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| 1 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 2 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 3 | A Single Transcript CRISPR-Cas9 System for Efficient Genome Editing in Plants显示文摘 | Tang, Xu Zheng, Xuelian Qi, Yiping Zhang, Dengwei Cheng, Yan Tang, Aiting Voytas, Daniel F. Zhang, Yong | 2016 | Molecular Plant2016，9，7： | 8 |
| 4 | Ultrathin Acoustic Parity-Time Symmetric Metasurface Cloak显示文摘Invisibility or unhearability cloaks have been made possible by using metamaterials enabling light or sound to fow around obstacle without the trace of refections or shadows.Metamaterials are known for being fexible building units that can mimic a host of unusual and extreme material responses,which are essential when engineering artifcial material properties to realize a coordinate transforming cloak.Bending and stretching the coordinate grid in space require stringent material parameters;therefore,small inaccuracies and inevitable material losses become sources for unwanted scattering that are decremental to the desired efect.Tese obstacles further limit the possibility of achieving a robust concealment of sizeable objects from either radar or sonar detection.By using an elaborate arrangement of gain and lossy acoustic media respecting parity-time symmetry,we built a one-way unhearability cloak able to hide objects seven times larger than the acoustic wavelength.Generally speaking,our approach has no limits in terms of working frequency,shape,or size,specifcally though we demonstrate how,in principle,an object of the size of a human can be hidden from audible sound. | Hao-xiang Li Mar-a Rosendo-López Yi-fan Zhu Xu-dong Fan Daniel Torrent Bin Liang Jian-chun Cheng Johan Christensen | 2019 | Research2019，，1： | 4 |
| 5 | Tunable nonlinear refractive index of two-dimensional MoS2, WS2, and MoSe2 nanosheet dispersions [Invited]显示文摘Liquid-phase-exfoliation technology was utilized to prepare layered MoS2, WS2, and MoSe2 nanosheets in cyclohexylpyrrolidone. The nonlinear optical response of these nanosheets in dispersions was investigated by observing spatial self-phase modulation(SSPM) using a 488 nm continuous wave laser beam. The diffraction ring patterns of SSPM were found to be distorted along the vertical direction right after the laser traversing the nanosheet dispersions. The nonlinear refractive index of the three transition metal dichalcogenides dispersions n2 was measured to be 10-7cm2W-1, and the third-order nonlinear susceptibility χ(3)10-9 esu. The relative change of effective nonlinear refractive index Δn2e∕n(2e) of the MoS2, WS2, and MoSe2 dispersions can be modulated 0.012–0.240, 0.029–0.154, and 0.091–0.304, respectively, by changing the incident intensities. Our experimental results imply novel potential application of two-dimensional transition metal dichalcogenides in nonlinear phase modulation devices. | Gaozhong Wang Saifeng Zhang Xiaoyan Zhang Long Zhang Ya Cheng Daniel Fox Hongzhou Zhang Jonathan N.Coleman Werner J.Blau Jun Wang | 2015 | Photonics Research2015，3，2： | 4 |
| 6 | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization显示文摘NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectively. Although p100 responds to noncanonical NF-κB stimuli for processing, it does not undergo degradation, but rather becomes accumulated, along with canonical NF-κB activation. We show here that the stability of p100 is tightly controlled by a deubiquitinase, Otub1. Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-κB activation but also causes steady-state p100 degradation, leading to aberrant NF-κB activation in the canonical pathway. B-cell-conditional deletion of Otub1 results in B-cell hyperplasia, antibody hyper-production, and lupus-like autoimmunity. Otub1-deficient B cells display aberrantly activated phenotypes and overproduce the cytokine IL-6, contributing to autoimmunity induction. Thus, maintenance of p100 stability by Otub1 serves as an unusual mechanism of NF-κB regulation that prevents autoimmunity. | Yanchuan Li Jin-Young Yang Xiaoping Xie Zuliang Jie Lingyun Zhang Jianhong Shi Daniel Lin Meidi Gu Xiaofei Zhou Haiyan S. Li Stephanie S. Watowich Antrix Jain Sung Yun Jung Jun Qin Xuhong Cheng Shao-Cong Sun | 2019 | Cell Research2019，29，6： | 3 |
