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| 1 | 美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准显示文摘背景和目的:1/3的个体会罹患卒中和(或)痴呆,而且,除卒中或痴呆外,2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能,而痴呆的诊断标准则集中在认知障碍的晚期阶段,且在很大程度上偏向Alzheimer病(AD)的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体,尤其是在早期阶段,而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法:美国国立神经疾病和卒中研究所(MINDS)与加拿大卒中网(CSN)召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员,为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果:将这些讨论的结果发表于此。结论:一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者,使不同的研究具有可比性,并且通过整合知识来加速研究进展的步伐。 | Vladimir Hachinski Costantino Iadecola Ron C.Petersen Monique M.Breteler David L.Nyenhuis Sandra E.Black William J.Powers Charles DeCarli Jose G.Merino Raj N.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dichgans John R.Marler Gabrielle G.Leblanc 李焰生(译) 俞羚(译) 高枚春(译) 张静芳(译) 熊昕丽(译) 邹静(译) 林岩(译) 潘元美(译) | 2007 | 国际脑血管病杂志2007，15，1： | 63 |
| 2 | 川滇菱形块体顺时针转动的构造学与古地磁学证据显示文摘川滇菱形块体内部受NE向丽江 -小金河断裂的切割 ,可进一步划分为川西北次级块体和滇中次级块体等南北 2个部分 ;各次级块体东边界断裂有规律地左旋滑动、西边界断裂的右旋滑动及其滑动速率值的差异 ,反映出新生代时期各次级块体作向SE的水平滑移叠加绕垂直轴顺时针转动的复合运动。其中 ,川西北次级块体SE向的水平滑移速率 5mm/a ,顺时针转动角速度 1 4°/Ma ;滇中次级块体SE向的水平滑移速率 3 5mm/a ,顺时针转动角速度约 1 5°/Ma。在滇中次级块体内部姚安、大姚、永仁、昆明北马街等地采集到约 90个古新世地层的定向样品 ,通过交变退磁和热退磁获得了它们各自的剩磁矢量 (实验磁偏角和磁倾角 ) ,由实测磁偏角与期望磁偏角相比可知川滇地区滇中次级块体中新世早期以来的顺时针转动累积量可达 30°~ 4 8°。次级块体的整体转动与块边活动断裂的左旋滑动符合左旋走滑断裂作用区块体作顺时针转动的运动学模式。 | 徐锡伟 程国良 于贵华 宋方敏 向宏发 张兰凤 Hagai Ron 王洋龙 闻学泽 | 2003 | 地震地质2003，25，1： | 55 |
| 3 | Diagnosis and management challenges of in-stent restenosis in coronary arteries显示文摘Over the course of the 3 decades, percutaneous coronary intervention(PCI) with stent implantation transformed the practice of cardiology. PCI with stenting is currently the most widely performed procedure for the treatment of symptomatic coronary disease. In large trials, drugeluting stents(DES) have led to a significant reduction in in-stent restenosis(ISR) rates, one of the major limitations of bare-metal stents. Due to these favorable findings, DES was rapidly and widely adopted enabling more complex coronary interventions. Nevertheless, ISR remains a serious concern as late stent complications. ISR mainly results from aggressive neointimal proliferation and neoatherosclerosis. DES-ISR treatment continues to be challenging complications for interventional cardiologists. | M Chadi Alraies Fahed Darmoch Ramyashree Tummala Ron Waksman | 2017 | World Journal of Cardiology2017，9，8： | 50 |
