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    题名 作者 年代 出处 被引量
1东准噶尔盆地巴塔玛依内山组火山岩锆石U-Pb年代及Hf同位素研究显示文摘对准噶尔盆地陆梁隆起东部三参1井所钻巴塔玛依内山组玄武岩,开展了详细锆石内部结构研究基础上的U-Pb年代学、微量元素和Hf同位素系统分析.结果显示,所有锆石都属岩浆成因,都有一致的稀土配分型式,都具明显的Ce正异常(δCe=5.06~134)、Eu负异常(δEu=0.06~0.55)和重稀土元素富集特征.25颗锆石中,谐和年龄主要分成3组,分别是(300.4±1.3)Ma(n=11),(339.2±2.7)Ma(n=3)和(392.0±1.7)Ma(n=8);此外,还有3颗近谐和年龄锆石,它们的206Pb/238U年龄分别是(510±7),(488±6)和(453±6)Ma.最小的谐和年龄为(300.4±1.3)Ma,可以代表巴塔玛依内山组火山岩的形成时代(如晚阶段年龄).其他年龄如早泥盆世、奥陶纪等,与盆地周缘岛弧火山岩(富集Pb)和蛇绿岩的时代一致,而且这些年龄锆石都具有正的εHf(t)值(+3.6^+10.5),推测所研究火山岩穿越的盆地基底,可能与由早古生代-中古生代的残余洋壳和岛弧地体组成有关.晚石炭世锆石的εHf(t)值变化于+17.1^+4.2,显示该玄武岩主要来源于软流圈地幔或亏损岩石圈地幔熔融作用,熔体在上升-侵位过程中混染了少量较古老基底物质组分.由于这些玄武岩是后碰撞幔源岩浆直接加入到地壳的物质表现,推测东准噶尔地区晚石炭世已经有了大规模的陆壳垂向生长过程.苏玉平 郑建平 Griffin William L 汤华云 O'Reilly Suzanne Y 林向洋 2010科学通报2010,55,30:50
2State-of-the-art review of soft computing applications in underground excavations显示文摘Soft computing techniques are becoming even more popular and particularly amenable to model the complex behaviors of most geotechnical engineering systems since they have demonstrated superior predictive capacity,compared to the traditional methods.This paper presents an overview of some soft computing techniques as well as their applications in underground excavations.A case study is adopted to compare the predictive performances of soft computing techniques including eXtreme Gradient Boosting(XGBoost),Multivariate Adaptive Regression Splines(MARS),Artificial Neural Networks(ANN),and Support Vector Machine(SVM) in estimating the maximum lateral wall deflection induced by braced excavation.This study also discusses the merits and the limitations of some soft computing techniques,compared with the conventional approaches available.Wengang Zhang Runhong Zhang Chongzhi Wu Anthony Teck Chee Goh Suzanne Lacasse Zhongqiang Liu Hanlong Liu 2020Geoscience Frontiers2020,11,4:33
3慢性阻塞性肺疾病全球创议(2011年修订版)概述显示文摘自10年前第一份慢性阻塞性肺疾病(COPD)全球创议(GOLD)报告——全球COPD诊断、治疗和预防策略发表后,该创议已进行了多次修订,有相当多的内容得到了更新。本次修订的内容主要基于COPD的新研究成果和相关新知识。Jcrgen Vestbo Suzanne S Hurd Roberto Rodriguez-Roisin 申永春(译校) 文富强(译校) 贺蓓(译校) 2012中华医学杂志2012,92,14:27
4Zircon U-Pb and Hf isotopes of volcanic rocks from the Batamayineishan Formation in the eastern Junggar Basin显示文摘内部结构的研究被进行从 Batamayineishan 形成调查 U-Pb 年龄,踪迹元素和玄武岩的锆石的 Hf 同位素。暗岩从练习井圣罐头被获得 1 在 Junggar 盆以内在东方 Luliang 上高举。跟踪所有样品是 magmatic 的锆石表演的元素数据,与类似的 REE 模式,包括积极 Ce (Ce=5.06134 ) ,而是否定 Eu (Eu=0.06 ? 0.55 ) 在重稀土元素元素的异例和丰富。在 25 谷物之中,一致年龄被细分进三个组;300.4 整潲祺潧整的年龄?SU YuPing ZHENG JianPing GRIFFIN William L TANG HuaYun O'REILLY Suzanne Y LIN XiangYang 2010Chinese Science Bulletin2010,55,36:21
