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| 1 | Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion显示文摘Xerostomia is a severe side effect of radiation therapy in head and neck cancer patients. To date, no satisfactory treatment option has been established. Because mesenchymal stem cells(MSCs) have been identified as a potential treatment modality, we aimed to evaluate stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyse the effects of MSC injections on the recruitment of immune cells. The submandibular gland ducts of rats were surgically ligated. Syngeneic adult MSCs were isolated, immortalised by simian virus 40(SV40) large T antigen and characterized by flow cytometry. MSCs were injected intravenously and intraglandularly. After 1, 3 and 7 days, the organs of interest were analysed for stem cell recruitment. Inflammation was analysed by immunohistochemical staining. We were able to demonstrate that, after intravenous injection, MSCs were recruited to normal and damaged submandibular glands on days 1, 3 and 7. Unexpectedly, stem cells were recruited to ligated and non-ligated glands in a comparable manner. After intraglandular injection of MSCs into ligated glands, the presence of MSCs, leucocytes and macrophages was enhanced, compared to intravenous injection of stem cells. Our data suggest that injected MSCs were retained within the inflamed glands, could become activated and subsequently recruited leucocytes to the sites of tissue damage. | Silke Schwarz Ralf Huss Michaela Schulz-Siegmund Breda Vogel Sven Brandau Stephan Lang Nicole Rotter | 2014 | International Journal of Oral Science2014，6，3： | 5 |
| 2 | Microbiological spoilage of fish and fish products显示文摘 | Lone Gram Hans Henrik Huss | 1996 | International Journal of Food Microbiology1996，，1： | 3 |
| 3 | The effect of biogenic amine production by single bacterial cultures and metabiosis on coldsmoked salmon显示文摘 | Jorgensen L V Huss H H Dalgaard P | 2000 | J Appl Microbiol2000，89，： | 2 |
| 4 | Molecular evolution of pteri dophytes and their relationship to seed plants: Evidence from complete 18S rRNA gene sequences显示文摘 | Kranz H D Huss V A R | 1996 | Plant Systematics and Evolution1996，202，1： | 1 |
| 5 | Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic re- generation in vivo 显示文摘 | Conrad C Niess H Huss R | 2009 | Circulation2009，119，2： | 1 |
| 6 | Enterocutaneous intestinal fis- tula: Are treatments improving显示文摘 | Draus JM Huss SA Harry NJ | 2006 | Surgery2006，140，： | 1 |
| 7 | Enterocutaneous fistula: Are treatments improving?显示文摘 | John M. Draus Sara A. Huss Niall J. Harty William G. Cheadle Gerald M. Larson | 2006 | Surgery2006，，4： | 1 |
| 8 | The acquisition of robust and flexible cognitive skills显示文摘 | Taatgen N. A D. Huss D. Dickison J.R.Anderson | | 0，，： | 1 |
| 9 | Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children显示文摘 | Jan Philipp Schuchardt Michael Huss Manuela Stauss-Grabo Andreas Hahn | 2010 | European Journal of Pediatrics2010，，2： | 1 |
| 10 | Oxygen isotopic compositions of chonch-ules: Implications for evolution of oxygen isotopic reservoirs in the inner solar nebula显示文摘 | Krot A N Yurimoto H Mckeegan K D Leshin L Chaussidon M Libourel G Yoshitake M Huss G R Guan Y Zanda B | 2006 | Chem Erde2006，66，4： | 1 |
| 11 | Evidence of peripheralblood-derived,plastic adherent CD34 hematopoietic stemcell clones with mesenchymal stem cell characteristics显示文摘 | Huss R Lange C Weissinger EM | 2000 | Stem Cells2000，18，4： | 1 |
| 12 | A review of treatment with mepolizumab, an anti - IL - 5 mAb, in hypereosinophilic syndromes and asthma 显示文摘 | Busse WW Ring J Huss - Marp J | 2010 | J AUergy Clin Immunol2010，125，4： | 1 |
| 13 | Nuclear receptor signaling and cardiac energetics 显示文摘 | Huss J M Kelly DP | 2004 | Circ Res2004，95，： | 1 |
| 14 | Dendritic cells in precancerous lesions of the larynx显示文摘 | Sprinzl GM Huss B Obrist P | 2000 | Laryngoscope2000，110，1： | 1 |
| 15 | Going-concern opinions:the effects of partner compensation plans and client size显示文摘 | Carcello J Hermanson D Huss H | 2000 | Auditing2000，19，： | 1 |
| 16 | Evidence of peripheral blood-derived,plastic-adherent CD34(-/low) hematopoietic stem cell clones with mesenchymal stem cell characteristics显示文摘 | Huss R Lange C Weissinger EM | 2000 | Stem Cells2000，18，4： | 1 |
| 17 | LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models显示文摘 | S. Betty Yan Victoria L. Peek Rose Ajamie Sean G. Buchanan Jeremy R. Graff Steven A. Heidler Yu-Hua Hui Karen L. Huss Bruce W. Konicek Jason R. Manro Chuan Shih Julie A. Stewart Trent R. Stewart Stephanie L. Stout Mark T. Uhlik Suzane L. Um Yong Wang Wenj | 2013 | Investigational New Drugs2013，，4： | 1 |
| 18 | Lightning injuries-a mixture of electrical, thermal and multiple trauma 显示文摘 | Huss F Erlandsson U Cooray V | 2004 | Lakartidningen2004，101，2829： | 1 |
| 19 | Aetnorhizal symbioses and their N2 fixation显示文摘 | HUSS -DANELL K | 1997 | New Phytol1997，136，： | 1 |
| 20 | PGC-1a coactivates PDK4 gene phan nuclear receptor ERRα: a expression via the or for tran scriptional control of muscle glucose metabolism 显示文摘 | WENDE A R HUSS J M SCHAEFFER P J | 2005 | Mol Cell Biol2005，25，10： | 1 |
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