| 4 | Smart Grids with Intelligent Periphery:An Architecture for the Energy Internet显示文摘A future smart grid must fulfi ll the vision of the Energy Internet in which millions of people produce their own energy from renewables in their homes, offi ces, and factories and share it with each other. Electric vehicles and local energy storage will be widely deployed. Internet technology will be utilized to transform the power grid into an energysharing inter-grid. To prepare for the future, a smart grid with intelligent periphery, or smart GRIP, is proposed. The building blocks of GRIP architecture are called clusters and include an energy-management system(EMS)-controlled transmission grid in the core and distribution grids, micro-grids, and smart buildings and homes on the periphery; all of which are hierarchically structured. The layered architecture of GRIP allows a seamless transition from the present to the future and plug-and-play interoperability. The basic functions of a cluster consist of ①dispatch, ② smoothing, and ③ mitigation. A risk-limiting dispatch methodology is presented; a new device, called the electric spring, is developed for smoothing out fl uctuations in periphery clusters; and means to mitigate failures are discussed. | Felix F.Wu Pravin P.Varaiya Ron S.Y.Hui | 2015 | Engineering2015，1，4： | 23 |
| 5 | 儿童早期发展综合干预策略对改善贫困农村地区0~35月龄儿童养育照护的效果显示文摘目的 分析儿童早期发展综合干预策略对改善贫困地区0~35月龄儿童早期家庭养育照护的效果.方法 儿童早期发展综合干预项目(IECD)于2014年开始在4个贫困县农村地区试点开展,通过多种途径为项目地区0~35月龄儿童及其看护人提供儿童养育照护多维度综合干预.采用人群干预对照设计,评价干预对看护人健康与心理、儿童营养、早期学习、儿童保护和社会保障等方面的改善效果,分别于2013年和2016年开展基线和中期调查,采用双重差分模型估计干预效果,并控制社会人口学特征等混杂因素.结果 基线调查纳入0~35月龄儿童干预组1 468名、对照组1 485名,中期调查分别纳入1 384名和1 361名.干预组通过2年的干预,看护人抑郁患病率下降9.1%[中期34.8% (479/1 377)比基线43.9% (621/1 414)],对照组下降1.6%[34.3% (464/1 353)比35.9%(509/1 419)],双重差分模型控制因素混杂后,结果显示干预组下降幅度较同期对照组高7.0%(P=0.008);6~23月龄儿童辅食添加频次合格的比例上升10.4%[69.0% (532/771)比58.6%(481/821)],对照组上升幅度2.9%[66.4% (469/706)比63.5%(508/800)],双重差分模型控制混杂因素后,干预组上升幅度比对照组高8.2%(P=0.021);干预组儿童遭受暴力管教的比例下降6.2% [49.1% (478/973)比55.3%(554/1 001)],同期对照组上升4.5%[58.4% (560/959)比53.9%(558/1 036)],双重差分模型控制混杂因素后,两组变化幅度相差11.0%(P=0.001);干预组家庭拥有儿童图书≥3本的比例上升12.7%[42.7% (588/1 378)比30.0% (432/1 440)],同期对照组上升幅度4.2%[25.7% (349/1 357)比21.5%(298/1 388)]双重差分模型控制混杂因素后,干预组比对照组幅度高6.1%(P=0.007).结论 多部门合作儿童早期发展综合干预策略可以有效改善看护人心理状况、促进儿童喂养、支持儿童早期学习,并减少暴力管教等不恰当的养育行为,从而为儿童早期健康发展创造良好养育照护环境. | 石慧峰 张敬旭 王晓莉 徐媛媛 董胜利 赵春霞 黄小娜 赵颀 陈学锋 周烨 Mayo O'Sullivan Ron Pouwels Robert W.Scherpbier | 2018 | 中华儿科杂志2018，56，2： | 17 |
| 6 | Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. | Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf | 2012 | World Journal of Gastroenterology2012，18，6： | 16 |