5国际糖尿病足工作组:糖尿病足感染诊断与治疗指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘国际糖尿病足工作组(IWGDF)从1999年开始发布糖尿病足病防治指南。本指南是有关糖尿病足感染的诊断和治疗的指南,是在2015年糖尿病足感染指南基础上更新的。糖尿病足感染指南编辑委员会基于患者-干预-比较-结局(PICO)原则,整合内部与外部专家顾问的建议,并对2016年以后有关糖尿病足感染和处治的文献进行系统评价后,提出了27条推荐要点。这些推荐要点涵盖了软组织与骨组织感染的诊断,包括感染的严重性分级。这是IWGDF15年以来第一次对这个分级表进行更新。此外,指南还评估了糖尿病足感染的微生物学,包括如何收集标本及如何识别致病菌。最后,指南讨论了治疗糖尿病足感染的方法,包括经验性抗生素的选择、软组织和骨组织感染的抗微生物治疗、何时和如何进行外科处理以及各种辅助治疗对糖尿病足感染的有效性。本版指南在原指南的基础上更新了4个表格和1个图。我们认为该指南可以为糖尿病足感染的临床诊断和治疗提供更好的帮助。Benjamin A.Lipsky Eric Senneville Zulfqarali G.Abbas Javier Aragón-Sánchez Mathew Diggle John M.Embil Shigeo Kono Lawrence A.Lavery Matthew Malone Suzanne A.van Asten Vilma Urbancic-Rovan Edgar J.G.Peters 徐俊(译) 许樟荣(审校) 2019感染.炎症.修复2019,20,4:18
6古老大陆岩石圈地幔再循环与蛇绿岩中铬铁矿床成因显示文摘不同地区、不同时代蛇绿岩中不同类型铬铁矿岩的Re-Os同位素研究表明,在铬铁矿石或围岩中均存在极度亏损的具有大陆岩石圈地幔属性的物质。新疆达拉布特古生代蛇绿岩带中萨尔托海富Al铬铁矿岩的Os同位素组成为0.1109~0.1256,对应的模式年龄为3.5~0.6Ga;西藏班公湖—怒江中生代蛇绿岩带中东巧富Cr铬铁矿石及围岩Os同位素组成介于0.1175~0.1261,对应的模式年龄为1.5~0.1Ga;雅鲁藏布江中生代蛇绿岩带中罗布莎富Cr铬铁矿岩的Os同位素变化范围为0.1038~0.1266,对应的模式年龄为3.37~0.28Ga,而该带中不含矿的泽当二辉橄榄岩的Os同位素组成为0.1256~0.1261,没有古老大陆岩石圈地幔属性的物质存在,与新特提斯洋地幔Os组成较为接近。推测在蛇绿岩形成过程中,古老大陆岩石圈地幔参与循环有利于形成铬铁矿床,明确提出'熔体与古老大陆岩石圈地幔反应成矿'的假说,指出蛇绿岩带中存在的古老微陆块可能是找矿的指示标志。史仁灯 黄启帅 刘德亮 樊帅权 张晓冉 丁林 William L GRIFFIN Suzanne Y O'REILLY 2012地质论评2012,58,4:15
7Ablation techniques for primary and metastatic liver tumors显示文摘Ablative treatment methods have emerged as safe and effective therapies for patients with primary and secondary liver tumors who are not surgical candidates at the time of diagnosis.This article reviews the current literature and describes the techniques,complications and results for radiofrequency ablation,microwave ablation,cryoablation,and irreversible electroporation.Michael J Ryan Jonathon Willatt Bill S Majdalany Ania Z Kielar Suzanne Chong Julie A Ruma Amit Pandya 2016World Journal of Hepatology2016,8,3:13
8A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response显示文摘病毒的 RNA 的识别由 cytosolic 传感器 retinoic 组织酸可诱导的基因 --(RIG-I ) 我导致表明与类型的产生达到顶点的串联的激活我干扰素(IFN ) 抗病毒的反应。对病毒的病原体的抗病毒、煽动性的回答的发作要求表明改编者, kinases 和 transcriptional 蛋白质到 mitochondrial 的调整空间与时间的招募抗病毒的发信号蛋白质(MAVS ) 。我们以前示威了 serine/threonine kinase IKKε被招募到 MAVS 后面的仙台或小囊的口炎病毒(VSV ) 感染的 C 终端区域,在 Lys500 由 MAVS 的连接 Lys63 的 polyubiquitination 调停了,导致下游的 IFN 发信号的抑制(Paz 等,摩尔房间 Biol, 2009 ) 。在这研究,我们证明 MAVS 的 C 终点在 MAVS 的 aa450-468 区域怀有一个新奇 TRAF3 有约束力的地点。一个一致交往 TRAF 主题(提姆) , 455-PEENEY-460,在这以内,地点为 TRAF3 绑定和 IFN 抗病毒的反应基因的激活被要求,而 TIM 的变化消除 TRAF3 绑定和下游的 IFN 反应。有表示 MAVS 的一个变异提姆的版本的构造的 MAVS −/− 老鼠胚胎成纤维细胞的宪法没能恢复抗病毒的反应或块 VSV 复制,而野类型的 MAVS 重新组成 VSV 复制的抗病毒的抑制。而且, IKKε 的招募;到在经由 Lys500 的 MAVS 的一个邻近的 C 终端地点(aa 468-540 ) , ubiquitination 减少了 TRAF3 绑定和蛋白质稳定性,因此贡献 IKKε调停 IFN 反应关机。这研究证明 MAVS 怀有功能的 C 终端参予 IFN 抗病毒的反应的积极、否定的规定的 TRAF3 有约束力的地点。Suzanne Paz Myriam Vilasco Steven J Werden Meztli Arguello Deshanthe Joseph-Pillai Tiejun Zhao Thi Lien-Anh Nguyen Qiang Sun Eliane F Meurs Rongtuan Lin John Hiscott 2011Cell Research2011,21,6:12
