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| 1 | Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers显示文摘 | M. Joerger T. M. Bosch V. D. Doodeman J. H. Beijnen P. H. M. Smits J. H. M. Schellens | 2006 | European Journal of Clinical Pharmacology2006，，8： | 1 |
| 2 | Characterization of composite materials of electroconductive polymer and cobalt as electrocatalysts for the oxygen reduction reaction显示文摘 | W. Martínez Millán T. Toledano Thompson L.G. Arriaga Mascha A. Smit | 2008 | International Journal of Hydrogen Energy2008，，2： | 1 |
| 3 | A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families显示文摘 | Jeroen P.P. Smits Tamara T. Koopmann Ronald Wilders Marieke W. Veldkamp Tobias Opthof Zahir A. Bhuiyan Marcel M.A.M. Mannens Jeffrey R. Balser Hanno L. Tan Connie R. Bezzina Arthur A.M. Wilde | 2005 | Journal of Molecular and Cellular Cardiology2005，，6： | 1 |
| 4 | A conceptual framework for understanding HIV risk behavior in the context of supporting fertility goals among HIV-serodiscordant couples显示文摘 | Tamaryn L. Crankshaw Lynn T. Matthews Janet Giddy Angela Kaida Norma C. Ware Jennifer A. Smit David R. Bangsberg | 2012 | Reproductive Health Matters2012，，39： | 1 |
| 5 | Endoscopic Treatment of Chronic Pancreatitis: A Multicenter Study of 1000 Patients with Long-Term Follow-Up显示文摘 | T. R?sch S. Daniel M. Scholz K. Huibregtse M. Smits T. Schneider C. Ell G. Haber J.-F. Riemann R. Jakobs R. Hintze A. Adler H. Neuhaus M. Zavoral F. Zavada V. Schusdziarra N. Soehendra | 2002 | Endoscopy2002，，10： | 1 |
| 6 | Outcomes and resource use of non-small cell lung cancer (NSCLC) patients treated with first-line platinum-based chemotherapy across Europe: FRAME prospective observational study显示文摘 | Denis Moro-Sibilot Egbert Smit Javier de Castro Carpe?o Krzysztof Lesniewski-Kmak Joachim Aerts Rosa Villatoro Kees Kraaij Karim Nacerddine Yulia Dyachkova Karen T. Smith Kaisa Taipale Allicia C. Girvan Carla Visseren-Grul Philipp A. Schnabel | 2015 | Lung Cancer2015，，2： | 1 |
| 7 | Origin of eclogite and pyroxenite xenoliths from the Victor kimberlite, Canada, and implications for Superior craton formation显示文摘 | K.V. Smit T. Stachel R.A. Creaser R.B. Ickert S.A. DuFrane R.A. Stern M. Seller | 2014 | Geochimica et Cosmochimica Acta2014，，： | 1 |
| 8 | Near‐infrared fluorescence‐guided resection of colorectal liver metastases显示文摘 | Joost R. van der Vorst Boudewijn E. Schaafsma Merlijn Hutteman Floris P. R. Verbeek Gerrit‐Jan Liefers Henk H. Hartgrink Vincent T. H. B. M. Smit Clemens W. G. M. L?wik Cornelis J. H. van de Velde John V. Frangioni Alexander L. Vahrmeijer | 2013 | Cancer2013，，18： | 1 |
| 9 | Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer显示文摘 | J. Sven D. Mieog Merlijn Hutteman Joost R. Vorst Peter J. K. Kuppen Ivo Que Jouke Dijkstra Eric L. Kaijzel Frans Prins Clemens W. G. M. L?wik Vincent T. H. B. M. Smit Cornelis J. H. Velde Alexander L. Vahrmeijer | 2011 | Breast Cancer Research and Treatment2011，，3： | 1 |
| 10 | Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy显示文摘 | R. Meerwaldt T. P. Links R. Graaff K. Hoogenberg J. D. Lefrandt J. W. Baynes R. O. B. Gans A. J. Smit | 2005 | Diabetologia2005，，8： | 1 |
| 11 | Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy显示文摘 | R. Meerwaldt T. P. Links R. Graaff K. Hoogenberg J. D. Lefrandt J. W. Baynes R. O. B. Gans A. J. Smit | 2005 | Diabetologia2005，，8： | 1 |
| 12 | Endoscopic Treatment of Chronic Pancreatitis: A Multicenter Study of 1000 Patients with Long-Term Follow-Up显示文摘 | T. R?sch S. Daniel M. Scholz K. Huibregtse M. Smits T. Schneider C. Ell G. Haber J.-F. Riemann R. Jakobs R. Hintze A. Adler H. Neuhaus M. Zavoral F. Zavada V. Schusdziarra N. Soehendra | 2002 | Endoscopy2002，，10： | 1 |
| 13 | Regional and Global Tropopause Fold Occurrence and Related Ozone Flux Across the Tropopause显示文摘 | M. Beekmann G. Ancellet S. Blonsky D. De Muer A. Ebel H. Elbern J. Hendricks J. Kowol C. Mancier R. Sladkovic H. G. J. Smit P. Speth T. Trickl Ph. Van Haver | 1997 | Journal of Atmospheric Chemistry (-)1997，，1： | 1 |
| 14 | Cardiovascular effects of sulphonylurea derivatives显示文摘 | Dr. P. Smits T. Thien | 1995 | Diabetologia1995，，1： | 1 |
| 15 | Liver transplantation for glycogen storage disease types I, III, and IV显示文摘 | D. Matern T. E. Starzl W. Arnaout J. Barnard J. S. Bynon A. Dhawan J. Emond E. B. Haagsma G. Hug A. Lachaux G. P. A. Smit Y-T. Chen | 1999 | European Journal of Pediatrics1999，，2： | 1 |
| 16 | Expression of CD44 in Apc and Tcf Mutant Mice Implies Regulation by the WNT Pathway显示文摘 | Vera J.M. Wielenga Ron Smits Vladimir Korinek Lia Smit Menno Kielman Riccardo Fodde Hans Clevers Steven T. Pals | 1999 | The American Journal of Pathology1999，，2： | 1 |
