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| 1 | The unique structural and functional features of CXCL12显示文摘The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, includingembryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or induces migration ofhematopoietic progenitor and stem cells, endothelial cells and most leukocytes. Therefore, CXCL12 activity istightly regulated at multiple levels. CXCL12 has the unique property of existing in six splice variants in humans,each having a specific tissue distribution and in vivo activity. Controlled splice variant transcription and mRNAstability determine the CXCL12 expression profile. CXCL12 fulfills its functions in homeostatic and pathologicalconditions by interacting with its receptors CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3(ACKR3) and by binding to glycosaminoglycans (GAGs) in tissues and on the endothelium to allow a properpresentation to passing leukocytes. Homodimerizaton and heterodimerization of CXCL12 and its receptors can altertheir signaling activity, as exemplified by the synergy between CXCL12 and other chemokines in leukocyte migrationassays. Receptor binding may also initiate CXCL12 internalization and its subsequent removal from theenvironment. Furthermore, CXCL12 activity is regulated by posttranslational modifications. Proteolytic removal ofNH2- or COOH-terminal amino acids, citrullination of arginine residues by peptidyl arginine deiminases or nitrationof tyrosine residues reduce CXCL12 activity. This review summarizes the interactions of CXCL12 with the cellularenvironment and discusses the different levels of CXCL12 activity regulation. | Rik Janssens Sofie Struyf Paul Proost | 2018 | Cellular & Molecular Immunology2018，15，4： | 28 |
| 2 | 纬度对云南咖啡质量的影响研究显示文摘云南是中国仅有的小粒种咖啡生产省份,也是世界上咖啡种植纬度最北的地区(世界其它咖啡种植最北的纬度为22°N,而云南为25.5°N),具有独特的地理和气候类型。在这次调查研究中,笔者从小粒种咖啡主要种植区普洱、德宏和保山搜集了52个样品,在德国柏林由一个专业杯品测试小组对其进行测评。在对比相同海拔下(大约1 000m)的不同Catimor7963样品时,发现纬度与杯品质量之间存在正相关。这说明与相同海拔低纬度地区相比,高纬度地区的咖啡豆具有较好的杯品质量。因此纬度可作为杯品质量的一个地理因素。 | 李锦红 周华 张洪波 夏红云 胡永亮 林兴文 陈路 Marc Janssens | 2011 | 热带农业科学2011，31，10： | 18 |
| 3 | 定向结构刨花板产品市场现状与展望显示文摘详述近10年来全球范围定向结构刨花板(OSB)的生产能力、实际产量、主要用途、进出口贸易情况,分析和预测未来几年OSB的全球发展趋势,指出中国OSB的发展存在可观的潜在市场。 | 李薇 姜征 Dominique Janssens | 2006 | 木材工业2006，20，1： | 15 |
| 4 | 混合聚类方法用于科学结构研究--以“心理学、社会学和教育学”领域为例显示文摘在前期的相关研究中,一种基于'引文-文本'相似度的混合聚类方法被用来对2002-2006年期间Webof Science数据库中8305种期刊进行了聚类分析,得到22聚类和7聚类两种体系。与之前的宏观分析不同,7聚类体系中的一个特定的聚类,即'心理学、社会学和教育学'聚类,将被集中研究。该聚类的内部学科结构以及其在22聚类体系中如何分解为三个子聚类将被细致地讨论和分析。对聚类之间的互引网络以及聚类中不同类型的'重要期刊'进行了展示,此外,还进一步将该聚类中760种期刊的混合聚类结果与Thomson-Reuters公司的ESI学科分类进行了对比,基于比较分析的结果,对该领域内部的科学结构进行了量化解读。 | 张琳 梁立明 Frizo Janssens Wolfgang Glanzel | 2010 | 科学学研究2010，28，6： | 15 |
| 5 | Future prospectives for the management of chronic hepatitis B显示文摘Chronic hepatitis B virus infection affects about 400 million people around the globe and causes approximately one million deaths a year. Since the discovery of interferon-α as a therapeutic option the treatment of hepatitis B has evolved fast and management has become increasingly complicated. The amount of viral replication reflected in the viral load (HBV-DNA) plays an important role in the development of cirrhosis and hepatocellular carcinoma. The current treatment modalities for chronic hepatitis B are immunomodulatory (interferons) and antiviral suppressants (nucleoside and nucleotide analogues) all with their own advantages and limitations. An overview of the treatment efficacy for both immunomodulatory as antiviral compounds is provided in order to provide the clinician insight into the factors influencing treatment outcome. With nucleoside or nucleotide analogues suppression of viral replication by 5-7 log10 is feasible, but