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| 1 | Evolving management of colorectal cancer显示文摘This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ('outside in integrin signaling') is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future. | Jochem van der Voort van Zijp Harald J Hoekstra Marc D Basson | 2008 | World Journal of Gastroenterology2008，14，25： | 16 |
| 2 | Resource use efficiency, ecological intensification and sustainability of intercropping systems显示文摘The rapidly growing demand for food, feed and fuel requires further improvements of land and water management, crop productivity and resource-use efficiencies.Combined field experimentation and crop growth modelling during the past five decades made a great leap forward in the understanding of factors that determine actual and potential yields of monocrops.The research field of production ecology developed concepts to integrate biological and biophysical processes with the aim to explore crop growth potential in contrasting environments.To understand the potential of more complex systems(multi-cropping and intercropping) we need an agro-ecosystem approach that integrates knowledge derived from various disciplines: agronomy, crop physiology, crop ecology, and environmental sciences(soil, water and climate).Adaptation of cropping systems to climate change and a better tolerance to biotic and abiotic stresses by genetic improvement and by managing diverse cropping systems in a sustainable way will be of key importance in food security.To accelerate sustainable intensification of agricultural production, it is required to develop intercropping systems that are highly productive and stable under conditions with abiotic constraints(water, nutrients and weather).Strategies to achieve sustainable intensification include developing tools to evaluate crop growth potential under more extreme climatic conditions and introducing new crops and cropping systems that are more productive and robust under conditions with abiotic stress.This paper presents some examples of sustainable intensification management of intercropping systems that proved to be tolerant to extreme climate conditions. | MAO Li-li ZHANG Li-zhen ZHANG Si-ping Jochem B Evers Wopke van der Werf WANG Jing-jing SUN Hong-quan SU Zhi-cheng Huub Spiertz | 2015 | Journal of Integrative Agriculture2015，14，8： | 5 |
| 3 | LIGHT INTERCEPTION AND USE EFFICIENCY DIFFER WITH MAIZE PLANT DENSITY IN MAIZE-PEANUT INTERCROPPING显示文摘Intercropping increases crop yields by optimizing light interception and/or use efficiency.Although intercropping combinations and metrics have been reported,the effects of plant density on light use are not well documented.Here,we examined the light interception and use efficiency in maize-peanut intercropping with different maize plant densities in two row configurations in semiarid dryland agriculture over a two-year period.The field experiment comprised four cropping systems,i.e.,monocropped maize,monocropped peanut,maize-peanut intercropping with two rows of maize and four rows of peanut,intercropping with four rows of maize and four rows of peanut,and three maize plant densities(3.0,4.5 and 6.0 plants m^(-1) row)in both monocropped and intercropping maize.The mean total light interception in intercropping across years and densities was 779 MJ·m^(-2),5.5%higher than in monocropped peanut(737 MJ·m^(-2))and 7.6%lower than in monocropped maize(843 MJ·m^(-2)).Increasing maize density increased light interception in monocropped maize but did not affect the total light interception in the intercrops.Across years the LUE of maize was 2.9 g·MJ–1 and was not affected by cropping system but increased with maize plant density.The LUE of peanut was enhanced in intercropping,especially in a wetter year.The yield advantage of maize-peanut intercropping resulted mainly from the LUE of peanut.These results will help to optimize agronomic management and system design and provide evidence for system level light use efficiency in intercropping. | Qi WANG Zhanxiang SUN Wei BAI Dongsheng ZHANG Yue ZHANG Ruonan WANG Wopke VAN DER WERF Jochem B.EVERS Tjeerd-Jan STOMPH Jianping GUO Lizhen ZHANG | 2021 | Frontiers of Agricultural Science and Engineering2021，8，3： | 4 |
| 4 | Formation of the highest sand dunes on Earth显示文摘 | Xiaoping Yang Louis Scuderi Tao Liu Philippe Paillou Hongwei Li Jufeng Dong Bingqi Zhu Weiwei Jiang Andrew Jochems Gary Weissmann | 2011 | Geomorphology2011，，1： | 2 |
| 5 | Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease显示文摘 | Maarten F. Corsten Robert Dennert Sylvia Jochems Tatiana Kuznetsova Yvan Devaux Leon Hofstra Daniel R. Wagner Jan A. Staessen Stephane Heymans Blanche Schroen | 2010 | Circulation: Cardiovascular Genetics2010，，6： | 2 |
