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| 1 | Seven Things We Think We Know about Auxin Transport显示文摘植物激素植物生长素的极的运输和最大值调整的局部性的植物生长素的建立胚胎的开发,干细胞维护,根和射击建筑学,和回归线生长回答。过去的十年被戏剧的进步在阐明的努力标记植物生长素运输由调整的复杂机制种生长。作为植物生长素的理解,运输规定逐渐地被详细描述,这个过程在某些方面涉及几乎所有植物生长和环境回答,变得清楚。然而,我们仍然关于这基本规章的机制的一些基本方面缺乏信息。在这评论,我们在场我们知道什么(或我们认为什么我们知道) 并且我们什么不知道大约七个调整植物生长素的过程。我们在主要、侧面的根,向光性,分叉的射击,叶扩大,和脉络在 gravitropism 讨论植物生长素运输的角色。我们也在根尖端,植物生长素运输过程的 flavonoid 调整,和植物生长素 transporters 的 translational 以后规定的突出的方面讨论植物生长素倒流 / 喷泉模型。这讨论没打算彻底,但是加亮在哪个通常认为假设要求更真实的确认的区域。 | Wendy Ann Peer Joshua J. Blakeslee Haibing Yang Angus S. Murphy | 2011 | Molecular Plant2011，4，3： | 29 |
| 2 | Cirrhotic portal hypertension: From pathophysiology to novel therapeutics显示文摘Portal hypertension and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in patients with cirrhosis. Portal hypertension is initiated by increased intrahepatic vascular resistance and a hyperdynamic circulatory state. The latter is characterized by a high cardiac output, increased total blood volume and splanchnic vasodilatation, resulting in increased mesenteric blood flow. Pharmacological manipulation of cirrhotic portal hypertension targets both the splanchnic and hepatic vascular beds. Drugs such as angiotensin converting enzyme inhibitors and angiotensin Ⅱ type receptor 1 blockers, which target the components of the classical renin angiotensin system(RAS), are expected to reduce intrahepatic vascular tone by reducing extracellular matrix deposition and vasoactivity of contractile cells and thereby improve portal hypertension. However, these drugs have been shown to produce significant offtarget effects such as systemic hypotension and renal failure. Therefore, the current pharmacological mainstay in clinical practice to prevent variceal bleeding and improving patient survival by reducing portal pressure is non-selective-blockers(NSBBs). These NSBBs work by reducing cardiac output and splanchnic vasodilatation but most patients do not achieve an optimal therapeutic response and a significant proportion of patients are unable to tolerate these drugs.Although statins, used alone or in combination with NSBBs, have been shown to improve portal pressure and overall mortality in cirrhotic patients, further randomized clinical trials are warranted involving larger patient populations with clear clinical end points. On the other hand, recent findings from studies that have investigated the potential use of the blockers of the components of the alternate RAS provided compelling evidence that could lead to the development of drugs targeting the splanchnic vascular bed to inhibit splanchnic vasodilatation in portal hypertension. This review outlines the mechanisms related to the pathogenesis of portal hypertension and attempts to provide an update on currently available therapeutic approaches in the management of portal hypertension with special emphasis on how the alternate RAS could be manipulated in our search for development of safe, specific and effective novel therapies to treat portal hypertension in cirrhosis. | Lakmie S Gunarathne Harinda Rajapaksha Nicholas Shackel Peter W Angus Chandana B Herath | 2020 | World Journal of Gastroenterology2020，26，40： | 24 |
