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| 1 | Intra-abdominal pressure:Time ripe to revise managementguidelines of acute pancreatitis?显示文摘AIM: To systematically review evidence on pathophysiology of intra-abdominal pressure(IAP) in acute pancreatitis(AP) with its clinical correlates. METHODS: Systematic review of available evidence in English literature with relevant medical subject heading terms on Pub Med, Medline and Scopus with further search from open access sources on internet as suggested by articles retrieved. RESULTS: Intra-abdominal hypertension(IAH) is increasingly gaining recognition as a point of specific intervention with potential to alter disease outcome and improve mortality in AP. IAH can be expected in at least 17% of patients presenting with diagnosis of AP to a typical tertiary care hospital(prevalence increasing to 50% in those with severe disease). Abdominal compartment syndrome can be expected in at least 15% patients with severe disease. Recent guidelines on management of AP do not acknowledge utility of surveillance for IAP other than those by Japanese Society of Hepato-BiliaryPancreatic Surgery. We further outline pathophysiologic mechanisms of IAH; understanding of which advances our knowledge and helps to coherently align common observed variations in management related conundrums(such as fluid therapy, nutrition and antibiotic prophylaxis) with potential to further individualize treatment in AP. CONCLUSION: We suggest that IAP be given its due place in future practice guidelines and that recommendations be formed with help of a broader panel with inclusion of clinicians experienced in management of IAH. | jiten jaipuria vimal bhandari avneet singh chawla mohit singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 14 |
| 2 | 移位跟骨骨折——不良结果的预后因素显示文摘关于移位跟骨骨折的治疗方法的争论使许多文献问世,在争论中,少数的研究报告了患者及创伤的类型与治疗结果间的关系。那些报告中的与治疗结果不良的有关因素包括工伤赔偿情况、Bhler角小于0°的骨折、男性患者、重体力劳动职业、双侧跟骨骨折及SandersⅣ型骨折。 | Beate P.Hanson Mohit Bhandari 陈滨 姜小惟 | 2005 | 中华创伤骨科杂志2005，7，11： | 12 |
| 3 | Role of endoscopic ultrasound/SpyScope in diagnosis and treatment of choledocholithiasis in pregnancy显示文摘Cholelithiasis and choledocholithiasis occur frequently in pregnancy and their management can be complicated. Traditional endoscopic retrograde cholangiopancreatography(ERCP)is the first line treatment for choledocholithiasis,but in addition to its baseline risks,fluoroscopy poses an additional radiation risk to the fetus. Endoscopic ultrasound(EUS)is an accurate modality for detecting common bile duct stones,but its role has not been defined in pregnancy.We describe an alternative management strategy to conventional ERCP in a pregnant patient with choledocholithiasis and cholangitis detected using EUS and choledochoscopy. | Mohit Girotra Niraj Jani | 2010 | World Journal of Gastroenterology2010，16，28： | 11 |
| 4 | 雄激素补充疗法的诸多争议显示文摘雄激素已经成为目前在全世界各地被广泛使用的疗法之一。雄激素市场在过去十年中的迅猛增长归因于很多因素。比如,目前全球老龄化人群的增多。在美国,65岁以上人群的增加速度是65岁以下人群的2到3倍。再比如,整体不是很好的健康状况以及…些特殊的疾病(糖尿病、代谢综合症、心血管疾病和骨质疏松等)都与低血清睾酮水平有关。目前,关于雄激素治疗后前列腺癌的发展情况极少有报告,这就使得雄激素疗法成为一种具有吸引力的治疗方法。最后,不同形式的雄激素替代疗法的引入及其日益增多的市场宣传、促销和直接面对消费者的推广也促进了雄激素市场的增长。随着对雄激素替代疗法需求的增加,临床医生就越应该了解如何诊断和使用小剂量雄激素给予患者合适的治疗。 | Mohit Khera | 2015 | Asian Journal of Andrology2015，17，2： | 9 |
