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| 1 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 2 | T cell immune responses to SARS-CoV-2 and variants of concern(Alpha and Delta)in infected and vaccinated individuals显示文摘Our understanding of immune responses to SARS-CoV-2 and variants of concern(VOCs)has been primarily acquired through analysis of Spike-specific IgG responses.However,a more comprehensive understanding of the breadth and longevity of immune responses after infection and vaccination requires analysis of cellular immunity.Herein,we report on T cell immunity in infected and vaccinated individuals,identifying CD4+/CD8+T cell cytokine responses to SARS-CoV-2 and variant peptides(Alpha,B.1.1.7 and Delta,B.1.617.2). | Stanley C.Jordan Bong-Ha Shin Terry-Ann M.Gadsden Maggie Chu Anna Petrosyan Catherine N.Le Rachel Zabner Jillian Oft Isabel Pedraza Susan Cheng Ashley Vo Noriko Ammerman Jasmine Plummer Shili Ge Max Froch Anders Berg Mieko Toyoda Ruan Zhang | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 3 | Field Cancerization in the Intestinal Epithelium of Patients With Crohn’s Ileocolitis显示文摘 | Susan Galandiuk Manuel Rodriguez–Justo Rosemary Jeffery Anna M. Nicholson Yong Cheng Dahmane Oukrif George Elia Simon J. Leedham Stuart A.C. McDonald Nicholas A. Wright Trevor A. Graham | 2012 | Gastroenterology2012，，4： | 2 |
| 4 | Pneumothorax as a presenting feature of granulomatous disease of the lung in a patient with Crohn?s disease显示文摘 | Paul A. Smith John R. Crampton Susan Pritchard Cheng Li | 2009 | European Journal of Gastroenterology & Hepatology2009，，2： | 2 |
| 5 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 6 | Echocardiographic Speckle-Tracking Based Strain Imaging for Rapid Cardiovascular Phenotyping in Mice显示文摘 | Michael Bauer Susan Cheng Mohit Jain Soeun Ngoy Catherine Theodoropoulos Anna Trujillo Fen-Chiung Lin Ronglih Liao | 2011 | Circulation Research2011，，8： | 1 |
| 7 | Velamentous cord insertion: is it associated with adverse perinatal outcomes?*显示文摘 | Tania F. Esakoff Yvonne W. Cheng Jonathan M. Snowden Susan H. Tran Brian L. Shaffer Aaron B. Caughey | 2014 | The Journal of Maternal-Fetal & Neonatal Medicine2014，，： | 1 |
| 8 | Determination of total mercury in seafood by cold vapor-atomic absorption spectroseopy ( CVAAS ) after microwave decomposition 显示文摘 | SUSAN C HIGHT JOHN CHENG | 2005 | Food chemistry2005，91，3： | 1 |
| 9 | Active canopy sensing of winter wheat nitrogen status: An evaluation of two sensor systems显示文摘 | Qiang Cao Yuxin Miao Guohui Feng Xiaowei Gao Fei Li Bin Liu Shanchao Yue Shanshan Cheng Susan L. Ustin R. Khosla | 2014 | Computers and Electronics in Agriculture2014，，： | 1 |
| 10 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 11 | A new method for mapping variability in vertical seepage flux in streambeds显示文摘 | Xunhong Chen Jinxi Song Cheng Cheng Deming Wang Susan O. Lackey | 2009 | Hydrogeology Journal2009，，3： | 1 |
| 12 | TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation显示文摘 | Xiping Cheng Jie Jin Lily Hu Dongbiao Shen Xian-ping Dong Mohammad A. Samie Jayne Knoff Brian Eisinger Mei-ling Liu Susan M. Huang Michael J. Caterina Peter Dempsey Lowell Evan Michael Andrzej A. Dlugosz Nancy C. Andrews David E. Clapham Haoxing Xu | 2010 | Cell2010，，2： | 1 |
| 13 | Adiposity, Cardiometabolie Risk, and VitaminD Status: the Framinghan Heart Study 显示文摘 | SUSAN CHENG JOSEPH M M CAROLINE S F | 2010 | Diabetes2010，59，1： | 1 |
| 14 | Detecting diurnal and seasonal variation in canopy water content of nut tree orchards from airborne imaging spectroscopy data using continuous wavelet analysis显示文摘 | Tao Cheng David Ria?o Susan L. Ustin | 2014 | Remote Sensing of Environment2014，，： | 1 |
| 15 | Expression of Maspin in Non-Muscle Invasive Bladder Carcinoma: Correlation with Tumor Angiogenesis and Prognosis显示文摘 | Martin G Friedrich Marieta I Toma Susan Petri Jonathan C Cheng Peter Hammerer Andreas Erbersdobler Hartwig Huland | 2003 | European Urology2003，，6： | 1 |
| 16 | Cardiac natriuretic peptides,obesity,and insulin resistance:evidence from two community-based studies显示文摘 | Thomas J.Wang Abigail May Khan Susan Cheng | | 0，，10： | 1 |
| 17 | Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebo-controlled pilot study显示文摘 | Jennifer A.J. Madden Susan F. Plummer James Tang Iveta Garaiova Nigel T. Plummer Mary Herbison John O. Hunter Takashi Shimada Lei Cheng Taro Shirakawa | 2005 | International Immunopharmacology2005，，6： | 1 |
| 18 | Structure–activity studies of phenanthroindolizidine alkaloids as potential antitumor agents显示文摘 | Wenli Gao Scott Bussom Susan P. Grill Elizabeth A. Gullen You-Cai Hu Xueshi Huang Sanbao Zhong Conrad Kaczmarek Julio Gutierrez Samson Francis David C. Baker Shishan Yu Yung-Chi Cheng | 2007 | Bioorganic & Medicinal Chemistry Letters2007，，15： | 1 |
| 19 | Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure?显示文摘 | Grace L. Smith Viola Vaccarino Mikhail Kosiborod Judith H. Lichtman Susan Cheng Suzanne G. Watnick Harlan M. Krumholz | 2003 | Journal of Cardiac Failure2003，，： | 1 |
| 20 | Echocardiographic speckle-tracking-based strain imaging for rapid cardiovascular phe- notyping in mice 显示文摘 | Michael Bauer Susan Cheng Mohit Jain | 2011 | Circulation Research2011，108，8： | 1 |
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