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| 1 | 不同植物人工湿地净化效果及基质微生物状况差异分析显示文摘为研究不同植物对人工湿地污染物净化效果和基质微生物状况的影响,采用序批式运行的沙培模拟人工湿地,探讨了菖蒲、香蒲、千屈菜、芦苇和白鹤芋5种湿地植物在不同HRT(水力停留时间,分别为1,3和5 d)下对模拟废水中TP,NH4+-N和CODCr去除效果的影响,比较了不同植物类型模拟人工湿地中基质微生物的数量差异.结果表明,不同植物系统对污染物的去除随HRT延长逐渐提高,HRT为5 d时各植物系统对污染物的去除效果最佳.TP,NH4+-N和CODCr的最高去除率分别达90.4%,61.7%和96.4%.相对于其他试验系统,菖蒲系统对各污染指标均具有最优的去除效果.植物种类对基质微生物数量的影响无显著差异.研究还发现,各系统中亚硝酸细菌数量与NH4+-N去除率之间呈显著相关. | 奉小忧 宋永会 曾清如 彭剑峰 刘雪瑜 RHEE Jae Seong IAMCHATURAPATR Janjit | 2011 | 环境科学研究2011，24，9： | 34 |
| 2 | Microstructures of brazing zone between titanium alloy and stainless steel using various filler metals显示文摘Titanium alloy (Ti-Al-V alloy) substrate was brazed with stainless steel (STS304) using filler metal.At an optimized brazing condition,various filler metals were used.Microstructures were observed at each condition.Filler metals were titanium based 40Ti-20Zr-20Cu-20Ni,silver based Ag 5Pd,and nickel based Ni-7Cr-3.1B-4.5Si-3Fe-0.06C (BNi2) and Ni-14Cr-10P-0.06C (BNi7).To select a good filler metal for brazing process,wetting test was performed at 880-1050 °C.It was not brazed using silver based filler metals,but at the conditions using titanium and nickel based filler metals had brazed zone between titanium alloy and stainless steel.However,titanium alloy was eroded during brazing using titanium based filler metals.Nickel based filler metal has a good brazed zone between titanium alloy and stainless steel among the filler metals. | Taeshin CHUNG Jungsoo KIM Jeongseok BANG Byoungho RHEE Daegeun NAM | 2012 | 中国有色金属学会会刊:英文版2012，22，S3： | 12 |
| 3 | Unraveling the ties between irritable bowel syndrome and intestinal microbiota显示文摘Irritable bowel syndrome(IBS)is the most prevalent functional gastrointestinal disorder.It is a multifactoria disorder.Intestinal microbiota may cause the pathogenesis of IBS by contributing to abnormal gastrointestina motility,low-grade inflammation,visceral hypersensitivity,communication in the gut-brain axis,and so on.Previous attempts to identify the intestinal microbiota composition in IBS patients have yielded inconsistent and occasionally contradictory results.This inconsistency may be due to the differences in the molecular techniques employed,the sample collection and handling methods,use of single samples that are not linked to fluctuating symptoms,or other factors such as patients diets and phenotypic characterizations.Despite these difficulties,previous studies found that the intestina microbiota in some IBS patients was completely different from that in healthy controls,and there does appear to be a consistent theme of Firmicutes enrichment and reduced abundance of Bacteroides.Based on the differences in intestinal microbiota composition,many studies have addressed the roles of microbiotatargeted treatments,such as antibiotics and probiotics,in alleviating certain symptoms of IBS.This review summarizes the current knowledge of the associations between intestinal microbiota and IBS as well as the possible modes of action of intestinal microbiota in the pathogenesis of IBS.Improving the current level of understanding of host-microbiota interactions in IBS is important not only for determining the role of intestinal microbiota in IBS pathogenesis but also for therapeutic modulation of the microbiota. | Sung Noh Hong Poong-Lyul Rhee | 2014 | World Journal of Gastroenterology2014，20，10： | 11 |
| 4 | Epstein-Barr virus-associated lymphoepithelioma-like early gastric carcinomas and endoscopic submucosal dissection: Case series显示文摘Epstein-Barr virus(EBV)-associated lymphoepitheliomalike gastric carcinoma(LELC) is characterized by a lower lymph node(LN) metastasis rate and a higher survival rate than other forms of gastric cancer. Although current prognosis for LELC is favorable, the most common approach is radical gastrectomy involving an extensive D2 lymph node dissection. Here, we report four cases of EBV-associated early LELC that were treated by an alternative approach, endoscopic submucosal dissection(ESD). The long-term outcome of this procedure is discussed. All patients were