| 7 | 建构主义教学实验研究:演进性学习进阶的构建取向显示文摘学习进阶强调对学生在探究某主题时的思维变化进行连续与精致化的描述,并由此设计课程、组织教学,促进学生对核心概念的理解。我国已有关于学习进阶的研究大多集中在科学教育领域,且主要遵循自上而下的验证性研究路径。而建构主义教学实验作为探究和构建学生思维发展过程的纵向的质的研究方法,其所具有的持续性、动态性、互动性和双重性特征为演进性学习进阶模型的构建提供了可能。研究者通过探索性教学、提出假设、诊断性访谈、系列教学与即时性分析、回溯性分析、模型构建与修订等一系列过程对学生的思维轨迹进行刻画,自下而上地构建学生在特定概念中的学习进阶。建构主义教学实验研究与认知诊断和信息技术的融合能够提高学习进阶模型的稳定性与解释性,进而发挥其在课程编制、教师教学与评价中的实践指导价值。 | 丁锐 金轩竹 Ron Tzur 卫冰倩 马云鹏 | 2019 | 教育科学研究2019，0，7： | 15 |
| 8 | 年长男子的生育年龄对生育质量的影响显示文摘最近几十年来,妇女生第一胎的年龄越来越大。同样的趋势在男性群体也逐渐表现出来了。母亲年龄对生育、染色体异常、孕期并发症、先天缺陷以及对后代的整体健康的影响已经得到全面的研究,而且这些研究结果已经应用于临床受孕咨询和产前咨询中。但男性的年龄及其对生育结果的影响相对来说得到的关注度较低。本综述的目的是对最近相关文献中父亲年龄对生育结果的影响做一个综合评述。 | Zofnat Wiener-Megnazi Ron Auslender Martha Dirnfeld | 2012 | Asian Journal of Andrology2012，14，1： | 12 |
| 9 | GEX3, Expressed in the Male Gametophyte and in the Egg Cell of Arabidopsisthaliana, Is Essential for Micropylar Pollen Tube Guidance and Plays a Role during Early Embryogenesis显示文摘当时,在 flowering 植物的两倍授精发生二个精子房间,由花粉试管带了,在胚胎囊的一个 synergid 房间被释放然后使肥沃卵和中央房间。精子的表面上的蛋白质,鸡蛋,中央,并且 synergid 房间可能为配偶子的指导和识别 / 熔化是重要的。这里,我们 Arabidopsis GEX3 的现在的功能的分析,它编码血浆在另外的植物有相当或相同的事物的膜局部性的蛋白质。GEX3 在两个被表示植物并且男配偶体并且在女配偶体的卵房间的精子房间。用 Arabidopsis GEX2 倡导者, GEX3 是下面调整的转基因的在线或 overexpressed 减少了种子集合。在有一根记者线的授粉以后的相互的十字和成像证明在两个盒子中,引起减少的种子的缺点设定发生在女性。在 antisense 线, micropylar 花粉试管指导失败了。在 overexpression 线,因为花粉试管指导失败了,变异的小卵的授精主要被堵住,偶尔,不能生存的胚胎被形成。我们断定在 Arabidopsis 的卵房间的 GEX3 的那适当地调整的表情为花粉试管指导是必要的。 | Monica Alandete-Saez Mily Ron Sheila McCormick | 2008 | Molecular Plant2008，1，4： | 10 |
| 10 | Endoscopic transluminal pancreatic necrosectomy using a self-expanding metal stent and high-flow water-jet system显示文摘Walled-off pancreatic necrosis and a pancreatic abscess are the most severe complications of acute pancreatitis. Surgery in such critically ill patients is often associated with significant morbidity and mortality within the first few weeks after the onset of symptoms. Minimal invasive approaches with high success and low mortality rates are therefore of considerable interest. Endoscopic therapy has the potential to offer safe and effective alternative treatment. We report here on 3 consecutive patients with infected walled-off pancreatic necrosis and 1 patient with a pancreatic abscess who underwent direct endoscopic necrosectomy 19-21 d after the onset of acute pancreatitis. The infected pancreatic necrosis or abscess was punctured transluminally with a cystostome and, after balloon dilatation, a non-covered self-expanding biliary metal stent was placed into the necrotic cavity. Following stent deployment, a nasobiliary pigtail catheter was placed into the cavity to ensure continuous irrigation. After 5-7 d, the metal stent was removed endoscopically and the necrotic cavity was entered with a therapeutic gastroscope. Endoscopic debridement was performed