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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Bronchopulmonary dysplasia: pathogenesis, risk factors and early prevention strategies显示文摘 | Egbert Herting | 2010 | Chinese Medical Journal2010，，20： | 9 |
| 3 | 期待很久的2004年9月28日M6.0级帕克菲尔德地震的震磁效应显示文摘1976年以来,在加利福尼亚帕克菲尔德地区沿圣安德烈斯断层上长约60km的闭锁—蠕动过渡带,布设了由7个采样同步的质子磁力仪构成的差动连接的台阵,对该地区的局部磁场进行了准确的测量。2004年9月28日的M6.0级帕克菲尔德地震的震中恰好位于这个台阵之内,此次地震在其中的5个台站的观测中产生了0.2nT~0.5nT的同震磁场变化。但是从地震发生前1个月、前1周及前数天的地磁观测数据中,都检测不到明显高于背景噪声水平的震前磁场变化(由于没有可检测出的形变、地震活动或孔隙压力变化数据,理论上也应观测不到震前磁场变化)。在地震破裂末端附近的一个台站也记录了0.01Hz~20Hz频带内的电场和磁场数据,借助于沿断层的北西延长线上距该台站约115km的另一个台站的观测数据,对来自电离层和磁层的同模式噪声进行了校正。校正后的数据中既没有发现1989年ML7.1级洛马普列塔地震前可能存在ULF频带(0.01Hz~20Hz)的异常磁噪声,也没有发现相同震级的希腊地震震前产生的电场变化。基于应变、位移和地震数据反演得到的地震一致滑动和可变滑动压磁模型,能够计算出与磁力仪台阵观测到的结果相符的磁场扰动。1993年以来,该区域内长期存在着与荷载增加一致的较高磁场变化,与之相伴的是由一个两色EDM台网和另一个较小的钻孔应变仪台网观测到的剪应变率的长期增长及表现在1992、1993和1994年各发生了一次M4.5~5.0级地震的地震活动性的增强。集成了所有这些数据建立的模型揭示了该区域在深度剖面上有增大的滑动,这也许对2004年9月28日M6.0级帕克菲尔德地震的最后发生起到了重要的作用。本次地震以及其他发生于圣安德烈斯断层系内其他地方的M5~7.3级地震的震前电场和磁场前兆的缺乏,表明了仅利用现有的这些电磁数据来对破坏性地震做出有意义的预测看来并不可能。 | M. J. S. Johnston Y. Sasai G. D. Egbert R. J. Mueller 张素琴(译) 杨冬梅(校) | 2006 | 世界地震译丛2006，37，6： | 8 |
| 4 | 眼前节内眼手术应用5%吡咯烷酮碘两种不同用法的前瞻性随机化比较研究显示文摘目的:确定5%吡咯烷酮碘采用两种不同的方法(结膜囊滴两滴和10ml溶液穹窿结膜冲洗)对降低结膜囊菌群的功效。方法:在这项前瞻性对照实验中。将行眼前节手术的200只眼随机分为对照组和研究组。两组病例术前均给予氧氟沙星滴眼液局部点眼和5%吡咯烷酮碘眶周区域皮肤擦洗消毒。术前对照组眼结膜囊内给予2滴5%吡咯烷酮碘溶液,研究组眼用5%吡咯烷酮碘溶液冲洗穹窿结膜。分别于术前和术后4个时间点行结膜细菌培养。结果:研究组78只眼中20只眼(26%)术前结膜细菌培养阳性:对照组94只眼中40只眼(43%)为阳性(P=0.02)。手术结束时。研究组78只眼中14只眼(18%)、对照组94只眼中30只眼(32%)结膜细菌培养阳性(PP=0.05)。结论:手术时应用5%吡咯烷酮碘溶液冲洗穹窿结膜与结膜囊仅点入两滴相比。前者显著降低了结膜细菌培养阳性率。 | Herminia Mino de Kaspar Robert T. Chang Kuldev Singh Peter R. Egbert Mark S. Blumenkranz Christopher N. Ta 董白霞(译) 马景学(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 6 |
| 5 | 台湾山地雾林带的水分与养分循环研究显示文摘本文回顾台湾扁柏森林生态系的养分及水分循环研究现况。研究样区位于台湾宜兰县栖兰山区,海拔高度1 400m^1 800m,为一个台湾扁柏天然下种更新林,树龄在50年以下。在此长期生态系研究的初期阶段(2002年~2005年),研究项目主要为生态系基础数据的建立,包括气象数据、生物量、养分存量、大气养分输入量、枯落物量、土壤水养分输出量、及蒸发散量的监测。在大气养分输入研究中,云雾水分以及养分的沉降量估算,是研究重点项目。除了基础监测项目外,本样区也进行了枯落物控制实验,以探讨台风对土壤养分输出的影响。 | 陈耀德 叶青峯 刘美娟 吴敏如 罗匀谦 邓振华 朱慧君 冯哲明 陈俐如 陈凯欣 王巧萍 夏禹九 Egbert Matzner 张世杰 | 2006 | 资源科学2006，28，3： | 5 |
| 6 | Successful endoscopic treatment of a large impacted gallstone in the duodenum using laser lithotripsy,Bouveret’s syndrome:A case report显示文摘BACKGROUND Bouveret´s syndrome is defined as a gastric outlet obstruction after passage of a gallstone through a fistula into the duodenum.Due to its rarity,the diagnosis of Bouveret’s syndrome is often delayed and causes a high morbidity and mortality rate.CASE SUMMARY A 93-year-old female presented with worsening pain in the right upper abdomen and vomiting.A gastroscopy revealed fluid retention caused by a massive obstructive stone in the bulbus.Endoscopic laser lithotripsy of the impacted stone was planned after multidisciplinary consultation.A Dornier Medilas H Solvo lithotripsy 350μm laser fiber(10 Hz,2 Joules)was used to disintegrate the stone into smaller pieces.The patient recovered completely.CONCLUSION A mechanical obstruction due to a gallstone that has entered the gastrointestinal tract is a complication that appears in 0.3%-0.5%of patients who have cholelithiasis.Stones larger than 2 cm can become impacted in the digestive tract,which occurs mostly in the terminal ileum.In approximately 1%-3%of cases,the stones cause obstruction in the duodenum.This phenomenon is called Bouveret’s syndrome.As this condition is mostly observed in elderly individuals with multiple comorbidities,treatment by an open surgical approach is unsuitable.Endoscopic removal is the preferred technique.The benefit of using laser lithotripsy is the precise targeting of energy onto the stone with minimal tissue injury.Endoscopic laser lithotripsy is a safe and feasible treatment option for Bouveret’s syndrome. | Sofie Hendriks Mareille Maria Verseveld Egbert Roeland Boevé Robert Roomer | 2020 | World Journal of Gastroenterology2020，26，19： | 4 |