| 3 | Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease显示文摘AIM: To determine characteristics and prognosticpredictors of patients with hepatocellular carcinoma(HCC) in association with non-alcoholic fatty liver disease(NAFLD).METHODS: We reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index(BMI), and the presence of diabetes, hypertension, or dyslipidaemia.RESULTS: Fifty-four patients with NAFLD associated HCC were identified. Mean age was 64 years with 87% male. Fifteen percent(8/54) were not cirrhotic. 11%, 24% and 50% had a BMI of < 25 kg/m2, 25-29 kg/m2 and ≥ 30 kg/m2 respectively. Fifty-nine percent were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had ≤ 1 of these risk factors. Non-cirrhotics had a significantly larger mean tumour diameter at diagnosis than cirrhotics(P = 0.041). Multivariate analysis did not identify any other patient characteristics that predicted the size or number of HCC.CONCLUSION: HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis. | Christopher Leung Sern Wei Yeoh Desmond Patrick Shara Ket Kaye Marion Paul Gow Peter W Angus | 2015 | World Journal of Gastroenterology2015，21，4： | 24 |
| 4 | Intrahepatic cholestasis of pregnancy:When should you look further?显示文摘Pruritis with abnormal liver function tests is the classical presentation of intrahepatic cholestasis of pregnancy(ICP),a condition associated with significant fetal complications.Although the etiology of ICP is unclear in many cases,certain features of the clinical presentation should alert the practitioner to the possibility of an underlying metabolic defect, which may not only affect subsequent pregnancies, but may be an indicator of more serious subsequent liver disease.We report a kindred of Anglo-Celtic descent,among whom many members present with ICP,gallstones or cholestasis related to use of oral contraception.Genetic studies revealed a novel mutation in the ABCB4 gene,which codes for a phospholipid transport protein.The clinical significance of this mutation and the importance of identifying such patients are discussed. | Winita Hardikar Shivani Kansal Ronald P J Oude Elferink Peter Angus | 2009 | World Journal of Gastroenterology2009，15，9： | 22 |
| 5 | An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots显示文摘改变根建筑学是到磷酸盐(Pi ) 的植物的主要发展回答缺乏并且被认为在表层土为可得到的 Pi 提高一个植物能力到牧草。然而,控制这回答的内在的机制糟糕被理解。在这研究,我们识别了 Arabidopsis 异种, hps10 (对 Pi 饥饿 10 过分敏感) ,它在 Pi 足够的状况下面是词法上正常的,但是在 Pi 下面显示出主要的根生长和侧面的根的提高的生产的增加的抑制缺乏。hps10 是 ALUMINUM SENSITIVE3 (ALS3 ) 基因的以前识别的等位基因(als3-3 ) ,它涉及植物忍耐到铝毒性。我们的结果证明 ALS3 和它的交往的蛋白质 AtSTAR1 在 tonoplast 形成 ABC transporter 建筑群。这蛋白质建筑群调停一高度在 Xenopus 卵母细胞的 electrogenic 运输。在 Pi 缺乏下面, als3 比野类型在它的根积累 Fe 3+ 的高水平。在 Arabidopsis, LPR1 (低磷酸盐 ROOT1 ) 和 LPR2 编码 ferroxidases,当变异时,它在根和原因根生长减少 Fe 3+ 累积对 Pi 缺乏感觉迟钝。这里,我们提供证明 ALS3 与 LPR1/2 合作调整 Pi 的引人注目的证据在根的由 modulating Fe 动态平衡的根建筑学的导致缺乏的改变。 | Jinsong Dong Miguel A. PiSeros Xiaoxuan Li Haibing Yang Yu Liu Angus S. Murphy Leon V. Kochian Dong Liu | 2017 | Molecular Plant2017，10，2： | 13 |
| 6 | 从其他慢性疾病的研究证据看社区干预能否降低老年痴呆病的危险显示文摘目的用科学的证据支持老年痴呆病社区教育战略的开发。方法通过对国家健康优先领域的证据分析,提出慢性疾病社区干预的共性特点,并特别提出针对少数和弱势人群的干预策略。结果需要采取全方位干预策略,并通过周密的计划和评价来保证目标人群能获得足够的健康教育信息。结论应该进一步对降低老年痴呆病危险的干预策略进行深入研究。国际上各种证据一致表明,社区健康教育是现在采取的主要策略。 | Jocelyn Angus Jane Sims Susan Feldman Harriet Radermacher | 2008 | 中国全科医学2008，11，19： | 9 |