| 5 | Nonalcoholic steatohepatitis in Asian Indians is neither associated with iron overload nor with HFE gene mutations显示文摘AIM: The pathogenesis of occurrence of liver inflammation and fibrosis in patients with nonalcoholic steatohepatitis (NASH) is not completely understood. Other than insulin resistance, iron abnormalities have been thought to be one of the triggering factors. Therefore, our aim was to study the role of iron abnormalities and HFE gene mutations in patients with NASH.METHODS: Thirty-one patients of NASH diagnosed on the basis of clinical examination biochemistry, ultrasonography and liver biopsy (n = 14) were included in the study. Serum iron parameters (n = 23) (iron, ferritin, total iron-binding capacity and transferrin saturation), Peris' iron staining on liver biopsies (n = 14) and HFE gene mutations (C282Y and H63D) (n = 16) were studied in these patients. The association between iron staining, necroinflammatory activity and fibrosis stage on liver biopsies was also determined.RESULTS: Elevated serum iron, ferritin and transferrin saturation above 55% were observed in 4.3% of patients.On histology, 71% of the patients had negative iron staining,21.4% had 1+ staining, 7.2% had 2+ staining and none had 3+ or 4+ staining. There was no association between the degree of iron staining and necroinflammatory activity (P = 0.55) and fibrosis stage (P = 0.09) on histology. None of the patients had C282Y HFE gene mutation and four patients (25%) were found to be heterozygotes for H63D gene mutation.CONCLUSION: Our study does not favor iron overload and HFE gene mutations as major factors in the pathogenesis of NASH in Asian Indians. | Ajay Duseja Reena Das Mohit Nanda Ashim Das Gurjeewan Garewal Yogesh Chawla | 2005 | World Journal of Gastroenterology2005，11，3： | 9 |
| 6 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 7 | Source apportionment of PM10 in Delhi, India using PCA/APCS, UNMIX and PMF显示文摘 | Srishti Jain S.K. Sharma T.K. Mandal Mohit Saxena | 2018 | Particuology2018，16，2： | 7 |
| 8 | Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation显示文摘The integrity of the basal stem cell layer is critical for epithelial homoeostasis.In this paper,we review the expression of oral mucosal stem cell markers(OM-SCMs)in oral submucous fibrosis(OSF),oral potentially malignant disorders(OPMDs)and oral squamous cell carcinoma(OSCC)to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF.While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF,the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness.The vacillating expression patterns of OM-SCMs confirm the role of keratins 5,14,19,CD44,β1-integrin,p63,sex-determining region Y box(SOX2),octamer-binding transcription factor 4(Oct-4),c-MYC,B-cell-specific Moloney murine leukaemia virus integration site 1(Bmi-1)and aldehyde dehydrogenase 1(ALDH1)in OSF,OPMDs and OSCC.The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review. | Mohit Sharma Felipe Paiva Fonseca Keith D.Hunter Raghu Radhakrishnan | 2020 | International Journal of Oral Science2020，12，3： | 7 |
| 9 | Management of gastric variceal bleeding:Role of endoscopy and endoscopic ultrasound显示文摘Gastric varices(GVs)are notorious to bleed massively and often difficult to manage with conventional techniques.This mini-review addresses endoscopic management principles for gastric variceal bleeding,including limitations of ligation and sclerotherapy and merits of endoscopic variceal obliteration.The article also discusses how emerging use of endoscopic ultrasound provides optimism of better diagnosis,improved classification,innovative management strategies and confirmatory tool for eradication of GVs. | Mohit Girotra Saikiran Raghavapuram Rtika R Abraham Mrinal Pahwa Archna R Pahwa Rayburn F Rego | 2014 | World Journal of Hepatology2014，6，3： | 6 |
| 10 | 髋部骨折——经皮加压钢板固定与髋螺钉固定的探讨显示文摘研究表明,经皮加压钢板固定(PCCP)和髋螺钉固定(HS)在治疗髋部骨折相比较的结果各式各样。研究结果推荐PCCP,因为它需求的平均输血量较低,术后疼痛较轻。PCCP和HS两种治疗方法的置入失败率都很低。然而,置入失败和二次手术在PCCP组可能更为常见。额外的随机对照实验可以被用来检验这些结果。 | Beate P.Hanson Mohit Bhandari 陈滨(译校) 姜小惟(译校) | 2005 | 中华创伤骨科杂志2005，7，10： | 6 |