| 7 | Topology impacts TRAIL therapy: Differences in primary cancer growth and liver metastasis between orthotopic and subcutaneous xenotransplants of pancreatic ductal adenocarcinoma cells显示文摘Background: To study novel treatment modalities for pancreatic ductal adenocarcinoma(PDAC), we need to transfer the knowledge from in vitro to in vivo. It is important to mirror the clinical characteristics of the typically local invasive growth of pancreatic cancer and the distant spread resulting in liver metastasis. Notably, for xenotransplant studies using human specimen, two models, i.e. subcutaneous(s.c.) and orthotopic(o.t.) transplantation are widely used. Methods: The subcutaneously and orthotopically inoculated Colo357 Bcl-x L cell-derived tumors were directly compared with and without TNF-related apoptosis inducing ligand(TRAIL) treatment. The size of primary tumors, number of liver metastasis and the histologic markers Ki67, M30, TNF-α and CD31 were assessed. Results: Upon TRAIL treatment, the primary tumors did not change their size, neither in the s.c. nor in the o.t. approaches. But when s.c. was compared to o.t., the size of the s.c. tumors was more than twofold bigger than that of the o.t. tumors( P<0.01). However, mice with orthotopically inoculated PDAC cells developed liver metastasis upon TRAIL treatment much more frequently( n=13/17) than mice with subcutaneously inoculated PDAC cells( n=1/11)( P<0.01). As a likely driving force for this increased metastasis, a higher TNF-α staining intensity in the o.t. tumors was observed by immunohistochemistry. Conclusions: These data from a direct side-by-side comparison underline the importance of the proper inoculation site of the PDAC cells. Local invasion and liver metastases are a hallmark of PDAC in the clinic;the o.t. model is clearly superior in reflecting this setting. Moreover, a serious side-effect of a possible new therapeutic compound became obvious only in the o.t. model. | Bastian Kettler Anna Trauzold Christian Röder Jan-Hendrik Egberts Holger Kalthoff | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，3： | 3 |
| 8 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 9 | Large-area crop mapping using time-series MODIS 250 m NDVI data: An assessment for the U.S. Central Great Plains显示文摘 | Brian D. Wardlow Stephen L. Egbert | 2007 | Remote Sensing of Environment2007，，3： | 2 |
| 10 | 临界转换的早期预警信号显示文摘从生态系统到金融市场和气候在内的很多复杂动力系统,都会有临界点,在这样的点上系统可能会发生突变,从而演变到一个对立的动力模式上。在这样的临界点到达之前对其进行预测极为困难,但是现在,不同科学领域的研究工作表明,普遍性的早期预警信号有迹可循。对一系列不同类型的系统来说,这些信号会指示是否正在趋近一个临界阈值。 | Marten Scheffer Jordi Bascompte William A. Brock Victor Brovkin Stephen R. Carpenter Vasilis Dakos Hermann Held Egbert H. van Nes Max Rietkerk George Sugihara 李迎春 闫伟 蒋长胜(译) 左玉玲(校) | 2009 | 国际地震动态2009，，9： | 2 |
| 11 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 12 | Analysis of time-series MODIS 250 m vegetation index data for crop classification in the U.S. Central Great Plains显示文摘 | Brian D. Wardlow Stephen L. Egbert Jude H. Kastens | 2006 | Remote Sensing of Environment2006，，3： | 2 |
| 13 | Clinical assessment of patients with advanced non-small-cell lung cancer eligible for second-line chemotherapy: A prognostic score from individual data of nine randomised trials显示文摘 | Massimo Di Maio Nicola Lama Alessandro Morabito Egbert F. Smit Vassilis Georgoulias Koji Takeda Elisabeth Quoix Dora Hatzidaki Floris M. Wachters Vittorio Gebbia Chun-Ming Tsai Carlos Camps Wolfgang Schuette Paolo Chiodini Maria Carmela Piccirillo Frances | 2009 | European Journal of Cancer2009，，4： | 2 |