| 7 | Therapeutic potential of targeting the renin angiotensin system in portal hypertension显示文摘Portal hypertension is responsible for the bulk of the morbidity and mortality in patients with cirrhosis.Drug therapy to reduce portal pressure involves targeting two vascular beds.The first approach is to reduce intra hepatic vascular tone induced by the activity of powerful vasocontrictors such as angiotensin Ⅱ,endothelin-1 and the sympathetic system and mediated via contraction of perisinusoidal myofibroblasts and pervascular smooth muscle cells.The second approach is to reduce mesenteric and portal blood flow.Non-selective b-blockers are widely used and have been shown to prolong patient survival and reduce oesophageal variceal bleeding in advanced cirrhosis.However many patients are unable to tolerate these drugs and they are ineffective in a significant proportion of patients.Unfortunately there are no other drug therapies that have proven efficacy in the treatment of portal hypertension and prevention of variceal bleeding.This review briefly outlines current therapeutic approaches to themanagement of portal hypertension,and the evidence supporting the role of the renin angiotensin system(RAS) and the use of RAS blockers in this condition.It will also outline recent advances in RAS research that could lead to the development of new treatments focusing in particular on the recently discovered 'alternate axis' of the RAS. | Chandana B Herath Josephine A Grace Peter W Angus | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 9 |
| 8 | 老年痴呆的负担以及通过社区干预降低老年痴呆的危险显示文摘本文讨论老年痴呆的病因学以及与其他疾病的关系,并讨论采用社区干预方法降低人群的老年痴呆危险。认为针对可治疗的并发症采取积极的诊断和社区教育策略,可以降低或延迟老年痴呆的发病,从而提高病人的生活质量和改善卫生资源的有效利用。 | Jane Sims Jocelyn Angus Susan Feldman Harriet Radermacher | 2008 | 中国全科医学2008，11，17： | 8 |
| 9 | Large-area nanopatterned graphene for ultrasensitive gas sensing显示文摘 | Alberto Cagliani David Micheal Angus Mackenzie Lisa Katharina Tschammer Filippo Pizzocchero Kristoffer Almdal Peter Boggild | 2014 | Nano Research2014，7，5： | 7 |
| 10 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 11 | 不同叶龄杉木叶片形态及光合特性分析显示文摘以成年实生杉木青杉YXC3、灰杉YXG1的老叶和幼叶为试材,采用室外采集法,探讨杉木叶片生长过程中的生理特性。结果表明,老叶的叶面积、周长与幼叶差异均达显著水平,其中灰杉YXG1的差异较大。青杉YXC3和灰杉YXG1幼叶PSⅡ反应中心电子传递能力、热耗散能力、PSⅡ激发能捕获效率及PSⅡ反应中心光能转换效率均高于老叶。老叶光泽度低,颜色更深,且光吸收能力和转化能力均大于幼叶,说明幼叶的叶绿素更易遭到强光破坏。 | 理挪 王培 PEGGY Cellya Angue Edou 林思祖 陈宇 | 2018 | 亚热带农业研究2018，14，3： | 7 |
| 12 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008显示文摘 | R. Phillip Dellinger Mitchell M. Levy Jean M. Carlet Julian Bion Margaret M. Parker Roman Jaeschke Konrad Reinhart Derek C. Angus Christian Brun-Buisson Richard Beale Thierry Calandra Jean-Francois Dhainaut Herwig Gerlach Maurene Harvey John J. Marini Joh | 2008 | Intensive Care Medicine2008，，1： | 7 |
| 13 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference显示文摘 | Mitchell M. Levy Mitchell P. Fink John C. Marshall Edward Abraham Derek Angus Deborah Cook Jonathan Cohen Steven M. Opal Jean-Louis Vincent Graham Ramsay | 2003 | Critical Care Medicine2003，，4： | 7 |
| 14 | Antioxidant and hepatoprotective effects of Hypsizygus ulmarius polysaccharide on alcoholic liver injury in rats显示文摘Hypsizygus ulmarius polysaccharide(HUP)is a water-soluble polysaccharide obtained by hot water extraction,followed by precipitation and deproteinization.The characteristics of HUP,antioxidant activity and liver protection against alcohol-induced liver damage were studied.Structural characteristics indicate that the HUP is a pyran-type polysaccharide with a molecular weight of 2076 Da.In antioxidant scavenging assay,HUP showed moderate DMPD radical scavenging activity,cupric ion reducing antioxidant capacity and inhibitory effect against lipid peroxidation in a dose-dependent manner.Regarding in vivo hepatoprotective activity,compared with the ethanol induction group,pre-treatment of low and high doses of HUP signifi cantly reduced the behaviours of serum enzymes,lowered the levels of hepatic oxidative stress markers,restored the levels of biochemical constituents,enhanced