9边坡位移智能预测算法显示文摘目的:边坡位移预测是实现滑坡灾害预报的有效手段,对降低滑坡灾害导致的损失具有重要意义。本文针对三峡库区广泛分布的'阶跃型'滑坡,采用三种不同的机器学习算法:长短期记忆(LSTM)神经网络、随机森林(RF)算法和门控递归单元(GRU),预测三个不同的三峡库区边坡位移,并对比三种算法的预测精度,从而选择适用于边坡位移预测的机器学习算法。创新点:1.建立了基于时间序列分解和机器学习算法的动态预测模型,并能够准确预测边坡位移。2.对比了不同的机器学习算法预测边坡周期项位移的精度。方法:1.基于时间序列分解原理,将边坡累积位移分解为趋势项位移和周期项位移。2.利用多项式拟合对边坡趋势项位移进行预测。3.基于位移影响因素采用三种机器学习模型(LSTM、GRU和RF)预测边坡周期项位移。结论:1.本文提出的基于时间序列分解和机器学习算法的动态预测模型可以准确预测三峡库区'阶跃型'边坡位移。2.LSTM和GRU算法可以充分利用滑坡历史信息,精确预测边坡位移的周期项。Zhong-qiang LIU Dong GUO Suzanne LACASSE Jin-hui LI Bei-bei YANG Jung-chan CHOI 2020Journal of Zhejiang University-Science A(Applied Physics & Engineering)2020,21,6:12
10Identifying Materials of Photographic Images and Photorealistic Computer Generated Graphics Based on Deep CNNs显示文摘Currently,some photorealistic computer graphics are very similar to photographic images.Photorealistic computer generated graphics can be forged as photographic images,causing serious security problems.The aim of this work is to use a deep neural network to detect photographic images(PI)versus computer generated graphics(CG).In existing approaches,image feature classification is computationally intensive and fails to achieve realtime analysis.This paper presents an effective approach to automatically identify PI and CG based on deep convolutional neural networks(DCNNs).Compared with some existing methods,the proposed method achieves real-time forensic tasks by deepening the network structure.Experimental results show that this approach can effectively identify PI and CG with average detection accuracy of 98%.Qi Cui Suzanne McIntosh Huiyu Sun 2018Computers, Materials & Continua2018,,5:12
11Surveillance for hepatocellular carcinoma in chronic liver disease:Evidence and controversies显示文摘Primary liver cancer is the sixth most common cancer in the world and the third cause of cancer-related death.Hepatocellular carcinoma(HCC)represents more than90%of primary liver cancers and generally occurs in patients with underlying chronic liver disease such as viral hepatitis,hemochromatosis,primary biliary cirrhosis and non-alcoholic steatohepatitis.Especially cirrhotic patients are at risk of HCC and regular surveillance could enable early detection and therapy,with potentially improved outcome.We here