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| 1 | Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance. | Asmaa Ibrahim Gomaa Shahid A Khan Mireille B Toledano Imam Waked Simon D Taylor- Robinson | 2008 | World Journal of Gastroenterology2008，14，27： | 78 |
| 2 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 3 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 4 | Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us?显示文摘 | Shahid A. Khan Shireen Emadossadaty Nimzing G. Ladep Howard C. Thomas Paul Elliott Simon D. Taylor-Robinson Mireille B. Toledano | 2011 | Journal of Hepatology2011，，4： | 2 |
| 5 | Yielding to (cyber)-temptation: Exploring the buffering role of self-control in the relationship between organizational justice and cyberloafing behavior in the workplace显示文摘 | Simon Lloyd D. Restubog Patrick Raymund James M. Garcia Lemuel S. Toledano Rajiv K. Amarnani Laramie R. Tolentino Robert L. Tang | 2011 | Journal of Research in Personality2011，，2： | 2 |
| 6 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 7 | Improving the quality of the quartz fiber postcore bond using sodium ethoxide etching and combined silane/adhesive coupling显示文摘 | Monticelli F Osorio R Toledano M | 2006 | J Endod2006，32，5： | 1 |
| 8 | Kinetics of SO2 adsorption on photoexcited t-FeeO3显示文摘 | Toledano D S Henrich V E | 2001 | J Phys Chem B2001，105，： | 1 |
| 9 | Surface roughness analysis of fiber post conditioning processes 显示文摘 | Mazzitelli C Ferrari M Toledano M Osorio E Monticelli F Osorio R | 2008 | J Dent Res2008，87，2： | 1 |
| 10 | Sealing ef- fectiveness of etch-and-rinse vs self-etching adhesives af- ter water aging: influence of acid etching and NaOC1 dentin pretreatment显示文摘 | Monticelli F Toledano M Simoes Silva A | 2008 | Adhes Dent2008，10，： | 1 |
| 11 | Pulmonary arteries in- volvement in Takayasu' s arteritis: two eases and literature re- view显示文摘 | Toledano K Guralnik L Lorber A | 2011 | Semin Arthritis Rheum2011，41，3： | 1 |
| 12 | On the Integral of the Lebesgue Function Induced by Interpolation at the Chebyshev Nodes显示文摘 | L. Brutman I. Gopengauz D. Toledano | 2001 | Acta Mathematica Hungarica (-)2001，，1： | 1 |
| 13 | Reactive hemophagocytic syndrome presenting as a component of multiple organ dysfunction syndrome显示文摘 | Gauvin F Toledano B Champagne J | 2000 | Crit Care Med2000，28，9： | 1 |
| 14 | Bleaching agents increase metalloproteinases- mediated collagen degradation in dentin 显示文摘 | Toledano M Yamauti M Osorio E | 2011 | J Endod2011，37，12： | 1 |
| 15 | Waste incineration and adverse birth and neonatal outcomes: a systematic review 显示文摘 | Ashworth DC Elliott P Toledano MB | 2014 | Environ Int2014，69，： | 1 |
| 16 | In vitro hydrolytic degradation of composite quartz fiber-post bonds created by hydrophilic silane couplings显示文摘 | Monticelli F Osorio R Toledano M | 2006 | Oper Dent2006，31，6： | 1 |
| 17 | Regulation of bacterial gene expression in response to oxidative stress显示文摘 | Storz G Toledano M B | 1994 | Methods Enzymol1994，236，： | 1 |
| 18 | Disulfide bond-mediated muhimerization of Askl and its reduction by thioredoxin-1 regulate H2O2 induced c-Jun NH (2)-terminal kinase activation andapoptosis 显示文摘 | Nadeau P J Charette SJ Toledano MB | 2007 | Mol Biol Cell2007，18，10： | 1 |
| 19 | Adverse effects of antiepileptic drugs显示文摘 | Toledano R Gil-Nagel A | 2008 | Semin Neurol2008，28，3： | 1 |
| 20 | Brain abnormalities in new ly diagnosed neuropsychiatric lupus:systematic MRI approach and correlation with clinical and laboratory data in a large multicenter cohort显示文摘 | Sarbu N Alobeidi F Toledano P | 2015 | Autoimmun Rev2015，14，15： | 1 |
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