not all patients respond to therapy. Known factors influencing treatment outcome are viral load, ALT levels and compliance. Many other factors which might influence treatment are scarcely investigated. Identifying the factors associated with response might result in stopping rules, so treatment could be adapted in an early stage to provide adequate treatment and avoid the development of resistance. The efficacy of compounds for the treatment of mutant virus and the cross- resistance is largely unknown. However, genotypic and phenotypic testing as well as small clinical trials provided some data on efficacy in this population. Discontinuation of nucleoside or nucleotide analogues frequently results in viral relapse; however, some patients have a sustained response. Data on the risk factors for relapse are necessary in order to determine when treatment can be discontinued safely. In conclusion: chronic hepatitis B has become a treatable disease; however, much research is needed to tailor therapy to an individual patient, to predict the sustainability of response and determine thebest treatment for those failing treatment. | WF Leemans HLA Janssen RA de Man | 2007 | World Journal of Gastroenterology2007，13，18： | 14 |
| 6 | 基于OPAQ的城市空气质量预报系统研究显示文摘空气质量预测在国内的关注度日益提高,传统的空气质量预测系统通常运用数值化学传输模型,利用物理方程来计算污染物的扩散、沉降和化学反应。而化学传输模型的预测准确性很大程度上需要依赖详细的污染源排放信息和气象模型的输出结果。基于统计模型的OPAQ空气质量预报业务系统,采用人工神经网络算法,可预测各污染物的日均值或日最大值。并对北京空气质量预报的结果进行了评价,OPAQ空气质量预报业务系统对空气质量预测的准确性较高,能够利用较低的计算资源得到较为准确的预测结果。与数值预报相比,OPAQ空气质量预报业务系统不需要大量的基础数据作为输入,可弥补数值预报的不足,并成为数值预报的有力补充。 | 王淑莹 许荣 尹翠芳 Bino Maiheu Stijn Janssen Lisa Blyth | 2016 | 中国环境监测2016，32，3： | 10 |
| 7 | Optimization of Metal Coverage on the Emitter in n-Type Interdigitated Back Contact Solar Cells Using a PC2D Simulation显示文摘In interdigitated back contact(IBC)solar cells,the metal-electrode coverage on a p-type emitter is optimized by a PC2D simulation.The result shows that the variation of the metal coverage ratio(MCR)will affect both the surface passivation and the electrode-contact properties for the p-type emitter in IBC solar cells.We find that when R_(c) ranges from 0.08 to 0.16Ω·cm^(2),the MCR is optimized with a value of 25%and 33%,resulting in a highest energy-conversion efficiency.The dependences of both Voc and fill factor on MCR are simulated in order to explore the mechanism of the IBC solar cells. | 张巍 陈晨 贾锐 Janssen G.J.M. 张代生 邢钊 Bronsveld P.C.P. Weeber A.W. 金智 刘新宇 | 2013 | Chinese Physics Letters2013，30，7： | 9 |
| 8 | Molecular mechanisms of heavy metal tolerance and evolution in invertebrates显示文摘跟随基因组学革命,我们对应力位于防卫下面的分子的机制的知识极大地被扩展了。在强壮的选择压力下面,许多动物可以发展提高的应力忍耐。这能被改变蛋白质的结构完成(通过在基因的编码区域的变化) 或由改变蛋白质的数量(通过在 transcriptional 的变化规定) 。进化的后者类型能被替换在兴趣(cis 规章的变化) 或由改变 transcriptional 管理者蛋白质(trans 规章的变化) 的结构或数量的基因的倡导者完成。metallothionein 系统是在重金属的上下文的最好学习的压力反应系统之一。Metallothionein 表示被假定被金属抄写因素 1 调整(MTF-1 ) ;然而,直到现在, MTF-1 的参与仅仅为一些脊椎动物和果蝇被证明了。象线虫和蚯蚓那样的无脊椎动物上的数据建议 metallothionein 正式就职的另外的机制可能是在场的。Cd 忍耐的详细研究为土壤生活跳虫的种被做, Orchesella cincta。种类是完了的这的 metallothionein 基因在暴露金属的领域人口表示了。metallothionein 倡导者的分析表明了有功能的意义,出现在简历记者试金的广泛的多型性。在比较 20 张不同人口的研究,高快车的倡导者等位基因的频率断然在土壤与金属的集中被相关,特别 Cd。跳虫学习证明涉及细胞的应力反应的基因的那个 cis 规章的变化可以贡献金属公差的进化。 | Thierry K. S. Janssens Dick Roelofs Nico M. van Straalen | 2009 | Insect Science2009，16，1： | 9 |
| 9 | DPOAE增长曲线在中耳和耳蜗病变中的应用显示文摘DPOAE输入输出函数曲线可以了解耳蜗的非线性,耳蜗障碍输入输出函数曲线陡峭。由于中耳在传导声音过程中是线性的,可以假设DPOAE增长曲线在传导性聋中无改变,而耳蜗损伤发现陡峭的DPOAE输入输出函数曲线,反映了耳蜗感音功能的丧失。 | 张贤芬 于黎明 Daniel D.Gehr Thomas Janssen Christiane E.Michaelis Kerstin Deingruber Kerstin Lamm | 2005 | 国外医学(耳鼻咽喉科学分册)2005，29，6： | 8 |
| 10 | The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a pilot study显示文摘 | Janssens GO Gidding CE Van Lindert E J Oldenburger FR Erasmus CE Schouten-Meeteren A Y Kaanders JH | 2009 | 中国神经肿瘤杂志2009，7，3： | 8 |
