plant and Soil2003，，2： | 8 |
| 15 | Bio-char Sequestration in Terrestrial Ecosystems – A Review显示文摘 | Johannes Lehmann John Gaunt Marco Rondon | 2006 | Mitigation and Adaptation Strategies for Global Change2006，，2： | 8 |
| 16 | 开裂混凝土中水分侵入过程的可视化追踪及其特征分析显示文摘采用热中子辐射成像技术,对开裂混凝土中的水分侵入过程进行了试验研究与特征分析。结果表明:中子成像能够突破混凝土材料的非透明性局限,实现对开裂混凝土中水分侵入过程的可视化追踪和水分空间分布的定量计算;水分在开裂混凝土中不仅由与水初始接触面沿垂直方向推进,而且还沿裂缝两侧向其水平方向,以及钢筋与水泥基体界面外围方向同时入侵;裂缝区和钢筋与水泥基体界面区成为水分持续侵入的二次水源;水分侵入初期约2h内,根据试验中裂缝宽度为0.35mm试件的中子图像估算的水分侵入量与称量法测得的水分侵入量基本一致。 | 张鹏 赵铁军 WITTMANN F H LEHMANN E 金祖权 VONTOBEL P | 2010 | 硅酸盐学报2010，38，4： | 8 |
| 17 | 混凝土冻融损伤后的吸水特性显示文摘对掺与未掺引气剂的混凝土进行了冻融破坏,通过吸水试验和中子辐射试验,研究了冻融损伤对掺与未掺引气剂混凝土吸水特性的影响.结果表明,中子成像技术能够实现对非透明性混凝土材料吸水演进过程的可视化观测和定量分析.未掺引气剂的混凝土其抗冻性较差,在10次冻融循环后动弹模量损失14%的情况下,其水分渗透深度约增30%;掺加引气剂后,即使遭受200次冻融循环,混凝土的整体动弹模量也无明显损失,但200次冻融循环后,混凝土表层出现部分剥落,水分渗透速率及深度均相应增大.在评价混凝土冻融损伤时,除整体动弹模量损失外,还需考虑冻融损伤对混凝土吸水性能的影响. | 张鹏 张连水 赵铁军 F. H. WITTMANN E. LEHMANN 金祖权 | 2011 | 建筑材料学报2011，14，2： | 7 |
| 18 | 一个西方人对中医的思考:阴阳和五行学说的哲学和医学解读(英文)显示文摘The Yinyang concept and the Wuxing concept are two basic concepts of Chinese philosophy,as well as of traditional Chinese medicine(TCM).When I started studying TCM in Shanghai 30 years ago,I met the Yinyang concept and the | Hanjo Lehmann | 2012 | 中西医结合学报2012，10，3： | 7 |
| 19 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 20 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
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