| 6 | Quanti?cation of Tyrosine Hydroxylase and Erb B4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin显示文摘The locus coeruleus(LC) has been studied in major depressive disorder(MDD) and bipolar disorder(BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown pigment neuromelanin. Here, we used a multispectral method to untangle the two colors: blue immunocytochemical staining and brown neuromelanin.We found significantly increased tyrosine hydroxylase(TH) in the LC of MDD patients—thus validating the method—but not in BD patients, and we did not find significant changes in the receptor tyrosine-protein kinase ErbB4 in the LC in MDD or BD patients. We observed clear co-localization of ErbB4, TH, and neuromelanin in the LC neurons. The different stress-related molecular changes in the LC may contribute to the different clinical symptoms in MDD and BD. | Lei Guo Jochem StormmesAND Zheng Fang Qingbin Zhu Rawien Balesar Joop van Heerikhuize Arja Sluiter Dick Swaab Ai-Min Bao | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 7 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 8 | Eggs of Ephestia kuehniella and Ceratitis capitata, and motile stages of the astigmatid mites Tyrophagus putrescentiae and Carpoglyphus lactis as factitious foods for Orius spp.显示文摘几虚假食物为饲养 anthocorid 食肉动物 Orius thripoborus (Hesse ) 和 Orius naivashae (Poppius ) 被估计(半翅类:Anthocoridae ) 在实验室。当提供了地中海面粉蛾的冻结的鸡蛋时,两 Orius 种的发展、繁殖的特点被检验, Ephestia kuehniella Zeller,冻结的处理鸡蛋 medfly, Ceratitis capitata Wiedemann,或 astigmatid 螨 Tyrophagus putrescentiae (Schrank ) 或 Carpoglyphus lactis (L) 的混合能动阶段。而 C。lactis 和 T。putresecentiae 证明了是为饲养 O 的劣等的食物。thripoborus 和 O。naivashae, C 的鸡蛋。capitata 充分支持了两个食肉动物的开发和复制。结果在上 medfly 鸡蛋类似于 E 上的那些或稍微劣等。kuehniella 鸡蛋,它是为 culturing 的标准食物这些 anthocorid 臭虫。O。thripoborus 能在 C 上为 4 连续的代被维持。capitata 鸡蛋显示那 medfly 处理了鸡蛋能是 E 的一种合适、更便宜的选择。为这些 Orius spp 高耸延长的 kuehniella 鸡蛋。 | Jochem Bonte Anais Van de Walle Des Conlong Patrick De Clercq | 2017 | Insect Science2017，24，4： | 2 |
| 9 | 基于植物功能-结构模型的玉米-大豆条带间作光截获行间差异研究显示文摘间作种植形成了异质冠层空间结构,但因此导致的作物生长、表型和光截获的行间差异目前还少有定量化。为解析条带间作生产力的行间差异,本研究基于田间观测数据构建植物功能-结构模型(Functional-Structural Plant Model,FSPM),量化间作系统中光截获的行间差异。于2017—2018年开展了玉米和大豆单作、2行玉米和2行大豆的2:2 MS间作以及3行玉米和6行大豆的3:6 MS间作田间试验。基于植物生长平台GroIMP开发了玉米-大豆间作的FSPM,模型较好地模拟了叶面积指数(Leaf Area Index,LAI)、株高和光截获系数动态三个指标,均方根误差(Root Mean Square Error,RMSE)分别为0.24~0.70 m^(2)/m^(2)、0.06~0.17 m和0.06~0.10。田间试验结果表明,间作种植显著增加了玉米节间直径。受玉米遮阴影响,大豆节间变长、变细,且随大豆条带变窄差异越明显。模型模拟的2:2 MS间作玉米光截获比单作玉米高35.6%,3:6 MS边行玉米和内行玉米的光截获分别比单作玉米高27.8%和20.3%。2:2 MS与3:6 MS边行大豆的光截获比单作大豆分别少36.0%和28.8%;3:6 MS大豆内Ⅰ行和内Ⅱ行比单作大豆的光截获分别少4.1%和1.8%。基于三维FSPM,未来可进行不同生长环境下间作种植模式等的布局优化,以达到最佳系统光截获优势。 | 李双伟 朱俊奇 Jochem B.EVERS Wopke VAN DER WERF 郭焱 李保国 马韫韬 | 2022 | 智慧农业(中英文)2022，4，1： | 2 |
| 10 | Irradiation Induces a Biphasic Expression of Pro-Inflammatory Cytokines in the Lung显示文摘 | Claudia E. Rübe MD Falk Wilfert Jan Palm Jochem K?nig Susanne Burdak-Rothkamm Li Liu Andreas Schuck Normann Willich Christian Rübe | 2004 | Strahlentherapie und Onkologie2004，，7： | 2 |
| 11 | Image processor drives across America显示文摘 | POMERLEAU D JOCHEM T | 1996 | Photonics Spectra1996，11，2： | 2 |
| 12 | Genetic analysis of mengovirus protein 2A: its function in polyprorein processing and virus reproduction 显示文摘 | Jan Z Frank J M K Jochem M D | 1998 | J Virol1998，79，： | 1 |
| 13 | Circulating micro- RNA-208b and microRNA-499 reflect myocardial damage in car- diovascular disease 显示文摘 | Corsten MF Dennert R Jochems S | 2010 | Circ Cardiovasc Genet2010，3，6： | 1 |
| 14 | Circulating microRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease显示文摘 | Corsten MF Dennert R Jochems S | 2010 | Circ Cardiovasc Genet2010，3，6： | 1 |
| 15 | Indirect Hurricane Effects on Resource Availability and Microbial Communities in a Subtropical Wetland-Estuary Transition Zone显示文摘 | Clayton J. Williams Joseph N. Boyer Frank J. Jochem | 2008 | Estuaries and Coasts2008，，1： | 1 |
| 16 | The Tran- scription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells 显示文摘 | Jenny Mjtisberg Jochem Bernink Korneliusz Golebski | 2012 | Immunity2012，37，4： | 1 |
| 17 | Circulating micro RNA-208b and micro RNA-499 reflect myocardial damage in cardiovascular disease显示文摘 | Corsten MF Dennert R Jochems S | 2010 | Circulation2010，3，6： | 1 |
| 18 | Super-resolution optical DNA Mapping via DNA methyltransferase-directed click chemistry显示文摘 | Charlotte Vranken Jochem Deen Lieve Dirix Tim | 2014 | Nucleic acids research2014，42，7： | 1 |
| 19 | Rapidly adapting machine vision for automated vehicle steering显示文摘 | Pomerleau D Jochem T | 1996 | IEEE Intelligent Systems1996，11，2： | 1 |
| 20 | The compact city and the environment: a re- view显示文摘 | JOCHEM F M DER WAALS V | 2000 | Tijdschrift voor Economische en Sociale Geografie2000，91，2： | 1 |
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