| 11 | Carbon dioxide for gut distension during digestive endoscopy:Technique and practice survey显示文摘AIM:To assess the adoption of Carbon dioxide(CO2)insufflation by endoscopists from various European countries,and its determinants.METHODS:A survey was distributed to 580 endoscopists attending a live course on digestive endoscopy.RESULTS:The response rate was 24.5%.Fewer than half the respondents(66/142,46.5%)were aware of the fact that room air can be replaced by CO2 for gut distension during endoscopy,and 4.2%of respondents were actually using CO2 as the insufflation agent.Endoscopists aware of the possibility of CO2 insufflation mentioned technical difficulties in implementing the system and the absence of significant advantages of CO2 in comparison with room air as barriers to adoption in daily practice(84%and 49%of answers,respectively;two answers were permitted for this item).CONCLUSION:Based on this survey,adoption of CO2 insufflation during endoscopy seems to remain relatively exceptional.A majority of endoscopists were not aware of this possibility,while others were not aware of recent technical developments that facilitate CO2 implementation in an endoscopy suite. | Filip Janssens Jacques Deviere Pierre Eisendrath Jean-Marc Dumonceau | 2009 | World Journal of Gastroenterology2009，15，12： | 6 |
| 12 | Toll-Like Receptor Expression in the Peripheral Nerve显示文摘Toll样受体(TLRs)是由进化上相对保守的蛋白家族构成的一组识别受体,是固有免疫系统的第一道防线。受到微生物配体刺激后,TLRs通过激活各种信号通路引发机体一系列防御反应。TLRs还能被内源性危险信号激活,因此推断神经退行性变也可能通过TLRs激活免疫反应。近来研究发现中枢神经系统表达各种类型的TLRs,但周围神经系统中TLRs的表达形式尚无定论。本研究结果显示,施万细胞上表达大量TLRs,主要为TLR3和TLR4。感觉神经元和运动神经元上几乎没有TLRs表达。对NF-κB信号通路的检测显示,施万细胞上所有的TLRs都是有功能的,可被细菌脂蛋白(TLR1/TLR2配体)激活,产生强烈反应。静息状态下,坐骨神经上TLRs的表达形式与施万细胞相似,主要为TLR3、TLR4和TLR7,可能在免疫监督中扮演重要角色。通过显微外科方式对坐骨神经造成急性神经退行性变后,诱导TLR1大量表达,其它TLRs的表达水平无变化。综上所述,本研究结果显示,施万细胞可能在周围神经中扮演类似中枢神经系统小胶质细胞的角色。急性神经退行性变诱导TLR表达变化,说明在分布于周围神经的TLRs在静息状态和激活状态下具有不同功能。 | SOFIE GOETHALS ELKE YDENS VINCENT TIMMERMAN SOPHIE JANSSENS | 2010 | 神经损伤与功能重建2010，5，6： | 6 |
| 13 | Hepatitis B surface antigen quantification: Why and how to use it in 2011 – A core group report显示文摘 | Henry Lik-Yuen Chan Alex Thompson Michelle Martinot-Peignoux Teerha Piratvisuth Markus Cornberg Maurizia Rossana Brunetto Hans L. Tillmann Jia-Horng Kao Ji-Dong Jia Heiner Wedemeyer Stephen Locarnini Harry L.A. Janssen Patrick Marcellin | 2011 | Journal of Hepatology2011，，5： | 5 |
| 14 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 15 | Surgery for calcifying tendinitis of the shoulder: A systematic review显示文摘AIM To systematically search literature and determine a preferable surgical procedure in patients with failed conservative treatment of calcifying tendinitis of the shoulder.METHODS The electronic online databases MEDLINE(through PubMed), EMBASE(through OVID), CINAHL(through EBSCO), Web of Science and Cochrane Central Register of Controlled Trials were systematically searched in May 2016. Eligible for inclusion were all available studies with level Ⅱ and level Ⅲ evidence(LoE). Data was assessed and extracted by two independent review authors using a specifically for this study designed data extraction form.RESULTS Six studies(294 surgically treated shoulders) were included in this review. No significant differences between the three available treatment options(acromioplasty with the removal of the calcific deposits, acromioplasty or solely the removal of the calcific deposits) were detected regarding the functional and clinical outcome. The followup ranged from 12 mo to 5 years. Complication rates were low. No reoperations were necessary and the only reported complication was adhesive capsulitis, which in all cases could be treated conservatively with full recovery. CONCLUSION We found that all three available treatment options show good functional and clinical outcomes in the short and midterm. However, a favorable procedure is difficult to determine due to the lack of high-quality comparing studies. | Freek U Verstraelen Eric Fievez Loes Janssen Wim Morrenhof | 2017 | World Journal of Orthopedics2017，8，5： | 4 |
