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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Subcutaneous cervical emphysema and pneumomediastinum due to a lower gastrointestinal tract perforation显示文摘This case report describes a 69-year-old man presen-ting with an extensive subcutaneous emphysema in his neck and generalized peritonitis caused by a lower gastrointestinal tract perforation. This case emphasizes that subcutaneous emphysema patients with negative thoracic findings should be scrutinized for signs of retroperitoneal hollow viscus perforation. | Georg B Schmidt Maarten W Bronkhorst Henk H Hartgrink Lee H Bouwman | 2008 | World Journal of Gastroenterology2008，14，24： | 6 |
| 3 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet . 2009 (9688)2009，，9688： | 4 |
| 4 | Extended lymph node dissection for gastric cancer:who may benefit?Final results of the randomized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | | 0，，11： | 3 |
| 5 | Neo-adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomised FAMTX trial 1显示文摘 | H.H Hartgrink C.J.H van de Velde H Putter I Songun M.E.T Tesselaar E.Klein Kranenbarg J.E de Vries J.A Wils J van der Bijl J.H.J.M van Krieken | 2004 | European Journal of Surgical Oncology2004，，6： | 2 |
| 6 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet2009，，9688： | 2 |
| 7 | Neo - adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomized FAMTX triM显示文摘 | Hartgrink HH van de Vetde C J Putter H | 2004 | Eur J Surg Oncol2004，30，6： | 1 |
| 8 | Status of extended lymph node dissection:Locoregional control is the only way to survive gastric cancer显示文摘 | Hartgrink HH van de Velde CJ | 2005 | J Surg Oncol2005，90，3： | 1 |
| 9 | Extended lymph node dissection for gastric cancer:who may benefit? Final results of the randomized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | 2004 | J Clini On- col2004，22，11： | 1 |
| 10 | Gastric cancer显示文摘 | Hartgrink HH Jansen EP van Grieken NC | 2009 | Lancet2009，374，9688： | 1 |
| 11 | Status of extended lymph node dissection;locoregional control is the only way to survive gastric cancer显示文摘 | Hartgrink HH van de Velde CJ | 2005 | J Surg 0ncol2005，90，3： | 1 |
| 12 | Extended lymph node dissection fro gastric cancer:who may benefit?Final results of the randomized Dutch Gastric Cancer Group Tria1显示文摘 | Hartgrink HH Velde CJ Putter H | 2004 | J Clin Oncol2004，22，11： | 1 |
| 13 | Value of palliative resection in gastric cancer显示文摘 | Hartgrink H H Putter H Klein Kranenbarg E | 2002 | Br J Surg2002，89，11： | 1 |
| 14 | Lymph nodedissection in resectable advanced gastric cancer显示文摘 | DE STEUR WO DIKKEN JL HARTGRINK HH | 2013 | Dig Surg2013，30，2： | 1 |
| 15 | Lymph node dissection in resectable advanced gastric cancer显示文摘 | de Steur WO Dikken JL Hartgrink HH | 2013 | Dig Surg2013，30，2： | 1 |
| 16 | Value of palliative resection in gastric cancer显示文摘 | Hartgrink HH Putter H Klein Kranenbarg E | 2002 | BrJ Surg2002，89，11： | 1 |
| 17 | Status of extended lymph node dis- seetion:locoregional control is the only way to survive gastric cancer 显示文摘 | Hartgrink HH van de Velde CJ | 2005 | J Surg Oncol2005，90，3： | 1 |
| 18 | Status of extendedlymph node dissection:locoregional control is the only way to survive gastric cancer显示文摘 | Hartgrink HH Van de Velde CJ | 2005 | J Surg Oncol2005，90，3： | 1 |
| 19 | The treatment of patients with gastric carcinoma based on the results of Dutch studies显示文摘 | Hartgrink HH Velde CJ | 2005 | Ned Tijdschr Geneeskd2005，149，5： | 1 |
| 20 | Should we remove splenic hilus lymph nodes for esophagogastric junction adenocarcinoma? 显示文摘 | Hartgrink HH | 2013 | Gastric Cancer2013，16，4： | 1 |
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