summarize existing evidence for surveillance including ultrasound,other radiological modalities and various serum biomarkers,and current international guideline recommendations for surveillance.Ultrasound andα-fetoprotein(alone or in combination)are most frequently used for surveillance,but their sensitivities and specificities are still far from perfect,and evidence for surveillance remains weak and controversial.Various other potential surveillance tools have been tested,including serum markers as des-carboxyprothrombin,lectin-boundα-fetoprotein,and(most recently)circulating TIE2-expressing monocytes,and radiological investigations such as computed tomographyscan or magnetic resonance imaging-scan.Although early results appear promising,these tools have generally been tested in diagnostic rather than surveillance setting,and in most cases,no detailed information is available on their cost-effectiveness.For the near future,it remains important to define those patients with highest risk of HCC and most benefit from surveillance,and to restrict surveillance to these categories.Suzanne van Meer Robert A de Man Peter D Siersema Karel J van Erpecum 2013World Journal of Gastroenterology2013,19,40:10
12四价人乳头瘤病毒疫苗的效力和效果:10年真实世界研究的系统综述显示文摘预防性人乳头瘤病毒(HPV)疫苗接种计划是全球性的重要公共卫生措施。本文分析了四价HPV疫苗对HPV感染和相关疾病的全球影响。系统检索PubMed和Embase数据库2007年1月至2016年2月发表的四价HPV疫苗对感染、肛门生殖器疣、宫颈癌或癌前病变的效力或效果的观察性研究的报道。十年来,真实世界环境中HPV疫苗效果越来越明显,尤其在疫苗接种率较高国家中那些在HPV暴露发生之前接种的女孩。据报道,疫苗可使HPV6、11、16、18感染最多减少约90%,生殖器疣减少约90%,低度宫颈细胞学异常减少约45%,经组织学证实的高度宫颈异常减少约85%。但HPV疫苗接种计划的公共卫生潜力尚未完全实现,HPV相关疾病仍具有较高的发病率和死亡率,因此仍需要提高HPV疫苗接种计划的人群覆盖率。Suzanne M.Garland Susanne K.Kjaer Nubia Muoz Stan L.Block Darron R.Brown Mark J.DiNubile Brianna R.Lindsay Barbara J.Kuter Gonzalo Perez Geraldine Dominiak-Felden Alfred J.Saah Rosybel Drury Rituparna Das Christine Velicer 王华庆 2018中国病毒病杂志2018,8,4:9
13体育教育领域中的体育素养——挑战与机遇(英文)显示文摘自2000年以来,以'体育素养'为主题的文章发表数量显著增加。本文运用归纳法对已发表的以'体育素养'为主题的经过同行评议文章的频次及重要主题进行探索性文献综述。在EBSCO数据库中以'体育素养'和'体育素养和实证'为关键词搜索相关文章。文章检索包括国际体育科学与体育教育理事会(ICSSPE)公告中的'体育素养'特刊。研究围绕3个关键主题:'体育素养'概念的假设前提及其教育作用;体育的发展与体育素养;体育素养的评估。未来研究需检验所提倡的以'体育素养'概念为基础的教学策略是否会导致重新设置有活力的学校课程。现在还有一些批判观点,如将'体育素养'作为理想的基本运动技能和运动员选材的中立化概念。体育素养如何得到社会认可、如何培养体育素养、体育素养与实践如何结合,高等教育在进一步完善这一科学体系中起到至关重要的作用。Suzanne Lundvall 2015Journal of Sport and Health Science2015,4,2:8
