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| 1 | An Update on Abscisic Acid Signaling in Plants and More显示文摘 | Aleksandra Wasilewsk.a Florina Vlad Caroline Sirichandra Yulia Redko Fabien Jammes Christiane Valon Nicolas Frei dit Frey Jeffrey Leung | 2008 | Molecular Plant2008，1，2： | 46 |
| 2 | 早期帕金森病患者健康相关生活质量显示文摘目的研究中国早期帕金森病(PD)患者健康相关生活质量(healthrelatedqualityoflife,HR—QOL)的特点;探讨运动症状和非运动症状对早期PD患者HR—QOL的影响。方法在全国范围内共筛选出391例早期PD患者入组。采用统一帕金森病评分表(UPDRS)和Hoehn—Yahr评价运动症状,采用流行病学研究中心编制的抑郁量表(CES—D)、匹兹堡睡眠质量指数(PSQI)、疲劳量表(rss)、阿尔茨海默病评定量表的认知部分(ADAS—Cog)和便秘量表分别对抑郁、睡眠障碍、疲劳、认知功能和便秘等非运动症状进行评价;采用36条目简化医疗结局调查问卷(SF-36)评价HR—QOL。比较PD患者与同龄健康老年人SF-36分值的差异。采用逐步多元线性回归分析深入探讨各种运动及非运动症状变量对HR-QOL的影响。结果早期PD患者除SF-36躯体疼痛维度外,其余各维度分值较同龄健康老年人均下降。UPDRS第3部分分值(23.8±11.8)、Hoehn—Yahr分期(2.0±0.7)和强直分值(4.4±3.1)仅能解释SF-36总分变化的18.9%(R2=0.189)。CES—D、FSS和PSQ1分值等非运动症状变量引入回归方程后,SF-36总分可被解释的部分由18.9%增加至61.7%(R2=0.617)。并且,引入CES-D分值后,SF-36总分可被解释的部分增加了43.3%(R2=0.433)。结论PD症状严重影响早期患者的HR—QOL。运动症状对HR—QOL存在影响,但影响作用有限。抑郁、疲劳和睡眠障碍这3个非运动症状是导致早期PD患者HR—QOL恶化的主要原因。其中,抑郁症状是HR-QOL恶化的最强预测因素。临床上,应重视非运动症状,运动和非运动症状兼治,才能真正提高疗效显著改善患者的HR—QOL。 | 秦朝晖 陈彪 张丽燕 樊文辉 孙菲 方向华 孟琛 Caroline Tanner | 2009 | 中华神经科杂志2009，42，8： | 42 |
| 3 | 湖北成人CD_4、CD_8T淋巴细胞计数正常值调查及CD_4与总淋巴细胞数的相关性分析显示文摘目的了解中国湖北成人CD4抗原阳性的T淋巴细胞(CD4)、CD8抗原阳性的T淋巴细胞(CD8)、CD3抗原阳性的T淋巴细胞(CD3)及CD4/CD8、CD4/CD3正常值参考范围,以及总淋巴细胞计数(TLC)与CD4之间的关系.方法选取120例15~60岁健康人不同年龄组的血标本,用Becton Dickinson公司生产的FACSCount自动化仪检测CD4、CD8、CD3、CD4/CD8、CD4/CD3,计算相关数据的正常值参考范围,并将其与国外数据作比较.用美国雅培CEILDYN(R)3700血液全自动分析仪作全血总淋巴细胞计数.结果CD4值为681±21/mm3(-x±Sd,以下相同),CD8值为510±26/mm3,CD3值为1 299±38/mm3,CD4/CD8值为1.43±0.06,CD4/CD3值为0.54±0.10,TLC值为1 752±48/mm3.CD4、CD8、CD3计数及CD4/CD8、CD4/CD3在不同性别、年龄组之间差别无显著性.CD4与TLC之间有显著的直线正相关性,r=0.647,回归方程为√CD4=0.422√TLC+8.444.结论CD4、CD3、CD8等正常值在不同性别、年龄间相近.中国湖北成人CD4值与中国上海成人之间无差别,但显著低于国外值.在无条件检测CD4计数的情况下,可用TLC推测CD4的值.中国现有的治疗标准需要进一步探讨. | 陈铁龙 桂希恩 邓莉萍 Caroline Teter 孙静 | 2005 | 中国艾滋病性病2005，11，4： | 35 |
| 4 | New Opportunities for Lanthanide Luminescence显示文摘三价的 lanthanide 离子显示迷人的光性质。相应元素和他们的第一工业使用的发现亲密地被连接到他们的光性质。这种关系被使活着直到什么时候的今天象节省精力的灯光的设备,显示,光纤维和放大器,激光,为生物医学的分析并且在察觉到的 celluio 的应答的光污点和成像那样的包含 lanthanide 材料的许多高科技应用,重重地依靠 lanthanide 离子的灿烂、纯颜色的排放。在这评论,我们首先在 f-f 转变,促进感受性机制,和对包含 lanthanide 的光效率的评价上与强调构画出 lanthanide 光的基础放射性的分子的大厦。强调然后被放在 lanthanide 光的二个快发展中方面上:为电信和轻射出二极管的材料,和生物医学的成像并且察觉到。在为塑料放大器和波导的射出 NIR 材料的最近的进展被描述,和最小化激动的状态的非放射的释放的研究人员带的主要答案。在 1999 那耳 tris (8-hydroxyquinolinate ) 的示范显示了合适的明亮绿的排出物因为射出二极管(OLED ) 的器官的光被认识到在 OLED, 25% 刺激精力导致汗衫状态, 75% 说到三位字节跟随。因为 lanthanide 离子是好三位字节,熄灭 ers,他们现在也在这些灯光的设备的发展起一个关键作用。生物分子的光分析在知道的最敏感的分析技术之中。lanthanide 的长一生使状态激动允许解决时间的光谱学被过去常,压制样品汽车荧光并且到达很低的察觉限制。可见 lanthanide 传感器现在无所不在地不仅在医药诊断并且在房间成像被规定,而且使用象 Yb (III ) 那样的离子的 NIR 排放的可行性现在是因为更深的穿入,在生物纸巾被测试。 | Jean-Claude G. Bünzli Steve Comby Anne-Sophie Chauvin Caroline D. B. Vandevyver | 2007 | Journal of Rare Earths2007，25，3： | 31 |
| 5 | Thermal Treatment of Hydrocarbon-Impacted Soils" A Review of Technology Innovation for Sustainable Remediation显示文摘在受烃污染的土壤和底泥的修复处理工艺中,热处理工艺因其能快速且稳定地达到修复标准而占有重要地位。然而,持续高温属于能源密集型操作,且可破坏土壤性质,因此尽管此工艺被广泛应用,关于这些工艺的环境兼容性和可持续性却极少被报道。鉴于此,我们对几个针对烃污染土壤的常用热处理工艺进行了概述,对它们的潜在环境影响进行了评估;并基于能源需求、水需求、系统生态和土壤科学的全面考虑,提出了可持续且影响较小的发展框架。至今还没有一种通用适合的热处理工艺。工艺的恰当选择要根据污染状况(包括环境中存在的烃种类)和场地特征(如被污染土壤的性质、水含量和热敏性)而定。总之,处理工程与土壤科学、生态系统和植物生物学研究的有机结合是攻克技术瓶颈、提高去除率和促进热处理工艺可持续性发展的关键所在。 | Julia E. Vidonish Kyriacos Zygourakis Caroline A. Masiello Gabriel Sabadell Pedro J. J. Alvarez | 2016 | Engineering2016，2，4： | 27 |