the levels of liver and serum enzymatic antioxidants and non-enzymatic antioxidants,and improved the serum lipid levels of alcohol-intoxicated rats.The hepatoprotective effect of HUP was comparable to positive control silymarin.Besides,HUP pre-treatment signifi cantly normalized the histopathological changes induced by ethanol.The results indicate that HUP could be used as a functional food and may protect the biological system from oxidative stress through its antioxidant activity,thus having a signifi cant protective effect on acute alcoholic liver injury. | Sudha Govindan Angu Jayabal Jayasakthi Shanmugam Prasanna Ramani | 2021 | Food Science and Human Wellness2021，10，4： | 6 |
| 15 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference显示文摘 | Mitchell M. Levy Mitchell P. Fink John C. Marshall Edward Abraham Derek Angus Deborah Cook Jonathan Cohen Steven M. Opal Jean-Louis Vincent Graham Ramsay | 2003 | Critical Care Medicine2003，，4： | 6 |
| 16 | 新型太阳电池模拟软件——wxAMPS显示文摘介绍了一款新型模拟软件wxAMPS的物理模型,其在原物理模型的基础上添加了两种隧穿电流模型,重写了程序内核,改进了求解算法,并与软件AMPS进行功能对比,分析了wxAMPS前沿应用。大量模拟计算的实践表明,wxAMPS不仅使一维太阳电池模拟软件性能更加稳定、通用性更强,而且具有更加便捷的用户操作界面,支持批处理功能,兼容其他光学模型,可很好地模拟更多的新型太阳电池。 | 刘一鸣 孙云 Angus Rockett | 2013 | 太阳能2013，，3： | 6 |
| 17 | Investigation of lead and zinc dispersion from an abandoned mine site at Tyndrum, Scotland, using tree bark measurements显示文摘 | Nurlidia Mansor Ian D. Pulford Angus B. MacKenzie | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 5 |
| 18 | Use of scoring systems for assessing and reporting the outcome results from shoulder surgery and arthroplasty显示文摘To investigate shoulder scoring systems used in Europe and North America and how outcomes might be classified after shoulder joint replacement. All research papers published in four major journals in 2012 and 2013 were reviewed for the shoulder scoring systems used in their published papers. A method of identifying how outcomes after shoulder arthroplasty might be used to categorize patients into fair, good, very good and excellent outcomes was explored using the outcome evaluations from patients treated in our own unit. A total of 174 research articles that were published in the four journals used some form of shoulder scoring system. The outcome from shoulder arthroplasty in our unit has been evaluated using the constant score(CS) and the oxford shoulder score and these scores have been used to evaluate individual patient outcomes. CSs of < 30 = unsatisfactory; 30-39 = fair; 40-59 = good; 60-69 = very good; and 70 and over = excellent. The most popular shoulder scoring systems in North America were Simple Shoulder Test and American shoulder and elbow surgeons standard shoulder assessment form score and in Europe CS, Oxford Shoulder Score and DASH score. | Simon Booker Nawaf Alfahad Martin Scott Ben Gooding W Angus Wallace | 2015 | World Journal of Orthopedics2015，6，2： | 5 |
| 19 | Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care显示文摘 | Derek C. Angus Walter T. Linde-Zwirble Jeffrey Lidicker Gilles Clermont Joseph Carcillo Michael R. Pinsky | 2001 | Critical Care Medicine2001，，7： | 5 |
| 20 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008显示文摘 | R Phillip Dellinger Mitchell M. Levy Jean M. Carlet Julian Bion Margaret M. Parker Roman Jaeschke Konrad Reinhart Derek C. Angus Christian Brun-Buisson Richard Beale Thierry Calandra Jean-Francois Dhainaut Herwig Gerlach Maurene Harvey John J. Marini John | 2008 | Critical Care Medicine2008，，1： | 4 |
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