14Ages, Trace Elements and Hf-Isotopic Compositions of Zircons from Claystones around the Permian-Triassic Boundary in the Zunyi Section, South China: Implications for Nature and Tectonic Setting of the Volcanism显示文摘证据的成长身体证明二叠三叠纪的边界(PTB ) 附近的那个火山作用可能在触发 PermianTriassic (PTr ) 是关键的集体扑灭。因此,在华南的 PTB 附近的灰床可以在这个事件上带信息。三暴烈的灰层,改变了到泥土,在在 Zunyi 节的 PTB 床上的 outcropped,贵州省,西南中国。从这三张灰床的锆石谷物的 U-Pb 年龄,踪迹元素,和 Hf 同位素作文用 LA-ICPMS 和 LA-MC-ICPMS 被分析。锆石主要除了二 inherited/xenocrystic 锆石(939 和 2 325 妈) 是在起源(241-279 妈) 的 magmatic。这些 magmatic 锆石的年龄显示发生在中间附近的 magmatism 的三个事件 -- 晚二叠的边界(~ 261.5 妈, MLPB ) , Wuchiapingian-Changhsingian 边界(~ 254.5 妈, WCB ) ,并且 PTB (~ 250.5 妈) 分别地。MLPB 和 WCB 附近的 magmatism 的开始的二个事件可以被归因于 magmatic 继承或重新免职。所有 magmatic 锆石分享类似的踪迹元素和 Hf 同位素作文。他们有 Y, Hf, Th 和 U 内容和 Nb/Ta 比率典型地代表从硅的计算碱的岩浆的锆石。这些锆石也与 -11.4 的 Hf (t) 价值展出充实的 Hf 同位素作文到 +0.2,它建议三个 magmatic 事件涉及大陆人外壳融化。更多的充实的 Hf 同位素作文(床 ZY13 的 Hf (t)=-11.4--4.8)(~ 250.5 妈) 在岩浆暗示古老的外壳的材料的更多的输入。magmatic 锆石的 Hf 同位素和踪迹元素作文的集成建议 magmatism 的这三个事件可以由于 Palaeo-Tethys 海洋的闭合沿着会聚的大陆边缘发生在或在西南的华南附近。Qiuling Gao Zhong-Qiang Chen Ning Zhang William L.Griffin Wenchen Xia Guoqing Wang Tengfei Jiang Xuefei Xia Suzanne Y.O'Reilly 2015Journal of Earth Science2015,26,6:8
15华南晚古生代岩浆活动的新发现:岛弧还是陆内造山?显示文摘在福建省周宁县五凤楼村发现了一个形成于313±4Ma的片麻状花岗岩.该岩石具有高的K2O和Al2O3含量和低的SiO2和Na2O含量,其A/CNK比值高达1.22,指示其源区为经过化学风化的沉积岩,因此属于S型花岗岩.所含锆石为柱状自形形态,其U-Pb年龄变化于326~301Ma(加权平均年龄为313±4Ma),具有负的?Hf(t)值(?8.35~?1.74)和1.43~1.84Ga的二阶段Hf模式年龄.这是首次在华南发现有确凿同位素年代学证据的晚石炭世S型花岗质岩浆活动.该S型花岗岩最可能形成于陆内造山阶段,源岩主要为古元古代晚期生长的地壳.结合前人对岩相古地理、古生代盆地性质、早二叠世火山作用以及晚古生代-早中生代沉积岩中碎屑锆石的U-Pb-Hf同位素资料,本文推断华夏东部可能曾经存在一个晚古生代造山带.从晚石炭世(340~310Ma)的挤压造山阶段演化到早二叠世(285~270Ma)的后造山或板内伸展阶段,华南东部经历了一个较为完整的晚古生代造山旋回,所形成的晚古生代岩浆岩是陆内造山作用的产物,而不是岛弧岩浆作用产物.于津海 刘潜 胡修棉 王勤 O'REILLY Suzanne Y 2012科学通报2012,57,31:7
16Adjuvant therapies for colorectal cancer显示文摘The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced (stage Ⅲ and selected stage Ⅱ) colorectal cancer. Improved surgical techniques, chemotherapeutics and radiotherapy are resulting in higher cure rates and the development of agents targeting proliferative and angiogenic pathways offer further promise. Here we explore risk factors for local and distant recurrence after resection of colon and rectal cancer, and the role of adjuvant treatments. Discussion will focus on the evidence base for adjuvant therapies utilised in colorectal cancer, and the treatment of sub-groups such as the elderly and stage Ⅱ disease. The role of adjuvant radiotherapy in rectal cancer in reduction of recurrence will be explored and the role and optimal methods for surveillance post-curative resection with or without adjuvant therapy will also be addressed.Suzanne Kosmider Lara Lipton 2007World Journal of Gastroenterology2007,13,28:7
