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| 1 | Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity显示文摘Background:Lentinan(LNT)may regulate many important physiological functions of human and animals.This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus(RV)-challenged weaned pigs.Methods:Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d(n=14).RV infection was executed on d 15.After extracting polysaccharides from LNT product,its major monosaccharides were analyzed.Then,LNT polysaccharide was used to administrate RV-infected IPEC-J2 cells.Results:Dietary LNT supplementation supported normal function of piglets even when infected with RV,as reflected by reduced growth performance loss and diarrhea prevalence,and maintained gut immunity(P<0.05).The polysaccharide was isolated from LNT product,which molecular weight was 5303 Da,and major monosaccharides included glucose,arabinose and galactose.In RV-infected IPEC-J2 cells,this polysaccharide significantly increased cell viability(P<0.05),and significantly increased anti-virus immunity via regulating pattern recognition receptors and host defense peptides(P<0.05).Conclusion:Those results suggest that LNT administration increases the piglets’resistance to RV-induced stress,likely by supporting intestinal immunity. | Xiangqi Fan Haiyan Hu Daiwen Chen Bing Yu Jun He Jie Yu Junqiu Luo Erik Eckhardt Yuheng Luo Jianping Wang Hui Yan Xiangbing Mao | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 8 |
| 2 | Population pharmacokinetic model of PI-88, a heparanase inhibitor显示文摘 | Susan F. Hudachek S. Gail Eckhardt Barbara Hicks Daniel L. Gustafson | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 3 | Opportunities and Entrepreneurship显示文摘 | Jonathan T. Eckhardt | 2002 | Journal of Management2002，，3： | 2 |
| 4 | Comparison of two dif ferent approaches of sensitivity analysis显示文摘 | Lenhart L Eckhardt K Fohrer N | 2002 | Physics and Chemistry of the Earth2002，27，910： | 1 |
| 5 | Phase I and pharmaokinetie study of GI147211, a water-soluble camptothecin analogue, administered for five consecutive days every three weeks显示文摘 | Eckhardt SG Sharyn DB John R E | 1998 | Clinical Catwer Research1998，4，： | 1 |
| 6 | Dynamicmeasuring of frequency and frequency oscillations in multiphase power systems显示文摘 | Eckhardt V Hippe P Hosemann G | 1989 | IEEE Trans PD1989，4，4： | 1 |
| 7 | Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics显示文摘 | Fils-Aime M Eckhardt M George D | 1996 | Arch Gen Psychiatry1996，53，： | 1 |
| 8 | Hydrologic respomse to land use changes on the catchment scale显示文摘 | Fohrer N Haverkamp S Eckhardt K | 2001 | Physics and Chemistry of the Earth(B)2001，26，78： | 1 |
| 9 | Correlations of urodynamic changes in symptoms and well- being after transurethral resection of the prostate 显示文摘 | van VENROOIJ G E van MELICK H H ECKHARDT M D | 2002 | J Urol2002，168，2： | 1 |
| 10 | 8- ( 3-( R ) -Aminopiperidin-1 -yl ) -7-but-2-ynyl-3-meth- yl-1- ( 4-methyl-quinazolin-2-ylmethyl ) -3,7-dihydro- purine-2,6-dione ( BI1356 ), a highly potent, selec- five, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes 显示文摘 | ECKHARDT M LANGKOPF E MARK M | 2007 | J Med Chem2007，50，26： | 1 |
| 11 | Gabapentin enhances the analgesic effect of morphine in healthy volunteers显示文摘 | Eckhardt K Ammon S Hofmann U Riebe A Gugeler N Mikus G | 2000 | Anesth Analg2000，91，： | 1 |
| 12 | Clinical results and pharmacokinitics of high-dose cytosine arabinoside(HD ARA-C)显示文摘 | Breithaupt H Pralle H Eckhardt T | 1982 | Cancer1982，50，7： | 1 |
| 13 | Comparison of two different approaches of sensitivity analysis显示文摘 | Lenhart T Eckhardt K Fohrer N | 2002 | Phys Chem Earth2002，27，910： | 1 |
| 14 | Just Friends,Good Acquaintances or Soul Mates An Exploration of Web Site Connectedness显示文摘 | Maulana A.E Eckhardt G.M | | 0，，： | 1 |
| 15 | Ligand-based targeting of apoptosis in cancer:the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL)显示文摘 | Ashkenazi A Holland P Eckhardt SG | | 0，，： | 1 |
| 16 | Recent advances in chlorophyll biosynthesis and breakdown in higher plants显示文摘 | Ulrich Eckhardt Bernhard Grimm Stefan H?rtensteiner | 2004 | Plant Molecular Biology2004，，1： | 1 |
| 17 | Potential impacts of climatechange on groundwater recharge and streamflow in a cen- tral European low mountain range显示文摘 | Eckhardt K Ulbrich U | 2003 | Journal of Hydrol- ogy2003，284，： | 1 |
| 18 | Sunitinib: from rational design to clinical efficacy显示文摘 | Chow LQ Eckhardt SG | 2007 | J Clin Oncol2007，25，7： | 1 |
| 19 | Opportunities and entreneurship显示文摘 | JONATHAN J ECKHARDT SCOTT A SHANE | 2003 | Journal of Management2003，29，3： | 1 |
| 20 | Factors affecting the stability of screws in human cortical osteoporotic bone显示文摘 | Thiele OC Eckhardt C Linke B | 2007 | J Bone Joint Surgery(Br)2007，89，5： | 1 |
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