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| 1 | 虚拟水贸易在我国粮食安全问题中的应用显示文摘借助虚拟水的概念,分析以粮食为载体的虚拟水国际、区际流量关系,以勾勒我国虚拟水贸易的基本格局。通过对未来我国在不同粮食发展战略下的粮食供需情况,确定我国粮食进口基本规模,对未来我国虚拟水贸易格局进行展望。分析结果表明,1999年我国北方通过粮食贸易向南方地区输出的虚拟水量达到184亿m^3。我国北方地区以有限的水资源在支持其他区域发展、确保国家粮食安全方面发挥了不可替代的作用。未来30年中国将面临新增粮食需求1.4亿~2.0亿t的巨大压力,在保持较高自给水平的前提下,我国虚拟水贸易的格局不会发生重大变化。外流域调水工程是保障国家粮食安全,维护社会稳定,促进可持续发展和造福中国人民的重大举措。虚拟水战略可作为跨流域调水的补充,在保障缺水地区水安全方面发挥重要作用。 | 马静 汪党献 A. Y. Hoekstra 夏海霞 | 2006 | 水科学进展2006，17，1： | 80 |
| 2 | 虚拟水贸易与跨流域调水显示文摘虚拟水贸易被认为是提高全球水资源利用效率及保障缺水地区水安全的有效工具。借助于虚拟水的概念,以我国南北方及各区域间的虚拟水贸易量为切入点,计算了我国各区域间的虚拟水流量关系,分析了水以真实形式和虚拟形式在我国南北方之间逆向流动的主要原因。在目前及将来虚拟水区域关系不发生根本性变化的情况下,南水北调工程不仅是解决我国北方地区水资源短缺和优化农业资源合理配置的有效途径,也是保障国家粮食安全,维护社会稳定,促进社会经济可持续发展的重大举措。虚拟水贸易可以作为跨流域调水的补充在保障缺水地区水安全方面发挥重要作用。 | 马静 汪党献 Hoekstra A.Y. | 2004 | 中国水利2004，，13： | 39 |
| 3 | Evolving management of colorectal cancer显示文摘This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ('outside in integrin signaling') is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future. | Jochem van der Voort van Zijp Harald J Hoekstra Marc D Basson | 2008 | World Journal of Gastroenterology2008，14，25： | 16 |
| 4 | Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region显示文摘Recommendations for probiotics are available in several regions. This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed. Evidence-based recommendations and randomized controlled trials in the region were revised. Cultural aspects,health management issues and economic factors were also considered. Final recommendations were approved by applying the Likert scale and rated using the GRADE system. Saccharomyces boulardii CNCM I-745(Sb) and Lactobacillus rhamnosus GG(LGG) were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis. Lactobacillus reuteri could also be considered. Probiotics may be considered for prevention of(with the indicated strains): antibiotic-associated diarrhea(LGG or Sb); Clostridium difficile-induced diarrhea(Sb); nosocomial diarrhea(LGG); infantile colic(L reuteri) and as adjunct treatment of Helicobacter pylori(Sb and others). Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries. These need to be validated with local randomized-controlled trials. | Donald Cameron Quak Seng Hock Musal Kadim Neelam Mohan Eell Ryoo Bhupinder Sandhu Yuichiro Yamashiro Chen Jie Hans Hoekstra Alfredo Guarino | 2017 | World Journal of Gastroenterology2017，23，45： | 14 |
| 5 | Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism显示文摘Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. | Menno Hoekstra Theo JC Van Berkel Miranda Van Eck | 2010 | World Journal of Gastroenterology2010，16，47： | 11 |
| 6 | 神经退行性疾病与2型糖尿病显示文摘阿尔茨海默病(Alzheimer's disease,AD)和帕金森病(Parkinson's disease,PD)是最常见的神经退行性疾病,AD是老年性痴呆最常见的形式之一,临床特征为进行性的认知和记忆功能减退;PD是最常见的运动障碍疾病,主要临床症状为静止性震颤、肌强直、运动迟缓以及姿势步态异常。2型糖尿病(type 2 diabetes mllitus,T2DM)为复杂性代谢性疾病,以胰岛素抵抗和胰岛β细胞功能损害为特点。通常认为这三者是独立的疾病,然而最近的流行病学调查显示AD、PD与T2DM之间存在密切的联系;基础研究提示三者之间可能存在共同的病理生理机制,涉及淀粉样蛋白生成机制、胰岛素抵抗以及线粒体功能障碍等方面,最终分别导致大脑神经元损失、黑质致密部多巴胺能神经元死亡和胰岛β细胞功能障碍。本文就AD、PD与T2DM之间的联系及相关治疗进展进行综述。 | 刘长勤 Jake Hoekstra 熊康平 章京 | 2014 | 转化医学研究(电子版)2014，4，2： | 4 |