treated by ESD en bloc, and all ESD specimens showed tumor-free lateral resection margins. None of the lesions showed lymphovascular invasion. A pathological examination of ESD specimens revealed submucosal invasion of more than 500 μm in all four cases. One patient underwent additional radical surgery post-ESD; no residual tumor or LN metastasis was noted in the surgical specimen. The other three patients did not undergo additional surgery, either because of severe comorbidity or their refusal to undergo operation, but were subjected to medical follow-up. None of the ESD-treated patients reported local recurrence or distant metastases during the 27-32 mo of follow-up after ESD. | Ji Young Lee Kyoung-Mee Kim Byung-Hoon Min Jun Haeng Lee Poong-Lyul Rhee Jae Jun Kim | 2014 | World Journal of Gastroenterology2014，20，5： | 8 |
| 5 | In-situ synthesis of TiC/Fe alloy composites with high strength and hardness by reactive sintering显示文摘Fe alloy composites reinforced with in-situ titanium carbide(Ti C) particles were fabricated by reactive sintering using different reactant C/Ti ratios of 0.8,0.9,1 and 1.1 to investigate the microstructure and mechanical properties of in-situ Ti C/Fe alloy composites.The microstructure showed that the in-situ synthesized Ti C particles were spherical with a size of 1–3 μm,irrespective of C/Ti ratio.The stoichiometry of in-situ Ti C increased from 0.85 to 0.88 with increasing C/Ti ratio from 0.8 to 0.9,but remained almost unchanged for C/Ti ratios between 0.9 and 1.1 due to the same driving force for carbon diffusion in Ti Cxat the common sintering temperature.The in-situ Ti C/Fe alloy composite with C/Ti = 0.9 showed improved mechanical properties compared with other C/Ti ratios because the presence of excess carbon(C/Ti = 1 and 1.1) resulted in unreacted carbon within the Fe alloy matrix,while insufficient carbon(C/Ti = 0.8)caused the depletion of carbon from the Fe alloy matrix,leading to a significant decrease in hardness.This study presents that the maximized hardness and superior strength of in-situ Ti C/Fe alloy composites can be achieved by microstructure control and stoichiometric analysis of the in-situ synthesized Ti C particles,while maintaining the ductility of the composites,compared to those of the unreinforced Fe alloy.Therefore,we anticipate that the in-situ synthesized Ti C/Fe alloy composites with enhanced mechanical properties have great potential in cutting tool,mold and roller material applications. | Junho Lee Dongju Lee Myung Hoon Song Wonhyuk Rhee Ho Jin Ryu Soon Hyung Hong | 2018 | Journal of Materials Science & Technology2018，34，8： | 8 |
| 6 | Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells显示文摘There are extensive studies on the applications of extracellular vesicles(EVs)produced in cell culture for therapeutic drug development.However,large quantities of EVs are needed for in vivo applications,which requires high production costs and time.Thus,the development of new EV sources is essential to facilitate their use.Accordingly,plant-derived exosome-like nanovesicles are an emerging alternative for culture-derived EVs.Until now,however,few studies have explored their biological functions and uses.Therefore,it is necessary to elucidate biological activities of plant-derived exosome-like nanovesicles and harness vesicles for biomedical applications.Herein,cabbage and red cabbage were used as nanovesicle sources owing to their easy cultivation.First,an efficient method for nanovesicle isolation from cabbage(Cabex)and red cabbage(Rabex)was developed.Furthermore,isolated nanovesicles were characterized,and their biological functions were assessed.Both Cabex and Rabex promoted mammalian cell proliferation and,interestingly,suppressed inflammation in immune cells and apoptosis in human keratinocytes and fibroblasts.Finally,therapeutic drugs were encapsulated in Cabex or Rabex and successfully delivered to human cells,demonstrating the potential of these vesicles as alternative drug delivery vehicles.Overall,the current results provide strong evidence for the wide application of Cabex and Rabex as novel therapeutic biomaterials. | Jae Young You Su Jin Kang Won Jong Rhee | 2021 | Bioactive Materials2021，6，12： | 7 |