via the simultaneous application of a high-flow water-jet system; using a flush knife, a Dormia basket, and hot biopsy forceps. The transluminal endotherapy was repeated 2-5 times daily during the next 10 d. Supportive care included parenteral antibiotics and jejunal feeding. All patients improved dramatically and with resolution of their septic conditions; 3 patients were completely cured without any further complications or the need for surgery. One patient died from a complication of prolonged ventilation severe bilateral pneumonia, not related to the endoscopic procedure. No procedure related complications were observed. Transluminal endoscopic necrosectomy with temporary application of a self-expanding metal stent and a high-flow water-jet system shows promise for enhancing the potential of this endoscopic approach in patients with walled-off pancreatic necrosis and/or a pancreatic abscess. | István Hritz Roland Fejes András Székely Iván Székely László Horváth gnes Sárkány ron Altorjay László Madácsy | 2013 | World Journal of Gastroenterology2013，19，23： | 10 |
| 11 | 随钻声波测井新技术显示文摘在诸多钻井决策中,优选泥浆比重是最具挑战性而且也是最重要的决策之一。如今,新型随钻声波测井仪器的应用能够更好地帮助钻井工程师进行这些钻井决策。 | Jeff Alford Roger B.Goobie Colin M.Sayers Ed Tollefsen Jay Cooke Andy Hawthorn John C.Rasmus Ron Thomas | 2007 | 国外测井技术2007，22，1： | 8 |
| 12 | 油砂的蠕变特性与本构模型研究显示文摘油砂是一种富含天然沥青的沉积砂。作为一种软化材料,油砂的蠕变性质较松砂和正常固结黏土等硬化材料更为复杂。通过开展油砂三轴蠕变试验,获得了不同应力和应变状态下油砂的蠕变特性;讨论了蠕变势与塑性势之间的关系,提出了等效变形过程的概念,分析等效变形过程的微观机制;讨论了蠕变速率与时间和不可恢复应变之间的关系,提出采用不可恢复应变作为内变量可以描述复杂条件下油砂的蠕变性质,并据此提出了油砂的内变量蠕变模型;应用临界状态理论,分析了硬化型和软化型土的蠕变性质;讨论了剪切带对密砂蠕变性质的影响。 | 王者超 Ron Wong 乔丽苹 | 2012 | 岩土工程学报2012，34，8： | 8 |
| 13 | NaCl及生物降解活性剂对曝气灌溉水氧传输特性的影响显示文摘曝气灌溉可有效调节植物根区环境、改善土壤通气性。微咸水中NaCl的存在及活性剂添加对提高曝气灌溉的氧传质效率,实现节能高效的灌溉有重要作用。为研究NaCl介质及生物降解活性剂对纯氧曝气灌溉水氧传输特性的影响,该文采用变压分离制氧技术-氧气扩散系统-空气注射技术耦合系统,分析NaCl介质(未添加和添加)及生物降解活性剂BS1000(醇烷氧基化物质量浓度0、1、2、4 mg/L)2个因素对氧总传质系数、溶氧饱和度、流量均匀系数和溶氧均匀系数的影响。结果表明:BS1000的添加促进氧传质过程的发生,提高了曝气水中的溶氧饱和度;随着BS1000浓度增加,氧总传质系数逐渐增加,而溶氧饱和度呈现下降的趋势;BS1000质量浓度在2 mg/L及以上时,NaCl介质对氧总传质系数的增幅显著;NaCl介质对曝气水中的溶氧饱和度起到抑制作用。各组合条件下,曝气滴灌中流量均匀系数均在95%以上,溶氧均匀系数均在97%以上。添加活性剂BS1000可使氧总传质系数平均提高18.85%以上(P<0.05)。无论添加NaCl与否,添加1 mg/L BS1000的溶氧饱和度均最大,故1 mg/L BS1000是适宜的活性剂添加浓度。 | 雷宏军 刘欢 张振华 Bhattarai Surya Balsys Ron | 2017 | 农业工程学报2017，33，5： | 7 |
| 14 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 15 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 16 | 分数度量意义发展的认知根基及轨迹:分数图式进阶理论显示文摘斯特芬(Steffe)、撒冷(Tzur)等人通过长期的质的建构主义教学实验研究,对西方儿童的分数学习轨迹进行了探索,提出的分数图式进阶理论为学生对分数度量意义理解的发展提供了认知依据.撒冷的'活动-效果关系'反省理论可以解释图式的构建和转化机制,迭代和均分是分数图式构建的两种重要认知操作,而分数图式进阶模型共包括8个进阶水平,前4个图式主要基于迭代操作,后4个图式主要基于均分操作.总之,分数概念的本质不是'部分-整体',而是度量意义;学生的分数图式是对整数计数图式的顺应;迭代和均分操作能够促进学生对分数度量意义的理解. | 丁锐 卫冰倩 Ron Tzur 田然 孙文娟 | 2021 | 数学教育学报2021，30，3： | 6 |