| 7 | Panel positioning error and support mechanism for a 30-m THz radio telescope显示文摘A 30-m TeraHertz(THz) radio telescope is proposed to operate at 200 μm with an active primary surface.This paper presents sensitivity analysis of active surface panel positioning errors with optical performance in terms of the Strehl ratio.Based on Ruze's surface error theory and using a Monte Carlo simulation,the effects of six rigid panel positioning errors,such as piston,tip,tilt,radial,azimuthal and twist displacements,were directly derived.The optical performance of the telescope was then evaluated using the standard Strehl ratio.We graphically illustrated the various panel error effects by presenting simulations of complete ensembles of full reflector surface errors for the six different rigid panel positioning errors.Study of the panel error sensitivity analysis revealed that the piston error and tilt/tip errors are dominant while the other rigid errors are much less important.Furthermore,as indicated by the results,we conceived of an alternative Master-Slave Concept-based(MSC-based) active surface by implementating a special Series-Parallel Concept-based(SPC-based) hexapod as the active panel support mechanism.A new 30-m active reflector based on the two concepts was demonstrated to achieve correction for all the six rigid panel positioning errors in an economically feasible way. | De-Hua Yang Daniel Okoh Guo-Hua Zhou Ai-Hua Li Guo-Ping Jing-Quan Cheng | 2011 | Research in Astronomy and Astrophysics2011，11，6： | 3 |
| 8 | Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients显示文摘Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease burden.We aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan criteria.Methods:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan criteria.Meta-analyses and meta-regression were conducted using random-effects models.Results:We screened 2,278 studies and included 35 studies with 18,421 patients.LR was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;P<0.01]and DFS(HR=2.71;95%CI:2.23-3.28;P<0.01)compared to LT,with similar findings among intention-to-treat(ITT)studies.In uninodular disease,OS in LR was comparable to LT(P=0.13)but DFS remained poorer(HR=2.95;95%CI:2.30-3.79;P<0.01).By region,LR had poorer OS versus LT in North America and Europe(P≤0.01),but not Asia(P=0.25).LR had inferior survival versus LT in studies completed before 2010(P=0.01),but not after 2010(P=0.12).Cohorts that underwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to LT.Survival between LR and LT were similar in uninodular disease.The risk of recurrence after LR is threefold that of LT. | Jin Hean Koh Darren Jun Hao Tan Yuki Ong Wen Hui Lim Cheng Han Ng Phoebe Wen Lin Tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning Qi Pang Beom Kyung Kim Nicholas Syn Alfred Kow Brian K.P.Goh Daniel Q.Huang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 9 | Detection of Stage I nasopharyngeal carcinoma by serologicscreening and clinical examination显示文摘In a prospective study, 42 048 adults residing in Zhongshan City, Guangdong, China, were followed for 16 years, and 171 of them developed nasopharyngeal carcinoma (NPC). Although Epstein-Barr virus (EBV) antibody levels of the cohort fluctuated, the antibody levels of 93% of the patients with NPC were raised and maintained at high levels for up to 10 years prior to diagnosis. This suggests that the serologic window affords an opportunity to monitor tumor progression during the preclinical stage of NPC development, facilitating early NPC detection. We reviewed the clinical records of the 171 patients with NPC in the prospective study to assess the efficacy of early NPC detection by serologic screening and clinical examination. Of the 171 patients, 51 had Stage I tumor (44 were among the 73 patients detected by clinical examination and 7 were among the 98 patients presented to outpatient department). Initial serologic screening predicted 58 (95.1%) of the 61 patients detected within 2 years. The risk of the screened population (58/3093) raised 13 times relative to cohort (61/42 048) during this period. Clinical examination detected all the 58 predicted cases, and 35 (60.3%) of which were diagnosed with Stage I tumor. The serologic prediction rate fell to 33.6% (37/110) 2 to 16 years after screening. The proportion of cases detected by clinical examination fell to 40.5% (15/37). The proportion of Stage I tumors among the cases detected by clinical examination during both periods remained at about 60%. We concluded that early detection of NPC can be accomplished by repeated serologic screening to maintain high prediction rates and by promptly examining screened subjects to detect tumors before the symptoms develop. | Ming-Fang Ji Yuan-Long Yu Wei-Ming Cheng Yong-Sheng Zong Park Sze-Park Ng Daniel Tsin-Tien Chua Mun-Hon Ng | 2011 | Chinese Journal of Cancer2011，30，2： | 3 |