| 14 | Microbiological screenings for infection control in unaccompanied minor refugees: the German Armed Forces Medical Service's experience显示文摘Background:The German Military Medical Service contributed to the medical screening of unaccompanied minor refugees(UMRs)coming to Germany in 2014 and 2015.In this study,a broad range of diagnostic procedures was applied to identify microorganisms with clinical or public health significance.Previously,those tests had only been used to screen soldiers returning from tropical deployments.This instance is the first time the approach has been studied in a humanitarian context.Methods:The offered screenings included blood cell counts,hepatitis B serology and microscopy of the stool to look for protozoa and worm eggs as well as PCR from stool samples targeting pathogenic bacteria,protozoa and helminths.If individuals refused certain assessments,their decision to do so was accepted.A total of 219 apparently healthy male UMRs coming from Afghanistan,Egypt,Somalia,Eritrea,Syria,Ghana,Guinea,Iran,Algeria,Iraq,Benin,Gambia,Libya,Morocco,Pakistan,and Palestine were assessed.All UMRs who were examined at the study department were included in the assessment.Results:We detected decreasing frequencies of pathogens that included diarrhoea-associated bacteria[Campylobacter(C.)jejuni,enteropathogenic Escherichia(E.)coli(EPEC),enterotoxic E.coli(ETEC),enteroaggregative E.coli(EAEC),enteroinvasive E.coli(EIEC)/Shigella spp.),Giardia(G.)duodenalis,helminths(comprising Schistosoma spp.,Hymenolepis(H.)nana,Strongyloides(S.)stercoralis]as well as hepatitis B virus.Pathogenic microorganisms dominated the samples by far.While G.duodenalis was detected in 11.4%of the assessed UMRs,the incidence of newly identified cases in the German population was 4.5 cases per 100,000 inhabitants.Conclusion:We conclude that the applied in-house PCR screening systems,which have proven to be useful for screening military returnees from tropical deployments,can also be used for health assessment of immigrants from the respective sites.Apparently healthy UMRs may be enterically colonized with a broad variety of pathogenic and apathogenic microorganisms.Increased colonization rates,as shown for G.duodenalis,can pose a hygiene problem in centralized homes for asylum seekers. | Winfried Maaβen Dorothea Wiemer Claudia Frey Christina Kreuzberg Egbert Tannich Rebecca Hinz Andreas Wille Andreas Fritsch Ralf Matthias Hagen Hagen Frickmann | 2018 | Military Medical Research2018，5，1： | 2 |
| 15 | Benign abdominal and pulmonary metastasizing leiomyoma of the uterus显示文摘 | Egberts J H Schafmayer C Bauerschlag D O | 2006 | Arch Gynecol Obstet2006，274，5： | 1 |
| 16 | Characterization of major histocompatibility complex class Ⅱ A and B genes in gynogenetic carp clone显示文摘 | Van Erp S H M Egberts E Stet R | 1996 | Immunogenetics1996，44，3： | 1 |
| 17 | Robust multiple-station magnetotelluric data processing显示文摘 | Egbert G D | 1997 | Geophysical Journal International1997，130，2： | 1 |
| 18 | Three-Dimensional Magnetotelluric Inversion:Data Space Method显示文摘 | Siripunvaraporn W Egbert G Lenbury Y et ai | 2005 | Phys Earth Planet Inter2005，150，： | 1 |
| 19 | Biological effects of oxidized phytosterols: A review of the cur- rent knowledge显示文摘 | Egbert Hovenkamp Isabelle Demonty Elke A Trautwein | 2008 | Progress in Lipid Research2008，，47： | 1 |
| 20 | Anti-Ro52 antibodies frequently co-occur with anti-Jo-1 antibodies in sera from patients with idiopathic inflammatory myopathy显示文摘 | Rutjes SA Vree Egberts WT Jongen P | | 0，，01： | 1 |
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