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| 1 | International NeuroAIDS: prospects of HIV-1 associated neurological com-plications显示文摘Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain. | J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO | 2005 | Cell Research2005，15，11： | 4 |
| 2 | New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2显示文摘The 2004 discovery of EGFR mutations,followed by ALK rearrangements,ushered in a targeted therapy era for advanced non-small cell lung cancer(NSCLC).Tyrosine kinase inhibitors targeting gene alterations have substantially improved survival and quality of life for patients with NSCLC.In the last decade,rearrangements of the ROS1 oncogene have been incorporated into healthcare practice that are applicable to another small subgroup of patients who benefit from similar targeted strategies.Recent genome studies of lung adenocarcinoma have identified other possible therapeutic targets,including RET,NTRK fusions,c-MET alterations,and activating mutations in KRAS,BRAF,and HER2,all with frequencies greater than 1%.Lung cancers harbouring these genome changes can potentially be treated with agents approved for other indications or under clinical development.This review updates the therapeutic arsenal that especially targets those genes. | Maria Eugenia Olmedo Raquel Cervera Luis Cabezon-Gutierrez Yolanda Lage Elena Corral de la Fuente Ana Gomez Rueda1,Xabier Mielgo-Rubio Juan Carlos Trujillo Felipe Counago | 2022 | World Journal of Clinical Oncology2022，13，4： | 3 |
| 3 | Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa显示文摘 | Miano MG Testa F Strazzullo M Trujillo M De Bernardo C Grammatico B | | 0，，： | 2 |
| 4 | Sharp weighted estimates for multilinear commutators显示文摘 | PEREZ C TRUJILLO G R | 2002 | J London Math Soe2002，65，2： | 1 |
| 5 | Increased response to ketamine following treatment at long intervals:implications for intermittent use显示文摘 | Trujillo KA Zamora JJ Warmoth KP | 2008 | Biol Psychiatry2008，63，2： | 1 |
| 6 | Arizona's near real time school-based syndromic surveillance program显示文摘 | Trujillo L Qiu Y Komatsu K | 2007 | Advances in Disease Surveillance2007，4，： | 1 |
| 7 | Adiponectin-joumey from an adipocyte secretory protein to biomarker of the metabolic syndrome 显示文摘 | Trujillo ME Scherer PE | 2005 | J Intern Med2005，257，2： | 1 |
| 8 | Separation of liquid-liquid dispersions in a deep-layer gravity settler: Part I Experimental study of the separation process 显示文摘 | Padilla R Ruiz M C Trujillo W | 1996 | Hydrometallurgy1996，42，2： | 1 |
| 9 | Extending OCL for OLAP querying on conceptual multidimensional models of data warehouses显示文摘 | Pardillo J Mazon J N Trujillo J | | 0，，05： | 1 |
| 10 | Aquaporin water channels AQP1 and AQP3, are expressed in equine ar- ticular chondrocytes显示文摘 | MOBASHERI A TRUJILLO E BELL S | 2004 | Vet J2004，168，2： | 1 |
| 11 | Interventions to reduce HIV/ AIDS stigma: what have we learned显示文摘 | Brown L Macintyre K Trujillo L | 2003 | AIDS Educ Prey2003，15，1： | 1 |
| 12 | T regulatory ceils and attenuated bleomycin-induced fibrosis in lungs of CCR7-/- mice 显示文摘 | Trujillo G Harfigan AJ Hogaboam CM | 2010 | Fibrogenesis Tissue Repair2010，3，： | 1 |
| 13 | Concerning the significance of paraoxonase-1 and SR-B1 genes in atherosclerosis显示文摘 | Rodríguez Esparragón F Hernández Trujillo Y Macías Reyes A | 2006 | Rev Esp Cardiol2006，59，2： | 1 |
| 14 | Improving nutritional screening of hospitalized patients: The role of prealbumin显示文摘 | Robinson Mk Trujillo EB Mogensen KM | 2003 | JPEN2003，27，6： | 1 |
| 15 | Proliferation of human colon cancer cells: Role of epidemal growth factor and transforming growth factor alpha显示文摘 | Huang S Trujillo JM Chakraharty S | 1992 | Int J Cancer1992，52，6： | 1 |
| 16 | Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome显示文摘 | Trujillo ME Scherer PE | 2005 | J Intern Med2005，257，2： | 1 |
| 17 | Construction of a homodimeric dihydrofolate reductase - thymidylate synthase bifunctional en- zyme 显示文摘 | Trujillo M Duncan R Santi D | 1997 | Protein Eng1997，10，5： | 1 |
| 18 | Application of quantitative fluorescent PGR with short tandem repeat markers to the study of aneuploidies in spontaneous miscarriages显示文摘 | Diego-Alvarez D Garcia-Hoyos M Trujillo MJ | 2005 | Hum Reprod2005，20，5： | 1 |
| 19 | Echocardiographic Speckle-Tracking Based Strain Imaging for Rapid Cardiovascular Phenotyping in Mice显示文摘 | Michael Bauer Susan Cheng Mohit Jain Soeun Ngoy Catherine Theodoropoulos Anna Trujillo Fen-Chiung Lin Ronglih Liao | 2011 | Circulation Research2011，，8： | 1 |
| 20 | Proteolysis of ultra-high pressure homogenised treated milk during refrigerated storage显示文摘 | J. Pereda V. Ferragut M. Buffa B. Guamis A.J. Trujillo | 2008 | Food Chemistry2008，，3： | 1 |
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