| 10 | Uncommon features of pulmonary Langerhans' cell histiocytosis: analysis of 11 cases and a review of the literature显示文摘 | LING Chun-hua JI Cheng Daniel P Raymond Patricia A Bourne XU Hao-dong | 2010 | Chinese Medical Journal2010，，4： | 2 |
| 11 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 12 | SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography显示文摘 | Gilbert L. Raff Chair Aiden Abidov Stephan Achenbach Daniel S. Berman Lawrence M. Boxt Matthew J. Budoff Victor Cheng Tony DeFrance Jeffrey C. Hellinger Ronald P. Karlsberg | 2009 | Journal of Cardiovascular Computed Tomography2009，，： | 1 |
| 13 | Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering显示文摘Dimer impurity in the solution of a generation five(G5) polyamidoamine(PAMAM) dendrimer has been investigated by small-angle neutron scattering(SANS). The existence of dimer impurity in dendrimer solution was evidenced by indirect Fourier transform(IFT) analysis of the SANS data, in which the maximum dimension of particles in solution was found to be about twice the diameter of G5 dendrimer. We then developed an analytical model which accounts for the scattering contribution from both dendrimer monomer and dimer. The experimental data were well fitted by using the established model. The results showed that the amount of dimer impurities is significant for the measured three batches of G5 PAMAM dendrimers. | Tian-Fu Li Yi-Yun Cheng Yu Wang Hui Wang Dong-Feng Chen Yun-Tao Liu Li Zhang Wen-Ze Han Rong-Deng Liu Zi-Jun Wang Chun-Ming Yang Charl J. Jafta Daniel Clemens Uwe Keiderling | 2019 | Chinese Journal of Polymer Science2019，37，8： | 1 |
| 14 | Perioperative and anaesthetic-related mortality in developed and developing countries: a systematic review and meta-analysis显示文摘 | Daniel Bainbridge Janet Martin Miguel Arango Davy Cheng | 2012 | The Lancet2012，，9847： | 1 |
| 15 | Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell–selectin interaction kinetics显示文摘 | Hao Cheng Marta Byrska-Bishop Cathy T. Zhang Christian J. Kastrup Nathaniel S. Hwang Albert K. Tai Won Woo Lee Xiaoyang Xu Matthias Nahrendorf Robert Langer Daniel G. Anderson | 2012 | Biomaterials2012，，20： | 1 |
| 16 | 10 Gbps wavelength division multiplexing using UV-A, UV-B, and UV-C micro-LEDs显示文摘Deep ultraviolet(DUV) optical wireless communications have seen increased interest in recent years due to the unique properties of light in this spectral region. However, the reported DUV data rates remain significantly lower than comparable demonstrations at visible wavelengths due to lower modulation bandwidths and/or output power of the sources. Here, we present a wavelength division multiplexing demonstration using three UV microlight-emitting diodes emitting at nominal peak wavelengths of 285, 317, and 375 nm, respectively, each with an emitting area of approximately 1369 μm^(2)(equivalent to circular device pixels of diameter;0 μm). Using orthogonal frequency division multiplexing, data rates of 4.17, 3.02, and 3.13 Gbps were achieved from the 285, 317, and 375 nm devices, respectively, for a combined data rate of 10.32 Gbps transmitted over a distance of 0.5 m. | Daniel M.Maclure Jonathan J.D.McKendry Mohamed Sufyan Islim Enyuan Xie Cheng Chen Xiaobin Sun Xudong Liang Xiaohui Huang Hanaa Abumarshoud Johannes Herrnsdorf Erdan Gu Harald Haas Martin D.Dawson | 2022 | Photonics Research2022，10，2： | 1 |
| 17 | An Information Diffusion -Based Recommendation Frame- work for Micro - Blogging显示文摘 | Jiesi Cheng Sun Aaron Hu Daning Zeng Daniel | 2011 | Journal of the Associa- tion for Information Systems2011，12，7： | 1 |
| 18 | Layered maximum likelihood detection for MIMO systems in frequency selective fading channels显示文摘 | DANIEL K C CHENG R S | 2006 | IEEE Transactions on Wireless Communications2006，5，4： | 1 |
| 19 | Molecular properties that influence the oral bioavailability of drug candidates显示文摘 | Daniel EV Johnson SR Cheng HY | | 0，，12： | 1 |
| 20 | A microfluidic device for practical label -free CD4 + T cell counting of HIV- infected subjects显示文摘 | Xuanhong Cheng Daniel Irimia Meredith Dixon | 2007 | Lab on a Chip2007，7，2： | 1 |
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