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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo显示文摘Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully understood.Here we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific manner.The inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of ovary.Gene expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TERT),in response to estrogen deficiency.Estrogen replacement therapy led to increases in TERT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four weeks.Our data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TERT in vivo.Estrogen deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through estrogen regulation of telomere remodeling. | Sharyn Bayne He Li Margaret E.E.Jones Alex R.Pinto Michelle van Sinderen Ann Drummond Evan R.Simpson Jun-Ping Liu | 2011 | Protein & Cell2011，2，4： | 8 |
| 3 | Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice显示文摘雌激素缺乏调停变老,但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺导致 telomerase 活动的重要抑制。基因表示分析证明当雌激素不在时, telomerase 颠倒 transcriptase (TERT ) 基因表示在肾上腺外皮和肾的萎缩与损害房间增长联合被减少。在 c 工具包积极的干细胞被识别在肾的外皮的实质占据。telomeres 的分析表明那雌激素缺乏比那在肾的外皮导致显著地更短的 telomeres 在野类型(WT ) 控制鼠标。为了推进,建立雌激素的原因的效果,我们在这些雌激素缺乏的动物进行了雌激素代替治疗。为 3 个星期的雌激素的管理在雌激素缺乏的老鼠恢复 TERT 基因表示, telomerase 活动和房间增长。因此,我们第一次,那雌激素缺乏在 vivo 在鼠标的肾上腺引起 TERT 基因表示, telomerase 活动, telomere 维护,和房间增长的抑制的数据表演,建议那 telomerase 抑制并且 telomere 弄短可以调停在肾上腺的房间增长拘捕,因此贡献雌激素在生理的条件下面的导致缺乏的老化。 | Sharyn Bayne Margaret EE Jones He Li Alex R Pinto Evan R Simpson Jun-Ping Liu | 2008 | Cell Research2008，18，11： | 6 |
| 4 | Dealing with detection error in site occupancy surveys: what can we do with a single survey?显示文摘Aim Site occupancy probabilities of target species are commonly used in various ecological studies,e.g.to monitor current status and trends in biodiversity.Detection error introduces bias in the estimators of site occupancy.Existing methods for estimating occupancy probability in the presence of detection error use replicate surveys.These methods assume population closure,i.e.the site occupancy status remains constant across surveys,and independence between surveys.We present an approach for estimating site occupancy probability in the presence of detection error that requires only a single survey and does not require assumption of population closure or independence.In place of the closure assumption,this method requires covariates that affect detection and occupancy.Methods Penalized maximum-likelihood method was used to estimate the parameters.Estimability of the parameters was checked using data cloning.Parametric boostrapping method was used for computing confidence intervals.Important Findings The single-survey approach facilitates analysis of historical datasets where replicate surveys are unavailable,situations where replicate surveys are expensive to conduct and when the assumptions of closure or independence are not met.This method saves significant amounts of time,energy and money in ecological surveys without sacrificing statistical validity.Further,we show that occupancy and habitat suitability are not synonymous and suggest a method to estimate habitat suitability using single-survey data. | Subhash R.Lele Monica Moreno Erin Bayne | 2012 | Journal of Plant Ecology2012，5，1： | 2 |
| 5 | 用密度差异参数可估算含烃饱和度吗?显示文摘密度差异参数可以显示烃类物质的存在性与饱和度等重要信息。本文详细介绍了密度差异与气饱和之间的关系,以及由地震数据提取该参数的算法。我们使用了AVA方程的线性与非线性形式。气田的数据实例给出了一个鉴别低饱和度气田与有经济价值的储集区的成功案例。通过与测井数据的比较,可以发现反演密度参数与密度测井数据吻合得很好。 | N. Kabir R. Crider R. Ramkhelawan C. Baynes 周哲(译) 王真理(译) 葛洪魁(校) | 2007 | 世界地震译丛2007，38，2： | 2 |
| 6 | Laboratory animal welfare:status and resources显示文摘1 IntroductionThere is a diversity of opinion in society regardingthe use of animals in research.However,there isconsensus that the welfare of research animals is amoral imperative and is critical to producing highquality science. | Kathryn Bayne | 2013 | 中国比较医学杂志2013，23，1： | 2 |
| 7 | Physiological energetics of marine molluscs显示文摘 | Bayne B L Newell R C | 1983 | The Mollusca1983，4，1： | 2 |
| 8 | Hybrid vigor in Pacific oysters: an experimental approach using crosses among inbred lines显示文摘 | Dennis Hedgecock Daniel J. McGoldrick Brian L. Bayne | 1995 | Aquaculture1995，，1： | 2 |
| 9 | Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer显示文摘 | Lauren J. Bayne Gregory L. Beatty Nirag Jhala Carolyn E. Clark Andrew D. Rhim Ben Z. Stanger Robert H. Vonderheide | 2012 | Cancer Cell2012，，6： | 2 |
| 10 | Pharmacokinetics of melamine in pigs following intravenous administration 显示文摘 | Baynes B E Smith G Mason S E | 2008 | Food Chem Toxicol2008，6，： | 1 |
| 11 | Bivalve mollusc hemocyte behaviors: characterization of hemocyte aggregation and adhesion and their inhibition in California mussel (Mytilus californianus) 显示文摘 | Chen J H Bayne C J | 1995 | Biol Bull1995，188，： | 1 |
| 12 | Amadorins:novel post-Amadori inhibitors of advanced glycation reactions显示文摘 | Hudson BG Khalifah RG Baynes JW | 1999 | Biochem Biophys Res Commun1999，257，2： | 1 |
| 13 | Vitamin D,glucose tolerance and insulinaemia in elderly men显示文摘 | Baynes KC Boucher BJ Feskens EJ | 1997 | Diabetologia1997，40，： | 1 |
| 14 | A characterization of first- generation flowable composites 显示文摘 | Bayne SG Thompson JY Swift Jr EJ | 1998 | J Am Dent Ass1998，129，5： | 1 |
| 15 | Selective interactions between prostate fibroblast and epithelial cells in co-culture maintain the BPH phenotype显示文摘 | Bayne CW Ross M Donnelly F | 1998 | Urol Int1998，61，1： | 1 |
| 16 | Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model 显示文摘 | Buur J L Baynes R E Riviere J E | 2008 | Regul Toxicol Pharmacol2008，51，3： | 1 |
| 17 | Pharmacokinetics of melamine in pigs following intravenous administration显示文摘 | Baynes R E Smith G Mason S E | 2008 | Food Chem Toxicol2008，46，3： | 1 |
| 18 | Role of oxidative stress in development of complications in diabetes显示文摘 | Baynes JW | 1991 | Diabetes1991，40，4： | 1 |
| 19 | Mechanical properties of a new mica- based machinable glass ceramics for CAD/CAM restorations显示文摘 | Thompson JY Bayne SC Heymann HO | 1996 | J Prosthet Dent1996，76，6： | 1 |
| 20 | Effects of acute stress]on blood dotting and yeast killing by phagocytes of rainbow trout显示文摘 | RUIS M A W BAYNE C J | 1997 | Journal of Aquatic Animal Health1997，9，： | 1 |
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