| 11 | Endoscopic retrograde cholangiopancreatography in cirrhosis-a systematic review and meta-analysis focused on adverse events显示文摘AIM To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography(ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events.METHODS We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017.RESULTS A total of 6,505 patients from 15 studies were analyzed(male ratio 59%, mean age 59 years), 11% with alcoholic and 89% with non-alcoholic cirrhosis, with 56.2% Child-Pugh class A, and 43.8% class B or C. Indications for ERCP included choledocholithiasis 60.9%, biliary strictures 26.2%, gallstone pancreatitis 21.1% and cholangitis 15.5%. Types of interventions included endoscopic sphincterotomy 52.7%, biliary stenting 16.7% and biliary dilation 4.6%. Individual adverse events included hemorrhage in 4.58%(95%CI: 2.77-6.75%, I^2 = 85.9%), post-ERCP pancreatitis(PEP) in 3.68%(95%CI: 1.83-6.00%, I^2 = 89.5%), cholangitis in 1.93%(95%CI: 0.63-3.71%, I^2 = 87.1%) and perforation in 0.00%(95%CI: 0.00-0.23%, I^2 = 37.8%). Six studies were used for comparison of ERCPrelated complications in cirrhosis vs non-cirrhosis, which showed higher overall rates of complications in cirrhosis patients with pooled OR of 1.63(95%CI: 1.27-2.09, I2 = 65%): higher rates of hemorrhage with OR of 2.05(95%CI: 1.62-2.58, I^2 = 2.1%) and PEP with OR of 1.33(95%CI: 1.04-1.70, I2=65%), but similar cholangitis rates with OR of 1.23(95%CI: 0.67-2.26, I^2 = 44.3%).CONCLUSION There is an overall higher rate of adverse events related to ERCP in patients with cirrhosis, especially hemorrhage and PEP. A thorough risk/benefit assessment should be performed prior to undertaking ERCP in patients with cirrhosis. | Shailender Singh Mashiana Amaninder Singh Dhaliwal Harlan Sayles Banreet Dhindsa Ji Won Yoo Qing Wu shailender singh Ali A Siddiqui Gordon Ohning Mohit Girotra Douglas G Adler | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 6 |
| 12 | Utility of endoscopic ultrasound and endoscopy in diagnosis and management of hepatocellular carcinoma and its complications: What does endoscopic ultrasonography offer above and beyond conventional cross-sectional imaging?显示文摘Hepatocellular carcinoma constitutes over 90% of the primary liver tumors, the rest being cholangiocarcinoma. It has an insidious presentation, which is responsible for the delayed presentation. Hence, the management strategy relies on screening to diagnose it an early stage for curative resection and/or treatment with local ablative techniques or chemotherapy. However, even with different screening programs, more than 60% of tumors are still detected at an advanced stage, leading to an unchanged mortality rate, thereby implying a room for improvement in the screening and diagnostic process. In the last few years, there has been evolution of utility of endoscopy, specifically endoscopic ultrasonography along with Fine needle aspiration, for this purpose, which we comprehensively review in this article. | Mohit Girotra Kaartik Soota Amaninder S Dhaliwal Rtika R Abraham Mauricio Garcia-Saenz-de-Sicilia Benjamin Tharian | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，2： | 5 |