| 6 | 早期帕金森病患者非运动性症状与健康相关生活质量的研究:随机对照临床试验显示文摘目的探讨早期帕金森病患者非运动性症状与健康相关生活质量的关系,以及健康相关生活质量的影响因素。方法391例原发性帕金森病患者,采用美国国立卫生研究院流行病学研究中心抑郁量表(CES—D)、匹兹堡睡眠质量指数(PSQI)、疲劳量表(FSS)、阿尔茨海默病评价量表一认知分量表(ADAS—Cog)和便秘量表(CSS)评价其抑郁、睡眠障碍、疲劳、认知障碍和便秘程度,简化36医疗结局研究量表(SF-36)评价其健康相关生活质量。结果391例患者中,抑郁、睡眠障碍、疲劳、记忆障碍和便秘者分别占37.34%(146/391)、54.73%(214/391)、40.15%(157/391)、34.78%(136/391)和46.55%(182/391)。抑郁症状者与无抑郁症状者(t=18.469,P=0.000)、睡眠障碍者与无睡眠障碍者(t=7.411,P=0.000)、疲劳者与无疲劳者(t=3.992,P=0.000)比较,SF-36总评分差异具有统计学意义;而记忆障碍者与无记忆障碍者(t=1.234,P=0.221)、便秘者与无便秘者(t=2.032,P=0.051)比较,SF-36总评分差异无统计学意义。将CES—D评分、PSQI评分和FSS评分引入回归方程,雕值由0.277增至0.649,提示SF-36总评分可被预测的部分由27.70%增至64.90%;CES.D评分不仅对SF-36总评分有预测价值,而且对8个维度评分均有预测价值(P〈0.05)。结论早期帕金森病患者普遍存在非运动性症状,其中抑郁、睡眠障碍、疲劳是导致健康相关生活质量恶化的主要原因。抑郁全面影响患者健康相关生活质量,是早期帕金森病患者健康相关生活质量恶化的最强预测因素。 | 秦朝晖 陈彪 张丽燕 樊文辉 孙菲 刘宏军 方向华 丁晖 孟琛 Caroline Tanner | 2009 | 中国现代神经疾病杂志2009，9，3： | 24 |
| 7 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 8 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 9 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 10 | Liver transplantation: Current status and challenges显示文摘Great progress has been made in the field of liver transplantation over the past two decades. This progress, however, also brings up the next set of challenges: First, organ shortage remains a major limitation, and accounts for a large proportion of wait list mortality. While living donation has successfully increased the total number of liver transplants done in Asian countries, the total number of such transplants has been stagnant in the western hemisphere. As such, there has been a significant effort over the past decade to increase the existing deceased donor pool. This effort has resulted in a greater use of liver allografts following donation after cardiac death(DCD) along with marginal and extended criteria donors. Improved understanding of the pathophysiology of liver allografts procured after circulatory arrest has not only resulted in better selection and management of DCD donors, but has also helped in the development of mechanical perfusion strategies. Early outcomes demonstrating the clinical applicability of both hypothermic and normothermic perfusion and its potential to impact patient survival and allograft function have generated much interest. Second, long-term outcomes of liver transplant recipients have not improved significantly, as recipients continue to succumb to complications of long-term immunosuppression, such as infection, malignancy and renal failure. Furthermore, recent evidence suggests that chronic immune-mediated injury to the liver may also impact graft function. | Caroline C Jadlowiec Timucin Taner | 2016 | World Journal of Gastroenterology2016，22，18： | 23 |
| 11 | Effect of alcohol consumption on liver stiffness measured by transient elastography显示文摘AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or continuation.METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver disease.TE was performed at least one week apart by senior operator.TE examinations with less than ten successful measures or with an interquartile range above 30% were excluded.We retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was available.Concomitant biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were recorded.Putative fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis C.Initial and final putative fibrosis score were compared according to alcohol consumption during follow-up.RESULTS:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two examinations.Thirty-seven patients met our criteria with a median follow-up of 32.5 wk.At the end of the study,13(35%) were abstinent,and 24(65%) relapsers.Eight patients had liver biopsy during follow-up.TE decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off value.In