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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Budd-Ghiari syndrome in a patient with paroxysmal nocturnal haemoglobinuria显示文摘 | Balm Z Nattermann J Flacke S | 2005 | Dtsch Med Wochenschr2005，130，40： | 1 |
| 3 | Research on the pressurized gasification of coal with steam carbon dioxide 显示文摘 | Nattermann C Hfittinger KJ | 1994 | Petrochemie vereinigt mlt Brennstoff-Chemle1994，，47： | 1 |
| 4 | Activated gammadelta T cells express the natural cytotoxicity receptor natural killer p 44 and show cytotoxic activity against myeloma cells显示文摘 | von Lilienfeld-Toal M Nattermann J Feldmann G | 2006 | Clin Exp Immunol2006，144，3： | 1 |
| 5 | Rapid and sensitive identification of pathogenic and apathogenic Bacillus anthraeis by real time PCR 显示文摘 | Ellerbrok H Nattermann H Ozel M | 2002 | FEMS Microbiol Lett2002，214，1： | 1 |
| 6 | Impaired CD4 + T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients<!-- Doctopic: VH -->显示文摘 | Andreas Gl?ssner Marianne Eisenhardt Pavlos Kokordelis Benjamin Kr?mer Franziska Wolter Hans Dieter Nischalke Christoph Boesecke Tilman Sauerbruch Jürgen K. Rockstroh Ulrich Spengler Jacob Nattermann | 2013 | Journal of Hepatology2013，，： | 1 |
| 7 | Partial remission of a newly diagnosed diffuse large B - cell non - Hodgkin's lymphoma in a hemodialysis patient after administration of immuno - chemotherapy with rituximab - CHOP Int 显示文摘 | Feldmann G Nattermann J Gerhardt T | 2007 | Jnl Lab Hem2007，29，469： | 1 |
| 8 | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients显示文摘 | Hans Dieter Nischalke Cordula Berger Carolin Luda Tobias Müller Thomas Berg Martin Coenen Benjamin Kr?mer Christian K?rner Jonel Trebicka Frank Grünhage Frank Lammert Jacob Nattermann Tilman Sauerbruch Ulrich Spengler | 2011 | Journal of Hepatology2011，，4： | 1 |
| 9 | Rapid and sensitive identification of pathogenic and apathogenic Bacillus anthracis by real-time PCR 显示文摘 | Ellerbrok H Nattermann H Ozel M | 2002 | FEMS Microbiol Lett2002，214，1： | 1 |
| 10 | The HLA-A2 Restricted T Cell Epitope HCV Core 35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells显示文摘 | Jacob Nattermann Hans Dieter Nischalke Valeska Hofmeister Golo Ahlenstiel Henning Zimmermann Ludger Leifeld Elisabeth H. Weiss Tilman Sauerbruch Ulrich Spengler | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 11 | Regulation of CC chemokine receptor 5 in hepatitis G virus infection 显示文摘 | Nattermann J Nischalke HD Kupfer B | 2003 | AIDS2003，17，10： | 1 |
| 12 | Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C 显示文摘 | Nattermann J Feldmann G Ahlenstiel G | 2006 | Gut2006，55，6： | 1 |
| 13 | Irritable bowel syn- drome: colonoscopy painful and difficult? 显示文摘 | Nattermann C Fimmers R Bayer B | 2004 | Med Klin (Munich)2004，99，12： | 1 |
| 14 | Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis 显示文摘 | Zimmermann HW Seidler S Nattermann J | 2010 | PIoS One2010，5，11： | 1 |
| 15 | Binding of HCV E2 to CD81 induces RANTES secretion and internalization of CC chemokine receptor 5 显示文摘 | Nattermann J Nischalke H D Feldmann G | 2004 | J Viral Hepatitis2004，11，： | 1 |
| 16 | Interferon-lambda serum levels in hepatitis C显示文摘 | Bettina Langhans Bernd Kupfer Ingrid Braunschweiger Simone Arndt Wibke Schulte Hans Dieter Nischalke Jacob Nattermann Johannes Oldenburg Tilman Sauerbruch Ulrich Spengler | 2010 | Journal of Hepatology2010，，5： | 1 |
| 17 | Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C 显示文摘 | Nattermann J Zimmermann H Iwan A | 2006 | Hepatology2006，44，4： | 1 |
| 18 | Rapid and sensitive identification of pathogenic and apathogenic Bacilus anthracis by real-time PCR显示文摘 | Heinz E H Nattermann M O Lothar B | 2002 | FEMS Microbiology Letters2002，214，： | 1 |
| 19 | Binding of HCV E2 to CD81 induces RANTES secretion and internalization of CC chemokine receptor 5 显示文摘 | Nattermann J Nischalke HD Feldmann G | 2004 | J Viral Hepat2004，11，6： | 1 |
| 20 | Functional contri- bution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis 显示文摘 | Zimmermann HW Seidler S Nattermann J | 2010 | PLoS One2010，5，11： | 1 |
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