| 13 | Operative vs non-operative management of displaced proximal humeral fractures in the elderly: A systematic review and meta-analysis of randomized controlled trials显示文摘AIM: To perform a systematic review and meta-analysis comparing operative vs non-operative treatment of displaced proximal humerus fractures in elderly patients.METHODS: A systematic literature search was performed using EMBASE and MEDLINE through the OVID interface,CINAHL,the Cochrane Central Register of Controlled Trials(CENTRAL),Proquest,Web of Science,SAE digital library,and Transportation Research Board's TRID database.Searches of conference proceedings were also conducted.All available randomized controlled trials comparing operative vs non-operative management of displaced three- and four-part proximal humerus fractures in elderly patients were included.The primary outcomes measures included physical function,pain,health related quality of life,mortality,and the re-operation rate.RESULTS: Six randomized controlled trials(n = 287) were included.There was no statistically significant difference in function(MD = 1.72,95%CI:-2.90-6.34,P = 0.47),as measured by the Constant score,between the operative and the non-operative treatment groups.There was no statistically significance difference insecondary outcomes of health related quality of life(standardized MD = 0.27,95%CI:-0.05-0.59,P = 0.09),and mortality(relative risk 1.29,95%CI: 0.50-3.35,P = 0.60).Operative treatment had a statistically significant higher re-operation rate(relative risk 4.09,95%CI: 1.50-11.15,P = 0.006),and statistically significant decreased pain(MD = 1.26,95%CI: 0.02-2.49,P = 0.05).CONCLUSION: There is moderate quality evidence to suggest that there is no difference in functional outcomes between the two treatments.Further high quality randomized controlled trials are required to determine if certain subgroup populations benefit from surgical management. | Santa Rabi Nathan Evaniew Sheila A Sprague Mohit Bhandari Gerard P Slobogean | 2015 | World Journal of Orthopedics2015，6，10： | 5 |
| 14 | Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians显示文摘AIM To investigate the association of NFKB1 gene-94 ATTG insertion/deletion(rs28362491) polymorphism with inflammatory markers and risk of diabetic nephropathy in Asian Indians.METHODS A total of 300 subjects were recruited(100 each), normoglycemic,(NG); type 2 diabetes mellitus(T2DM) without any complications(DM) and T2 DM with diabetic nephropathy [DM-chronic renal disease(CRD)]. Analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism and ELISA. Pearson's correlation, analysis of variance and logistic regression wereused for statistical analysis.RESULTS The allelic frequencies of-94 ATTG insertion/deletion were 0.655/0.345(NG), 0.62/0.38(DM) and 0.775/0.225(DM-CRD). The-94 ATTG ins allele was associated with significantly increased levels of urinary monocyte chemoattractant protein-1(u MCP-1); u MCP-1(P = 0.026) and plasma tumor necrosis factor-alpha(TNF-α); TNF-α(P = 0.030) and almost doubled the risk of diabetic nephropathy(OR = 1.91, 95%CI: 1.080-3.386, P = 0.025).CONCLUSION-94 ATTG ins/ins polymorphism might be associated with increased risk of developing nephropathy in Asian Indian subjects with diabetes mellitus. | Amar Gautam Stuti Gupta Mohit Mehndiratta Mohini Sharma Kalpana Singh Om P Kalra Sunil Agarwal Jasvinder K Gambhir | 2017 | World Journal of Diabetes2017，8，2： | 4 |
| 15 | Physiological normal levels of androgen inhibit proliferation of prostate cancer cells in vitro显示文摘为超过 70 年,浆液雄激素层次的严重减小引起了前列腺癌症(PCa ) 的回归并且增加的雄激素层次提高了 PCa 的生长,这被相信了。然而,众多的最近的研究询问了这个传统的信仰。在我们的学习, LNCaP 和 MDA PCa 2b PCa 房间与雄激素的各种各样的层次被对待 10 或 20 天,并且房间生长与水晶被测量紫 mitogenic 试金。结果显示 PCa 细胞的增长上的雄激素的效果发生在一个 biphasic 模式,与支持在为 LNCaP 细胞并且在为 MDA PCa 2b 细胞的 1 和 2 ng ml −1 之间的约 0.23 ng ml −1 的最佳的细胞生长的雄激素层次。两最佳的雄激素层次在成年的人的生理的低范围以内(< 2.4 ng ml −1) 。比最佳的雄激素在更低的集中铺平,增加支持的雄激素集中 PCa 房间的增长。在更高的集中,然而增加雄激素集中导致了剂量依赖者 proliferative 抑制。我们断定雄激素的生理地正常的层次在 vitro 禁止 PCa 房间的增长。然而,在很底层雄激素为 PCa 房间的起始的生长是必要的。 | Weitao Song Mohit Khera | 2014 | Asian Journal of Andrology2014，16，6： | 4 |