relapsers TE increased in 45% and decreased in 54% of patient.There was no statistical difference between initial and final TE in relapsers.In the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final TE.Using 19.5 kPa as cut-off for cirrhosis,7 patients had cirrhosis at initial TE and 5 patients had cirrhosis at final TE.Using 12.5 kPa as cut-off for cirrhosis,16 patients had cirrhosis at initial TE and 15 patients had cirrhosis at final TE.Evolution of biological data was in accordance with the relapse or abstinent status:abstinence ratio(duration of abstinence/duration follow-up) was correlated with AST ratio(r =-0.465,P = 0.007) and GGT ratio(r =-0.662,P<0.0001).GGT was correlated with initial(r = 0.488,P = 0.002) and final TE(r = 0.49,P<0.005).Final TE was correlated with AST(r = 0.362,P<0.05).Correlation between TE ratio and AST ratio(r = 0.44,P = 0.01) revealed that TE varied proportionally to AST for all patients irrespective of their alcohol status.The same relationship was observed between TE ratio and GGT ratio(r = 0.65,P<0.0001).Evolution of TE was significantly correlated with the ratio of time of abstinence to observation time(r =-0.387,P = 0.016) and the evolution of liver enzymes.CONCLUSION:TE significantly decreased with abstinence.Results of TE in alcoholic liver disease cannot be interpreted without taking into account alcohol consumption and liver enzymes. | Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand | 2013 | World Journal of Gastroenterology2013，19，4： | 20 |
| 12 | Systems Biology of Plant-Microbiome Interactions显示文摘In natural environments,plants are exposed to diverse microbiota that they interact with in complex ways.While plant-pathogen interactions have been intensely studied to understand defense mechanisms in plants,many microbes and microbial communities can have substantial beneficial effects on their plant host.Such beneficial effects include improved acquisition of nutrients,accelerated growth,resilience against pathogens,and improved resistance against abiotic stress conditions such as heat,drought,and salinity.However,the beneficial effects of bacterial strains or consortia on their host are often cultivar and species specific,posing an obstacle to their general application.Remarkably,many of the signals that trigger plant immune responses are molecularly highly similar and often identical in pathogenic and beneficial microbes.Thus,it is unclear what determines the outcome of a particular microbe-host interaction and which factors enable plants to distinguish beneficials from pathogens.To unravel the complex network of genetic,microbial,and metabolic interactions,including the signaling events mediating microbe-host interactions,comprehensive quantitative systems biology approaches will be needed. | Patricia A.Rodriguez Michael Rothballer Soumitra Paul Chowdhury Thomas Nussbaumer Caroline Gutjahr Pascal Falter-Braun | 2019 | Molecular Plant2019，12，6： | 20 |
| 13 | Use of antibiotics in broiler production:Global impacts and alternatives显示文摘Antibiotics are used to fight bacterial infections.However, a selective pressure gave rise to bacteria resistant to antibiotics.This leaves scientists worried about the danger to human and animal health.Some strategies can be borrowed to reduce the use of antibiotics in chicken farms.Much research has been carried out to look for natural agents with similar beneficial effects of growth promoters.The aim of these alternatives is to maintain a low mortality rate, a good level of animal yield while preserving environment and consumer health.Among these, the most popular are probiotics, prebiotics, enzymes,organic acids, immunostimulants, bacteriocins, bacteriophages, phytogenic feed additives, phytoncides,nanoparticles and essential oils. | Youcef Mehdi Marie-Pierre Létourneau-Montminy Marie-Lou Gaucher Younes Chorfi Gayatri Suresh Tarek Rouissi Satinder Kaur Brar Caroline Cté Antonio Avalos Ramirez Stéphane Godbout | 2018 | Animal Nutrition2018，，2： | 19 |