17Renal cell carcinoma: Evolving and emerging subtypes显示文摘Our knowledge of renal cell carcinoma(RCC) is rapidly expanding. For those who diagnose and treat RCC, it is important to understand the new developments. In recent years, many new renal tumors have been described and defined, and our understanding of the biology and clinical correlates of these tumors is changing. Evolving concepts in Xp11 translocation carcinoma, mucinous tubular and spindle cell carcinoma, multilocular cystic clear cell RCC, and carcinoma associated with neuroblastoma are addressed within this review. Tubulocystic carcinoma, thyroid-like follicular carcinoma of kidney, acquired cystic disease-associated RCC, and clear cell papillary RCC are also described. Finally, candidate entities, including RCC with t(6;11) translocation, hybrid oncocytoma/chromophobe RCC, hereditary leiomyomatosis and RCC syndrome, and renal angiomyoadenomatous tumor are reviewed. Knowledge of these new entities is important for diagnosis, treatment and subsequent prognosis. This review provides a targeted summary of new developments in RCC.Suzanne M Crumley Mukul Divatia Luan Truong Steven Shen Alberto G Ayala Jae Y Ro 2013World Journal of Clinical Cases2013,1,9:7
18Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined.Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu 2022Stroke & Vascular Neurology2022,7,1:7
19论朗读显示文摘直到本世纪初,朗读一直是西化方文中流行的阅读教学方法。随着二十世纪初期默读教学的出现,在如何看待朗读学上,逐渐形成三个流派。第一个流派将朗读看作精通默读的手段;第二个流派认为朗读不利于培养默读能力;第三个流派则认为朗读是一门艺术,有其本身值得掌握的技巧。到了五十年代,人们认识到朗读和默读所需的技能不同(Allington,1984),因而有关默读和朗读的相对价值问题的辨论也有所减弱。Suzanne M.Griffin 常晨光 1995外语教学理论与实践1995,,1:5
20Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis显示文摘干细胞(hPSC ) 人口着急地在基本研究并且在基于房间的治疗应用为质量控制被需要的为孤立人的 pluripotent 的快速、可靠的方法。用 lectin 数组,我们分析了从 26 件 hPSC 样品和 22 件区分的房间样品提取的 glycoproteins,并且与是足够的把 hPSCs 与许多 non-pluripotent 房间类型区分开来的特殊有约束力的签名识别了 lectins 的一个小组。这些特定的 biomarkers 被所有 12 人的胚胎的干细胞和检验的 14 件人的导致的 pluripotent 干细胞样品分享,不管起源,文化条件,体的房间类型 reprogrammed,或使用的 reprogramming 方法的实验室。我们演示了由检测有调停 lectin 的染色的一张区分的房间人口由荧光显微镜学和流动 cytometry,并且由充实并且清除跟随了的在内的 hPSCs 有约束力的特定的 lectin 的一个实际应用程序从用调停 lectin 的房间分离的混合房间人口的可行 hPSCs。全球基因表示分析显示出特定的 fucosyltransferases 和 sialyltransferases 的联系 pluripotency 的微分表示,它可以在蛋白质 glycosylation 和 lectin 绑定位于这些差别下面。一起拿,我们的结果证明蛋白质 glycosylation 在 pluripotent 和 non-pluripotent 房间之间更加不同,并且证明 lectins 可以被用作 biomarkers 从混合房间人口在干细胞人口并且为可行 hPSCs 的移动监视 pluripotency。Yu-ChiehWang MasatoNakagawa IbonGaritaonandia IleanaSlavin GulsahAltun Robert MLacharite Kristopher LNazor Ha TTran Candace LLynch Trevor RLeonardo YingLiu Suzanne EPeterson Louise CLaurent ShinyaYamanaka Jeanne FLoring 2011Cell Research2011,21,11:5
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