| 16 | Assessment of performance,combustion and emissions characteristics of methanol-diesel dual-fuel compression ignition engine:A review显示文摘The energy security concern and rapidly diminishing fossil fuel resources demand the development of renewable and economically attractive fuel for reciprocating engines.Methanol is a promising renewable alternative fuel.Numerous studies have been carried out to explore the various aspects of the utilization of methanol in compression ignition(CI)engine.This review paper presents a detailed analysis of the effect of methanol on performance,combustion,and emission(NOx,CO,HC,and soot)characteristics of conventional CI-engine along with dual-fuel combustion mode.This study focuses on methanol utilization in dual-fuel mode,which is an advanced engine combustion mode.First,methanol production and solubility issues of methanol in diesel are briefly discussed.This study discusses the soot and nano-particle emission from the methanol fueled CI-engine,which is one of the main concerns in the current emission legislation.It was found that the utilization of methanol in CI-engine has the potential to improve the performance and simultaneously with a significant reduction in NOx,CO,soot,and nano-particle emissions in comparison to neat diesel operation.However,unburnt HC emission reduces for methanol-diesel blended fuel operation whereas HC emissions are higher for methanoldiesel dual-fuel operation. | Mohit Raj Saxena Rakesh Kumar Maurya Prashant Mishra | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，5： | 4 |
| 17 | 水刺非织造布的水刺工艺流程及其性能显示文摘非织造布需具备一定的初始强力以承受固结过程中受到由机械力、热和化学反应等引起的应力作用,最终得到所需强力。水刺工艺是通过一系列高速水针使纤维相互抱合缠结的技术。水刺法能够制备出具有特殊物理、力学和其他功能性的非织造布。综述了水刺法工艺参数设置对非织造布性能的影响,包括水针直径、水针间距、管压力及管数对非织造布结构和性能的影响。 | Sujit Gulhane Ranjit Turukmane Chetan Mahajan Mohit Joshi 童艺翾 | 2019 | 国际纺织导报2019，47，10： | 4 |
| 18 | A secondary bile acid from microbiota metabolism attenuates ileitis and bile acid reduction in subclinical necrotic enteritis in chickens显示文摘Background:Clostridium perfringens-induced chicken necrotic enteritis(NE)is responsible for substantial economic losses worldwide annually.Recently,as a result of antibiotic growth promoter prohibition,the prevalence of NE in chickens has reemerged.This study was aimed to reduce NE through titrating dietary deoxycholic acid(DCA)as an effective antimicrobial alternative.Materials and methods:Day-old broiler chicks were assigned to six groups and fed diets supplemented with 0(basal diet),0.8,1.0 and 1.5 g/kg(on top of basal diet)DCA.The birds were challenged with Eimeria maxima(20,000 oocysts/bird)at d 18 and C.perfringens(109 CFU/bird per day)at d 23,24,and 25 to induce NE.The birds were sacrificed at d 26 when ileal tissue and digesta were collected for analyzing histopathology,mRNA accumulation and C.perfringens colonization by real-time PCR,targeted metabolomics of bile acids,fluorescence in situ hybridization(FISH),or terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay.Results:At the cellular level,birds infected with E.maxima and C.perfringens developed subclinical NE and showed shortening villi,crypt hyperplasia and immune cell infiltration in ileum.Dietary DCA alleviated the NE-induced ileal inflammation in a dose-dependent manner compared to NE control birds.Consistent with the increased histopathological scores,subclinical NE birds suffered body weight gain reduction compared to the uninfected