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| 1 | Macro-or microencapsulation of pig islets to cure type 1 diabetes显示文摘Although allogeneic islet transplantation can successfully cure type 1 diabetes,it has limited applicability.For example,organs are in short supply;several human pancreas donors are often needed to treat one diabetic recipient;the intrahepatic site may not be the most appropriate site for islet implantation;and immunosuppressive regimens,which are associated with side effects,are often required to prolong survival of the islet graft.An alternative source of insulinproducing cells would therefore be of major interest.Pigs represent a possible alternative source of beta cells.Grafting of pig islets may appear difficult because of the immunologic species barrier,but pig islets have been shown to function in primates for at least 6 mo with clinically incompatible immunosuppression.Therefore,a bioartificial pancreas made of encapsulated pig islets may resolve issues associated with islet allotransplantation.Although several groups have shown that encapsulated pig islets are functional in small-animal models,less is known about the use of bioartificial pancreases in large-animal models.In this review,we summarize current knowledge of encapsulated pig islets,to determine obstacles to implantation in humans and possible solutions to overcome these obstacles. | Denis Dufrane Pierre Gianello | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 2 | A micromethod for the assay of aldose reductase, its application to pancreatic islets 显示文摘 | Dufrane S P Malaisse W J Sener A | 1984 | Biochem Med1984，32，1： | 1 |
| 3 | Streptozotocin-induced diabetes in large animals(pigs/primates):role of GLUT2 transporter and [beta]-cel Plasticity显示文摘 | Dufrane D van Steenberghe M Guiot Y | | 0，，01： | 1 |
| 4 | Regeneration of abdominal wal musculofascial defects by a human acel ular col agen matrix显示文摘 | Dufrane D Mourad M van Steenberghe M | | 0，，14： | 1 |
| 5 | A micromethod for the as- say of aldose reductase, its application to pancreatic islets 显示文摘 | Dufrane S P Malaisse W J Sener A | 1984 | Biochem Med1984，32，1： | 1 |
| 6 | Six-months survival of microencapsulated pig islets and alginate biocompatibility in primates:proof of concept显示文摘 | Dufrane D Goebbels RM Saliez A | 2006 | Transplantation2006，81，9： | 1 |
| 7 | Indirect cytotoxicity evaluation of pseudowollastonite显示文摘 | D. Dufrane C. Delloye I. J. McKay P. N. De Aza S. De Aza Y. J. Schneider M. Anseau | 2003 | Journal of Materials Science: Materials in Medicine2003，，1： | 1 |
| 8 | Physical and chemical processing for a human dura mater substitute显示文摘 | Dufrane D Cornu O Delloye C | 2002 | Biomaterials2002，23，： | 1 |
| 9 | Clinical application of aphysically and chemically processed human substitute for duramater 显示文摘 | Dufrane D Marchal C Comu 0 | 2003 | Neurosurg2003，98，6： | 1 |
| 10 | Clinical application of a physically and chemically processed human substitute for dura mater显示文摘 | Dufrane D Marchal C Cornu O | 2003 | J Neurosurg2003，98，： | 1 |
| 11 | A micromethod for the assay of aldose reductase, its application to pancreatic islets 显示文摘 | Dufrane SP Malaisse WJ Sener A | 1984 | Biochem Med1984，32，1： | 1 |
| 12 | A micromethod for the assay of aldose reductase,its application to pancreatic islets显示文摘 | Dufrane SP Malaisse WJ Sener A | 1984 | Biochem Med1984，32，： | 1 |
| 13 | Streptozotocin-induced diabetes in large animals (pigs/primates): role of GLUT2 transporter and beta-cell plasticity 1998 显示文摘 | Dufrane D van Steenberghe M Guiot Y | 2006 | Transplantation2006，81，： | 1 |
| 14 | Pig islets for clinical islet xenotransplantation显示文摘 | Dufrane D Gianello P | | 0，，06： | 1 |
| 15 | Streptozotocin-induced diabetes in large animals (pigs/primates): role of GLUT2 transporter and beta-cell plasticity 显示文摘 | Dufrane D Van Steenberghe M Guiot Y | 2006 | Translpantation2006，81，1： | 1 |
| 16 | Six-Month Survival of Microencapsulated pig islets and alginate biocompatibility in primates: Proof of Concept显示文摘 | Dufrane D Goebbels RM saliez A | 2006 | Transplantation2006，81，9： | 1 |
| 17 | Origin of eclogite and pyroxenite xenoliths from the Victor kimberlite, Canada, and implications for Superior craton formation显示文摘 | K.V. Smit T. Stachel R.A. Creaser R.B. Ickert S.A. DuFrane R.A. Stern M. Seller | 2014 | Geochimica et Cosmochimica Acta2014，，： | 1 |
| 18 | Impact of porcine islet size on cellular structure and engraftment after transplantation: adult versus young pigs显示文摘 | Dufrane D Goebbels RM Fdilat I | 2005 | Pancreas2005，30，： | 1 |
| 19 | Indirect cytotoxicity e- valuation of pseudowollastonite显示文摘 | Dufrane D Delloye C Mckay IJ etal | 2003 | J Mater Sci Mater Med2003，14，1： | 1 |
| 20 | Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates:proof of concept显示文摘 | Dufrane D Goebbels R M Saliez A | 2006 | 81 (9):1345-13532006，81，9： | 1 |
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