| 7 | Water footprints of nations: Water use by people as a function of their consumption pattern显示文摘 | A. Y. Hoekstra A. K. Chapagain | 2007 | Water Resources Management2007，，1： | 4 |
| 8 | Physiological and Biochemical Basis of Clinical Liver Function Tests: A Review显示文摘 | Lisette T. Hoekstra Wilmar de Graaf Geert A. A. Nibourg Michal Heger Roelof J. Bennink Bruno Stieger Thomas M. van Gulik | 2013 | Annals of Surgery2013，，1： | 3 |
| 9 | The economic impact of restricted water supply: A computable general equilibrium analysis显示文摘 | Maria Berrittella Arjen Y. Hoekstra Katrin Rehdanz Roberto Roson Richard S.J. Tol | 2007 | Water Research2007，，8： | 2 |
| 10 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 11 | A global and high-resolution assessment of the green, blue and grey water footprint of wheat显示文摘 | Mekonnen M. M. Hoekstra A. Y | 2010 | Hydrology and Earth System Sciences2010，，121： | 2 |
| 12 | Water footprints of nations: Water use by people as a function of their consumption pattern显示文摘 | A. Y. Hoekstra A. K. Chapagain | 2007 | Water Resources Management2007，，1： | 2 |
| 13 | Causes and consequences of ischemic-type biliary lesions after liver transplantation显示文摘 | Carlijn I. Buis Harm Hoekstra Robert C. Verdonk Robert J. Porte | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，6： | 2 |
| 14 | FDG-PET has no definite role in preoperative imaging in gastric cancer显示文摘 | A.E. Dassen D.J. Lips C.J. Hoekstra J.F.M. Pruijt K. Bosscha | 2008 | European Journal of Surgical Oncology2008，，5： | 2 |
| 15 | The water footprint of energy from biomass: A quantitative assessment and consequences of an increasing share of bio-energy in energy supply显示文摘 | P.W. Gerbens-Leenes A.Y. Hoekstra Th. van der Meer | 2008 | Ecological Economics2008，，4： | 2 |
| 16 | Apoptosis in developing anthers and the role of ABA in this process during androgenesis in Hordeum vulgate L显示文摘 | WANG M HOEKSTRA S VAN BERGEN S LAMERS GEM OPPEDIJK B J VAN DER HEUDEN M W DE PRIESTER W SCHILPEROORT RA 1 | 1999 | Plant Mol Biol1999，39，： | 1 |
| 17 | Dispersal of suspended sediments in the turbid and highly stratified Red River plume 显示文摘 | Van Maren and Hoekstra | 2005 | Continental Shelf Researeh (2005)2005，25，： | 1 |
| 18 | The impact of robotics on practice management of endometrial cancer:transitioning from traditional surgery显示文摘 | Hoekstra AV Jairam-Thodla A Rademaker A | 2009 | Int J Med Robot2009，5，4： | 1 |
| 19 | Stress cardiac magnetic resonance imaging with observation unit care reduces cost for patients with emergent chest pain: a randomized trial显示文摘 | Miller CD Hwang W Hoekstra JW | 2010 | Ann Emerg Med2010，56，3： | 1 |
| 20 | The water footprint of cotton consumption: An assessment of the impact of worldwide consumption of cotton products on the water resources in the cotton producing countries显示文摘 | CHAPAGAIN A K HOEKSTRA A Y SAVENIJE H H G | 2006 | Eco- logical Economics2006，60，1： | 1 |
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