birds,an effect attenuated with increased doses of dietary DCA.At the molecular level,the highest dose of DCA at 1.5 g/kg reduced C.perfringens luminal colonization compared to NE birds using PCR and FISH.Furthermore,the dietary DCA reduced subclinical NE-induced intestinal inflammatory gene expression and cell apoptosis using PCR and TUNEL assays.Upon further examining ileal bile acid pool through targeted metabolomics,subclinical NE reduced the total bile acid level in ileal digesta compared to uninfected birds.Notably,dietary DCA increased total bile acid and DCA levels in a dose-dependent manner compared to NE birds.Conclusion:These results indicate that DCA attenuates NE-induced intestinal inflammation and bile acid reduction and could be an effective antimicrobial alternative against the intestinal disease. | Mohit Bansal Ying Fu Bilal Alrubaye Mussie Abraha Ayidh Almansour Anamika Gupta Rohana Liyanage Hong Wang Billy Hargis Xiaolun Sun | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 3 |
| 19 | 在L-缬氨酸介质中应用聚二苯并-18-冠醚-6分离铈(Ⅲ)(英文)显示文摘A column chromatographic method has been developed for the separation and determination of cerium(Ⅲ) using poly[dibenzo-18-crown-6].The separation was carried out in L-valine medium.The adsorption of cerium(Ⅲ) was quantitative from 1×10-1 to 1×10-4 mol/L L-valine.Amongst the various eluents,1.0-8.0 mol/L hydrochloric acid,1.0-8.0 mol/L hydrobromic acid,1.0-8.0 mol/L perchloric acid,1.0-2.0 mol/L sulfuric acid and 4.0-5.0 mol/L acetic acid,were found to be the efficient eluents for cerium(Ⅲ).The capacity of poly[dibenzo-18-crown-6] for cerium(Ⅲ) was(0.428±0.01) mmol/g.The method was applied to the separation of cerium(Ⅲ) from associated elements link uranium(Ⅵ) and thorium(Ⅳ).It was also applied for the determination of cerium(Ⅲ) in geological samples.The method is simple,rapid and selective with good reproducibility(approximately±2%). | SABALE Sandip R MOHITE Baburao S | 2009 | 色谱2009，27，2： | 3 |
| 20 | Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines显示文摘AIM: To study the effect of anti-copper treatment for survival of hepatic cells expressing different ATP7 B mutations in cell culture. METHODS: The most common Wilson disease(WD) mutations p.H1069 Q, p.R778 L and p.C271*, found in the ATP7 B gene encoding a liver copper transporter, were studied. The mutations represent major genotypes of the United States and Europe, China, and India, respectively. A human hepatoma cell line previously established to carry a knockout of ATP7 B was used to stably express WD mutants. m RNA and protein expression of mutant ATP7 B, survival of cells, apoptosis, and protein trafficking were determined.RESULTS: Low temperature increased ATP7 B protein expression in several mutants. Intracellular ATP7 B localization was significantly impaired in the mutants. Mutants were classified as high, moderate, and no survival based on their viability on exposure to toxic copper. Survival of mutant p.H1069 Q and to a lesser extent p.C271* improved by D-penicillamine(DPA) treatment, while mutant p.R778 L showed a pronounced response to zinc(Zn) treatment. Overall, DPA treatment resulted in higher cell survival as compared to Zn treatment; however, only combined Zn + DPA treatment fully restored cell viability. CONCLUSION: The data indicate that the basic impact of a genotype might be characterized by analysis of mutant hepatic cell lines. | Gursimran Chandhok Judit Horvath Annu Aggarwal Mohit Bhatt Andree Zibert Hartmut HJ Schmidt | 2016 | World Journal of Gastroenterology2016，22，16： | 3 |
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