| 7 | Clinical course of subepithelial lesions detected on upper gastrointestinal endoscopy显示文摘AIM:To evaluate the natural history of subepithelial lesions.METHODS:We reviewed the medical records of 104 159 patients who underwent upper gastrointestinal endoscopy at the Center for Health Promotion of Samsung Medical Center between 1996 and 2003.Subepithelial lesions were detected in 795 patients(0.76%);252 patients were followed using upper gastrointestinal endoscopy for 82.5 ± 29.2 mo(range,12-160 mo;median,84 mo;1st quartile,60 mo;3rd quartile,105 mo).The median interval of follow-up endoscopy was 12 mo(range,6-105 mo;1st quartile,12 mo;3rd quartile,24 mo).RESULTS:The mean patient age was 53 years(range,22-80 years),and the male-to-female ratio was 2.36:1(177/75).The lesion size at initial measurement averaged 8.9 mm(range,2-25 mm;median,8 mm;1st quartile,5 mm;3rd quartile,10 mm).Of the 252 lesions,244(96.8%) were unchanged and 8(3.2%) were significantly increased in size(from 12.9 ± 6.0 to 21.2 ± 12.2 mm) after a mean interval of 59.1 ± 27.5 mo(range,12-86 mo).Surgical resection of lesions was performed when the lesions were ≥ 3 cm in diameter.Two lesions were diagnosed as gastrointestinal stromal tumors with an intermediate or high risk of malignancy and one lesion was classified as a schwannoma.CONCLUSION:Most small subepithelial lesions do not change as shown by endoscopic examination,and regular follow-up with endoscopy may be considered in small,subepithelial lesions,especially lesions < 1 cm in size. | Yeun Jung Lim Hee Jung Son Jong-Soo Lee Young Hye Byun Hyun Joo Suh Pool Lyul Rhee Jae J Kim Jong Chul Rhee | 2010 | World Journal of Gastroenterology2010，16，4： | 6 |
| 8 | Schizonepeta tenuifolia inhibits collagen stimulated platelet function via suppressing MAPK and Akt signaling显示文摘The prevalence of cardiovascular diseases(CVDs)is increasing at a rapid pace in developed countries,and CVDs are the leading cause of morbidity and mortality.Natural products and ethnomedicine have been shown to reduce the risk of CVDs.Schizonepeta(S.)tenuifolia is a medicinal plant widely used in China,Korea,and Japan and is known to exhibit anti-inflammatory,antioxidant,and immunomodulatory activities.We hypothesized that given herbal plant exhibit pharmacological activities against CVDs,we specifically explored its effects on platelet function.Platelet aggregation was evaluated using standard light transmission aggregometry.Intracellular calcium mobilization was assessed using Fura-2/AM,and granule secretion(ATP release)was measured in a luminometer.Fibrinogen binding to integrin a_(Ⅱb)β_3,was assessed using flow cytometry.Phosphorylation of mitogen-activated protein kinase(MAPK)signaling molecules and activation of the protein kinase B(Akt)was assessed using Western blot assays.S.tenuifolia,extract potently and significantly inhibited platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin a_(Ⅱb)β_3.Moreover,all extracts significantly inhibited MAPK and Akt phosphorylation.S.tenuifolia extract inhibited platelet aggregation and granule secretion,and attenuated collagen mediated GPVI downstream signaling,indicating the potential therapeutic effects of these plant extracts on the cardiovascular system and platelet function.We suggest that S.tenuifolia extract may be a potent candidate to treat platelet-related CVDs and to be used as an antiplatelet and antithrombotic agent. | Bo-Ra Jeon Muhammad Irfan Minki Kim Seung Eun Lee Jeong Hoon Lee Man Hee Rhee | 2019 | The Journal of Biomedical Research2019，33，4： | 6 |