| 14 | Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening:A meta-analysis显示文摘AIM:To present a critical discussion of the efficacy of the faecal pyruvate kinase isoenzyme type M2(faecal M2-PK) test for colorectal cancer(CRC) screening based on the currently available studies.METHODS:A literature search in PubMed and Embase was conducted using the following search terms:fecal Tumor M2-PK,faecal Tumour M2-PK,fecal M2-PK,faecal M2-PK,fecal pyruvate kinase,faecal pyruvate kinase,pyruvate kinase stool and M2-PK stool.RESULTS:Stool samples from 704 patients with CRC and from 11 412 healthy subjects have been investigated for faecal M2-PK concentrations in seventeen independent studies.The mean faecal M2-PK sensitivity was 80.3%;the specificity was 95.2%.Four studies compared faecal M2-PK head-to-head with guaiacbased faecal occult blood test(gFOBT).Faecal M2PK demonstrated a sensitivity of 81.1%,whereas the gFOBT detected only 36.9% of the CRCs.Eight independent studies investigated the sensitivity of faecal M2-PK for adenoma(n = 554),with the following sensitivities:adenoma < 1 cm in diameter:25%;adenoma > 1 cm:44%;adenoma of unspecified diameter:51%.In a direct comparison with gFOBT of adenoma > 1 cm in diameter,47% tested positive with the faecal M2-PK test,whereas the gFOBT detected only 27%.CONCLUSION:We recommend faecal M2-PK as a routine test for CRC screening.Faecal M2-PK closes a gap in clinical practice because it detects bleeding and nonbleeding tumors and adenoma with high sensitivity and specificity. | Carolin Tonus Markus Sellinger Konrad Koss Gero Neupert | 2012 | World Journal of Gastroenterology2012，18，30： | 17 |
| 15 | Synthesis and purification of long copper nanowires. Application to high performance flexible transparent electrodes with and without PEDOT:PSS显示文摘 | Celine Mayousse Caroline Celle Alexandre Carella Jean-Pierre Simonato | 2014 | Nano Research2014，7，3： | 16 |
| 16 | Short and long term prognosis in perinatal asphyxia: An update显示文摘Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to neonatal encephalopathy(NE) and resultant long-term damage. While the majority of infants who are exposed to perinatal hypoxia-ischaemia will recover quickly and go on to have a completely normal survival, a proportion will suffer from an evolving clinical encephalopathy termed hypoxic-ischaemic encephalopathy(HIE) or NE if the diagnosis is unclear. Resultant complications of HIE/NE are wide-ranging and may affect the motor, sensory, cognitive and behavioural outcome of the child. The advent of therapeutic hypothermia as a neuroprotective treatment for those with moderate and severe encephalopathy has improved prognosis. Outcome prediction in these infants has changed, but is more important than ever, as hypothermia is a time sensitive intervention, with a very narrow therapeutic window. To identify those who will benefit from current and emerging neuroprotective therapies we must be able to establish the severity of their injury soon after birth. Currently available indicators such as blood biochemistry, clinical examination and electrophysiology are limited. Emerging biological and physiological