| 16 | Comparison of airway resistance measurements by the forced oscillation technique and the interrupter technique for detecting chronic obstructive pulmonary disease in elderly patients显示文摘 | GUO Yan-fei SUN Tie-ying Francois Herrmann Jean-Paul Janssens | 2005 | Chinese Medical Journal2005，，22： | 4 |
| 17 | External Validation of the Fatty Liver Index for Identifying Nonalcoholic Fatty Liver Disease in a Population-based Study显示文摘 | Edith M. Koehler Jeoffrey N.L. Schouten Bettina E. Hansen Albert Hofman Bruno H. Stricker Harry L.A. Janssen | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 4 |
| 18 | 一种新型的高频半导体量子点单电子泵显示文摘除了直流负电压外,还在浅法刻蚀出的GaAs/AlGaAs量子线上的两个金属指形门上分别叠加两个相位相差π的正弦信号,从而对形成量子点的两个势垒作不等幅调制.在无源漏偏压的情况下,通过周期形成的量子点实现了单电子的搬运.由于新的半导体量子点单电子泵不是依赖库仑阻塞效应通过隧穿进行单电子输运,因此,该器件就不会受到固定隧穿时间引起的低工作频率限制.在1.7K温度下,频率达到3GHz仍然可以观测到量子化电流平台,对应的电流值达到0.5nA量级.这种新器件提供了实现高速度、高精度搬运单电子的另一种可能途径. | 李玲 Kaestner B Blumenthal M D Giblin S Janssen T J B M Pepper M Anderson D Jones G Ritchie D A 高洁 | 2008 | 物理学报2008，57，3： | 4 |
| 19 | Arterial complications, venous thromboembolism and deep venous thrombosis prophylaxis after anterior cruciate ligament reconstruction: A systematic review显示文摘AIM To summarize the current knowledge on vascular complications and deep venous thrombosis(DVT) prophylaxis after anterior cruciate ligament(ACL) reconstruction.METHODS A systematic review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement. MEDLINE, EMBASE, Cochrane,Web of Science, CINAHL, PubMed publisher, and Google scholar medical literature databases were searched up to November 10, 2015. Any arthroscopic surgical method of primary or revision intra-articular ACL reconstruction of all graft types in humans was included. A risk of bias assessment was determined.RESULTS Fourty-seven studies were included in the review.Pseudaneurysms were the most frequently reported arterial complication after ACL reconstruction, irrespective of graft type or method of graft fixation with an incidence of 0.3%. The time to diagnosis of arterial complications after ACL reconstruction varied from days to mostly weeks but even years. After ACL reconstruction without thromboprophylaxis, the incidence of DVT was 9.7%, of which 2.1% was symptomatic. The incidence of pulmonary embolism was 0.1%. Tourniquet time > 2 h was related to venous thromboembolism.Thromboprophylaxis is indicated in patients with risk factors for venous thromboembolism.CONCLUSION After ACL reconstruction, the incidence of arterial complications,symptomatic DVT and pulmonary embolism was 0.3%, 2.1% and 0.1% respectively. Arterial complications may occur with all types of arthroscopic ACL reconstruction, methods of graft fixation as well as any type of graft. Patients considered to be at moderate or high risk of venous thromboembolism should routinely receive thromboprophylaxis after ACL reconstruction. | Rob Paulus Augustinus Janssen Max Reijman Daan Martijn Janssen Jan Bernardus Antonius van Mourik | 2016 | World Journal of Orthopedics2016，7，9： | 4 |
| 20 | 聚乙二醇干扰素α-2b单药或聚乙二醇干扰素α-2b联合拉米夫定治疗HBeAg阳性慢性乙型肝炎的多中心、随机、双盲、对照试验显示文摘 与干扰素非应答者相比,应答的慢性乙型肝炎(乙肝)患者发生肝硬化、肝衰竭及肝细胞癌的可能性明显下降[1,2].然而,大部分慢性乙肝患者不能获得应答.在已经获得批准治疗慢性乙肝的药物中,最常用的是干扰素和核苷类似物,如拉米夫定或阿德福韦.…… | Harry LA Janssen | 2005 | 传染病信息2005，18，z1： | 4 |
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