| 17 | 荧光多重实时PCR检测单纯疱疹病毒显示文摘目的建立单纯疱疹病毒的荧光多重实时PCR检测及分型技术,为生殖器疱疹的诊断及病毒分型提供快捷、敏感、特异的方法.方法以细胞培养法为对照,用Smart Cycler System作为实验平台,以DNA探针荧光标记技术建立荧光多重实时PCR,用于检测生殖器疱疹患者临床标本中的1型和2型单纯疱疹病毒(HSV1、HSV2)DNA.结果荧光多重实时PCR检测HSV1和HSV2 DNA的敏感性和特异性均为100%,可检测出低至1~5拷贝的HSV DNA,30 min左右即可完成整个检测过程,而细胞培养的敏感性和特异性分别为70.10%和100%.结论基于Smart Cycler System的荧光多重实时PCR是一种易于操作、扩增效率高、封闭式的核酸扩增技术,可用一次PCR反应就能快速、敏感、准确地对临床标本中的单纯疱疹病毒进行检测和分型. | 赖维 Cheng-Yen Chen 苏向阳 黄怀球 张玉清 Ron C Ballard Stephen A Morse | 2004 | 中华皮肤科杂志2004，37，5： | 6 |
| 18 | 正在崛起的高级结构材料——陶瓷复合材料显示文摘科研工作者把陶瓷纤维,晶须和其它材料的微粒添加到陶瓷基质内,制备出抗断裂性能、强度及热稳定性更好的高级复合材料。1987年,陶瓷界最令人振奋的消息是人们对液氮温度下氧化铜陶瓷的超导性的发现。这一完全出乎意料之外的重要发现迅速地打开了“超导革命的大门”。但是,还有另一场陶瓷革命也正在悄然而稳步地进行着。 | Dagain Ron 卫志孝 | 1989 | 机械工程材料1989，13，2： | 6 |
| 19 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 20 | Validity and Reliability of Chinese Physical Activity Questionnaire for Children Aged 10-17 Years显示文摘Objective This study is aimed to report the development,the reliability and validity of the Chinese Children Physical Activity Questionnaire(CCPAQ)which was designed for the assessment of physical activity pattern in young population in China.Methods The CCPAQ was administered for two times in 119 children(mean age 13.1±2.4 years;boys 47%)to examine reliability by using intraclass correlation coefficients.Validity was determined in 106 participants by agreement with the CCPAQ measures and the objective method,the ActiGraph accelerometer.Data on physical activity patter n including time spe nt on d iff ere nt intensi ties and total physical activity,sedentary behavior as well as physical activity energy expenditure were used to assess the validity with Spearman's correlation coefficient and the Bland-Altman plots.Results The reliability coefficient of the CCPAQ ranged from 0.63-0.93(Intra-class correlation coefficient).Spearman's correlation coefficient for validity of time spent on total physical activity and sedentary behavior were all 0.32(P<0.001),and for physical activity energy expenditure was 0.58(P<0.001).Time spent on moderate-to-vigorous physical activity and light physical activity showed a relatively low correlation with the accelerometer(rho=0.20,P=0.040;rho=0.19,P=0.054).Conclusion The CCPAQ appears to be a promising and feasible method to assess physical activity pattern in Chinese children. | YANG Xi JAGO Russell ZHAI Yi YANG Zhen Yu WANG Yu Ying SI Xiang WANG Jun GAO Jian Fen CHEN Jing Ron YU Ying Jie ZHAO Wen Hua | 2019 | Biomedical and Environmental Sciences2019，32，9： | 6 |
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