| 9 | Endoscopic ultrasonography-guided trucut biopsy for the preoperative diagnosis of peripancreatic castleman's disease: A case report显示文摘Castleman's disease (CD) of the pancreas/peripancreas is extremely rare. The recently introduced, endoscopic ultrasonography (EUS)-guided trucut biopsy (TCB) is a useful diagnostic modality for obtaining tissue samples from peripancreatic lesions. However, its role in diagnosing CD remains unknown. We report a case of localized, peripancreatic, hyaline-vascular CD biopsied using EUS. The pathology results were initially interpreted as an extranodal, marginal-zone B-cell lymphoma. However, polymerase chain reaction (PCR) study for the IgH gene rearrangement revealed a polyclonal pattern. We also reviewed the relevant literature. To our knowledge, this is the first illustrated report on EUS-TCB findings of CD with its pathology results of EUS-TCB mimicked a B-cell lymphoma. | Kyoung Hoon Rhee Sang Soo Lee Joo Ryung Huh | 2008 | World Journal of Gastroenterology2008，14，13： | 5 |
| 10 | Mitochondria as therapeutic targets for cancer stem cells显示文摘Cancer stem cells(CSCs) are maintained by theirsomatic stem cells and are responsible for tumor initiation, chemoresistance, and metastasis. Evidence for the CSCs existence has been reported for a number of human cancers. The CSC mitochondria have been shown recently to be an important target for cancer treatment, but clinical significance of CSCs and their mitochondria properties remain unclear. Mitochondriatargeted agents are considerably more effective compared to other agents in triggering apoptosis of CSCs, as well as general cancer cells, via mitochondrial dysfunction. Mitochondrial metabolism is altered in cancer cells because of their reliance on glycolytic intermediates, which are normally destined for oxidative phosphorylation. Therefore, inhibiting cancer-specific modifications in mitochondrial metabolism, increasing reactive oxygen species production, or stimulating mitochondrial permeabilization transition could be promising new therapeutic strategies to activate cell death in CSCs as well, as in general cancer cells. This review analyzed mitochondrial function and its potential as a therapeutic target to induce cell death in CSCs. Furthermore, combined treatment with mitochondriatargeted drugs will be a promising strategy for the treatment of relapsed and refractory cancer. | In Sung Song Jeong Yu Jeong Seung Hun Jeong Hyoung Kyu Kim Kyung Soo Ko Byoung Doo Rhee Nari Kim Jin Han | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 11 | Black TiO2: What are exact functions of disorder layer显示文摘Among the substantial amount of photocatalyst materials,TiO2 has been enthusiastically studied for a few decades due to its outstanding photocatalytic activity and stability.Recently,black TiO2 consisting of approximately 2 nm of thin disorder layer around the surface showed surprisingly high solar hydrogen generation ability.The disorder layer of TiO2 can enhance its light absorption,charge separation,and surface reaction abilities,however exact fundamentals of photocatalytic water-splitting pathways are still ambiguous.Herein,recent progress and investigations on exact functions of disorder layer and its application in photocatalytic CO2 reduction will be discussed.Throughout the comprehensive studies on disorder layer of TiO2,disorder engineering on photocatalyst materials will suggest the further extension of developing solarfuel production technologies. | Sungsoon Kim Yoonjun Cho Ryan Rhee Jong Hyeok Park | 2020 | Carbon Energy2020，2，1： | 4 |
| 12 | 旧金山市结核病流行病学中的性别差异显示文摘背景:在全球范围内,结核病性别发病率的差异仍无根本性的解释。目的:探究旧金山市1991~1996年有可能解释结核病发病率性别差异的各种因素。设计:对旧金山市1991~1996年结核病特定性别发病率进行回顾性流行病学分析。按诊断时年龄、种族群、人类免疫缺陷病毒(HIV)感染情况以及出生地等进行分层分析。使用带有IS6110数据的分子指纹研究新感染和复燃结核病例发病率的性别差异。结果:研究期内,男性与女性发病率之比为2.1(95%CI 1.9~2.3)。分层分析显示年龄超过14岁可见性别发病率差异,美国出生人群、白种人和黑种人其男性:女性发病率之比最高。具有成簇指纹的病例比值也较高,这与美国出生人群近似。在以结核病复燃病例为主的人群,比值在青春期后高于一般情况,但这种影响报告的较少。结论:结核病在美国出生人口中不断的感染是可解释旧金山市性别发病率不同的原因之一。观察到的两性结核病发病率的差异,可能是由于传播动力学的不同,而不是来自诊断和报告的偏倚。 | A. N. Martinez J. T. Rhee P. M. Small M. A. Behr 王延莉 | 2000 | 国际结核病与肺部疾病杂志2000，0，Z1： | 4 |
| 13 | Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization显示文摘AIM: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). METHODS: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. RESULTS: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. CONCLUSION: The Milan criteria are still a useful selec- tion criteria showing favorable outcomes in HCC patientsreceiving TACE before LT. | Do Young Kim Moon Seok Choi Joon Hyoek Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Sung Wook Shin Sung Wook Choo Young Soo Do Jong Chul Rhee | 2006 | World Journal of Gastroenterology2006，12，43： | 4 |