| 17 | Video Capsule Endoscopy in Patients With Nonresponsive Celiac Disease显示文摘 | Stijn J. B. Van Weyenberg Fokko Smits Maarten A. J. M. Jacobs Sietze T. Van Turenhout Chris J. Mulder | 2013 | Journal of Clinical Gastroenterology2013，，5： | 1 |
| 18 | Endoscopic Treatment of Chronic Pancreatitis: A Multicenter Study of 1000 Patients with Long-Term Follow-Up显示文摘 | T. R?sch S. Daniel M. Scholz K. Huibregtse M. Smits T. Schneider C. Ell G. Haber J.-F. Riemann R. Jakobs R. Hintze A. Adler H. Neuhaus M. Zavoral F. Zavada V. Schusdziarra N. Soehendra | 2002 | Endoscopy2002，，10： | 1 |
| 19 | 银屑病患者应用5-氨基乙酰丙酸后的荧光异质性:一项免疫组化研究显示文摘Background: Psoriasis has been shown to highly accumulate protoporphyrin IX (PpIX), but a variable distribution within plaques after fluorescence diagnosis is seen. It is unknown what causes this heterogeneity of fluorescence in psoriatic skin, despite adequate keratolytic treatment. Variations in fluorescence might explain the variable and the mostly partial clinical response of psoriasis seen after photodynamic therapy (PDT).Objectives: This study examines morphological and immunohistochemical differences in inhomogeneous PpIX-induced fluorescence in stable plaque psoriasis. Materials and methods: Fourteen patients with stable plaque psoriasis were included in this study. In each patient one psoriatic plaque was incubated with 20%5-aminolaevulinic acid (ALA) ointment for 3 h after keratolytic treatment. Fluorescence diagnosis with ALA induced porphyrins (FDAP) was performed and subsequently high-and low-fluorescent psoriatic skin samples were biopsied. Biopsies were investigated with respect to histologicalhyperkeratosis (thickness of stratum corneum), proliferation (Ki-67 antigen), keratinization (K10, filaggrin) and inflammation (CD3). Digital images acquired with FDAP were analysed using image analysis software. Results: Inhomogeneous fluorescence was seen in 12 of the 14 plaques. A significantly thicker stratum corneum was found in low-fluorescent psoriatic skin compared with highly fluorescent skin. Fluorescence intensity and thickness of the stratum corneum proved to be negatively correlated. The variable-fluorescent parts of the lesional psoriatic skin showed no differences in epidermal proliferation, keratinization or inflammation. Conclusions: Heterogeneous ALA-induced fluorescence in psoriasis plaques related to inhomogeneous distribution of PpIX in the epidermis may result from differences in penetration of ALA and/or light within a plaque caused by differences in stratum corneum thickness. The variable clinical response seen after PDT in psoriasis could be explained by this. These findings are consistent with the general assumption that optimal desquamation prior to FDAP or PDT is required for the most favourable results. | Kleinpenning M.M. Smits T. Ewalds E. 党倩丽 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，，12： | 0 |
| 20 | 银屑病和日光性角化病皮损应用氨基-γ-酮戊酸荧光染色后肉眼荧光强度与原卟啉Ⅸ含量的相互关系显示文摘In fluorescence diagnosis with 5-aminolevulinic acid (ALA)-induced porphyrins (FDAP), protoporphyrin IX (PpIX)-accumulation can be macroscopically visualized. Interpretation of these data is still problematic because of the low reproducibility of the procedure and poor understanding of the mechanisms involved in PpIX tumor selectivity. In this study, PpIX accumulation is investigated in patients with psoriasis and actinic keratosis (AK) following FDAP. For this purpose, desquamated lesional and non-lesional skin were incubated with 20% ALA ointment for 3 h, FDAP was performed, and highly fluorescing lesional skin and non-lesional skin were biopsied. In extracts from these biopsies, PpIX, protein, and dsDNA were quantified by spectrofluorometry. Digital images acquired with FDAP were analyzed using image analysis software. PpIX per biopsy in lesional skin in both psoriasis and AK was significantly higher than in non-lesional skin (p < 0.05). When corrected for epidermal involvement, only lesional psoriatic skin showed significantly higher PpIX levels than non-lesional skin. The PpIX-ratio lesional:non-lesional skin (mean(pmol per mL) ± SEM) was 4.12 ± 0.91 in psoriasis and 1.96 ± 0.24 in AK. In FDAP, the ratio of lesional: non-lesional skin was 1.77 ± 0.06 in psoriasis and 1.37 ± 0.07 in AK. Macroscopic fluorescence and PpIX content appeared to be well correlated (r = 0.73), thus making FDAP a good predictor of PpIX content. | Smits T. Robles C.A. Van Erp P.E.J. 任建文 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，8： | 0 |
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