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| 1 | Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats显示文摘AIM:To determine the temporal expression and pattern of Rel/nuclear factor(NF)-κB proteins in renal tissue in polycystic kidney disease(PKD). METHODS: The renal expression of Rel/NF-κB proteins was determined by immunohistochemistry, immunofluorescence and immunoblot analysis in Lewis polycystic kidney rats(LPK, a genetic ortholog of human nephronopthsis-9) from postnatal weeks 3 to 20. At each timepoint, renal disease progression and the mR NA expression of NF-κB-dependent genes(TNFa and CCL2) were determined. NF-κB was also histologicaly assessed in human PKD tissue.RESULTS: Progressive kidney enlargement in LPK rats was accompanied by increased renal cell proliferation and interstitial monocyte accumulation(peaking at weeks 3 and 10 respectively), and progressive interstitial fibrosis(with a smooth muscle actin and Sirius Red deposition significantly increased compared to Lewis kidneys from weeks 3 to 6 onwards). Rel/NF-κB proteins(phosphorylated-p105, p65, p50, c-Rel and RelB) were expressed in cystic epithelial cells(CECs) of LPK kidneys as early as postnatal week 3 and sustained until latestage disease at week 20. From weeks 10 to 20, nuclear p65, p50, Rel B and cytoplasmic IκBa protein levels, and TNFa and CCL2 expression, were upregulated in LPK compared to Lewis kidneys. NF-κB proteins were consistently expressed in CECs of human PKD. The DNA damage marker γ-H2AX was also identified in the CECs of LPK and human polycystic kidneys. CONCLUSION: Several NF-κB proteins are consistently expressed in CECs in human and experimental PKD. These data suggest that the upregulation of both the canonical and non-canonical pathways of NF-κB signaling may be a constitutive and early pathological feature of cystic renal diseases. | Michelle HT Ta Kristina G Schwensen David Liuwantara David L Huso Terry Watnick Gopala K Rangan | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 2 | Somatic PKD2 mutations in individual kidney and liver cysts support a 'two-hit'model for cystogenesis in type 2 autosomal polycystic kidney disease显示文摘 | Pei Y Watnick T He N | 1999 | J Am Soc Nephrol1999，10，： | 1 |
| 3 | Biofilm city of microbes 显示文摘 | Kolter R | 2000 | J Bacteriol2000，182，： | 1 |
| 4 | The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney DiseaseType 1显示文摘 | WATNICK TJ ONCHIC LF | 1996 | Cell1996，87，10： | 1 |
| 5 | The prevalence and treatment of depression among patients starting dialysis显示文摘 | Watnick S Kirwin P Mahnensmith R et a1 | 2003 | Am J Kidney Dis2003，41，1： | 1 |
| 6 | Steps in the development of a Vibrio cholerae biofilm 显示文摘 | Kolter R | 1999 | Mol Microbiol1999，34，： | 1 |
| 7 | Steps in the development of a Vibrio cholerae El Tor biofilm显示文摘 | Watnick PI Kolter R | 1999 | Molecular Microbiology1999，34，3： | 1 |
| 8 | Biofilm, city of microbes 显示文摘 | Watnick P Kolter R | 2000 | J Bacteri- al2000，182，10： | 1 |
| 9 | Signals,regulatory networks,and materials that build and break bacterial biofilms显示文摘 | Karatan E Watnick P | 2009 | Microbiol Mol Biol Rev2009，73，2： | 1 |
| 10 | A role for the mannose sensitive hemagglutinin in biofilm formation by Vibrrio cholerae 显示文摘 | Fullner K J Kolter R | 1999 | J Bacteriol1999，18，12： | 1 |
| 11 | Biofilms city of microbes显示文摘 | WATNICK P KOLTER R | 2000 | J Bacteriol2000，182，10： | 1 |
| 12 | The prevalence and treatment of depression among patients starting dialysis显示文摘 | Kirwin P Mahnensmith R | 2003 | Am J Kidney Dis2003，41，1： | 1 |
| 13 | Somatic mutation in individual liver cysts supports a two-hit model for cystogenesis in autosomal dominant polycystic kidney disease显示文摘 | Watnick TJ Torres VE Gandolph MA | 2000 | Mol Cell2000，21，2： | 1 |
| 14 | The use of combination internal fixation and hybrid external fixation in severe proximal tibia fractures显示文摘 | Weiner LS Kelley M Yang E Steaer J Watnick N Evans M Bergman M | | 0，，： | 1 |
| 15 | The Vibrio cholerae O139 O-antigen polysaceharide is essential for Ca^2+-dependent biofilm development in sea water显示文摘 | KIEREK K WATNICK P I | 2003 | PNAS2003，100，14： | 1 |
| 16 | Depression:a common but underrecognized condition associated with end-stage renal disease显示文摘 | Wang PL Watnick SG | 2004 | Semin Dial2004，17，： | 1 |
| 17 | A role for the mannose-sensitive hemagglutinin in biofilm formation by Vibrio cholerae El Tor显示文摘 | Watnick P Fullner KJ Kolter R | 1999 | J Bacteriol1999，181，11： | 1 |
| 18 | Biofilm, city of microbes 显示文摘 | Watnick P Kolter R | 2000 | J Bacteriol2000，182，10： | 1 |
| 19 | Genetic approaches to study of biofilms显示文摘 | O'TOOLE G A PRATT L A WATNICK P I | 1999 | Methods Enzymol1999，310，： | 1 |
| 20 | A flagellar polycystin-2 homolog required for male fertility in Drosophila显示文摘 | Watnick TJ Jin Y Matunis E | 2003 | Curr Biol2003，13，24： | 1 |
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