| 14 | Endoscopic cyanoacrylate injection for the treatment of gastric varices in children显示文摘AIM:To evaluate the efficacy and safety of N-butyl-2-cyanoacrylate in treating acute bleeding of gastric varices in children.METHODS:The retrospective study included 21 children with 47 episodes of active gastric variceal bleeding who were treated by endoscopic injection of N-butyl-2-cyanoacrylate at Asan Medical Center Children's Hospital between August 2004 and December 2011.To reduce the risk of embolism,each injection consisted of 0.1-0.5 mL of 0.5 mL N-butyl-2-cyanoacrylate diluted with 0.5 or 0.8 mL Lipiodol.The primary outcome was incidence of hemostasis after variceal obliteration and the secondary outcome was complication of the procedure.RESULTS:The 21 patients experienced 47 episodes of active gastric variceal bleeding,including rebleeding,for which they received a total of 52 cyanoacrylate injections.Following 42 bleeding episodes,hemostasis was achieved after one injection and following five bleeding episodes it was achieved after two injections.The mean volume of each single aliquot of cyanoacrylate injected was 0.3 ± 0.1 mL(range:0.1-0.5 m L).Injection achieved hemostasis in 45 of 47(95.7%) episodes of acute gastric variceal bleeding.Eleven patients(52.4%) developed rebleeding events,with the mean duration of hemostasis being 11.1 ± 11.6 mo(range:1.0-39.2 mo).No treatment-related complications such as distal embolism were noted with the exception of abdominal pain in one patient(4.8%).Among four mortalities,one patient died of variceal rebleeding.CONCLUSION:Endoscopic variceal obliteration using a small volume of aliquots with repeated cyanoacrylate injection was an effective and safe option for the treatment of gastric varices in children. | Seak Hee Oh Seung Jin Kim Kang Won Rhee Kyung Mo Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 4 |
| 15 | Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats显示文摘AIM: To investigate whether ezetimibe ameliorates hepatic steatosis and induces autophagy in a rat model of obesity and type 2 diabetes. METHODS: Male age-matched lean control LETO and obese and diabetic OLETF rats were administered either PBS or ezetimibe(10 mg/kg per day) via stomach gavage for 20 wk. Changes in weight gain and energy intake were regularly monitored. Blood and liver tissue were harvested after overnight fasting at the end of study. Histological assessment was performed in liver tissue. The concentrations of glucose, insulin, triglycerides(TG), free fatty acids(FFA), and total cholesterol(TC) in blood and TG, FFA, and TG in livertissue were measured. m RNA and protein abundance involved in autophagy was analyzed in the liver. To investigate the effect of ezetimibe on autophagy and reduction in hepatic fat accumulation, human Huh7 hepatocytes were incubated with ezetimibe(10 μmol/L) together with or without palmitic acid(PA, 0.5 mmol/L, 24 h). Transmission electron microscopy(TEM) was employed to demonstrate effect of ezetimibe on autophagy formation. Autophagic flux was measured with bafilomycin A1, an inhibitor of autophagy and following immunoblotting for autophagy-related protein expression.RESULTS: In the OLETF rats that received ezetimibe(10 mg/kg per day), liver weight were significantly decreased by 20% compared to OLETF control rats without changes in food intake and body weight(P < 0.05). Lipid parameters including TG, FFA, and TC in liver tissue of ezetimibe-administrated OLETF rats were dramatically decreased at least by 30% compared to OLETF controls(P < 0.01). The serum glucose, insulin, HOMA-IR, and lipid profiles were also improved by ezetimibe(P < 0.05). In addition, autophagy-related m RNA expression including ATG5, ATG6, and ATG7 and the protein level of microtubule-associated protein light chain 3(LC3) were significantly