markers have the potential to improve our ability to select those infants who will benefit most from intervention. Biomarkers identified from work in proteomics, metabolomics and transcriptomics as well as physiological markers such as heart rate variability, EEG analysis and radiological imaging when combined with neuroprotective measures have the potential to improve outcome in HIE/NE. The aim of this review is to give an overview of the literature in regards to short and longterm outcome following perinatal asphyxia, and to discuss the prediction of this outcome in the early hours after birth when intervention is most crucial; looking at both currently available tools and introducing novel markers. | Caroline E Ahearne Geraldine B Boylan Deirdre M Murray | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 16 |
| 17 | Nucleocytoplasmic shuttling of Smad proteins显示文摘活跃 Smad 建筑群的原子累积为转变生长因素尾的 transduction 是关键的(从进原子核的 transmembrane 受体的 TGF- 尾) 总科信号。在缺席和一个 TGF- 尾 - 总科信号的存在, Smads 的 nucleocytoplasmic 分布不是静态的,现在是清楚的,但是相反 Smads 是连续地,在原子核之间的 shuttling 和在两个的细胞质调节。这篇文章为 Smads 的连续 nucleocytoplasmic shuttling 介绍证据。它然后考察被建议了调停的不同机制 Smad 原子进出口,并且讨论在缺席的 Smad 不变的分布和一个 TGF- 尾 - 总科信号的存在怎么被建立。最后,为由 TGF- 尾总科成员发信号的连续 nucleocytoplasmic shuttling 的生物关联被讨论。 | Caroline S Hill | 2009 | Cell Research2009，19，1： | 16 |
| 18 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 19 | Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK显示文摘AIM: To evaluate the utility of the innovative fecal tumor M2-Pyruvate kinase (M2-PK) test in our daily clinical routine, as a marker for the pre-selection of patients who should subsequently undergo colonoscopy for the diagnosis or exclusion of colorectal cancer. METHODS: Fecal tumor M2-PK was measured in stool samples of 96 study participants (33 patients with colorectal cancer, 21 patients with rectal carcinoma and 42 controls) who all underwent total colonoscopy. RESULTS: In 39 of 42 individuals in the control group, fecal tumor M2-PK was below 4.0 kU/L (93% specificity). Colorectal tumors were accompanied by a highly significant increase (P < 0.001) in fecal tumor M2- PK levels (median: colon carcinoma, 23.1 kU/L; rectal carcinoma, 6.9 kU/L; colorectal carcinoma, 14.7 kU/L), which correlated with Duke’s staging and T-classification. The overall sensitivity was 78% for colorectal cancer, increasing from 60% for stage T1 to 100% for stage T4 and from 60% for Duke’s A to 90% for Duke’s D tumors. CONCLUSION: Fecal tumor M2-PK is an appropriately sensitive tool to pre-select those patients requiring colonoscopy for the further diagnostic confirmation or exclusion of colorectal cancer. | Carolin Tonus Gero Neupert Markus Sellinger | 2006 | World Journal of Gastroenterology2006，12，43： | 14 |
| 20 | Histone Acetyltransferase AtGCN5/HAG1 Is a Versatile Regulator of Developmental and Inducible Gene Expression in Arabidopsis显示文摘Histone acetylation/deacetylation 是一个动态过程并且在基因规定起一个重要作用。Histone acetylation 动态平衡被 histone acetyltransferases (帽子) 和 deacetylases (HDAC ) 的对手行动调整。植物染色体编码多重帽子和 HDAC。在许多植物开发的一个必要角色处理的 Arabidopsis 帽子基因 AtGCN5/HAG1plays 例如分裂组织功能,房间区别,叶和花的 organogenesis ,并且对象光和寒冷那样的环境条件的回答,在长期的发展开关和短期的可诱导的基因表示的规定显示这顶帽子的一个重要角色。AtGCN5 目标到很多倡导者并且为几 histone H3 离氨酸残余的 acetylation 被要求。到目标倡导者的 AtGCN5 的招募是可能的被和 DNA 有约束力的抄写因素的直接或间接的相互作用或由和 acetylated histone 离氨酸残余的相互作用在目标上调停。在 AtGCN5 和另外的帽子和 HDAC 之间的相互影响被表明控制特定的规章的小径。在光可诱导的基因表示的 AtGCN5 的角色的分析在为 priming 准备染色质承诺建议 AtGCN5 的功能在植物的可诱导的基因激活。 | Caroline Servet Natalia Conde e Silva Dao-Xiu Zhou | 2010 | Molecular Plant2010，3，4： | 14 |
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