increased in the liver in rats that received ezetimibe(P < 0.05). Likewise, for hepatocytes cultured in vitro, ezetimibe treatment significantly decreased PA-induced fat accumulation and increased PA-reduced m RNA and protein expression involved in autophagy(P < 0.05). Ezetimibe-increased autophagosomes was observed in TEM analysis. Immunoblotting analysis of autophagy formation with an inhibitor of autophagy demonstrated that ezetimibe-increased autophagy resulted from increased autophagic flux. CONCLUSION: The present study demonstrates that ezetimibe-mediated improvement in hepatic steatosis might involve the induction of autophagy. | Eugene Chang Lisa Kim Se Eun Park Eun-Jung Rhee Won-Young Lee Ki-Won Oh Sung-Woo Park Cheol-Young Park | 2015 | World Journal of Gastroenterology2015，21，25： | 3 |
| 16 | Efficacy and safety of ecabet sodium on functional dyspepsia:A prospective,double-blinded,randomized,multi-center controlled trial显示文摘瞄准:在减轻机能性消化不良的症状比较 ecabet 钠和 cimetidine。方法:我们执行了一个多中心,未来,使随机化,双 blinded 控制了试用在病人把 ecabet 钠和 cimetidine 的临床的功效与机能性消化不良作比较。二 -- 有完成 Rome-II 标准的消化不良的症状的 172 个病人从 7 个中心被注册。在学习组(115 个病人) , 1.5 g ecabet 钠一天被给两次。在控制组(121 个病人) , 400 mg cimetidine 一天被给两次。生命的质量的症状和参数在基线被分析,在开始治疗以后的 3, 14,和 28 d。结果:二 -- 136 个病人完成了临床的试用。在治疗的 4 wk 以后,在有消化不良的症状的病人的改进的率不在二个组之间是不同的(77.4% 在 ecabet 组织,分别地, 79.3% 在 cimetidine 组织 P >
0.05 ) 。同样,征兆的改进的率不在 3 d 和 14 d 是不同的。生命的质量的参数没在两个组在学习时期期间显著地变化。在两个组没有临床上重要的不利事件。结论:在有机能性消化不良的病人, ecabet 钠与 cimetidine 有类似的临床的功效。 | Jun Haeng Lee Jae J Kim Ki-Baik Hahm Dong Ho Lee Nayoung Kim Sung Kook Kim Jong Jae Park Seok Reyol Choi Jong Hun Lee Soo Teik Lee Eun Hyun Lee Jong Chul Rhee | 2006 | World Journal of Gastroenterology2006，12，17： | 3 |
| 17 | Microfluidic three-dimensional cell culture of stem cells for high-throughput analysis显示文摘Although the recent advances in stem cell engineering have gained a great deal of attention due to their high potential in clinical research,the applicability of stem cells for preclinical screening in the drug discovery process is still challenging due to difficulties in controlling the stem cell microenvironment and the limited availability of high-throughput systems.Recently,researchers have been actively developing and evaluating three-dimensional(3D)cell culture-based platforms using microfluidic technologies,such as organ-on-a-chip and organoid-on-a-chip platforms,and they have achieved promising breakthroughs in stem cell engineering.In this review,we start with a comprehensive discussion on the importance of microfluidic 3D cell culture techniques in stem cell research and their technical strategies in the field of drug discovery.In a subsequent section,we discuss microfluidic 3D cell culture techniques for high-throughput analysis for use in stem cell research.In addition,some potential and practical applications of organ-on-a-chip or organoid-on-a-chip platforms using stem cells as drug screening and disease models are highlighted. | Jeong Ah Kim Soohyun Hong Won Jong Rhee | 2019 | World Journal of Stem Cells2019，11，10： | 3 |
| 18 | Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease显示文摘 | Rhee YH Ko JY Chang MY | 2011 | Journal of Clinical Investigation2011，，06： | 3 |
| 19 | 一个与辣椒细胞核雄性不育性状连锁的高分辨率熔解曲线(HRM)标记的开发显示文摘雄性不育性状被用在植物育种中,以降低种子生产成本。雄性不育分为细胞核雄性不育(GMS)和细胞质雄性不育(CMS)2种类型,在辣椒商业育种中都有应用。因为缺少恢复源,细胞质雄性不育系统在诸如甜椒等一些辣椒品种上并不适用。因此,细胞核雄性不育对于甜椒的种子生产而言就非常重要。本研究构建了一个F2分离群体,利用集群分离分析法(BSA)和扩增片段长度多态性(AFLP)技术获得了一个与甜椒细胞核雄性不育连锁的标记。我们分析了1024对AFLP引物,发现Eco RI ACG/MseIGTT引物扩出了多态性。对多态性AFLP标记所扩增的395bp片段重新设计引物,进行高分辨率熔解曲线分析(HRM)。在92个F2单株中,有87个单株的性状和HRM标记表型相一致。这个HRM标记被定位在AC99连锁图的第5号染色体上。 | Heung-Ryul Lee Hye Jung An Dong Cheol Yang Soon Ho Choi Hyoun-Joung Kim Han Gheol Rhee Chee Hark Harn 孔秋生 | 2012 | 辣椒杂志2012，，4： | 3 |
| 20 | Association Between Markers of Glucose Metabolism and Risk for Colorectal Adenoma显示文摘 | Sanjay Rampal Moon Hee Yang Jidong Sung Hee Jung Son Yoon-Ho Choi Jun Haeng Lee Young-Ho Kim Dong Kyung Chang Poong-Lyul Rhee Jong Chul Rhee Eliseo Guallar Juhee Cho | 2014 | Gastroenterology2014，，： | 2 |
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